CR20210482A - Derivados de pirimidona de anillo fusionado para uso en el tratamiento de infección por vhb o enfermedades inducidas por vhb - Google Patents

Derivados de pirimidona de anillo fusionado para uso en el tratamiento de infección por vhb o enfermedades inducidas por vhb

Info

Publication number
CR20210482A
CR20210482A CR20210482A CR20210482A CR20210482A CR 20210482 A CR20210482 A CR 20210482A CR 20210482 A CR20210482 A CR 20210482A CR 20210482 A CR20210482 A CR 20210482A CR 20210482 A CR20210482 A CR 20210482A
Authority
CR
Costa Rica
Prior art keywords
hbv
treatment
fused ring
induced diseases
pyrimidone derivatives
Prior art date
Application number
CR20210482A
Other languages
English (en)
Inventor
Tim Hugo Maria Jonckers
Stefaan Julien Last
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Wim Gaston Verschueren
Edgar Jacoby
Jan Martin Berke
Bart Rudolf Romanie Kesteleyn
Serge Maria Aloysius Pieters
Abdellah Tahri
Meng-Yang Hsiao
Lili Hu
Lamenca Carolina Martinez
Sandrine Céline Grosse
Mathieu Perrier
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of CR20210482A publication Critical patent/CR20210482A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La presente solicitud se refiere a compuestos de acuerdo con la fórmula (I), composiciones farmacéuticas que comprenden al menos uno de dichos compuestos, su uso como medicamento y su uso en el tratamiento de la infección crónica por el virus de la hepatitis B (VHB). La divulgación se refiere además a métodos para preparar compuestos de acuerdo con la fórmula (I).
CR20210482A 2019-03-14 2020-03-13 Derivados de pirimidona de anillo fusionado para uso en el tratamiento de infección por vhb o enfermedades inducidas por vhb CR20210482A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19162954 2019-03-14
PCT/EP2020/056884 WO2020182990A1 (en) 2019-03-14 2020-03-13 Fused ring pyrimidone derivatives for use in the treatment of hbv infection or of hbv-induced diseases

Publications (1)

Publication Number Publication Date
CR20210482A true CR20210482A (es) 2021-11-09

Family

ID=65817822

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210482A CR20210482A (es) 2019-03-14 2020-03-13 Derivados de pirimidona de anillo fusionado para uso en el tratamiento de infección por vhb o enfermedades inducidas por vhb

Country Status (23)

Country Link
US (1) US20230091047A1 (es)
EP (1) EP3938362A1 (es)
JP (1) JP2022524456A (es)
KR (1) KR20210139319A (es)
CN (1) CN113710667A (es)
AR (1) AR118358A1 (es)
AU (1) AU2020235270A1 (es)
BR (1) BR112021017415A2 (es)
CA (1) CA3132531A1 (es)
CL (1) CL2021002390A1 (es)
CO (1) CO2021011295A2 (es)
CR (1) CR20210482A (es)
DO (1) DOP2021000185A (es)
EA (1) EA202192512A1 (es)
EC (1) ECSP21067189A (es)
IL (1) IL286210A (es)
JO (1) JOP20210249A1 (es)
MA (1) MA55286A (es)
MX (1) MX2021011107A (es)
PE (1) PE20212325A1 (es)
SG (1) SG11202109575UA (es)
TW (1) TW202100524A (es)
WO (1) WO2020182990A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202227435A (zh) * 2020-09-11 2022-07-16 愛爾蘭商健生科學愛爾蘭無限公司 用於治療ｈｂｖ感染或ｈｂｖ誘發的疾病之稠合環嘧啶酮衍生物
JP2023548031A (ja) * 2020-10-21 2023-11-15 アリゴス セラピューティクス インコーポレイテッド 二環式化合物
US11957683B2 (en) 2021-06-18 2024-04-16 Aligos Therapeutics, Inc. Bicyclic compounds
WO2023205653A1 (en) * 2022-04-20 2023-10-26 Aligos Therapeutics, Inc. Bicyclic compounds
US20230374008A1 (en) * 2022-04-20 2023-11-23 Aligos Therapeutics, Inc. Bicyclic compounds
WO2024015425A1 (en) 2022-07-14 2024-01-18 Fmc Corporation Herbicidal benzoxazines
US20240150351A1 (en) * 2022-09-30 2024-05-09 Aligos Therapeutics, Inc. Bicyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2008038768A1 (ja) 2006-09-28 2010-01-28 大日本住友製薬株式会社 二環性ピリミジン構造を有する化合物及びそれを含有する医薬組成物
EP2148869A1 (en) 2007-04-20 2010-02-03 Schering Corporation Pyrimidinone derivatives and methods of use thereof
CN101854597B (zh) 2009-04-03 2015-06-03 中兴通讯股份有限公司 大消息模式融合ip消息传输方法及系统
WO2011111880A1 (ko) * 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
JP2012126698A (ja) * 2010-12-17 2012-07-05 Tsutomu Takeuchi テトラヒドロピリドピリミジン誘導体を有効成分とするｂａｆｆの結合阻害剤
RU2742305C2 (ru) * 2014-12-30 2021-02-04 Новира Терапьютикс, Инк. Производные и способы лечения инфекций гепатита в
WO2018083081A1 (en) * 2016-11-03 2018-05-11 F. Hoffmann-La Roche Ag Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Also Published As

Publication number Publication date
JP2022524456A (ja) 2022-05-02
CA3132531A1 (en) 2020-09-17
ECSP21067189A (es) 2021-11-18
BR112021017415A2 (pt) 2022-02-01
TW202100524A (zh) 2021-01-01
US20230091047A1 (en) 2023-03-23
JOP20210249A1 (ar) 2023-01-30
MA55286A (fr) 2022-01-19
EA202192512A1 (ru) 2022-02-16
CO2021011295A2 (es) 2021-09-20
IL286210A (en) 2021-10-31
KR20210139319A (ko) 2021-11-22
MX2021011107A (es) 2022-01-19
PE20212325A1 (es) 2021-12-14
AU2020235270A1 (en) 2021-08-12
CN113710667A (zh) 2021-11-26
CL2021002390A1 (es) 2022-04-22
SG11202109575UA (en) 2021-09-29
WO2020182990A1 (en) 2020-09-17
DOP2021000185A (es) 2022-01-16
AR118358A1 (es) 2021-09-29
EP3938362A1 (en) 2022-01-19

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