CY1105415T1 - Οροδιασπειρομενη φαρμακευτικη συνθεση αγομελατινης - Google Patents

Οροδιασπειρομενη φαρμακευτικη συνθεση αγομελατινης

Info

Publication number
CY1105415T1
CY1105415T1 CY20061100898T CY061100898T CY1105415T1 CY 1105415 T1 CY1105415 T1 CY 1105415T1 CY 20061100898 T CY20061100898 T CY 20061100898T CY 061100898 T CY061100898 T CY 061100898T CY 1105415 T1 CY1105415 T1 CY 1105415T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical composition
serum
agomelatin
dispersable
agomelatine
Prior art date
Application number
CY20061100898T
Other languages
English (en)
Inventor
Patrick Wuthrich
Herve Rolland
Marc Julien
Francois Tharrault
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1105415T1 publication Critical patent/CY1105415T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Abstract

Η εφεύρεση έχει ως αντικείμενο μια στερεά οροδιασπειρόμενη φαρμακευτική σύνθεση αγομελατίνης η οποία χαρακτηρίζεται από το ότι περιέχει αγομελατίνη και κόκκους αποτελούμενους από λακτόζη και άμυλο ξηρανθέντα από κοινού.
CY20061100898T 2002-01-23 2006-06-30 Οροδιασπειρομενη φαρμακευτικη συνθεση αγομελατινης CY1105415T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0200792A FR2834890B1 (fr) 2002-01-23 2002-01-23 Composition pharmaceutique orodispersible d'agomelatine
PCT/FR2003/000197 WO2003061644A1 (fr) 2002-01-23 2003-01-22 Composition pharmaceutique orodispersible d’agomelatine

Publications (1)

Publication Number Publication Date
CY1105415T1 true CY1105415T1 (el) 2010-04-28

Family

ID=27589556

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100898T CY1105415T1 (el) 2002-01-23 2006-06-30 Οροδιασπειρομενη φαρμακευτικη συνθεση αγομελατινης

Country Status (28)

Country Link
US (2) US20050131071A1 (el)
EP (1) EP1467724B1 (el)
JP (2) JP4335011B2 (el)
KR (1) KR100605798B1 (el)
CN (1) CN1287780C (el)
AR (1) AR038207A1 (el)
AT (1) ATE324882T1 (el)
AU (1) AU2003220786B2 (el)
BR (1) BRPI0307072B1 (el)
CA (1) CA2473201C (el)
CY (1) CY1105415T1 (el)
DE (1) DE60304993T2 (el)
DK (1) DK1467724T3 (el)
EA (1) EA007299B1 (el)
ES (1) ES2262999T3 (el)
FR (1) FR2834890B1 (el)
GE (1) GEP20063818B (el)
HK (1) HK1076742A1 (el)
MA (1) MA27101A1 (el)
MX (1) MXPA04007198A (el)
NO (1) NO333712B1 (el)
NZ (1) NZ533843A (el)
PL (1) PL204937B1 (el)
PT (1) PT1467724E (el)
SI (1) SI1467724T1 (el)
UA (1) UA77752C2 (el)
WO (1) WO2003061644A1 (el)
ZA (1) ZA200405153B (el)

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* Cited by examiner, † Cited by third party
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FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
US20030228370A1 (en) * 2002-06-11 2003-12-11 Michel Serpelloni Orodispersible solid pharmaceutical form
AR047553A1 (es) * 2003-07-04 2006-01-25 Lundbeck & Co As H La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina
FR2884714B1 (fr) * 2005-04-20 2011-05-06 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles bipolaires
FR2890564B1 (fr) * 2005-09-09 2007-10-19 Servier Lab Nouvelle association entre l'agomelatine et un inhibiteur de la recapture de la noradrenaline et les compositions pharmaceutiques qui la contiennent
FR2890562B1 (fr) * 2005-09-09 2012-10-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime
FR2894475B1 (fr) * 2005-12-14 2008-05-16 Servier Lab Composition pharmaceutique orodispersible pour administra- -tion oromucosale ou sublinguale d'agomelatine
CA2644905A1 (en) * 2006-03-06 2007-09-13 Teva Pharmaceutical Industries Ltd. Ezetimibe compositions
CN101206200B (zh) * 2006-12-19 2011-12-28 北京德众万全药物技术开发有限公司 一种分离分析阿戈美拉汀中间体及其终产品的hplc方法
AU2008247805A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphthyl(ethyl) acetamides
EP2359813A1 (en) * 2010-02-04 2011-08-24 Ratiopharm GmbH Pharmaceutical composition comprising N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamid
CN101836966A (zh) * 2010-05-27 2010-09-22 北京万全阳光医药科技有限公司 一种含有阿戈美拉汀的口腔崩解片
CN102579415B (zh) * 2011-01-14 2014-11-05 成都康弘药业集团股份有限公司 一种含有阿戈美拉汀的口腔粘膜或舌下给药的药物组合物
US8426461B2 (en) 2011-01-17 2013-04-23 Takeda Pharmaceutical Company Limited Orally dispersible tablet
BR112013017600A2 (pt) 2011-01-17 2016-10-18 Takeda Pharmaceutical preparação para desintegração rápida, método para produzir uma preparação para desintegração rápida, preparação para absorção pela mucosa oral, método e droga para a profilaxia e / ou tratamento de um distúrbio bipolar, e, composto
WO2012130837A1 (en) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Solid agomelatine in non-crystalline form
FR2978916B1 (fr) * 2011-08-10 2013-07-26 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
EP2562151A1 (en) * 2011-08-25 2013-02-27 Dr. Reddy's Laboratories Ltd. Processes for the preparation of agomelatine and its intermediates
JP6061924B2 (ja) 2011-10-14 2017-01-18 武田薬品工業株式会社 口腔内分散性製剤
CN103169669B (zh) * 2011-12-26 2015-06-17 中国人民解放军军事医学科学院毒物药物研究所 阿戈美拉汀包衣微丸以及可在口中分散的药物组合物
EP2872129B1 (en) 2012-07-16 2017-03-08 ratiopharm GmbH Complex of agomelatine and cyclodextrin
CN102988315B (zh) * 2012-09-28 2017-11-17 浙江华海药业股份有限公司 阿戈美拉汀固体制剂的制备方法
FR3001894A1 (fr) * 2013-02-08 2014-08-15 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
PT2810656T (pt) 2013-06-06 2017-11-13 Zentiva As Formulações de agomelatina compreendendo agomelatina na forma de cocristais
EP2810647A1 (en) 2013-06-06 2014-12-10 Zentiva, a.s. Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid
CN103816129B (zh) * 2014-02-27 2020-04-28 浙江华海药业股份有限公司 阿戈美拉汀口崩片
CN104586797A (zh) * 2015-01-05 2015-05-06 万特制药(海南)有限公司 阿戈美拉汀分散片及其制备方法
CN106333929A (zh) * 2016-09-24 2017-01-18 万特制药(海南)有限公司 一种含有阿戈美拉汀的分散片及其制备方法

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DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
DE3506276C1 (de) * 1985-02-22 1986-04-24 Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring Direkttablettiermittel
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2710265B1 (fr) * 1993-09-22 1995-10-20 Adir Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs.
NZ278678A (en) * 1994-01-31 1998-03-25 Yamanouchi Pharma Co Ltd Compressed moulded tablet with quick disintegration/dissolution in the mouth, mixture of low and high moldable saccharides as carriers
EP0906089B1 (en) * 1996-05-13 2003-08-27 Novartis Consumer Health S.A. Buccal delivery system
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
CA2322315C (en) * 1998-03-06 2008-09-16 Eurand International S.P.A. Fast disintegrating tablets
JP2000273039A (ja) * 1999-01-20 2000-10-03 Taisho Pharmaceut Co Ltd 口腔内崩壊性組成物
ATE371439T1 (de) * 2000-07-27 2007-09-15 Roquette Freres Granulat bestehend aus stärke und laktose
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible

Also Published As

Publication number Publication date
DE60304993D1 (de) 2006-06-08
JP2009137994A (ja) 2009-06-25
JP2005523253A (ja) 2005-08-04
EA007299B1 (ru) 2006-08-25
WO2003061644A1 (fr) 2003-07-31
UA77752C2 (uk) 2007-01-15
BR0307072A (pt) 2004-12-28
MA27101A1 (fr) 2004-12-20
EP1467724B1 (fr) 2006-05-03
ES2262999T3 (es) 2006-12-01
PL204937B1 (pl) 2010-02-26
NO20043441L (no) 2004-08-18
KR20040075102A (ko) 2004-08-26
JP4335011B2 (ja) 2009-09-30
CN1622804A (zh) 2005-06-01
DE60304993T2 (de) 2007-01-18
NZ533843A (en) 2005-08-26
AR038207A1 (es) 2005-01-05
ZA200405153B (en) 2005-08-31
SI1467724T1 (sl) 2006-08-31
NO333712B1 (no) 2013-09-02
US20100260840A1 (en) 2010-10-14
MXPA04007198A (es) 2004-10-29
AU2003220786B2 (en) 2007-08-02
GEP20063818B (en) 2006-05-10
CA2473201C (fr) 2010-08-17
HK1076742A1 (en) 2006-01-27
KR100605798B1 (ko) 2006-08-01
FR2834890A1 (fr) 2003-07-25
EP1467724A1 (fr) 2004-10-20
EA200400928A1 (ru) 2004-12-30
FR2834890B1 (fr) 2004-02-27
CN1287780C (zh) 2006-12-06
DK1467724T3 (da) 2006-08-28
PT1467724E (pt) 2006-08-31
PL370160A1 (en) 2005-05-16
US20050131071A1 (en) 2005-06-16
BRPI0307072B1 (pt) 2017-05-02
ATE324882T1 (de) 2006-06-15
CA2473201A1 (fr) 2003-07-31

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