AR031511A1 - Metodo de separacion cromatografica de paclitaxel y cefalomanina - Google Patents

Metodo de separacion cromatografica de paclitaxel y cefalomanina

Info

Publication number
AR031511A1
AR031511A1 ARP010105483A ARP010105483A AR031511A1 AR 031511 A1 AR031511 A1 AR 031511A1 AR P010105483 A ARP010105483 A AR P010105483A AR P010105483 A ARP010105483 A AR P010105483A AR 031511 A1 AR031511 A1 AR 031511A1
Authority
AR
Argentina
Prior art keywords
paclitaxel
cephalomannin
cephalomanine
separation method
chromatographic separation
Prior art date
Application number
ARP010105483A
Other languages
English (en)
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of AR031511A1 publication Critical patent/AR031511A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Un método para separar paclitaxel de cefalomanina y otros compuestos relacionados mediante la obtencion de un material de partida que contiene paclitaxel y cefalomanina; la disolucion del material de partida en cualquiera de una cantidad de disolventes particularmente definidos como ser formiato de butilo y acetato de butilo para formar una mezcla; someter a la mezcla a cromatografía en columna para obtener una fraccion eluida de paclitaxel, una fraccion eluida de cefalomanina y un residuo; y el secado en forma separada de las fracciones de paclitaxel y cefalomanina para obtener formas cristalinas separadas de paclitaxel y cefalomanina, respectivamente.
ARP010105483A 2000-11-28 2001-11-26 Metodo de separacion cromatografica de paclitaxel y cefalomanina AR031511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/724,504 US6333419B1 (en) 2000-11-28 2000-11-28 Chromatographic separation method of paclitaxel and cephalomannin

Publications (1)

Publication Number Publication Date
AR031511A1 true AR031511A1 (es) 2003-09-24

Family

ID=24910677

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105483A AR031511A1 (es) 2000-11-28 2001-11-26 Metodo de separacion cromatografica de paclitaxel y cefalomanina

Country Status (23)

Country Link
US (1) US6333419B1 (es)
EP (1) EP1392669B1 (es)
JP (1) JP4177665B2 (es)
KR (1) KR100842457B1 (es)
CN (1) CN1187347C (es)
AR (1) AR031511A1 (es)
AT (1) ATE427305T1 (es)
AU (1) AU780761B2 (es)
CA (1) CA2398405C (es)
CZ (1) CZ304180B6 (es)
DE (1) DE60138229D1 (es)
DK (1) DK1392669T3 (es)
ES (1) ES2321160T3 (es)
HK (1) HK1050523A1 (es)
HU (1) HU229096B1 (es)
IL (2) IL150901A0 (es)
NO (1) NO328356B1 (es)
PL (1) PL202590B1 (es)
PT (1) PT1392669E (es)
RU (1) RU2276669C2 (es)
SI (1) SI1392669T1 (es)
SK (1) SK287109B6 (es)
WO (1) WO2002044162A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006014356A1 (en) * 2004-07-02 2006-02-09 Ivax Pharmaceuticals S.R.O. Process for the isolation of paclitaxel
KR20070045219A (ko) * 2004-07-02 2007-05-02 아이박스 파마슈티컬스 에스.알.오. 파클리탁셀과 세팔로마닌의 분리 방법
DE602004008903T2 (de) * 2004-07-13 2008-06-19 Indena S.P.A. Verfahren zur Gewinnung von Paclitaxel aus Taxuspflanzen
US7112687B2 (en) * 2004-07-15 2006-09-26 Indena, S.P.A. Methods for obtaining paclitaxel from taxus plants
CN102219764B (zh) * 2011-05-12 2013-06-26 河南省科学院化学研究所有限公司 一种工业化分离纯化紫杉醇的方法
KR102263764B1 (ko) * 2014-08-13 2021-06-09 주식회사 엘지생활건강 세팔로만닌 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백 또는 항염증용 화장료 또는 약학 조성물
CN104262300A (zh) * 2014-09-30 2015-01-07 江苏红豆杉药业有限公司 一种除去紫杉醇中三尖杉宁碱的方法
CN104251896B (zh) * 2014-09-30 2016-07-20 江苏红豆杉药业有限公司 一种半合成紫杉醇的检测方法
CN113512015A (zh) * 2021-05-26 2021-10-19 上海卓鼎生物技术有限公司 一种工业化提纯三尖杉宁碱的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475120A (en) 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
ATE180477T1 (de) 1991-04-19 1999-06-15 Univ Mississippi Verfahren und zubereitungen zur isolierung von taxanen
WO1997009443A1 (en) 1995-09-05 1997-03-13 Michigan State University PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
US5856532A (en) 1996-08-14 1999-01-05 Council Of Scientific & Industrial Research Process for the production of taxol
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US5969165A (en) * 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
US6002025A (en) 1999-02-24 1999-12-14 Bcm Developement Inc. Method for the purification of taxanes

Also Published As

Publication number Publication date
JP2004514715A (ja) 2004-05-20
IL150901A0 (en) 2003-02-12
US6333419B1 (en) 2001-12-25
KR100842457B1 (ko) 2008-07-01
RU2276669C2 (ru) 2006-05-20
EP1392669B1 (en) 2009-04-01
CZ304180B6 (cs) 2013-12-11
SK10922002A3 (sk) 2003-01-09
CA2398405A1 (en) 2002-06-06
NO20023555D0 (no) 2002-07-25
PL355683A1 (en) 2004-05-17
DK1392669T3 (da) 2009-05-18
SK287109B6 (sk) 2009-12-07
IL150901A (en) 2010-11-30
DE60138229D1 (de) 2009-05-14
CN1396917A (zh) 2003-02-12
NO20023555L (no) 2002-09-30
AU1908502A (en) 2002-06-11
SI1392669T1 (sl) 2009-06-30
CN1187347C (zh) 2005-02-02
CA2398405C (en) 2010-01-12
PL202590B1 (pl) 2009-07-31
ATE427305T1 (de) 2009-04-15
NO328356B1 (no) 2010-02-01
PT1392669E (pt) 2009-04-20
RU2002120482A (ru) 2004-01-10
JP4177665B2 (ja) 2008-11-05
HK1050523A1 (en) 2003-06-27
HUP0204028A2 (en) 2003-05-28
WO2002044162A1 (en) 2002-06-06
CZ20022490A3 (cs) 2002-10-16
HUP0204028A3 (en) 2004-01-28
KR20020068088A (ko) 2002-08-24
AU780761B2 (en) 2005-04-14
HU229096B1 (hu) 2013-07-29
EP1392669A1 (en) 2004-03-03
ES2321160T3 (es) 2009-06-03

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