CS236456B2 - Method of 5h-2,3-benzodiazepine derivative production - Google Patents

Method of 5h-2,3-benzodiazepine derivative production Download PDF

Info

Publication number
CS236456B2
CS236456B2 CS797020A CS702079A CS236456B2 CS 236456 B2 CS236456 B2 CS 236456B2 CS 797020 A CS797020 A CS 797020A CS 702079 A CS702079 A CS 702079A CS 236456 B2 CS236456 B2 CS 236456B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
methyl
group
ethyl
formula
Prior art date
Application number
CS797020A
Other languages
Czech (cs)
English (en)
Inventor
Jenoe Koeroesim
Tibor Lang
Jozsef Szekely
Ferenc Andrasi
Gabor Zolyomi
Jozsef Borsy
Katalin Goldschmidt
Tamas Hamori
Gabriela Szabo
Zsuzsa Meszaros
Erszebet Miglecz
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of CS236456B2 publication Critical patent/CS236456B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS797020A 1978-10-19 1979-10-16 Method of 5h-2,3-benzodiazepine derivative production CS236456B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1426A HU179018B (en) 1978-10-19 1978-10-19 Process for producing new 5h-2,3-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
CS236456B2 true CS236456B2 (en) 1985-05-15

Family

ID=10996876

Family Applications (1)

Application Number Title Priority Date Filing Date
CS797020A CS236456B2 (en) 1978-10-19 1979-10-16 Method of 5h-2,3-benzodiazepine derivative production

Country Status (25)

Country Link
US (1) US4322346A (es)
JP (1) JPS5592377A (es)
AT (1) AT373589B (es)
AU (1) AU532079B2 (es)
BE (1) BE879404A (es)
BG (1) BG60270B2 (es)
CA (1) CA1125749A (es)
CH (1) CH643835A5 (es)
CS (1) CS236456B2 (es)
DD (1) DD146596A5 (es)
DE (1) DE2940483A1 (es)
DK (1) DK155327C (es)
ES (1) ES485163A1 (es)
FI (1) FI66604C (es)
FR (1) FR2439189A1 (es)
GB (1) GB2034706B (es)
GR (1) GR74034B (es)
HU (1) HU179018B (es)
IT (1) IT1220947B (es)
NL (1) NL190552C (es)
NO (1) NO152048C (es)
PL (1) PL124063B1 (es)
SE (1) SE439919B (es)
SU (1) SU1402258A3 (es)
YU (1) YU41887B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) * 1986-05-21 1988-07-28 Gyogyszerkutato Intezet Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
JPH01311400A (ja) * 1988-06-09 1989-12-15 Kyocera Corp 発光標識体の点灯方法
JPH0251568U (es) * 1988-10-07 1990-04-11
JPH0324693U (es) * 1989-07-18 1991-03-14
HU207055B (en) * 1990-10-17 1993-03-01 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
HU208429B (en) * 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
DE69612413T2 (de) * 1995-02-09 2001-09-27 Egis Gyogyszergyar Rt., Budapest 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems, sowie Benzopyrylium Intermediate zu ihrer Herstellung
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19604920A1 (de) 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
FR2824065A1 (fr) * 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
DK1545546T3 (da) * 2002-09-13 2007-08-06 Motac Neuroscience Ltd Behandling af dyskinesi med 2,3-benzodiazepiner
PT1539135E (pt) * 2002-09-17 2007-07-12 Motac Neuroscience Ltd Tratamento da discinesia.
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US6638928B1 (en) * 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7745431B2 (en) * 2002-12-03 2010-06-29 Vela Acquisition Corporation Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
WO2004103154A2 (en) * 2003-05-16 2004-12-02 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202579A (en) * 1966-12-09 1970-08-19 Egyt Gyogyszervegyeszeti Gyar Pharmacologically active new isoquinoline derivative and process for preparing same
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
NO793349L (no) 1980-04-22
GR74034B (es) 1984-06-06
DD146596A5 (de) 1981-02-18
AU532079B2 (en) 1983-09-15
ES485163A1 (es) 1980-06-16
SE439919B (sv) 1985-07-08
NO152048B (no) 1985-04-15
HU179018B (en) 1982-08-28
FR2439189B1 (es) 1984-11-30
JPS5592377A (en) 1980-07-12
SE7908481L (sv) 1980-04-20
PL124063B1 (en) 1982-12-31
YU241079A (en) 1984-02-29
YU41887B (en) 1988-02-29
FI66604C (fi) 1984-11-12
DE2940483A1 (de) 1980-04-30
FI793209A (fi) 1980-04-20
NL190552B (nl) 1993-11-16
US4322346A (en) 1982-03-30
FI66604B (fi) 1984-07-31
DK155327B (da) 1989-03-28
NO152048C (no) 1985-07-24
CA1125749A (en) 1982-06-15
BE879404A (fr) 1980-04-15
DE2940483C2 (es) 1989-06-22
CH643835A5 (de) 1984-06-29
SU1402258A3 (ru) 1988-06-07
JPS6350354B2 (es) 1988-10-07
NL7907692A (nl) 1980-04-22
DK440179A (da) 1980-04-20
IT1220947B (it) 1990-06-21
BG60270B1 (bg) 1994-03-31
PL219034A1 (es) 1980-12-01
AT373589B (de) 1984-02-10
GB2034706A (en) 1980-06-11
BG60270B2 (bg) 1994-03-31
ATA647279A (de) 1983-06-15
DK155327C (da) 1989-08-21
GB2034706B (en) 1982-08-04
FR2439189A1 (fr) 1980-05-16
NL190552C (nl) 1994-04-18
IT7926579A0 (it) 1979-10-18

Similar Documents

Publication Publication Date Title
CS236456B2 (en) Method of 5h-2,3-benzodiazepine derivative production
IL100449A (en) History of N-Noble -1-) 4-Aminophenyl (-7 8-Methylenedioxy-H2-5 3-Benzodiazepine Preparation and Pharmaceutical Preparations Containing Them
US4423044A (en) 3,4-Dihydro-5H-2,3-benzodiazepine derivatives and pharmaceutical use thereof
DE68908374T2 (de) Propenonoximether, Verfahren zu dessen Herstellung sowie diese enthaltende Arzneinmittel.
DE3023626A1 (de) 1,9-dihydroxyoctahydrobenzo eckige klammer auf c eckige klammer zu chinoline und 1-hydroxyhexahydrobenzo eckige klammer auf c eckige klammer zu chinolin-9 (8h)- one als antiemetika
NO172392B (no) Analogifremgangsmaate for fremstilling av 1h,3h-(1,2-c)-pyrrolo-7-tiazolkarboksamider
PL114541B1 (en) Process for preparing novel,substituted in position 2,4a,9b-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido/4,3-b/indoles
SU1402251A3 (ru) Способ получени производных 3-фенил-2-пропенамина в виде геометрических изомеров или их смесей, а также фармакологически приемлемых солей
GB2297749A (en) 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives
JPH04282374A (ja) 新規５ｈ−ベンゾジアゼピン誘導体、それを含有してなる製剤組成物、およびそれらの製造方法
HU191702B (en) New process for preparing 1-aryl-5 h-2,3-benzodiazepines
US3503990A (en) 6-aryl-4,5,6,7-tetrahydro-4-oxoindole derivatives
US3304304A (en) Quinazolone derivatives
JPS6245870B2 (es)
US3432491A (en) Benzene sulfonyl semicarbazides
HU206090B (en) Process for producing new 1-phenyl-1,4-dihydro-3-amino-4-oxopyridazine derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HU177341B (en) Process for producing new substituted hexahydro-benzopirano-square bracket-3,2-c-square bracket closed-pyridines
DD146046A5 (de) Verfahren zur herstellung von auronderivaten
US4783455A (en) Substituted pyrimidoindoles and diazepinoindoles useful as hypoglycaemics
NO784094L (no) 3-di-n-propyl-acetoxy-benzodiazepin-2-oner og fremgangsmaate til deres fremstilling
US4622327A (en) 2H-azeto[2,1-a]-isoquinoline derivatives and pharmaceutical compositions containing them
US4880818A (en) 1-Acyl-4-[1-(4-quinolinyl)-hydrazin-2-ylidene]piperidines and their use as hypotensive agents
DE69612413T2 (de) 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems, sowie Benzopyrylium Intermediate zu ihrer Herstellung
US3669983A (en) Pyrazolothiazepines and isoxazolothiazepines
KR810000810B1 (ko) 11-치환된 5,11-디하이드로-6H-피리도[2,3-b][1,4] 벤조디아제핀-6-온류의 제조방법