CS479187A2 - Process for preparing derivatives of 2-brom-alpha-ergo-cryptine - Google Patents

Process for preparing derivatives of 2-brom-alpha-ergo-cryptine

Info

Publication number
CS479187A2
CS479187A2 CS874791A CS479187A CS479187A2 CS 479187 A2 CS479187 A2 CS 479187A2 CS 874791 A CS874791 A CS 874791A CS 479187 A CS479187 A CS 479187A CS 479187 A2 CS479187 A2 CS 479187A2
Authority
CS
Czechoslovakia
Prior art keywords
cryptine
ergo
brom
alpha
preparing derivatives
Prior art date
Application number
CS874791A
Other languages
English (en)
Other versions
CS264295B2 (en
Inventor
Gabor Dr Ing Megyeri
Tibor Dr Keve
Lajos Ing Kovacs
Bela Dr Stefko
Erik Ing Bogsch
Anna Kassai
Ferenc Dr Trischler
Gabor Dr Ing Szepesi
Maria Dr Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS479187A2 publication Critical patent/CS479187A2/cs
Publication of CS264295B2 publication Critical patent/CS264295B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS874791A 1986-06-27 1987-06-26 Process for preparing derivatives of 2-brom-alpha-ergo-cryptine CS264295B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862690A HU196394B (en) 1986-06-27 1986-06-27 Process for preparing 2-halogenated ergoline derivatives

Publications (2)

Publication Number Publication Date
CS479187A2 true CS479187A2 (en) 1988-09-16
CS264295B2 CS264295B2 (en) 1989-06-13

Family

ID=10960659

Family Applications (1)

Application Number Title Priority Date Filing Date
CS874791A CS264295B2 (en) 1986-06-27 1987-06-26 Process for preparing derivatives of 2-brom-alpha-ergo-cryptine

Country Status (19)

Country Link
US (1) US4816587A (cs)
EP (1) EP0251732B1 (cs)
JP (1) JPH085879B2 (cs)
AR (1) AR243194A1 (cs)
AT (1) ATE88705T1 (cs)
AU (1) AU597673B2 (cs)
BG (1) BG48811A3 (cs)
CA (1) CA1301163C (cs)
CS (1) CS264295B2 (cs)
DD (1) DD264430A5 (cs)
DE (1) DE3785613T2 (cs)
DK (1) DK328687A (cs)
ES (1) ES2054672T3 (cs)
FI (1) FI89048C (cs)
HU (1) HU196394B (cs)
PL (1) PL151562B1 (cs)
SU (1) SU1528320A3 (cs)
UA (1) UA5571A1 (cs)
YU (1) YU46557B (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) * 1990-10-20 1992-04-23 Sandoz Ag Neue ergolinderivate, ihre herstellung und verwendung
AU688751B2 (en) * 1993-01-12 1998-03-19 Biogen Idec Ma Inc. Recombinant anti-VLA4 antibody molecules
US20030157642A1 (en) * 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US6521421B1 (en) * 1997-07-16 2003-02-18 Genencor International, Inc. Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6316241B1 (en) * 1997-11-20 2001-11-13 Genencor International, Inc. Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) * 1998-11-24 2000-12-29 Aventis Laboratoire Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
AU2002258525A1 (en) * 2001-03-13 2002-09-24 Sierra Sciences, Inc. Telomerase expression repressor proteins and methods of using the same
DK1411962T3 (da) 2001-03-15 2011-04-04 Neogenix Oncology Inc Terapi for pancreacancer med monoklonalt stof
JP3708942B2 (ja) 2001-07-02 2005-10-19 積水化学工業株式会社 測定試薬用担体粒子ラテックス及び測定試薬
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) * 2004-09-15 2006-04-20 Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР") СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
ES2805873T3 (es) 2010-04-16 2021-02-15 Biogen Ma Inc Anticuerpos anti-VLA-4
KR101889111B1 (ko) 2010-06-11 2018-08-16 바스프 에스이 유기 첨가제를 포함하는 레이저-투명 ｐｂｔ
US8889768B2 (en) 2010-06-11 2014-11-18 Basf Se Laser-transparent PBT with organic additives
CN105560244B (zh) * 2014-10-10 2019-01-11 上海交通大学 一种γ-分泌酶抑制剂及其应用
MX388142B (es) 2014-11-19 2025-03-19 Axon Neuroscience Se Anticuerpos tau humanizados en enfermedad de alzheimer.
EP3470842B1 (en) 2016-06-14 2021-05-12 Denka Company Limited Membrane carrier for liquid sample test kit, liquid sample test kit, and method for producing liquid sample test kit
ES2923402T3 (es) 2017-03-28 2022-09-27 Denka Company Ltd Soporte de membrana y kit para probar muestra líquida usando el mismo
ES2912613T3 (es) 2017-03-28 2022-05-26 Denka Company Ltd Soporte de membrana, kit para probar una muestra líquida usando el mismo, y método de fabricación del mismo
KR102848349B1 (ko) 2018-06-04 2025-08-21 바이오젠 엠에이 인코포레이티드 감소된 효과기 기능을 갖는 항-ｖｌａ-4 항체
JP2025517241A (ja) * 2022-05-12 2025-06-03 ザ フロリダ ステート ユニバーシティ リサーチファウンデーション インコーポレイテッド リセルグ酸誘導体及び方法
US20240228479A1 (en) * 2022-12-31 2024-07-11 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
US3992422A (en) * 1975-08-14 1976-11-16 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) * 1978-09-26 1985-04-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

Also Published As

Publication number Publication date
HU196394B (en) 1988-11-28
PL151562B1 (en) 1990-09-28
PL266477A1 (en) 1988-07-21
BG48811A3 (bg) 1991-05-15
JPH085879B2 (ja) 1996-01-24
DE3785613D1 (de) 1993-06-03
YU46557B (sh) 1993-11-16
JPS6314783A (ja) 1988-01-21
FI89048C (fi) 1993-08-10
DK328687D0 (da) 1987-06-26
EP0251732A3 (en) 1989-05-10
CS264295B2 (en) 1989-06-13
DE3785613T2 (de) 1993-08-12
ES2054672T3 (es) 1994-08-16
FI89048B (fi) 1993-04-30
AU7476387A (en) 1988-01-07
SU1528320A3 (ru) 1989-12-07
DK328687A (da) 1987-12-28
US4816587A (en) 1989-03-28
HUT44541A (en) 1988-03-28
YU119987A (en) 1988-06-30
ATE88705T1 (de) 1993-05-15
EP0251732A2 (en) 1988-01-07
DD264430A5 (de) 1989-02-01
EP0251732B1 (en) 1993-04-28
FI872852L (fi) 1987-12-28
UA5571A1 (uk) 1994-12-28
CA1301163C (en) 1992-05-19
AU597673B2 (en) 1990-06-07
FI872852A0 (fi) 1987-06-26
AR243194A1 (es) 1993-07-30

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