JOP20210249A1 - مشتقات البيرميدون الحلقية المدمجة للاستخدام في علاج عدوىhbv أو الأمراض التي يسببها فيروس hbv - Google Patents

مشتقات البيرميدون الحلقية المدمجة للاستخدام في علاج عدوىhbv أو الأمراض التي يسببها فيروس hbv

Info

Publication number
JOP20210249A1
JOP20210249A1 JOP/2021/0249A JOP20210249A JOP20210249A1 JO P20210249 A1 JOP20210249 A1 JO P20210249A1 JO P20210249 A JOP20210249 A JO P20210249A JO P20210249 A1 JOP20210249 A1 JO P20210249A1
Authority
JO
Jordan
Prior art keywords
hbv
treatment
fused ring
induced diseases
pyrimidone derivatives
Prior art date
Application number
JOP/2021/0249A
Other languages
English (en)
Inventor
Tim Hugo Maria Jonckers
Koen Vandyck
Serge Maria Aloysius Pieters
Jan Martin Berke
Mathieu Perrier
Edgar Jacoby
Pierre Jean-Marie Bernard Raboisson
Abdellah Tahri
Sandrine Céline Grosse
Wim Gaston Verschueren
Bart Rudolf Romanie Kesteleyn
Stefaan Julien Last
Lamenca Carolina Martinez
Meng-Yang Hsiao
Lil Hu
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of JOP20210249A1 publication Critical patent/JOP20210249A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات وفقا للصيغة (I)، وتركيبات صيدلية تتضمن واحد على الأقل من المركبات المذكورة، واستخدامها كعلاج، واستخدامها في معالجة عدوى فيروس التهاب الكبد الوبائى B (HBV) المزمن. يتعلق الاختراع الحالي أيضا بطرق تحضير مركبات وفقا للصيغة (I).
JOP/2021/0249A 2019-03-14 2020-03-13 مشتقات البيرميدون الحلقية المدمجة للاستخدام في علاج عدوىhbv أو الأمراض التي يسببها فيروس hbv JOP20210249A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19162954 2019-03-14
PCT/EP2020/056884 WO2020182990A1 (en) 2019-03-14 2020-03-13 Fused ring pyrimidone derivatives for use in the treatment of hbv infection or of hbv-induced diseases

Publications (1)

Publication Number Publication Date
JOP20210249A1 true JOP20210249A1 (ar) 2023-01-30

Family

ID=65817822

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0249A JOP20210249A1 (ar) 2019-03-14 2020-03-13 مشتقات البيرميدون الحلقية المدمجة للاستخدام في علاج عدوىhbv أو الأمراض التي يسببها فيروس hbv

Country Status (23)

Country Link
US (1) US20230091047A1 (ar)
EP (1) EP3938362A1 (ar)
JP (1) JP2022524456A (ar)
KR (1) KR20210139319A (ar)
CN (1) CN113710667A (ar)
AR (1) AR118358A1 (ar)
AU (1) AU2020235270A1 (ar)
BR (1) BR112021017415A2 (ar)
CA (1) CA3132531A1 (ar)
CL (1) CL2021002390A1 (ar)
CO (1) CO2021011295A2 (ar)
CR (1) CR20210482A (ar)
DO (1) DOP2021000185A (ar)
EA (1) EA202192512A1 (ar)
EC (1) ECSP21067189A (ar)
IL (1) IL286210A (ar)
JO (1) JOP20210249A1 (ar)
MA (1) MA55286A (ar)
MX (1) MX2021011107A (ar)
PE (1) PE20212325A1 (ar)
SG (1) SG11202109575UA (ar)
TW (1) TW202100524A (ar)
WO (1) WO2020182990A1 (ar)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202227435A (zh) * 2020-09-11 2022-07-16 愛爾蘭商健生科學愛爾蘭無限公司 用於治療ｈｂｖ感染或ｈｂｖ誘發的疾病之稠合環嘧啶酮衍生物
KR20230091929A (ko) * 2020-10-21 2023-06-23 알리고스 테라퓨틱스 인코포레이티드 바이사이클릭 화합물
US11957683B2 (en) 2021-06-18 2024-04-16 Aligos Therapeutics, Inc. Bicyclic compounds
WO2023205653A1 (en) * 2022-04-20 2023-10-26 Aligos Therapeutics, Inc. Bicyclic compounds
US20230374008A1 (en) * 2022-04-20 2023-11-23 Aligos Therapeutics, Inc. Bicyclic compounds
WO2024015425A1 (en) 2022-07-14 2024-01-18 Fmc Corporation Herbicidal benzoxazines
WO2024073559A1 (en) * 2022-09-30 2024-04-04 Aligos Therapeutics, Inc. Bicyclic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078719A4 (en) * 2006-09-28 2009-11-11 Dainippon Sumitomo Pharma Co COMPOUND WITH BICYCLIC PYRIMIDINE STRUCTURE AND THE COMPOUND CONTAINING PHARMACEUTICAL COMPOSITION
US20100190687A1 (en) * 2007-04-20 2010-07-29 Boyle Craig D Pyrimidinone derivatives and methods of use thereof
CN101854597B (zh) 2009-04-03 2015-06-03 中兴通讯股份有限公司 大消息模式融合ip消息传输方法及系统
WO2011111880A1 (ko) * 2010-03-08 2011-09-15 주식회사 메디젠텍 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물
JP2012126698A (ja) * 2010-12-17 2012-07-05 Tsutomu Takeuchi テトラヒドロピリドピリミジン誘導体を有効成分とするｂａｆｆの結合阻害剤
CA2972434A1 (en) * 2014-12-30 2016-07-07 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis b infections
WO2018083081A1 (en) * 2016-11-03 2018-05-11 F. Hoffmann-La Roche Ag Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Also Published As

Publication number Publication date
US20230091047A1 (en) 2023-03-23
CO2021011295A2 (es) 2021-09-20
JP2022524456A (ja) 2022-05-02
CN113710667A (zh) 2021-11-26
TW202100524A (zh) 2021-01-01
ECSP21067189A (es) 2021-11-18
MX2021011107A (es) 2022-01-19
KR20210139319A (ko) 2021-11-22
AR118358A1 (es) 2021-09-29
DOP2021000185A (es) 2022-01-16
AU2020235270A1 (en) 2021-08-12
SG11202109575UA (en) 2021-09-29
PE20212325A1 (es) 2021-12-14
CA3132531A1 (en) 2020-09-17
EP3938362A1 (en) 2022-01-19
BR112021017415A2 (pt) 2022-02-01
IL286210A (en) 2021-10-31
EA202192512A1 (ru) 2022-02-16
WO2020182990A1 (en) 2020-09-17
CR20210482A (es) 2021-11-09
CL2021002390A1 (es) 2022-04-22
MA55286A (fr) 2022-01-19

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