SK287109B6 - Spôsob separácie paclitaxelu od cefalomanínu - Google Patents

Spôsob separácie paclitaxelu od cefalomanínu Download PDF

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Publication number
SK287109B6
SK287109B6 SK1092-2002A SK10922002A SK287109B6 SK 287109 B6 SK287109 B6 SK 287109B6 SK 10922002 A SK10922002 A SK 10922002A SK 287109 B6 SK287109 B6 SK 287109B6
Authority
SK
Slovakia
Prior art keywords
paclitaxel
cephalomannin
starting material
butyl
solvent
Prior art date
Application number
SK1092-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK10922002A3 (sk
Inventor
Bruno Gabetta
Gianfranco Zini
Original Assignee
Indena S. P. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S. P. A. filed Critical Indena S. P. A.
Publication of SK10922002A3 publication Critical patent/SK10922002A3/sk
Publication of SK287109B6 publication Critical patent/SK287109B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
SK1092-2002A 2000-11-28 2001-11-09 Spôsob separácie paclitaxelu od cefalomanínu SK287109B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/724,504 US6333419B1 (en) 2000-11-28 2000-11-28 Chromatographic separation method of paclitaxel and cephalomannin
PCT/EP2001/012982 WO2002044162A1 (en) 2000-11-28 2001-11-09 Chromatographic separation method of paclitaxel and cephalomannin

Publications (2)

Publication Number Publication Date
SK10922002A3 SK10922002A3 (sk) 2003-01-09
SK287109B6 true SK287109B6 (sk) 2009-12-07

Family

ID=24910677

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1092-2002A SK287109B6 (sk) 2000-11-28 2001-11-09 Spôsob separácie paclitaxelu od cefalomanínu

Country Status (23)

Country Link
US (1) US6333419B1 (es)
EP (1) EP1392669B1 (es)
JP (1) JP4177665B2 (es)
KR (1) KR100842457B1 (es)
CN (1) CN1187347C (es)
AR (1) AR031511A1 (es)
AT (1) ATE427305T1 (es)
AU (1) AU780761B2 (es)
CA (1) CA2398405C (es)
CZ (1) CZ304180B6 (es)
DE (1) DE60138229D1 (es)
DK (1) DK1392669T3 (es)
ES (1) ES2321160T3 (es)
HK (1) HK1050523A1 (es)
HU (1) HU229096B1 (es)
IL (2) IL150901A0 (es)
NO (1) NO328356B1 (es)
PL (1) PL202590B1 (es)
PT (1) PT1392669E (es)
RU (1) RU2276669C2 (es)
SI (1) SI1392669T1 (es)
SK (1) SK287109B6 (es)
WO (1) WO2002044162A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1765802E (pt) * 2004-07-02 2008-11-25 Ivax Pharmaceuticals Sro Processo para isolamento de paclitaxel
ES2320471T3 (es) * 2004-07-02 2009-05-22 Ivax Pharmaceuticals S.R.O. Procedimiento para la separacion de paclitaxel y cefalomanina.
DE602004008903T2 (de) * 2004-07-13 2008-06-19 Indena S.P.A. Verfahren zur Gewinnung von Paclitaxel aus Taxuspflanzen
US7112687B2 (en) * 2004-07-15 2006-09-26 Indena, S.P.A. Methods for obtaining paclitaxel from taxus plants
CN102219764B (zh) * 2011-05-12 2013-06-26 河南省科学院化学研究所有限公司 一种工业化分离纯化紫杉醇的方法
KR102263764B1 (ko) * 2014-08-13 2021-06-09 주식회사 엘지생활건강 세팔로만닌 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백 또는 항염증용 화장료 또는 약학 조성물
CN104262300A (zh) * 2014-09-30 2015-01-07 江苏红豆杉药业有限公司 一种除去紫杉醇中三尖杉宁碱的方法
CN104251896B (zh) * 2014-09-30 2016-07-20 江苏红豆杉药业有限公司 一种半合成紫杉醇的检测方法
CN113512015A (zh) * 2021-05-26 2021-10-19 上海卓鼎生物技术有限公司 一种工业化提纯三尖杉宁碱的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475120A (en) 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
JP3222466B2 (ja) 1991-04-19 2001-10-29 ザ・ユニバーシティ・オブ・ミシシッピー タクサン類を単離するための方法および組成物
WO1997009443A1 (en) 1995-09-05 1997-03-13 Michigan State University PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
US5856532A (en) 1996-08-14 1999-01-05 Council Of Scientific & Industrial Research Process for the production of taxol
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US5969165A (en) * 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
US6002025A (en) 1999-02-24 1999-12-14 Bcm Developement Inc. Method for the purification of taxanes

Also Published As

Publication number Publication date
RU2276669C2 (ru) 2006-05-20
IL150901A (en) 2010-11-30
CZ304180B6 (cs) 2013-12-11
KR100842457B1 (ko) 2008-07-01
NO328356B1 (no) 2010-02-01
JP4177665B2 (ja) 2008-11-05
CA2398405A1 (en) 2002-06-06
ES2321160T3 (es) 2009-06-03
RU2002120482A (ru) 2004-01-10
AU780761B2 (en) 2005-04-14
DE60138229D1 (de) 2009-05-14
HK1050523A1 (en) 2003-06-27
PT1392669E (pt) 2009-04-20
HUP0204028A3 (en) 2004-01-28
SK10922002A3 (sk) 2003-01-09
CN1187347C (zh) 2005-02-02
SI1392669T1 (sl) 2009-06-30
DK1392669T3 (da) 2009-05-18
AR031511A1 (es) 2003-09-24
CZ20022490A3 (cs) 2002-10-16
PL202590B1 (pl) 2009-07-31
EP1392669A1 (en) 2004-03-03
IL150901A0 (en) 2003-02-12
JP2004514715A (ja) 2004-05-20
EP1392669B1 (en) 2009-04-01
AU1908502A (en) 2002-06-11
HUP0204028A2 (en) 2003-05-28
NO20023555L (no) 2002-09-30
HU229096B1 (hu) 2013-07-29
US6333419B1 (en) 2001-12-25
PL355683A1 (en) 2004-05-17
NO20023555D0 (no) 2002-07-25
CA2398405C (en) 2010-01-12
CN1396917A (zh) 2003-02-12
KR20020068088A (ko) 2002-08-24
ATE427305T1 (de) 2009-04-15
WO2002044162A1 (en) 2002-06-06

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US5380916A (en) Method for the isolation and purification of taxane derivatives
US5969165A (en) Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
KR100315495B1 (ko) 항종양활성을갖는탁산
AU760242B2 (en) Method for high yield extraction of paclitaxel from paclitaxel-containing material
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SK287109B6 (sk) Spôsob separácie paclitaxelu od cefalomanínu
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US6229027B1 (en) Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin IV
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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20201109