CS228924B2 - Method of preparing peptides inhibiting the release of gonadotropine from mammalian hypophysis - Google Patents

Method of preparing peptides inhibiting the release of gonadotropine from mammalian hypophysis Download PDF

Info

Publication number
CS228924B2
CS228924B2 CS822832A CS283282A CS228924B2 CS 228924 B2 CS228924 B2 CS 228924B2 CS 822832 A CS822832 A CS 822832A CS 283282 A CS283282 A CS 283282A CS 228924 B2 CS228924 B2 CS 228924B2
Authority
CS
Czechoslovakia
Prior art keywords
phe
peptide
formula
ala
naphthyl
Prior art date
Application number
CS822832A
Other languages
Czech (cs)
English (en)
Inventor
Jean E F Rivier
Wylie W Vale Jr
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of CS228924B2 publication Critical patent/CS228924B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS822832A 1981-04-21 1982-04-20 Method of preparing peptides inhibiting the release of gonadotropine from mammalian hypophysis CS228924B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/256,063 US4409208A (en) 1980-04-15 1981-04-21 GnRH antagonists

Publications (1)

Publication Number Publication Date
CS228924B2 true CS228924B2 (en) 1984-05-14

Family

ID=22970967

Family Applications (1)

Application Number Title Priority Date Filing Date
CS822832A CS228924B2 (en) 1981-04-21 1982-04-20 Method of preparing peptides inhibiting the release of gonadotropine from mammalian hypophysis

Country Status (20)

Country Link
US (1) US4409208A (fr)
EP (1) EP0063423B1 (fr)
JP (1) JPS57181047A (fr)
KR (1) KR830010052A (fr)
AT (1) ATE14886T1 (fr)
AU (1) AU551892B2 (fr)
CA (1) CA1241950A (fr)
CS (1) CS228924B2 (fr)
DD (1) DD202694A5 (fr)
DE (1) DE3265349D1 (fr)
DK (1) DK151033C (fr)
ES (1) ES511525A0 (fr)
GR (1) GR75542B (fr)
HU (1) HU186007B (fr)
IE (1) IE52442B1 (fr)
IL (1) IL65371A (fr)
NO (1) NO821274L (fr)
NZ (1) NZ200125A (fr)
PH (1) PH18965A (fr)
ZA (1) ZA822053B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58162562A (ja) * 1982-03-05 1983-09-27 シンテツクス・（ユ−・エス・エイ）・インコ−ポレ−テツド Ｌｈｒｈのノナペプチド及びデカペプチドアナロ−グ
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
DE3634435A1 (de) * 1986-10-09 1988-04-14 Hoechst Ag Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
WO1988007056A1 (fr) * 1987-03-10 1988-09-22 Eastern Virginia Medical Authority PROCEDE ET KIT CONTRACEPTION AVEC UN ANTAGONISTE DE GnRH ET DE LA PROGESTINE
US5068221A (en) * 1989-05-09 1991-11-26 Mathias John R Treatment of motility disorders with a gnrh analog
US5434136A (en) * 1990-12-14 1995-07-18 Mathias; John R. Treatment of motility disorders with a GNRH analog
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
MY150763A (en) 2006-10-24 2014-02-28 Repros Therapeutics Inc Compositions and methods for suppressing endometrial proliferation
US20220257695A1 (en) 2017-03-31 2022-08-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) A gnrh antagonist for use in the treatment of a women affected with polycystic ovary syndrome

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH11571A (en) * 1973-10-03 1978-03-31 American Home Prod P-gui-d-phe-trp-ser-tyr-d-ala-leu-arg-pro-gly-nh2,its non-toxic salts and method of use thereof
US3933782A (en) * 1974-11-14 1976-01-20 American Home Products Corporation (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates
NZ188987A (en) * 1977-11-30 1982-02-23 Salk Inst For Biological Studi Peptide analogues of luteinizing hormone releasing factor
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
GB2053229B (en) * 1979-06-13 1983-03-02 Schally Andrew Victor Lh-rh antagonists
US4253997A (en) * 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
NZ196558A (en) * 1980-04-15 1984-10-19 Salk Inst For Biological Studi Lrf antagonists and pharmaceutical compositions

Also Published As

Publication number Publication date
ATE14886T1 (de) 1985-08-15
ES8307720A1 (es) 1983-07-16
AU551892B2 (en) 1986-05-15
IE820819L (en) 1982-10-21
IE52442B1 (en) 1987-10-28
HU186007B (en) 1985-05-28
NO821274L (no) 1982-10-22
IL65371A0 (en) 1982-05-31
KR830010052A (ko) 1983-12-24
AU8283882A (en) 1982-10-28
NZ200125A (en) 1984-10-19
DK173082A (da) 1982-10-22
DK151033C (da) 1988-03-14
DD202694A5 (de) 1983-09-28
US4409208A (en) 1983-10-11
GR75542B (fr) 1984-07-27
PH18965A (en) 1985-11-26
DE3265349D1 (en) 1985-09-19
CA1241950A (fr) 1988-09-13
ES511525A0 (es) 1983-07-16
JPS57181047A (en) 1982-11-08
EP0063423A1 (fr) 1982-10-27
DK151033B (da) 1987-10-12
EP0063423B1 (fr) 1985-08-14
ZA822053B (en) 1983-02-23
IL65371A (en) 1985-12-31

Similar Documents

Publication Publication Date Title
KR900003096B1 (ko) G_nRH 길항질 II
KR850001158B1 (ko) 펩타이드의 제조방법
KR900007083B1 (ko) GnRH 길항물질 제조방법
US4565804A (en) GnRH Antagonists VI
US6747125B1 (en) Peptide intermediates for making GnRH antagonists
CZ358699A3 (cs) Peptid, antagonizující GnRH
KR900007864B1 (ko) GnRH 길항제 IX의 제조방법
CS228924B2 (en) Method of preparing peptides inhibiting the release of gonadotropine from mammalian hypophysis
KR0123009B1 (ko) 쥐이엔알에이취(GnRH) 유사체
HU198089B (en) Process for producing hormone antagonist decapeptide derivatives releasing gonadotropin
JPH0139440B2 (fr)
KR850001159B1 (ko) 펩타이드의 제조방법
PT78209B (en) Gnrh antagonists iii
KR910002702B1 (ko) 펩티드의 제법
HU185308B (en) Process for preparing peptides influencing gonadotropic hormones
AU633384B2 (en) Gnrh analogs
JPS59186948A (ja) ＧｎＲＨ「きつ」抗物質
WO1982000004A1 (fr) Traitement contraceptif des mammiferes males
HU189504B (en) Process for preparing decapeptide derivatives inhibiting the release of luteinizing hormone