CS247073B2 - Production method of 2-substituted 4-amino-6,7-dimethoxyghinolins - Google Patents

Production method of 2-substituted 4-amino-6,7-dimethoxyghinolins Download PDF

Info

Publication number
CS247073B2
CS247073B2 CS835509A CS550983A CS247073B2 CS 247073 B2 CS247073 B2 CS 247073B2 CS 835509 A CS835509 A CS 835509A CS 550983 A CS550983 A CS 550983A CS 247073 B2 CS247073 B2 CS 247073B2
Authority
CS
Czechoslovakia
Prior art keywords
group
formula
alkyl
dimethoxy
benzyl
Prior art date
Application number
CS835509A
Other languages
Czech (cs)
English (en)
Inventor
Simon F Campbell
John D Hardstone
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS247073B2 publication Critical patent/CS247073B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195Radicals derived from nitrogen analogues of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
CS835509A 1982-07-24 1983-07-22 Production method of 2-substituted 4-amino-6,7-dimethoxyghinolins CS247073B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8221457 1982-07-24

Publications (1)

Publication Number Publication Date
CS247073B2 true CS247073B2 (en) 1986-11-13

Family

ID=10531886

Family Applications (1)

Application Number Title Priority Date Filing Date
CS835509A CS247073B2 (en) 1982-07-24 1983-07-22 Production method of 2-substituted 4-amino-6,7-dimethoxyghinolins

Country Status (26)

Country Link
US (3) US4656174A (hu)
EP (1) EP0100200B1 (hu)
JP (1) JPS5933264A (hu)
KR (1) KR880001315B1 (hu)
AU (1) AU548036B2 (hu)
CA (1) CA1255670A (hu)
CS (1) CS247073B2 (hu)
DD (1) DD211555A5 (hu)
DE (1) DE3371336D1 (hu)
DK (1) DK166821B1 (hu)
ES (1) ES8504131A1 (hu)
FI (1) FI78296C (hu)
GR (1) GR79603B (hu)
HK (1) HK32289A (hu)
HU (1) HU190907B (hu)
IE (1) IE55798B1 (hu)
IL (1) IL69311A (hu)
NO (1) NO171594C (hu)
NZ (1) NZ204996A (hu)
PH (1) PH19424A (hu)
PL (1) PL139498B1 (hu)
PT (1) PT77082B (hu)
SG (1) SG6489G (hu)
SU (2) SU1251801A3 (hu)
YU (1) YU42628B (hu)
ZA (1) ZA835355B (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
GB8716972D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Treatment of cardiac arrhythmias
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US4882337A (en) * 1988-08-12 1989-11-21 Pfizer Inc. Tetrahydroisoquinoline antiarrhythmic agents
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
TW304945B (hu) * 1992-06-27 1997-05-11 Hoechst Ag
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
NZ325248A (en) 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
YU49898A (sh) 1996-05-10 2000-03-21 Icos Corporation Hemijska jedinjenja
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
MXPA03000458A (es) 2000-07-20 2004-06-02 Neurogen Corp Ligandos receptores de capsaicina.
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
EP1178036A1 (en) * 2000-08-04 2002-02-06 Aventis Cropscience S.A. Fungicidal phenylimidate derivatives
US6900220B2 (en) 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
KR100420663B1 (ko) * 2001-01-09 2004-03-02 주식회사 켐온 퀴놀린 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
US6734303B2 (en) 2001-05-18 2004-05-11 Pfizer Inc. Process for the production of quinazolines
US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
CN102743382B (zh) * 2005-09-19 2016-12-07 诺伊罗纳森特公司 刺激神经形成和抑制神经元变性的方法和组合物
AU2013211455B2 (en) * 2005-09-19 2017-12-07 Neuronascent, Inc. Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
EP2101772B1 (en) * 2006-12-06 2012-04-25 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
ES2584702T3 (es) 2012-06-20 2016-09-28 Novartis Ag Moduladores de ruta del complemento y usos de los mismos
TWI649308B (zh) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB890533A (en) * 1959-11-09 1962-03-07 Allen & Hanburys Ltd Improvements in or relating to heterocyclic quaternary ammonium salts
CH414637A (de) * 1962-08-31 1966-06-15 Geigy Ag J R Verfahren zur Herstellung von Carbostyrilderivaten
US3272824A (en) * 1962-12-06 1966-09-13 Norwich Pharma Co 4-amino-6, 7-di(lower) alkoxyquinolines
US3542785A (en) * 1967-05-15 1970-11-24 Ciba Geigy Corp 2-hydroxy-4-aryl-quinolines
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3629418A (en) * 1969-02-14 1971-12-21 Miles Lab Process for producing an anti-depressant effect with piperazine quinolines
GB1383409A (en) * 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
JPS54125688A (en) * 1978-02-27 1979-09-29 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative*its manufacture and antihypertensive drug
JPS5480372A (en) * 1977-12-12 1979-06-27 Toray Ind Inc Production of fishing rod made of carbon fiber-reinforced resin
JPS54122283A (en) * 1978-03-13 1979-09-21 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS54128582A (en) * 1978-03-30 1979-10-05 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
US4287341A (en) * 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
DE3034001A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Also Published As

Publication number Publication date
FI832658A0 (fi) 1983-07-21
IL69311A (en) 1987-01-30
ZA835355B (en) 1984-05-30
DD211555A5 (de) 1984-07-18
US4758568A (en) 1988-07-19
HU190907B (en) 1986-12-28
HK32289A (en) 1989-04-28
SU1251801A3 (ru) 1986-08-15
CA1255670A (en) 1989-06-13
GR79603B (hu) 1984-10-31
YU157283A (en) 1986-02-28
SU1340589A3 (ru) 1987-09-23
AU548036B2 (en) 1985-11-21
IE55798B1 (en) 1991-01-16
PT77082B (en) 1986-04-11
NO832688L (no) 1984-01-25
FI78296C (fi) 1989-07-10
YU42628B (en) 1988-10-31
SG6489G (en) 1989-06-09
KR840005428A (ko) 1984-11-12
KR880001315B1 (ko) 1988-07-23
PT77082A (en) 1983-08-01
FI78296B (fi) 1989-03-31
DE3371336D1 (en) 1987-06-11
US4686228A (en) 1987-08-11
FI832658A (fi) 1984-01-25
EP0100200B1 (en) 1987-05-06
IE831730L (en) 1984-01-24
NO171594C (no) 1993-04-07
EP0100200A1 (en) 1984-02-08
JPS5933264A (ja) 1984-02-23
PH19424A (en) 1986-04-15
AU1722283A (en) 1984-01-26
DK166821B1 (da) 1993-07-19
IL69311A0 (en) 1983-11-30
ES524320A0 (es) 1985-04-16
JPH0219112B2 (hu) 1990-04-27
DK337383A (da) 1984-01-25
US4656174A (en) 1987-04-07
PL139498B1 (en) 1987-01-31
PL243131A1 (en) 1984-12-17
NZ204996A (en) 1986-05-09
NO171594B (no) 1992-12-28
ES8504131A1 (es) 1985-04-16
DK337383D0 (da) 1983-07-22

Similar Documents

Publication Publication Date Title
CS247073B2 (en) Production method of 2-substituted 4-amino-6,7-dimethoxyghinolins
US4430343A (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
JPS6072891A (ja) ピリミド〔4,5−g〕キノリンおよびその製造中間体
US5654309A (en) Pyridopyrimidine derivatives, their production and use
EP0385237A2 (en) 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same
JPH05508660A (ja) ジアリールメチルピペリジンまたはピペラジンのピリジンおよびピリジンn−オキシド誘導体、並びにそれらの組成物および使用方法
US5041443A (en) Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
CA1168232A (en) Isoquinoline derivatives, a process for their preparation, pharmaceutical formulations containing them and their use
EP0198456B1 (en) 1,7-naphthyridine derivatives and medicinal preparations containing same
CS241549B2 (en) Method of 1,4-dihydropyridines production
KR20100031610A (ko) 아데노신 A3 수용체 리간드로서의 트리아졸로[1,5-a]퀴놀린
IE65125B1 (en) Imidazopyridine PAF/H1 antagonists
PL151696B1 (en) Method of obtaining derivatives of quinolone
US4243666A (en) 4-Amino-2-piperidino-quinazolines
JPS6322082A (ja) 1―(ヒドロキシスチリル)―5h―2,3―ベンゾジアゼピン誘導体およびその製造方法、並びに前記誘導体を含む薬剤
US4673682A (en) Isoquinoline derivatives, pharmaceutical formulations based on these compounds and the use thereof
JPS59216877A (ja) 置換フエニル−2−(1h)−ピリミジノン
CA1208643A (en) 1,5-diphenyl-pyrazolin-3-one compounds, process and intermediates for preparation thereof and pharmaceutical compositions containing them
JPH0377867A (ja) 新規オキサゾロピリジン誘導体
US3470185A (en) 2-(piperazino)methyl-2,3-dihydro-benzofurans
KR850000126B1 (ko) 이미다졸 유도체의 제조방법
US5114944A (en) 2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid derivatives exhibiting therapeutic effects
GB2162843A (en) Piperazine derivatives
IE49469B1 (en) Substituted quinazolines
JPH01151581A (ja) ピリミド[4,5−g]キノリンおよびその製造中間体