CS207459B2 - Method of making the neutralization antiacidic means - Google Patents
Method of making the neutralization antiacidic means Download PDFInfo
- Publication number
- CS207459B2 CS207459B2 CS773612A CS361277A CS207459B2 CS 207459 B2 CS207459 B2 CS 207459B2 CS 773612 A CS773612 A CS 773612A CS 361277 A CS361277 A CS 361277A CS 207459 B2 CS207459 B2 CS 207459B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- acid
- polyethyleneimine
- aqueous solution
- amount
- water
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 4
- 238000006386 neutralization reaction Methods 0.000 title description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229920002873 Polyethylenimine Polymers 0.000 claims abstract description 27
- 239000002253 acid Substances 0.000 claims abstract description 23
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 18
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000783 alginic acid Substances 0.000 claims abstract description 13
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 13
- 229960001126 alginic acid Drugs 0.000 claims abstract description 13
- 229920000615 alginic acid Polymers 0.000 claims abstract description 13
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 13
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 9
- 229920002230 Pectic acid Polymers 0.000 claims abstract description 8
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 8
- 239000010318 polygalacturonic acid Substances 0.000 claims abstract description 8
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 6
- QXKAIJAYHKCRRA-JJYYJPOSSA-N D-arabinonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(O)=O QXKAIJAYHKCRRA-JJYYJPOSSA-N 0.000 claims abstract description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 210000004211 gastric acid Anatomy 0.000 claims abstract description 6
- 239000001630 malic acid Substances 0.000 claims abstract description 6
- 235000011090 malic acid Nutrition 0.000 claims abstract description 6
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims abstract description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract description 5
- DSLZVSRJTYRBFB-UHFFFAOYSA-N Galactaric acid Natural products OC(=O)C(O)C(O)C(O)C(O)C(O)=O DSLZVSRJTYRBFB-UHFFFAOYSA-N 0.000 claims abstract description 5
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 5
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001530 fumaric acid Substances 0.000 claims abstract description 5
- DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 claims abstract description 5
- 239000011975 tartaric acid Substances 0.000 claims abstract description 5
- 235000002906 tartaric acid Nutrition 0.000 claims abstract description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001814 pectin Substances 0.000 claims abstract description 4
- 235000010987 pectin Nutrition 0.000 claims abstract description 4
- 229920001277 pectin Polymers 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims abstract description 3
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 12
- 235000011054 acetic acid Nutrition 0.000 claims description 11
- 230000001458 anti-acid effect Effects 0.000 claims description 8
- 235000011007 phosphoric acid Nutrition 0.000 claims description 8
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000001384 succinic acid Substances 0.000 claims description 5
- 235000011044 succinic acid Nutrition 0.000 claims description 5
- 235000011087 fumaric acid Nutrition 0.000 claims description 4
- 239000001648 tannin Substances 0.000 claims description 4
- 235000018553 tannin Nutrition 0.000 claims description 4
- 229920001864 tannin Polymers 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract description 6
- 239000003159 antacid agent Substances 0.000 abstract description 5
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract description 3
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 abstract 1
- 239000001263 FEMA 3042 Substances 0.000 abstract 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 abstract 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 abstract 1
- 229940033123 tannic acid Drugs 0.000 abstract 1
- 235000015523 tannic acid Nutrition 0.000 abstract 1
- 229920002258 tannic acid Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 2
- 235000019621 digestibility Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 229940040944 tetracyclines Drugs 0.000 description 2
- 208000005223 Alkalosis Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010020601 Hyperchlorhydria Diseases 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 239000000159 acid neutralizing agent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002340 alkalosis Effects 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 150000002681 magnesium compounds Chemical class 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- -1 peiktim Polymers 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Printed Circuit Boards (AREA)
- Control Of Combustion (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7606256A SE405445B (sv) | 1976-06-03 | 1976-06-03 | Forfarande for framstellning av ett magsyreneutraliserande antacidum i flytande form innehallande polyetylenimin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS207459B2 true CS207459B2 (en) | 1981-07-31 |
Family
ID=20328121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS773612A CS207459B2 (en) | 1976-06-03 | 1977-06-01 | Method of making the neutralization antiacidic means |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS52148630A (show.php) |
| AT (1) | AT353406B (show.php) |
| AU (1) | AU514929B2 (show.php) |
| BE (1) | BE855349A (show.php) |
| CA (1) | CA1087094A (show.php) |
| CS (1) | CS207459B2 (show.php) |
| DD (1) | DD131345A5 (show.php) |
| DE (1) | DE2722486A1 (show.php) |
| DK (1) | DK234077A (show.php) |
| FI (1) | FI59023C (show.php) |
| FR (1) | FR2353296A1 (show.php) |
| GB (1) | GB1539162A (show.php) |
| HU (1) | HU174584B (show.php) |
| IE (1) | IE45208B1 (show.php) |
| LU (1) | LU77480A1 (show.php) |
| NL (1) | NL7706085A (show.php) |
| NO (1) | NO771899L (show.php) |
| NZ (1) | NZ184237A (show.php) |
| SE (1) | SE405445B (show.php) |
| SU (1) | SU812156A3 (show.php) |
| ZA (1) | ZA772913B (show.php) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5936192B2 (ja) * | 2012-10-25 | 2016-06-15 | 学校法人神奈川大学 | キラル超分子結晶及びそれからなる固体触媒、並びにキラル超分子結晶の製造方法 |
-
1976
- 1976-06-03 SE SE7606256A patent/SE405445B/xx unknown
-
1977
- 1977-05-16 ZA ZA00772913A patent/ZA772913B/xx unknown
- 1977-05-18 DE DE19772722486 patent/DE2722486A1/de not_active Withdrawn
- 1977-05-24 FI FI771660A patent/FI59023C/fi not_active IP Right Cessation
- 1977-05-27 DK DK234077A patent/DK234077A/da unknown
- 1977-05-30 NZ NZ184237A patent/NZ184237A/xx unknown
- 1977-05-30 AU AU25612/77A patent/AU514929B2/en not_active Expired
- 1977-05-31 IE IE1120/77A patent/IE45208B1/en unknown
- 1977-05-31 NO NO771899A patent/NO771899L/no unknown
- 1977-06-01 CS CS773612A patent/CS207459B2/cs unknown
- 1977-06-01 DD DD7700199241A patent/DD131345A5/xx unknown
- 1977-06-01 HU HU77HE737A patent/HU174584B/hu unknown
- 1977-06-02 SU SU772490602A patent/SU812156A3/ru active
- 1977-06-02 NL NL7706085A patent/NL7706085A/xx not_active Application Discontinuation
- 1977-06-02 CA CA279,734A patent/CA1087094A/en not_active Expired
- 1977-06-02 GB GB23486/77A patent/GB1539162A/en not_active Expired
- 1977-06-02 FR FR7716916A patent/FR2353296A1/fr active Granted
- 1977-06-03 LU LU77480A patent/LU77480A1/xx unknown
- 1977-06-03 BE BE178155A patent/BE855349A/xx unknown
- 1977-06-03 JP JP6568177A patent/JPS52148630A/ja active Pending
- 1977-06-03 AT AT393877A patent/AT353406B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE405445B (sv) | 1978-12-11 |
| ATA393877A (de) | 1979-04-15 |
| NL7706085A (nl) | 1977-12-06 |
| AU514929B2 (en) | 1981-03-05 |
| FI59023C (fi) | 1981-06-10 |
| AT353406B (de) | 1979-11-12 |
| NZ184237A (en) | 1979-10-25 |
| BE855349A (fr) | 1977-12-05 |
| HU174584B (hu) | 1980-02-28 |
| JPS52148630A (en) | 1977-12-10 |
| SE7606256L (sv) | 1977-12-04 |
| CA1087094A (en) | 1980-10-07 |
| DK234077A (da) | 1977-12-04 |
| AU2561277A (en) | 1978-12-07 |
| FR2353296A1 (fr) | 1977-12-30 |
| FI59023B (fi) | 1981-02-27 |
| IE45208B1 (en) | 1982-07-14 |
| GB1539162A (en) | 1979-01-31 |
| ZA772913B (en) | 1978-04-26 |
| DE2722486A1 (de) | 1977-12-22 |
| FR2353296B1 (show.php) | 1981-01-16 |
| NO771899L (no) | 1977-12-06 |
| FI771660A7 (show.php) | 1977-12-04 |
| DD131345A5 (de) | 1978-06-21 |
| IE45208L (en) | 1977-12-03 |
| LU77480A1 (show.php) | 1978-01-26 |
| SU812156A3 (ru) | 1981-03-07 |
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