CS205023B2 - Process for preparing stable solutions of hydrogenated ergot alkaloids - Google Patents

Process for preparing stable solutions of hydrogenated ergot alkaloids Download PDF

Info

Publication number
CS205023B2
CS205023B2 CS763620A CS362076A CS205023B2 CS 205023 B2 CS205023 B2 CS 205023B2 CS 763620 A CS763620 A CS 763620A CS 362076 A CS362076 A CS 362076A CS 205023 B2 CS205023 B2 CS 205023B2
Authority
CS
Czechoslovakia
Prior art keywords
mixture
ethanol
propylene glycol
ergot alkaloids
stable solutions
Prior art date
Application number
CS763620A
Other languages
Czech (cs)
English (en)
Inventor
Lothar Ehrhardt
Ludwig Patt
Volker Hartmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CS205023B2 publication Critical patent/CS205023B2/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS763620A 1975-05-31 1976-05-31 Process for preparing stable solutions of hydrogenated ergot alkaloids CS205023B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2524184 1975-05-31

Publications (1)

Publication Number Publication Date
CS205023B2 true CS205023B2 (en) 1981-04-30

Family

ID=5947910

Family Applications (1)

Application Number Title Priority Date Filing Date
CS763620A CS205023B2 (en) 1975-05-31 1976-05-31 Process for preparing stable solutions of hydrogenated ergot alkaloids

Country Status (26)

Country Link
JP (1) JPS585167B2 (da)
AT (1) AT355725B (da)
AU (1) AU508625B2 (da)
BE (1) BE842348A (da)
CA (1) CA1069438A (da)
CS (1) CS205023B2 (da)
DD (1) DD125597A5 (da)
DK (1) DK154606C (da)
ES (1) ES448372A1 (da)
FI (1) FI761461A (da)
FR (1) FR2313059A1 (da)
GB (1) GB1539083A (da)
GR (1) GR60264B (da)
HK (1) HK15383A (da)
HU (1) HU171514B (da)
IE (1) IE42999B1 (da)
IL (1) IL49668A (da)
MY (1) MY8300013A (da)
NL (1) NL172616C (da)
NO (1) NO145262C (da)
NZ (1) NZ180984A (da)
PT (1) PT65151B (da)
SE (1) SE426782B (da)
SU (2) SU677664A3 (da)
YU (1) YU133076A (da)
ZA (1) ZA763138B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935515A1 (de) * 1979-09-03 1981-03-19 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Arzneipraeparat
FR2483235A1 (fr) * 1980-05-28 1981-12-04 Fabre Sa Pierre Compositions a usage topique contenant des alcaloides de l'ergot de seigle et de vinca rosea destinees au traitement des hyperseborrhees
DE3227122A1 (de) * 1982-07-20 1984-01-26 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Stabile loesungen von mutterkornalkaloiden
HU192050B (en) * 1983-04-22 1987-05-28 Sandoz Ag Process for production of medical preparative containing co-dergocrin and one piridin-dicarbonic acid diesthertype calcium-antagonist
IT1200609B (it) * 1985-04-04 1989-01-27 Poli Ind Chimica Spa Composizione farmaceutice per il trattamento delle turbe cerebrovascolari e del cervello anziano
DE102007014947B4 (de) 2007-03-23 2010-05-27 Axxonis Pharma Ag Stabilisierte wässrige Lösungen von Ergolinverbindungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD43402A (da) *
US2033921A (en) * 1931-08-28 1936-03-17 Squibb & Sons Inc Solution of ergot alkaloids
US1969382A (en) * 1932-05-21 1934-08-07 Squibb & Sons Inc Preparation of a stable hydro-alcoholic extract of ergot

Also Published As

Publication number Publication date
FR2313059A1 (fr) 1976-12-31
AT355725B (de) 1980-03-25
JPS585167B2 (ja) 1983-01-29
HK15383A (en) 1983-05-20
YU133076A (en) 1984-08-31
DK228676A (da) 1976-12-01
ZA763138B (en) 1978-01-25
SU952106A3 (ru) 1982-08-15
GR60264B (en) 1978-04-20
JPS51144720A (en) 1976-12-13
NL172616C (nl) 1983-10-03
IL49668A0 (en) 1976-09-30
HU171514B (hu) 1978-01-28
SU677664A3 (ru) 1979-07-30
NL172616B (nl) 1983-05-02
CA1069438A (en) 1980-01-08
DK154606B (da) 1988-12-05
DD125597A5 (da) 1977-05-04
ATA390476A (de) 1979-08-15
IE42999L (en) 1976-11-30
DK154606C (da) 1989-05-01
PT65151B (fr) 1978-02-06
NO145262B (no) 1981-11-09
NO761760L (da) 1976-12-01
SE426782B (sv) 1983-02-14
GB1539083A (en) 1979-01-24
NO145262C (no) 1982-02-17
MY8300013A (en) 1983-12-31
PT65151A (fr) 1976-06-01
AU1442276A (en) 1977-12-01
FR2313059B1 (da) 1978-12-15
NZ180984A (en) 1978-06-20
SE7605841L (sv) 1976-12-01
ES448372A1 (es) 1978-03-01
FI761461A (da) 1976-12-01
IL49668A (en) 1979-10-31
IE42999B1 (en) 1980-12-03
BE842348A (fr) 1976-11-29
NL7605745A (nl) 1976-12-02
AU508625B2 (en) 1980-03-27

Similar Documents

Publication Publication Date Title
DE833611T1 (de) Zusammensetzung, die ein in einem glasbildenden träger gelösten wirkstoff enthalt und ein verfahren zu deren herstellung
CA1177399A (en) Injectable composition of rapamycin
RU2000126836A (ru) Препараты с замедленным высвобождением
DE69824277T2 (de) Stabile medizinische zusammenstellungen die 4,5-epoxymorphinanderivate enthalten
AU718389B2 (en) Avermectin formulation
JP4073503B2 (ja) サイクロスポリンを含有する液体製剤とその調製方法
KR920009401A (ko) 현탁 조성물 및 그의 제조방법
PL184750B1 (pl) Kompozycja w postaci emulsji do stosowania miejscowego
KR890001521A (ko) 서방형 신규 제약 제제물
AU689488B2 (en) Rapamycin formulation for IV injection
US4138565A (en) Stable solutions and processes for their preparation
CS205023B2 (en) Process for preparing stable solutions of hydrogenated ergot alkaloids
WO2006029726A1 (en) Dermally applicable formulations for treating skin diseases in animals
GB1560406A (en) Solid solutions of ergot alkaholids in polymers
EP0407804B1 (de) Wasserlösliche pharmazeutische Metallocen-Komplex-Zusammensetzung
DD159289A1 (de) Verfahren zur herstellung stabiler injektionsloesungen von n-lostverbindungen
CS203199B2 (en) Method of making stabil solutions of hydrogenous ergot alcaloids,event.synthetic derivatives thereof
Rabasco et al. Dissolution rate of diazepam from polyethylene glycol 6000 solid dispersions
AU2017215603A1 (en) Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
AU707220B2 (en) Pharmaceutical composition for parenteral application containing an indole-carboxylic acid
US4402949A (en) Stable solutions of hydrogenated ergotalkaloids
KR860002507A (ko) 치환 7-옥소미토산의 제조방법
JPH0576929B2 (da)
AU699386B2 (en) A pharmaceutical composition for lowering the blood pressure and a process for the preparation thereof
KR980008219A (ko) 안정화된 주사제용 약제학적 조성물