CO2021001240A2 - Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1, y/o pd-l1 - Google Patents
Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1, y/o pd-l1Info
- Publication number
- CO2021001240A2 CO2021001240A2 CONC2021/0001240A CO2021001240A CO2021001240A2 CO 2021001240 A2 CO2021001240 A2 CO 2021001240A2 CO 2021001240 A CO2021001240 A CO 2021001240A CO 2021001240 A2 CO2021001240 A2 CO 2021001240A2
- Authority
- CO
- Colombia
- Prior art keywords
- compositions
- methods
- targeting flt3
- immunotherapy targeting
- flt3
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000008685 targeting Effects 0.000 title abstract 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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Abstract
Las células con CAR que se dirigen a antígenos FLT3 en combinación con anticuerpos anti-PD-1 y anti-PD-L1 secretados o anticuerpos biespecíficos anti-PD-1-anti-PD-L1 se describen como un nuevo método de tratamiento del cáncer. Se propone que estas terapias de combinación son seguras y eficaces en pacientes y pueden usarse para tratar tumores y cáncer humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862693977P | 2018-07-04 | 2018-07-04 | |
PCT/US2019/040654 WO2020010284A1 (en) | 2018-07-04 | 2019-07-03 | Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021001240A2 true CO2021001240A2 (es) | 2021-03-19 |
Family
ID=69059874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0001240A CO2021001240A2 (es) | 2018-07-04 | 2021-02-04 | Composiciones y métodos para inmunoterapia dirigida a flt3, pd-1, y/o pd-l1 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210301024A1 (es) |
EP (1) | EP3818146A4 (es) |
KR (1) | KR20210044774A (es) |
CN (1) | CN112673093A (es) |
AU (1) | AU2019299555A1 (es) |
CA (1) | CA3108460A1 (es) |
CO (1) | CO2021001240A2 (es) |
CR (1) | CR20210073A (es) |
EA (1) | EA202190181A1 (es) |
EC (1) | ECSP21008307A (es) |
PH (1) | PH12021550278A1 (es) |
SG (1) | SG11202101067XA (es) |
WO (1) | WO2020010284A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017053889A2 (en) | 2015-09-23 | 2017-03-30 | Precision Immunotherapy, Inc. | Flt3 directed car cells for immunotherapy |
US11913023B2 (en) * | 2020-03-31 | 2024-02-27 | Walking Fish Therapeutics, Inc. | Modified B cells and methods of use thereof |
CA3175392A1 (en) | 2020-04-17 | 2021-10-21 | Michael A. Caligiuri | Flt3-targeted chimeric antigen receptor modified cells for treatment of flt3-positive malignancies |
WO2021226984A1 (zh) * | 2020-05-15 | 2021-11-18 | 三生国健药业(上海)股份有限公司 | 一种抗pd-1和pd-l1的四价双特异性抗体 |
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KR20220144000A (ko) * | 2021-04-16 | 2022-10-26 | 주식회사 이뮤노로지컬디자이닝랩 | Programmed death-ligand 1(PD-L1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
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WO2020010284A1 (en) | 2020-01-09 |
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CR20210073A (es) | 2021-05-12 |
CN112673093A (zh) | 2021-04-16 |
AU2019299555A1 (en) | 2021-02-25 |
ECSP21008307A (es) | 2021-06-30 |
SG11202101067XA (en) | 2021-03-30 |
EA202190181A1 (ru) | 2021-05-27 |
US20210301024A1 (en) | 2021-09-30 |
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