CR20210073A - Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1 y / o pd-l1 - Google Patents

Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1 y / o pd-l1

Info

Publication number
CR20210073A
CR20210073A CR20210073A CR20210073A CR20210073A CR 20210073 A CR20210073 A CR 20210073A CR 20210073 A CR20210073 A CR 20210073A CR 20210073 A CR20210073 A CR 20210073A CR 20210073 A CR20210073 A CR 20210073A
Authority
CR
Costa Rica
Prior art keywords
compositions
methods
targeting flt3
immunotherapy targeting
flt3
Prior art date
Application number
CR20210073A
Other languages
English (en)
Inventor
Jianhua Yu
Michael Caligiuri
Original Assignee
Cytoimmune Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytoimmune Therapeutics Inc filed Critical Cytoimmune Therapeutics Inc
Publication of CR20210073A publication Critical patent/CR20210073A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/86—Viral vectors
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Abstract

Las células con CAR que se dirigen a antígenos FLT3 en combinación con anticuerpos anti-PD-1 y anti-PD-L1 secretados o anticuerpos biespecíficos anti-PD-1-anti-PD-L1 se describen como un nuevo método de tratamiento del cáncer. Se propone que estas terapias de combinación son seguras y eficaces en pacientes y pueden usarse para tratar tumores y cáncer humanos.
CR20210073A 2018-07-04 2019-07-03 Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1 y / o pd-l1 CR20210073A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862693977P 2018-07-04 2018-07-04
PCT/US2019/040654 WO2020010284A1 (en) 2018-07-04 2019-07-03 Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1

Publications (1)

Publication Number Publication Date
CR20210073A true CR20210073A (es) 2021-05-12

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CR20210073A CR20210073A (es) 2018-07-04 2019-07-03 Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1 y / o pd-l1

Country Status (13)

Country Link
US (1) US20210301024A1 (es)
EP (1) EP3818146A4 (es)
KR (1) KR20210044774A (es)
CN (1) CN112673093A (es)
AU (1) AU2019299555A1 (es)
CA (1) CA3108460A1 (es)
CO (1) CO2021001240A2 (es)
CR (1) CR20210073A (es)
EA (1) EA202190181A1 (es)
EC (1) ECSP21008307A (es)
PH (1) PH12021550278A1 (es)
SG (1) SG11202101067XA (es)
WO (1) WO2020010284A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180053744A (ko) 2015-09-23 2018-05-23 사이토이뮨 테라퓨틱스 엘엘씨 면역 요법을 위한 flt3 유도된 car 세포
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