WO2017053889A3 - Flt3 directed car cells for immunotherapy - Google Patents
Flt3 directed car cells for immunotherapy Download PDFInfo
- Publication number
- WO2017053889A3 WO2017053889A3 PCT/US2016/053577 US2016053577W WO2017053889A3 WO 2017053889 A3 WO2017053889 A3 WO 2017053889A3 US 2016053577 W US2016053577 W US 2016053577W WO 2017053889 A3 WO2017053889 A3 WO 2017053889A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- car cells
- flt3
- immunotherapy
- directed car
- cancer
- Prior art date
Links
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 abstract 1
- 206010054094 Tumour necrosis Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C07K—PEPTIDES
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201680065509.1A CN109310744A (en) | 2015-09-23 | 2016-09-23 | FLT3 for immunization therapy orients CAR cell |
AU2016326721A AU2016326721C1 (en) | 2015-09-23 | 2016-09-23 | FLT3 directed car cells for immunotherapy |
CA2999037A CA2999037A1 (en) | 2015-09-23 | 2016-09-23 | Flt3 directed car cells for immunotherapy |
EP16849810.3A EP3352784A4 (en) | 2015-09-23 | 2016-09-23 | Flt3 directed car cells for immunotherapy |
EP19170050.9A EP3569244A1 (en) | 2015-09-23 | 2016-09-23 | Flt3 directed car cells for immunotherapy |
KR1020187011302A KR20180053744A (en) | 2015-09-23 | 2016-09-23 | FLT3-induced CAR cells for immunotherapy |
JP2018534523A JP7054924B2 (en) | 2015-09-23 | 2016-09-23 | FLT3-oriented CAR cells for immunotherapy |
US15/811,608 US10961312B2 (en) | 2015-09-23 | 2017-11-13 | FLT3 directed car cells for immunotherapy |
HK19101399.4A HK1258921A1 (en) | 2015-09-23 | 2019-01-28 | Flt3 directed car cells for immunotherapy |
AU2021201329A AU2021201329A1 (en) | 2015-09-23 | 2021-03-02 | Flt3 directed car cells for immunotherapy |
US17/199,332 US20210269534A1 (en) | 2015-09-23 | 2021-03-11 | Flt3 directed car cells for immunotherapy |
JP2021189789A JP2022046461A (en) | 2015-09-23 | 2021-11-24 | Flt3-oriented car cell for immunotherapy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562222695P | 2015-09-23 | 2015-09-23 | |
US62/222,695 | 2015-09-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/811,608 Continuation-In-Part US10961312B2 (en) | 2015-09-23 | 2017-11-13 | FLT3 directed car cells for immunotherapy |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2017053889A2 WO2017053889A2 (en) | 2017-03-30 |
WO2017053889A3 true WO2017053889A3 (en) | 2017-05-26 |
Family
ID=58387435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/053577 WO2017053889A2 (en) | 2015-09-23 | 2016-09-23 | Flt3 directed car cells for immunotherapy |
Country Status (9)
Country | Link |
---|---|
US (2) | US10961312B2 (en) |
EP (2) | EP3569244A1 (en) |
JP (2) | JP7054924B2 (en) |
KR (1) | KR20180053744A (en) |
CN (1) | CN109310744A (en) |
AU (2) | AU2016326721C1 (en) |
CA (1) | CA2999037A1 (en) |
HK (1) | HK1258921A1 (en) |
WO (1) | WO2017053889A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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JP7054924B2 (en) * | 2015-09-23 | 2022-04-15 | サイトイミューン セラピューティクス, インコーポレイテッド | FLT3-oriented CAR cells for immunotherapy |
EP4413999A3 (en) | 2016-05-27 | 2024-08-28 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Flt3-specific chimeric antigen receptors and methods using same |
CA3045902A1 (en) | 2016-12-21 | 2018-06-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for flt3 and uses thereof |
WO2018222935A1 (en) * | 2017-06-02 | 2018-12-06 | Pfizer Inc. | Chimeric antigen receptors targeting flt3 |
MX2019014465A (en) | 2017-06-02 | 2020-01-23 | Pfizer | Antibodies specific for flt3 and their uses. |
CN111542323A (en) * | 2017-08-01 | 2020-08-14 | 尤利乌斯·马克西米利安维尔茨堡大学 | Use of FLT3CAR-T cells and FLT3 inhibitors in the treatment of acute myeloid leukemia |
AU2018311345A1 (en) * | 2017-08-02 | 2020-02-27 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered TCR and comprising a nucleotide sequence which is selectively expressed |
US11826385B2 (en) * | 2017-11-10 | 2023-11-28 | Jura Bio, Inc. | Major histocompatibility complex-based chimeric receptors and uses thereof for treating autoimmune diseases |
CN109988759A (en) * | 2017-12-29 | 2019-07-09 | 上海细胞治疗研究院 | A kind of chimeric promoters in T cell with high transcriptional activity |
US20190328785A1 (en) * | 2018-04-30 | 2019-10-31 | The Board Of Regents Of The University Of Oklahoma | Flt3-binding chimeric antigen receptors, cells, and uses thereof |
CN110305847B (en) * | 2018-07-27 | 2021-05-18 | 赛诺生(深圳)基因产业发展有限公司 | Genetically engineered cell for treating tumor |
CN109134665B (en) * | 2018-08-24 | 2021-06-11 | 上海先博生物科技有限公司 | BCMA chimeric antigen receptor based on single domain antibody and application |
WO2020113194A2 (en) * | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
EP3962527A4 (en) | 2019-04-30 | 2023-11-01 | Senti Biosciences, Inc. | Chimeric receptors and methods of use thereof |
US20220333079A1 (en) * | 2019-09-18 | 2022-10-20 | Slbigen Inc. | Genetically modified nk cell line transduced with gene encoding novel chimeric antigen receptor and use thereof |
KR102287180B1 (en) | 2019-10-01 | 2021-08-09 | 충북대학교 산학협력단 | Chimeric Antigen Receptor Specifically Binding to CD138, Immune Cell Expressing the Same, and Anti-Cancer Use Thereof |
US20230159644A1 (en) * | 2020-04-17 | 2023-05-25 | City Of Hope | Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies |
CN111647071B (en) * | 2020-06-17 | 2023-05-05 | 深圳豪石生物科技有限公司 | T cell receptor recognizing target cell surface antigen and composition thereof |
CN116410315A (en) * | 2021-12-31 | 2023-07-11 | 博生吉医药科技(苏州)有限公司 | Construction and application of novel chimeric antigen receptor modified T cell targeting human FLT3 |
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AU2016326721B2 (en) | 2020-12-03 |
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JP2018529380A (en) | 2018-10-11 |
CA2999037A1 (en) | 2017-03-30 |
KR20180053744A (en) | 2018-05-23 |
EP3352784A4 (en) | 2019-06-26 |
JP7054924B2 (en) | 2022-04-15 |
US20210269534A1 (en) | 2021-09-02 |
US10961312B2 (en) | 2021-03-30 |
WO2017053889A2 (en) | 2017-03-30 |
EP3352784A2 (en) | 2018-08-01 |
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