CR6538A - Anticuerpos de humano, anti-avb3 recombinantes, acidos nucleicos que codifican a los mismos y metodo de uso - Google Patents
Anticuerpos de humano, anti-avb3 recombinantes, acidos nucleicos que codifican a los mismos y metodo de usoInfo
- Publication number
- CR6538A CR6538A CR6538A CR6538A CR6538A CR 6538 A CR6538 A CR 6538A CR 6538 A CR6538 A CR 6538A CR 6538 A CR6538 A CR 6538A CR 6538 A CR6538 A CR 6538A
- Authority
- CR
- Costa Rica
- Prior art keywords
- avb3
- nucleic acids
- same
- human antibodies
- recombinant anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invencion proporciona anticuerpos injertados LM609 mejorados, que muestran una afinidad de enlace selectiva a la avB3, o un fragmento funcional de los mismos. Tambien proporciona moleculas de acido nucleico que codifican a los anticuerpos injertados LM609 mejorados. Adicionalmente, se proporcionan metodos para inhibir una funcion de la avB3 poniendo en contacto la avB3 con un anticuerpo injertado LM609 mejorado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/339,922 US6531580B1 (en) | 1999-06-24 | 1999-06-24 | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
Publications (1)
Publication Number | Publication Date |
---|---|
CR6538A true CR6538A (es) | 2006-02-06 |
Family
ID=23331188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR6538A CR6538A (es) | 1999-06-24 | 2001-12-20 | Anticuerpos de humano, anti-avb3 recombinantes, acidos nucleicos que codifican a los mismos y metodo de uso |
Country Status (19)
Country | Link |
---|---|
US (3) | US6531580B1 (es) |
EP (1) | EP1189946A1 (es) |
JP (2) | JP4521802B2 (es) |
KR (1) | KR100928748B1 (es) |
AU (3) | AU781501C (es) |
BR (1) | BR0011849A (es) |
CA (1) | CA2375236A1 (es) |
CR (1) | CR6538A (es) |
CZ (1) | CZ302177B6 (es) |
HU (1) | HUP0201783A3 (es) |
IL (2) | IL147145A0 (es) |
MX (1) | MXPA01013362A (es) |
NO (1) | NO20016243L (es) |
NZ (3) | NZ533727A (es) |
PL (1) | PL352251A1 (es) |
SK (1) | SK19072001A3 (es) |
TR (1) | TR200103703T2 (es) |
WO (1) | WO2000078815A1 (es) |
ZA (1) | ZA200110161B (es) |
Families Citing this family (77)
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US6590079B2 (en) * | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
US6596850B1 (en) * | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
US6531580B1 (en) * | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
WO2001079481A2 (en) * | 2000-04-17 | 2001-10-25 | Dyax Corp. | Methods of constructing display libraries of genetic packages for members of a diverse family of peptides |
US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
AU2002249854B2 (en) | 2000-12-18 | 2007-09-20 | Dyax Corp. | Focused libraries of genetic packages |
CA2439852A1 (en) * | 2001-03-02 | 2002-09-12 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
US7390885B2 (en) | 2001-11-26 | 2008-06-24 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
US7365167B2 (en) | 2001-11-26 | 2008-04-29 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
AU2003217930A1 (en) * | 2002-03-04 | 2003-09-22 | Medimmune, Llc | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
AU2003213682C1 (en) * | 2002-03-04 | 2008-06-12 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin alphavbeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate |
WO2005123131A2 (en) * | 2004-06-14 | 2005-12-29 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
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US20040208869A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Uses of anti-integrin alphanubeta3 antibody formulations |
US20040208870A1 (en) * | 2003-01-30 | 2004-10-21 | Medimmune, Inc. | Stabilized high concentration anti-integrin alphanubeta3 antibody formulations |
US20060234296A1 (en) * | 2003-02-01 | 2006-10-19 | Sanjaya Singh | Method for generating high affinity antibodies |
EP2316487B1 (en) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
US8668926B1 (en) | 2003-09-15 | 2014-03-11 | Shaker A. Mousa | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof |
AU2004273986B2 (en) * | 2003-09-15 | 2010-04-22 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use in angiogenesis |
US8071134B2 (en) | 2003-09-15 | 2011-12-06 | Ordway Research Institute, Inc. | Thyroid hormone analogs and methods of use |
US9198887B2 (en) | 2003-09-15 | 2015-12-01 | Nanopharmaceuticals Llc | Thyroid hormone analogs and methods of use |
WO2005068504A1 (ja) * | 2004-01-19 | 2005-07-28 | Medical And Biological Laboratories Co., Ltd. | 炎症性サイトカイン抑制剤 |
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EP1755673B1 (en) | 2004-04-12 | 2014-07-23 | MedImmune, LLC | Anti-il-9 antibody formulations and uses thereof |
US7351739B2 (en) | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
WO2005117936A2 (en) * | 2004-05-07 | 2005-12-15 | The University Of North Carolina At Chapel Hill | Method for enhancing or inhibiting insulin-like growth factor-i |
US8187595B2 (en) | 2004-05-07 | 2012-05-29 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor-I |
US7470521B2 (en) | 2004-07-20 | 2008-12-30 | Critical Therapeutics, Inc. | RAGE protein derivatives |
JP2008510008A (ja) * | 2004-08-16 | 2008-04-03 | メディミューン,インコーポレーテッド | 抗体依存性細胞性細胞傷害活性が増強されたインテグリンアンタゴニスト |
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AU2009269704B2 (en) | 2008-06-16 | 2014-06-12 | Patrys Limited | LM-antibodies, functional fragments, LM-1 target antigen, and methods for making and using same |
KR20110031369A (ko) | 2008-07-08 | 2011-03-25 | 아보트 러보러터리즈 | 프로스타글란딘 e2 이원 가변 도메인 면역글로불린 및 이의 용도 |
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ES2548030T3 (es) | 2009-06-01 | 2015-10-13 | Medimmune, Llc | Moléculas con semividas prolongadas y usos de las mismas |
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JP2013504602A (ja) * | 2009-09-14 | 2013-02-07 | ダイアックス コーポレーション | 新しく設計したhccdr3を含む遺伝子パッケージライブラリー |
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CA2861793C (en) | 2011-12-28 | 2023-08-01 | Immunoqure Ag | Method of providing monoclonal auto-antibodies with desired specificity |
TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對il-13及/或il-17之雙特異性結合蛋白 |
JP2015533117A (ja) | 2012-08-31 | 2015-11-19 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | インスリン様成長因子1(igf−1)を増強または阻害するためのモノクローナル抗体 |
MY194330A (en) | 2012-11-01 | 2022-11-28 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof |
CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
ES2911663T3 (es) | 2013-07-03 | 2022-05-20 | Immunoqure Ag | Anticuerpos humanos anti-IFN-alfa |
FR3024049A1 (fr) | 2014-07-28 | 2016-01-29 | Total Raffinage Chimie | Dispositif de terminaison d'un reacteur d'une unite de craquage catalytique fluide |
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EP3463477A4 (en) | 2016-06-07 | 2020-03-04 | NanoPharmaceuticals LLC | NON-CLeavable POLYMER CONJUGATED WITH THYROID ANTAGONISTS OF avß3 INTEGRIN |
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US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
JP3353209B2 (ja) | 1992-04-03 | 2002-12-03 | ジェネンテク,インコーポレイテッド | αvβ3インテグリンに対する抗体 |
IT1268004B1 (it) * | 1994-02-02 | 1997-02-20 | Giuseppe Lambertini | Dispositivo per il bloccaggio di un pezzo su un piano d'appoggio, quale una tavola di macchina operatrice. |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
CN1186439A (zh) | 1995-06-07 | 1998-07-01 | 森特克公司 | 血小板特异性的嵌合性免疫球蛋白及其使用方法 |
US6596850B1 (en) | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
US6590079B2 (en) * | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
US6531580B1 (en) * | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
-
1999
- 1999-06-24 US US09/339,922 patent/US6531580B1/en not_active Expired - Lifetime
-
2000
- 2000-06-23 TR TR2001/03703T patent/TR200103703T2/xx unknown
- 2000-06-23 AU AU56374/00A patent/AU781501C/en not_active Ceased
- 2000-06-23 BR BR0011849-4A patent/BR0011849A/pt not_active Application Discontinuation
- 2000-06-23 MX MXPA01013362A patent/MXPA01013362A/es active IP Right Grant
- 2000-06-23 CA CA002375236A patent/CA2375236A1/en not_active Abandoned
- 2000-06-23 JP JP2001505572A patent/JP4521802B2/ja not_active Expired - Fee Related
- 2000-06-23 PL PL00352251A patent/PL352251A1/xx not_active IP Right Cessation
- 2000-06-23 CZ CZ20014655A patent/CZ302177B6/cs not_active IP Right Cessation
- 2000-06-23 NZ NZ533727A patent/NZ533727A/en not_active IP Right Cessation
- 2000-06-23 HU HU0201783A patent/HUP0201783A3/hu unknown
- 2000-06-23 KR KR1020017016479A patent/KR100928748B1/ko not_active IP Right Cessation
- 2000-06-23 IL IL14714500A patent/IL147145A0/xx not_active IP Right Cessation
- 2000-06-23 EP EP00941707A patent/EP1189946A1/en not_active Withdrawn
- 2000-06-23 NZ NZ516251A patent/NZ516251A/xx not_active IP Right Cessation
- 2000-06-23 SK SK1907-2001A patent/SK19072001A3/sk not_active Application Discontinuation
- 2000-06-23 NZ NZ523291A patent/NZ523291A/en not_active IP Right Cessation
- 2000-06-23 WO PCT/US2000/017454 patent/WO2000078815A1/en active Application Filing
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2001
- 2001-12-11 ZA ZA200110161A patent/ZA200110161B/xx unknown
- 2001-12-19 NO NO20016243A patent/NO20016243L/no unknown
- 2001-12-20 CR CR6538A patent/CR6538A/es not_active Application Discontinuation
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2002
- 2002-11-25 US US10/305,231 patent/US7371382B2/en not_active Expired - Fee Related
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2005
- 2005-08-25 AU AU2005204251A patent/AU2005204251B2/en not_active Ceased
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2008
- 2008-04-14 US US12/102,818 patent/US7667007B2/en not_active Expired - Fee Related
- 2008-12-02 IL IL195649A patent/IL195649A0/en unknown
- 2008-12-19 AU AU2008261144A patent/AU2008261144A1/en not_active Abandoned
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2009
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