CS199610B2 - Process for preparing 8-8-disubstituted 6-methylergolines and derivatives thereof - Google Patents

Process for preparing 8-8-disubstituted 6-methylergolines and derivatives thereof Download PDF

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Publication number
CS199610B2
CS199610B2 CS757861A CS786175A CS199610B2 CS 199610 B2 CS199610 B2 CS 199610B2 CS 757861 A CS757861 A CS 757861A CS 786175 A CS786175 A CS 786175A CS 199610 B2 CS199610 B2 CS 199610B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
reacted
dimethyl
preparation
acid
Prior art date
Application number
CS757861A
Other languages
Czech (cs)
English (en)
Inventor
Nicholas J Bach
Edmund C Kornfeld
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS199610B2 publication Critical patent/CS199610B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS757861A 1974-12-06 1975-11-20 Process for preparing 8-8-disubstituted 6-methylergolines and derivatives thereof CS199610B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/530,320 US3968111A (en) 1974-12-06 1974-12-06 8,8-Disubstituted-6-methylergolines and related compounds

Publications (1)

Publication Number Publication Date
CS199610B2 true CS199610B2 (en) 1980-07-31

Family

ID=24113222

Family Applications (1)

Application Number Title Priority Date Filing Date
CS757861A CS199610B2 (en) 1974-12-06 1975-11-20 Process for preparing 8-8-disubstituted 6-methylergolines and derivatives thereof

Country Status (28)

Country Link
US (2) US3968111A (ro)
JP (1) JPS5813542B2 (ro)
AR (1) AR211257A1 (ro)
AT (1) AT348142B (ro)
AU (1) AU505194B2 (ro)
BE (1) BE836309A (ro)
BG (1) BG33289A3 (ro)
CA (1) CA1064918A (ro)
CH (1) CH605937A5 (ro)
CS (1) CS199610B2 (ro)
DD (1) DD123750A5 (ro)
DE (1) DE2554629A1 (ro)
DK (1) DK146128C (ro)
ES (1) ES443279A1 (ro)
FR (1) FR2293204A1 (ro)
GB (1) GB1535214A (ro)
GR (1) GR59201B (ro)
HU (1) HU173985B (ro)
IE (1) IE42198B1 (ro)
IL (1) IL48572A (ro)
NL (1) NL7514177A (ro)
PH (1) PH13133A (ro)
PL (1) PL102611B1 (ro)
RO (1) RO64606A (ro)
SE (1) SE421528B (ro)
SU (1) SU627757A3 (ro)
YU (1) YU304575A (ro)
ZA (1) ZA757510B (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
USRE30219E (en) * 1974-12-06 1980-02-19 Eli Lilly And Company Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
US4054567A (en) * 1975-08-11 1977-10-18 Eli Lilly And Company 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
US4238486A (en) * 1979-11-23 1980-12-09 Merck & Co., Inc. Indolobenzoxazines
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US2861074A (en) * 1956-10-22 1958-11-18 Lilly Co Eli Substituted hydroxyergolenes
BE755211A (fr) * 1969-08-29 1971-02-01 Spofa Usines Pharma Reunies Procede de preparation des nouvelles amides de l'acide d-6-methyl-8-ergolin/i/yle/acetique et de leurs sels, ainsi que les produits obtenus
AR206772A1 (es) * 1972-07-21 1976-08-23 Lilly Co Eli Procedimiento para preparar una nueva d-2-halo-6-metil-8-ciano(carboxamido)metil ergolina
US3968112A (en) * 1974-08-02 1976-07-06 Eli Lilly And Company Synthesis of penniclavine and elymoclavine
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds

Also Published As

Publication number Publication date
HU173985B (hu) 1979-10-28
DK146128C (da) 1983-12-05
FR2293204A1 (fr) 1976-07-02
AR211257A1 (es) 1977-11-15
AU8718175A (en) 1977-06-09
PH13133A (en) 1979-12-12
BE836309A (fr) 1976-06-08
SE421528B (sv) 1982-01-04
ES443279A1 (es) 1977-04-16
US3968111A (en) 1976-07-06
FR2293204B1 (ro) 1980-06-27
DK547475A (da) 1976-06-07
DE2554629A1 (de) 1976-06-10
IL48572A0 (en) 1976-01-30
CA1064918A (en) 1979-10-23
SE7513753L (sv) 1976-06-08
YU304575A (en) 1982-02-28
JPS5813542B2 (ja) 1983-03-14
IL48572A (en) 1978-12-17
RO64606A (fr) 1979-01-15
AU505194B2 (en) 1979-11-15
IE42198B1 (en) 1980-06-18
PL102611B1 (pl) 1979-04-30
JPS5182299A (ro) 1976-07-19
SU627757A3 (ru) 1978-10-05
ATA928075A (de) 1978-06-15
BG33289A3 (en) 1983-01-14
US4075212A (en) 1978-02-21
GB1535214A (en) 1978-12-13
DK146128B (da) 1983-07-04
NL7514177A (nl) 1976-06-09
GR59201B (en) 1977-11-26
CH605937A5 (ro) 1978-10-13
AT348142B (de) 1979-01-25
ZA757510B (en) 1977-07-27
DD123750A5 (ro) 1977-01-12
IE42198L (en) 1976-06-06

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