CS235329B2 - Method of 3-oxa-6a-carbaprostaglandine i 2 derivatives production - Google Patents

Method of 3-oxa-6a-carbaprostaglandine i 2 derivatives production Download PDF

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Publication number
CS235329B2
CS235329B2 CS835301A CS530183A CS235329B2 CS 235329 B2 CS235329 B2 CS 235329B2 CS 835301 A CS835301 A CS 835301A CS 530183 A CS530183 A CS 530183A CS 235329 B2 CS235329 B2 CS 235329B2
Authority
CS
Czechoslovakia
Prior art keywords
group
denotes
alkyl
oxa
radical
Prior art date
Application number
CS835301A
Other languages
Czech (cs)
English (en)
Inventor
Werner Skuballa
Bernd Raduechel
Helmut Vorbrueggen
Jorge Casals-Stenzel
Gerda Mannesmann
Ekkehardt Schillinger
Michael H Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS235329B2 publication Critical patent/CS235329B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Drawers Of Furniture (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
CS835301A 1982-07-13 1983-07-13 Method of 3-oxa-6a-carbaprostaglandine i 2 derivatives production CS235329B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823226550 DE3226550A1 (de) 1982-07-13 1982-07-13 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
CS235329B2 true CS235329B2 (en) 1985-05-15

Family

ID=6168531

Family Applications (1)

Application Number Title Priority Date Filing Date
CS835301A CS235329B2 (en) 1982-07-13 1983-07-13 Method of 3-oxa-6a-carbaprostaglandine i 2 derivatives production

Country Status (19)

Country Link
EP (1) EP0099538B1 (enrdf_load_stackoverflow)
JP (1) JPS5921636A (enrdf_load_stackoverflow)
AT (1) ATE67182T1 (enrdf_load_stackoverflow)
AU (1) AU571841B2 (enrdf_load_stackoverflow)
CA (1) CA1248525A (enrdf_load_stackoverflow)
CS (1) CS235329B2 (enrdf_load_stackoverflow)
DD (1) DD210027B3 (enrdf_load_stackoverflow)
DE (2) DE3226550A1 (enrdf_load_stackoverflow)
DK (1) DK163579C (enrdf_load_stackoverflow)
ES (1) ES524058A0 (enrdf_load_stackoverflow)
FI (1) FI77645C (enrdf_load_stackoverflow)
GR (1) GR78873B (enrdf_load_stackoverflow)
HU (1) HU191057B (enrdf_load_stackoverflow)
IE (1) IE57233B1 (enrdf_load_stackoverflow)
IL (1) IL69199A (enrdf_load_stackoverflow)
NZ (1) NZ204875A (enrdf_load_stackoverflow)
PH (1) PH25119A (enrdf_load_stackoverflow)
SU (1) SU1316555A3 (enrdf_load_stackoverflow)
ZA (1) ZA835109B (enrdf_load_stackoverflow)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971987A (en) * 1984-07-27 1990-11-20 Schering Aktiengesellschaft New carbacycline, process for their production and their use as a drug
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
EP0431571A3 (en) * 1989-12-05 1992-01-02 Sagami Chemical Research Center Cis-bicyclo(4.3.0)non-2-ene derivatives
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
BR0012907A (pt) 1999-08-05 2002-06-11 Teijin Ltd Agente para o remédio de dano neural, composto contendo nitrogênio, e, composição farmacêutica
CA2669763C (en) 2006-11-16 2015-02-17 Bayer Schering Pharma Aktiengesellschaft Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection
NZ599128A (en) 2009-10-14 2014-02-28 Gemmus Pharma Inc Combination therapy treatment for viral infections
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IE54303B1 (en) * 1981-08-19 1989-08-16 Merrell Dow France Fluorinated diaminoalkene derivatives
GR77976B (enrdf_load_stackoverflow) * 1982-03-12 1984-09-25 Schering Ag
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
AU1671883A (en) 1984-01-19
FI832557A7 (fi) 1984-01-14
ZA835109B (en) 1984-08-29
IL69199A0 (en) 1983-11-30
JPS5921636A (ja) 1984-02-03
CA1248525A (en) 1989-01-10
EP0099538B1 (de) 1991-09-11
EP0099538A1 (de) 1984-02-01
HU191057B (en) 1986-12-28
IE57233B1 (en) 1992-06-17
FI77645B (fi) 1988-12-30
ES8403865A1 (es) 1984-04-16
DD210027B3 (de) 1990-07-18
DE3382408D1 (de) 1991-10-17
DK163579B (da) 1992-03-16
JPH0324457B2 (enrdf_load_stackoverflow) 1991-04-03
ATE67182T1 (de) 1991-09-15
DK321283A (da) 1984-01-14
AU571841B2 (en) 1988-04-28
DK321283D0 (da) 1983-07-12
FI77645C (fi) 1989-04-10
IE831630L (en) 1984-01-13
FI832557A0 (fi) 1983-07-13
NZ204875A (en) 1986-11-12
SU1316555A3 (ru) 1987-06-07
PH25119A (en) 1991-02-19
DK163579C (da) 1992-08-03
DD210027A5 (de) 1984-05-30
GR78873B (enrdf_load_stackoverflow) 1984-10-02
ES524058A0 (es) 1984-04-16
DE3226550A1 (de) 1984-01-19
IL69199A (en) 1987-08-31

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