CS199609B2 - Method of producing 6-methyl-8-isocyanmethyl ergoline - Google Patents

Method of producing 6-methyl-8-isocyanmethyl ergoline Download PDF

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Publication number
CS199609B2
CS199609B2 CS757860A CS786075A CS199609B2 CS 199609 B2 CS199609 B2 CS 199609B2 CS 757860 A CS757860 A CS 757860A CS 786075 A CS786075 A CS 786075A CS 199609 B2 CS199609 B2 CS 199609B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
methyl
formula
acid
reacting
Prior art date
Application number
CS757860A
Other languages
Czech (cs)
English (en)
Inventor
Edmund C Kornfeld
Nicholas J Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS199609B2 publication Critical patent/CS199609B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS757860A 1974-12-06 1975-11-20 Method of producing 6-methyl-8-isocyanmethyl ergoline CS199609B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/530,318 US3985752A (en) 1974-12-06 1974-12-06 6-Methyl-8-(substituted) methylergolines

Publications (1)

Publication Number Publication Date
CS199609B2 true CS199609B2 (en) 1980-07-31

Family

ID=24113213

Family Applications (2)

Application Number Title Priority Date Filing Date
CS757859A CS200483B2 (en) 1974-12-06 1975-11-20 Process for preparing 6-methyl-8-/2-methylsulphinylethyl/ergoline
CS757860A CS199609B2 (en) 1974-12-06 1975-11-20 Method of producing 6-methyl-8-isocyanmethyl ergoline

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS757859A CS200483B2 (en) 1974-12-06 1975-11-20 Process for preparing 6-methyl-8-/2-methylsulphinylethyl/ergoline

Country Status (29)

Country Link
US (1) US3985752A (sv)
JP (2) JPS5946235B2 (sv)
AR (2) AR207664A1 (sv)
AT (2) AT348141B (sv)
AU (1) AU498226B2 (sv)
BE (1) BE836308A (sv)
BG (3) BG33435A3 (sv)
CA (2) CA1062252A (sv)
CH (2) CH617197A5 (sv)
CS (2) CS200483B2 (sv)
DD (2) DD123749A5 (sv)
DE (1) DE2554000A1 (sv)
DK (2) DK142321B (sv)
ES (3) ES443276A1 (sv)
FR (1) FR2293203A1 (sv)
GB (1) GB1526835A (sv)
GR (2) GR60025B (sv)
HU (3) HU173847B (sv)
IE (1) IE42372B1 (sv)
IL (1) IL48573A (sv)
MX (1) MX3113E (sv)
NL (1) NL7514058A (sv)
PH (1) PH12630A (sv)
PL (3) PL102195B1 (sv)
RO (2) RO64281A (sv)
SE (2) SE421423B (sv)
SU (3) SU685155A3 (sv)
YU (2) YU304875A (sv)
ZA (1) ZA757624B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
HU180467B (en) * 1979-07-12 1983-03-28 Gyogyszerkutato Intezet Process for producing new ergol-8-ene- and ergoline-sceleted compounds
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
JPH0541005Y2 (sv) * 1987-07-14 1993-10-18
JPH02174820A (ja) * 1988-12-27 1990-07-06 Sekisui Chem Co Ltd トイレット
WO2000054776A1 (en) * 1999-03-17 2000-09-21 Eugen Eigenmann Use of prolactin inhibitors for the treatment of fertility problems in animal species
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28388A (en) * 1966-07-29 1971-11-29 Farma Italia Soc History 1, 6 - Dimethyl - A 01 - Argolin
CH507248A (de) * 1967-03-16 1971-05-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure

Also Published As

Publication number Publication date
IE42372B1 (en) 1980-07-30
ZA757624B (en) 1977-07-27
SU724085A3 (ru) 1980-03-25
BE836308A (fr) 1976-06-08
ES443276A1 (es) 1977-08-16
IE42372L (en) 1976-06-06
US3985752A (en) 1976-10-12
AT347050B (de) 1978-12-11
AR207664A1 (es) 1976-10-22
DD123749A5 (sv) 1977-01-12
DK142321C (sv) 1981-03-09
HU173724B (hu) 1979-07-28
FR2293203B1 (sv) 1978-07-28
USB530318I5 (sv) 1976-01-13
SE421422B (sv) 1981-12-21
YU304775A (en) 1982-02-28
HU175228B (hu) 1980-06-28
DE2554000A1 (de) 1976-06-16
SE421423B (sv) 1981-12-21
GR60025B (en) 1978-03-31
CA1062253A (en) 1979-09-11
AT348141B (de) 1979-01-25
PH12630A (en) 1979-07-05
JPS5182300A (sv) 1976-07-19
SE7513640L (sv) 1976-06-08
NL7514058A (nl) 1976-06-09
ES443275A1 (es) 1977-09-16
HU173847B (hu) 1979-09-28
JPS59210085A (ja) 1984-11-28
SE7513641L (sv) 1976-06-08
YU304875A (en) 1982-02-28
BG33435A3 (en) 1983-02-15
CA1062252A (en) 1979-09-11
RO65456A (ro) 1980-01-15
IL48573A (en) 1979-03-12
BG33288A3 (en) 1983-01-14
AR208104A1 (es) 1976-11-30
BG33287A3 (en) 1983-01-14
PL102198B1 (pl) 1979-03-31
ES457709A1 (es) 1978-03-01
MX3113E (es) 1980-04-18
GR60026B (en) 1978-03-31
DK547675A (da) 1976-06-07
IL48573A0 (en) 1976-01-30
JPS6017795B2 (ja) 1985-05-07
JPS5946235B2 (ja) 1984-11-10
DK547575A (sv) 1976-06-07
CS200483B2 (en) 1980-09-15
FR2293203A1 (fr) 1976-07-02
RO64281A (fr) 1979-07-15
GB1526835A (en) 1978-10-04
CH619465A5 (sv) 1980-09-30
AU8718275A (en) 1977-06-09
AU498226B2 (en) 1979-02-22
PL102195B1 (pl) 1979-03-31
SU694075A3 (ru) 1979-10-25
CH617197A5 (sv) 1980-05-14
ATA927975A (de) 1978-04-15
DD123748A5 (sv) 1977-01-12
ATA927875A (de) 1978-06-15
PL106884B1 (pl) 1980-01-31
DK142321B (da) 1980-10-13
SU685155A3 (ru) 1979-09-05

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