DK164376A - Fremgangsmade til fremstilling af 3,4-dihydrospiro-2h-1,3-benzoxaziner - Google Patents

Fremgangsmade til fremstilling af 3,4-dihydrospiro-2h-1,3-benzoxaziner

Info

Publication number
DK164376A
DK164376A DK164376A DK164376A DK164376A DK 164376 A DK164376 A DK 164376A DK 164376 A DK164376 A DK 164376A DK 164376 A DK164376 A DK 164376A DK 164376 A DK164376 A DK 164376A
Authority
DK
Denmark
Prior art keywords
dihydrospiro
benzoxazines
procedure
preparation
Prior art date
Application number
DK164376A
Other languages
English (en)
Inventor
E J Cragoe Jr
E M Schultz
G E Stokker
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK164376A publication Critical patent/DK164376A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/16Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/62Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • C07D215/28Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
DK164376A 1975-04-25 1976-04-07 Fremgangsmade til fremstilling af 3,4-dihydrospiro-2h-1,3-benzoxaziner DK164376A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57146275A 1975-04-25 1975-04-25

Publications (1)

Publication Number Publication Date
DK164376A true DK164376A (da) 1976-10-26

Family

ID=24283809

Family Applications (1)

Application Number Title Priority Date Filing Date
DK164376A DK164376A (da) 1975-04-25 1976-04-07 Fremgangsmade til fremstilling af 3,4-dihydrospiro-2h-1,3-benzoxaziner

Country Status (8)

Country Link
US (1) US4092414A (da)
JP (1) JPS51128983A (da)
DE (1) DE2617673A1 (da)
DK (1) DK164376A (da)
FR (1) FR2308361A1 (da)
GB (1) GB1497638A (da)
NL (1) NL7603651A (da)
SE (1) SE7604095L (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815979A (ja) * 1981-07-11 1983-01-29 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体およびその製造法
US5102883A (en) * 1989-10-31 1992-04-07 Du Pont Merck Pharmaceutical Company Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
SE9701396D0 (sv) * 1997-04-15 1997-04-15 Astra Pharma Prod Compounds
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
EP3150585A1 (en) 2012-12-17 2017-04-05 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887550A (en) * 1969-11-20 1975-06-03 Sherwin Williams Co Method for producing heterocyclic acid anhydrides
US3809721A (en) * 1970-12-23 1974-05-07 Merck & Co Inc Substituted 2-aminomethyl-4,6-disubstituted phenols
US3794734A (en) * 1971-03-03 1974-02-26 Merck & Co Inc Methods of treating edema and hypertension using certain 2-aminoethylphenols
FR2137005B1 (da) * 1971-05-11 1974-08-23 Delalande Sa

Also Published As

Publication number Publication date
FR2308361A1 (fr) 1976-11-19
FR2308361B1 (da) 1979-09-21
US4092414A (en) 1978-05-30
JPS51128983A (en) 1976-11-10
DE2617673A1 (de) 1976-11-11
NL7603651A (nl) 1976-10-27
GB1497638A (en) 1978-01-12
SE7604095L (sv) 1976-10-26

Similar Documents

Publication Publication Date Title
DK282076A (da) Fremgangsmade til fremstilling af 2,3-dihydro6,7-disubstitueret-5-acyl-benzofuran-2-carboxylsyrer
DK138749C (da) Analogifremgangsmaade til fremstilling af 18-methyl-4,15-oestradiener
DK107876A (da) Fremgangsmade til fremstilling af thiocarbamider
DK164376A (da) Fremgangsmade til fremstilling af 3,4-dihydrospiro-2h-1,3-benzoxaziner
DK554076A (da) Fremgangsmade til fremstilling af 3,4i-dideoxykanamycin ]
DK535476A (da) Fremgangsmade til fremstilling af 7-methoxycephalosporiner
DK187577A (da) Fremgangsmade til fremstilling af 1,4-benzodioxsnderivater
DK150676A (da) Fremgangsmade til fremstilling af krystallinsk natrium-o-formyl-cefamandol
DK143757C (da) Analogifremgangsmaade til fremstilling af 16,16-disubstituerede 3-oxoandrostener
DK362676A (da) Fremgangsmade til fremstilling af 1,4-dihydropyridiner
DK415576A (da) Fremgangsmade til fremstilling af krystallinsk dipilocarpiniumpamoat
DK399976A (da) Fremgangsmade til fremstilling af aralkylamider
DK336676A (da) Fremgangsmade til fremstilling af 1,2,3,4-tetrahydroisoquinoliner
DK141584C (da) Fremgangsmaade til fremstilling af slagseje vinylaromat-podecopolymere
DK480676A (da) Fremgangsmade til fremstilling af s-alkylphosphordihalogeniddithioater
DK424676A (da) Fremgangsmade til fremstilling af 2-alkylindan
DK526676A (da) Fremgangsmade til fremstilling af 4-chlor-2-butynyl-m-chlorcarbanilat
DK149803C (da) Fremgangsmaade til fremstilling af 1,2-dichlorethan
DK544476A (da) Fremgangsmade til fremstilling af difluormethyl-1,2,2-trifluorethylether
DK305076A (da) Fremgangsmade til fremstilling af d,l-pantolacton
DK345477A (da) Fremgangsmaade til fremstilling af 2,3-dichloranisol
DK554176A (da) Fremgangsmade til fremstilling af 3,4-dideoxykanamycin b
DK46476A (da) Fremgangsmade til fremstilling af 5-nitrothiazolylimidazolidiner
DK580076A (da) Fremgangsmade til fremstilling af 6,6,6-trihalogen-3,3-dimethyl-4-hexenoater
DK31676A (da) Fremgangsmade til fremstilling af 1,4-naphthodinitril

Legal Events

Date Code Title Description
PBP Patent lapsed