CS219900B2 - Method of immunological determination of the enzyme and means for executing the same method - Google Patents

Method of immunological determination of the enzyme and means for executing the same method Download PDF

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Publication number
CS219900B2
CS219900B2 CS813163A CS316381A CS219900B2 CS 219900 B2 CS219900 B2 CS 219900B2 CS 813163 A CS813163 A CS 813163A CS 316381 A CS316381 A CS 316381A CS 219900 B2 CS219900 B2 CS 219900B2
Authority
CS
Czechoslovakia
Prior art keywords
enzyme
inhibitor
antibody
complex
coupling product
Prior art date
Application number
CS813163A
Other languages
Czech (cs)
English (en)
Inventor
Siegfried Neumann
Gerhard Gunzer
Norbert Hennrich
Hermann Lang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CS219900B2 publication Critical patent/CS219900B2/cs

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121Serpins
    • G01N2333/8125Alpha-1-antitrypsin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121Serpins
    • G01N2333/8128Antithrombin III
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/966Elastase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CS813163A 1980-04-30 1981-04-28 Method of immunological determination of the enzyme and means for executing the same method CS219900B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803016575 DE3016575A1 (de) 1980-04-30 1980-04-30 Verfahren zur immunologischen bestimmung von enzymen, mittel zur durchfuehrung des verfahrens und seine verwandung

Publications (1)

Publication Number Publication Date
CS219900B2 true CS219900B2 (en) 1983-03-25

Family

ID=6101282

Family Applications (1)

Application Number Title Priority Date Filing Date
CS813163A CS219900B2 (en) 1980-04-30 1981-04-28 Method of immunological determination of the enzyme and means for executing the same method

Country Status (7)

Country Link
EP (1) EP0038935B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS57551A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS219900B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD158676A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3016575A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL62728A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA812773B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
DE3172143D1 (en) * 1980-09-30 1985-10-10 Cornell Res Foundation Inc Process for determining inhibitor-enzyme complexes
EP0080279B1 (en) * 1981-11-02 1986-02-05 James Walter Ryan Method for assaying proteases with tagged proteinaceous inhibitors
US4629694A (en) * 1983-07-12 1986-12-16 Cornell Research Foundation, Inc. Detecting and distinguishing between plasminogen activators
EP0169549B1 (en) * 1984-07-26 1992-09-02 Teijin Limited Immunological determination of human plasmin/alpha2-plasmin inhibitor
JPS6134465A (ja) * 1984-07-26 1986-02-18 Teijin Ltd ヒトα↓2−プラスミンインヒビタ−に対するモノクロ−ナル抗体を用いた免疫学的測定試薬及びキツト
EP0243448A4 (en) * 1985-10-09 1989-05-30 Univ Florida Atlantic TEST METHOD FOR DETECTING COLONAL POLYPES.
WO1990003577A1 (en) * 1988-09-30 1990-04-05 The University Of Vermont And State Agricultural College Immunoassays for catalytically-active, serine proteases
JPH02304365A (ja) * 1989-05-18 1990-12-18 Shionogi & Co Ltd エラスターゼ1の測定方法
JPH0313863A (ja) * 1989-06-08 1991-01-22 Eiken Chem Co Ltd 免疫学的ラテックス凝集反応をもちいた糞便中のα1‐アンチトリプシンの測定方法および該方法に使用する試薬
EP1493825A3 (en) * 1990-06-11 2005-02-09 Gilead Sciences, Inc. Method for producing nucleic acid ligands
JP2614155B2 (ja) * 1991-06-18 1997-05-28 株式会社三和化学研究所 ヒト顆粒球エラスターゼの免疫学的測定方法
US5276139A (en) * 1991-08-26 1994-01-04 Merck & Co., Inc. Haptens useful in evaluating inhibition of PNN elastase by N-substituted azetidinones
US5229267A (en) * 1991-08-26 1993-07-20 Merck & Co., Inc. Assay for evaluating inhibition of PMN elastase by N-substituted azetidinones
EP0529719A1 (en) * 1991-08-26 1993-03-03 Merck & Co. Inc. Assay for evaluating inhibition of PMN elastase by N-Substituted Azetidinones
GB9119102D0 (en) * 1991-09-07 1991-10-23 Biosyn Ltd Bioimmunassay
EP0574599A1 (en) * 1992-06-13 1993-12-22 BEHRINGWERKE Aktiengesellschaft Process for the detection of complexed cathepsin G and alpha-1-antichymotrypsin
US5420010A (en) * 1993-07-30 1995-05-30 Merck & Co., Inc. Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones
FI100557B (fi) * 1994-08-26 1997-12-31 Ulf-Haakan Stenman Vapaan trypsinogeeni-2:n määritys
EP0759556A3 (de) * 1995-07-24 1998-05-20 BEHRINGWERKE Aktiengesellschaft Verfahren zur Quantifizierung aktivierter Faktoren
JP3298824B2 (ja) * 1998-03-13 2002-07-08 アークレイ株式会社 白血球計数方法および白血球計数装置
EP3431996A1 (en) * 2017-07-17 2019-01-23 PreviPharma Consulting GmbH Quantifying enzymatic entities and their active sites
JP7355140B2 (ja) * 2022-02-28 2023-10-03 住友ベークライト株式会社 セリンプロテアーゼの検出用または測定用試薬

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) * 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL7511055A (nl) * 1975-09-19 1977-03-22 Leuven Res & Dev Vzw Trombosetest.
NL7602422A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Trombosetest.
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
US4273756A (en) * 1978-07-28 1981-06-16 Abbott Laboratories Immunoassay for class specific antibodies
DE2836046A1 (de) * 1978-08-17 1980-02-28 Behringwerke Ag Immunologisches bestimmungsverfahren
JPS56118671A (en) * 1980-02-22 1981-09-17 Amano Pharmaceut Co Ltd Measuring method of specific enzyme immunity of hybrid type protein

Also Published As

Publication number Publication date
EP0038935A1 (de) 1981-11-04
DE3167677D1 (en) 1985-01-24
IL62728A0 (en) 1981-06-29
ZA812773B (en) 1982-04-28
JPH0370184B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-11-06
EP0038935B1 (de) 1984-12-12
JPS57551A (en) 1982-01-05
DE3016575A1 (de) 1981-11-05
DD158676A5 (de) 1983-01-26
IL62728A (en) 1984-08-31

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