CY1105650T1 - ΝΕΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΚΑΙ ΠΟΛΥΠΕΠΤΙΔΙΑ ΤΟΥ ΓΟΝΙΔΙΟΥ IFNα-21 - Google Patents

ΝΕΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΚΑΙ ΠΟΛΥΠΕΠΤΙΔΙΑ ΤΟΥ ΓΟΝΙΔΙΟΥ IFNα-21

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Publication number
CY1105650T1
CY1105650T1 CY20061101442T CY061101442T CY1105650T1 CY 1105650 T1 CY1105650 T1 CY 1105650T1 CY 20061101442 T CY20061101442 T CY 20061101442T CY 061101442 T CY061101442 T CY 061101442T CY 1105650 T1 CY1105650 T1 CY 1105650T1
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Cyprus
Prior art keywords
ifnα
gene
polypeptides
novel
new polynucleotides
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CY20061101442T
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English (en)
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Jean-Louis Escary
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Genodyssee
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Publication of CY1105650T1 publication Critical patent/CY1105650T1/el

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Abstract

Η παρούσα εφεύρεση σχετίζεται με νέα πολυνουκλεοτίδια που προέρχονται από την αλληλουχία νουκλεοτιδίων του γονιδίου IFNα-21 που περιλαμβάνουν νέους SNP (Single Nucleotide Polymorphisms - πολυμορφισμοί ενός νουκλεοτιδίου), και με νέα πολυπεπτίδια που προέρχονται από την φυσική πρωτεΐνη IFNα-21 άγριου τύπου που περιλαμβάνουν τουλάχιστον μία μετάλλαξη που προκαλείται από τουλάχιστον έναν SNP της εφεύρεσης, όπως επίσης και με τις θεραπευτικές χρήσεις τους.
CY20061101442T 2001-03-30 2006-10-06 ΝΕΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΚΑΙ ΠΟΛΥΠΕΠΤΙΔΙΑ ΤΟΥ ΓΟΝΙΔΙΟΥ IFNα-21 CY1105650T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104404A FR2822845B1 (fr) 2001-03-30 2001-03-30 Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
PCT/EP2002/004082 WO2002079249A2 (en) 2001-03-30 2002-03-29 New polynucleotides and polypeptides of the ifn$g(a)-21 gene

Publications (1)

Publication Number Publication Date
CY1105650T1 true CY1105650T1 (el) 2010-12-22

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CY20061101442T CY1105650T1 (el) 2001-03-30 2006-10-06 ΝΕΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΚΑΙ ΠΟΛΥΠΕΠΤΙΔΙΑ ΤΟΥ ΓΟΝΙΔΙΟΥ IFNα-21

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US (2) US7402305B2 (el)
EP (1) EP1379695B1 (el)
JP (1) JP2005503121A (el)
KR (1) KR20030093292A (el)
CN (1) CN1531600A (el)
AT (1) ATE333520T1 (el)
AU (1) AU2002257777B2 (el)
CA (1) CA2442775A1 (el)
CY (1) CY1105650T1 (el)
DE (1) DE60213221T2 (el)
DK (1) DK1379695T3 (el)
ES (1) ES2268023T3 (el)
FR (1) FR2822845B1 (el)
IL (1) IL158159A0 (el)
PT (1) PT1379695E (el)
WO (1) WO2002079249A2 (el)
ZA (1) ZA200307578B (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899770B1 (en) 1999-03-04 2005-05-31 Henkel Corporation Composition and process for treating metal surfaces
EP1351707B9 (en) * 2001-01-09 2012-01-25 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
FR2822845B1 (fr) * 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
EP1418428A1 (en) * 2002-11-07 2004-05-12 GenOdyssee Method to provide natural therapeutic agents with high therapeutic index
KR101363120B1 (ko) * 2005-02-10 2014-02-13 베일러 리서치 인스티튜트 항-인터페론 알파 모노클로날 항체 및 사용 방법
US7888481B2 (en) * 2005-02-10 2011-02-15 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
BRPI0912570B8 (pt) * 2008-05-07 2021-05-25 Argos Therapeutics Inc anticorpo anti-ifn-alfa humanizado, ou um fragmento de ligação ao antígeno do mesmo, composição terapêutica e seus usos
WO2013032883A2 (en) * 2011-08-26 2013-03-07 Ottawa Heart Institute Research Corporation Methods of detecting and treating cardiovascular diseases
CN102584980B (zh) * 2012-02-23 2013-11-20 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN102584981B (zh) * 2012-02-23 2013-08-28 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN103554246B (zh) * 2012-02-23 2015-04-01 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CN103467592B (zh) * 2012-02-23 2014-11-19 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CA3115089A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
TW202021986A (zh) 2018-10-11 2020-06-16 美商英伊布里克斯公司 5t4單域抗體及其治療性組合物
CN113166261A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 B7h3单域抗体及其治疗性组合物
JP7453219B2 (ja) 2018-10-11 2024-03-19 インヒブリックス， インコーポレイテッド Ｐｄ－１単一ドメイン抗体およびその治療用組成物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH657141A5 (de) 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
US6610830B1 (en) * 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
US4801685A (en) * 1981-08-14 1989-01-31 Hoffmann-La Roche Inc. Microbial production of mature human leukocyte interferon K and L
CA1217440A (en) * 1982-08-18 1987-02-03 Michael A. Innis INTERFERON .alpha. 6L
JPS6156199A (ja) 1984-08-27 1986-03-20 Shionogi & Co Ltd 新規ヒトインタ−フエロンα類
US6299887B1 (en) * 1995-02-24 2001-10-09 Kao Corporation Phosphoric triesters and external compositions containing the same
JP2001526033A (ja) * 1997-12-08 2001-12-18 ジェネンテク・インコーポレイテッド ヒトインターフェロン−イプシロンというｉ型インターフェロン
EP1140144A4 (en) * 1998-12-31 2002-10-30 Viragen Inc METHODS AND COMPOSITION OF EXTREMELY PURIFIED NATURAL MIXTURES OF TYPE I INTERFERONS DERIVED FROM LEUCOCYTES
CN1451045A (zh) * 1999-10-07 2003-10-22 马克西根公司 IFN－α同系物
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
FR2821625B1 (fr) * 2001-03-01 2003-05-16 Genodyssee Nouveaux polynucleotides comportant un polymorphisme de type snp fonctionnel dans la sequence nucleotidique du gene ifn-alpha-2 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2822845B1 (fr) * 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) * 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2823764B1 (fr) * 2001-04-24 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides du gene ifn alpha-17
FR2824333B1 (fr) * 2001-05-03 2003-08-08 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 5
FR2825102B1 (fr) * 2001-05-23 2003-08-29 Genodyssee Nouveaux polynucleotides et polypeptides de l'interferon alpha 14
FR2825716B1 (fr) * 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
EP1418428A1 (en) * 2002-11-07 2004-05-12 GenOdyssee Method to provide natural therapeutic agents with high therapeutic index

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FR2822845B1 (fr) 2003-12-12
US20040132139A1 (en) 2004-07-08
ATE333520T1 (de) 2006-08-15
DK1379695T3 (da) 2006-11-20
WO2002079249A2 (en) 2002-10-10
WO2002079249A3 (en) 2003-11-20
ZA200307578B (en) 2005-04-20
CA2442775A1 (en) 2002-10-10
KR20030093292A (ko) 2003-12-06
JP2005503121A (ja) 2005-02-03
IL158159A0 (en) 2004-03-28
EP1379695B1 (en) 2006-07-19
AU2002257777B2 (en) 2007-12-20
DE60213221T2 (de) 2007-06-06
US7402305B2 (en) 2008-07-22
US20080299081A1 (en) 2008-12-04
CN1531600A (zh) 2004-09-22
PT1379695E (pt) 2006-12-29
DE60213221D1 (de) 2006-08-31
ES2268023T3 (es) 2007-03-16
FR2822845A1 (fr) 2002-10-04
EP1379695A2 (en) 2004-01-14

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