DK547475A - Fremgangsmade til fremstilling af 8,8-disubstituerede 6-methylergoliner - Google Patents

Fremgangsmade til fremstilling af 8,8-disubstituerede 6-methylergoliner

Info

Publication number
DK547475A
DK547475A DK547475A DK547475A DK547475A DK 547475 A DK547475 A DK 547475A DK 547475 A DK547475 A DK 547475A DK 547475 A DK547475 A DK 547475A DK 547475 A DK547475 A DK 547475A
Authority
DK
Denmark
Prior art keywords
methylergolins
disubstituted
procedure
preparation
Prior art date
Application number
DK547475A
Other languages
English (en)
Other versions
DK146128C (da
DK146128B (da
Inventor
N J Bach
E C Kornfeld
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK547475A publication Critical patent/DK547475A/da
Publication of DK146128B publication Critical patent/DK146128B/da
Application granted granted Critical
Publication of DK146128C publication Critical patent/DK146128C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
DK547475A 1974-12-06 1975-12-04 Fremgangsmaade til fremstilling af 8,8-disubstituerede 6-methylergoliner eller -ergolener DK146128C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53032074 1974-12-06
US05/530,320 US3968111A (en) 1974-12-06 1974-12-06 8,8-Disubstituted-6-methylergolines and related compounds

Publications (3)

Publication Number Publication Date
DK547475A true DK547475A (da) 1976-06-07
DK146128B DK146128B (da) 1983-07-04
DK146128C DK146128C (da) 1983-12-05

Family

ID=24113222

Family Applications (1)

Application Number Title Priority Date Filing Date
DK547475A DK146128C (da) 1974-12-06 1975-12-04 Fremgangsmaade til fremstilling af 8,8-disubstituerede 6-methylergoliner eller -ergolener

Country Status (28)

Country Link
US (2) US3968111A (da)
JP (1) JPS5813542B2 (da)
AR (1) AR211257A1 (da)
AT (1) AT348142B (da)
AU (1) AU505194B2 (da)
BE (1) BE836309A (da)
BG (1) BG33289A3 (da)
CA (1) CA1064918A (da)
CH (1) CH605937A5 (da)
CS (1) CS199610B2 (da)
DD (1) DD123750A5 (da)
DE (1) DE2554629A1 (da)
DK (1) DK146128C (da)
ES (1) ES443279A1 (da)
FR (1) FR2293204A1 (da)
GB (1) GB1535214A (da)
GR (1) GR59201B (da)
HU (1) HU173985B (da)
IE (1) IE42198B1 (da)
IL (1) IL48572A (da)
NL (1) NL7514177A (da)
PH (1) PH13133A (da)
PL (1) PL102611B1 (da)
RO (1) RO64606A (da)
SE (1) SE421528B (da)
SU (1) SU627757A3 (da)
YU (1) YU304575A (da)
ZA (1) ZA757510B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30219E (en) * 1974-12-06 1980-02-19 Eli Lilly And Company Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
US4054567A (en) * 1975-08-11 1977-10-18 Eli Lilly And Company 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US4098790A (en) * 1976-09-15 1978-07-04 Eli Lilly And Company Ergoline chlorination process
US4238486A (en) * 1979-11-23 1980-12-09 Merck & Co., Inc. Indolobenzoxazines
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344731A (de) * 1956-05-18 1960-02-29 Sandoz Ag Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US2861074A (en) * 1956-10-22 1958-11-18 Lilly Co Eli Substituted hydroxyergolenes
BE755211A (fr) * 1969-08-29 1971-02-01 Spofa Usines Pharma Reunies Procede de preparation des nouvelles amides de l'acide d-6-methyl-8-ergolin/i/yle/acetique et de leurs sels, ainsi que les produits obtenus
AR206772A1 (es) * 1972-07-21 1976-08-23 Lilly Co Eli Procedimiento para preparar una nueva d-2-halo-6-metil-8-ciano(carboxamido)metil ergolina
US3968112A (en) * 1974-08-02 1976-07-06 Eli Lilly And Company Synthesis of penniclavine and elymoclavine
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds

Also Published As

Publication number Publication date
IL48572A0 (en) 1976-01-30
SE7513753L (sv) 1976-06-08
JPS5182299A (da) 1976-07-19
PH13133A (en) 1979-12-12
PL102611B1 (pl) 1979-04-30
GR59201B (en) 1977-11-26
ES443279A1 (es) 1977-04-16
FR2293204A1 (fr) 1976-07-02
CS199610B2 (en) 1980-07-31
CA1064918A (en) 1979-10-23
ATA928075A (de) 1978-06-15
GB1535214A (en) 1978-12-13
DE2554629A1 (de) 1976-06-10
AT348142B (de) 1979-01-25
AR211257A1 (es) 1977-11-15
AU505194B2 (en) 1979-11-15
SU627757A3 (ru) 1978-10-05
JPS5813542B2 (ja) 1983-03-14
IE42198B1 (en) 1980-06-18
AU8718175A (en) 1977-06-09
US3968111A (en) 1976-07-06
SE421528B (sv) 1982-01-04
IE42198L (en) 1976-06-06
YU304575A (en) 1982-02-28
NL7514177A (nl) 1976-06-09
FR2293204B1 (da) 1980-06-27
BE836309A (fr) 1976-06-08
DK146128C (da) 1983-12-05
IL48572A (en) 1978-12-17
HU173985B (hu) 1979-10-28
US4075212A (en) 1978-02-21
ZA757510B (en) 1977-07-27
BG33289A3 (en) 1983-01-14
DK146128B (da) 1983-07-04
CH605937A5 (da) 1978-10-13
RO64606A (fr) 1979-01-15
DD123750A5 (da) 1977-01-12

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PBP Patent lapsed