CR20200550A - Formulaciones de inmunoconjugado anti-cd79b estables - Google Patents

Formulaciones de inmunoconjugado anti-cd79b estables

Info

Publication number
CR20200550A
CR20200550A CR20200550A CR20200550A CR20200550A CR 20200550 A CR20200550 A CR 20200550A CR 20200550 A CR20200550 A CR 20200550A CR 20200550 A CR20200550 A CR 20200550A CR 20200550 A CR20200550 A CR 20200550A
Authority
CR
Costa Rica
Prior art keywords
cd79b immunoconjugate
stable anti
immunoconjugate formulations
formulations
cd79b
Prior art date
Application number
CR20200550A
Other languages
English (en)
Inventor
Ankit R Patel
Jun Liu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CR20200550A publication Critical patent/CR20200550A/es

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La divulgaciòn proporciona composiciones farmacèuticas estables que comprenden un inmunoconjugado anti-CD79b y un tensioactivo. La divulgaciòn tambièn proporciona mètodos para usar tales composiciones para el tratamiento del càncer.</p>
CR20200550A 2018-04-13 2019-04-12 Formulaciones de inmunoconjugado anti-cd79b estables CR20200550A (es)

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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009000062A1 (es) * 2008-01-31 2010-05-14 Genentech Inc Anticuerpo humanizado anti cd79b; con modificaciones de cisterna libre; inmunoconjugado que contiene dicho anticuerpo y una droga; polinucleotido que codifica el anticuerpo; vector, celula huesped; composicion farmaceutica y uso de dicha composicion para tratar cancer, preferentemente linfomas.
EP3689910A3 (en) 2014-09-23 2020-12-02 F. Hoffmann-La Roche AG Method of using anti-cd79b immunoconjugates
US11648317B2 (en) * 2018-04-13 2023-05-16 Genentech, Inc. Stable anti-CD79B immunoconjugate formulations
AU2018451747A1 (en) * 2018-12-06 2021-06-17 F. Hoffmann-La Roche Ag Combination therapy of diffuse large B-cell lymphoma comprising an anti-CD79b immunoconjugates, an alkylating agent and an anti-CD20 antibody
AU2020275415A1 (en) * 2019-05-14 2021-11-25 Genentech, Inc. Methods of using anti-CD79B immunoconjugates to treat follicular lymphoma
MX2022004443A (es) * 2019-10-18 2022-05-02 Genentech Inc Metodos para usar inmunoconjugados anti-cd79b para tratar linfoma difuso de linfocitos b grandes.
AU2021317378A1 (en) * 2020-07-27 2023-03-09 Tuojie Biotech (Shanghai) Co., Ltd. Anti-CD79B antibody-drug conjugate, and preparation method therefor and pharmaceutical use thereof
CN117677400A (zh) * 2021-09-16 2024-03-08 正大天晴药业集团股份有限公司 抗her3抗体药物偶联物及其组合物和用途

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
WO1985003357A1 (en) 1984-01-30 1985-08-01 Icrf Patents Ltd. Improvements relating to growth factors
US5401638A (en) 1986-06-04 1995-03-28 Oncogene Science, Inc. Detection and quantification of neu related proteins in the biological fluids of humans
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1991005264A1 (en) 1989-09-29 1991-04-18 Oncogenetics Partners Detection and quantification of neu related proteins in the biological fluids of humans
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1992022653A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. Method for making humanized antibodies
US5362852A (en) 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
EP0617706B1 (en) 1991-11-25 2001-10-17 Enzon, Inc. Multivalent antigen-binding proteins
DE69329503T2 (de) 1992-11-13 2001-05-03 Idec Pharma Corp Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
EP0616812B1 (en) 1993-03-24 1999-11-03 Berlex Biosciences Combination with anti-hormonal compounds and binding molecules for the treatment of cancer
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
CN100360184C (zh) * 1995-07-27 2008-01-09 基因技术股份有限公司 稳定等渗的冻干蛋白质制剂
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
DE69937291T2 (de) 1998-04-02 2008-07-10 Genentech, Inc., South San Francisco Antikörpervarianten und fragmente davon
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
KR20060067983A (ko) 1999-01-15 2006-06-20 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
BR122018071808B8 (pt) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
BRPI0614100A2 (pt) * 2005-08-03 2011-03-09 Immunogen Inc formulações de imunoconjugado lìquidas
ES2579323T3 (es) 2007-07-16 2016-08-09 Genentech, Inc. Anticuerpos anti-CD79B e inmunoconjugados y métodos de uso
CL2009000062A1 (es) 2008-01-31 2010-05-14 Genentech Inc Anticuerpo humanizado anti cd79b; con modificaciones de cisterna libre; inmunoconjugado que contiene dicho anticuerpo y una droga; polinucleotido que codifica el anticuerpo; vector, celula huesped; composicion farmaceutica y uso de dicha composicion para tratar cancer, preferentemente linfomas.
US9211319B2 (en) * 2009-01-09 2015-12-15 Seattle Genetics, Inc. Weekly dosing regimens for anti-CD30 VC-PAB-MMAE antibody drug-conjugates
EP2648506A1 (en) * 2010-12-10 2013-10-16 Merck Sharp & Dohme Corp. Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions
AU2013288932A1 (en) * 2012-07-09 2014-12-11 Genentech, Inc. Immunoconjugates comprising anti - CD79b antibodies
AR096183A1 (es) * 2013-05-02 2015-12-16 Hoffmann La Roche Terapia de combinación de un anticuerpo para cd20 afucosilado con un conjugado de anticuerpo para cd79b-fármaco
WO2015075201A1 (en) * 2013-11-21 2015-05-28 Genmab A/S Antibody-drug conjugate lyophilised formulation
JP2015209384A (ja) 2014-04-24 2015-11-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 医薬製剤
EP3689910A3 (en) 2014-09-23 2020-12-02 F. Hoffmann-La Roche AG Method of using anti-cd79b immunoconjugates
US11648317B2 (en) * 2018-04-13 2023-05-16 Genentech, Inc. Stable anti-CD79B immunoconjugate formulations

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CL2020002624A1 (es) 2021-01-29
TW202011994A (zh) 2020-04-01
KR20210003147A (ko) 2021-01-11
US20190314517A1 (en) 2019-10-17
TWI848769B (zh) 2024-07-11
TW202344272A (zh) 2023-11-16
CA3095186A1 (en) 2019-10-17
MX2020010729A (es) 2021-03-09
CN112040981A (zh) 2020-12-04
JP2020158505A (ja) 2020-10-01
US20240325559A1 (en) 2024-10-03
JP6761506B2 (ja) 2020-09-23
EP3773721A4 (en) 2022-01-26
EP3773721A1 (en) 2021-02-17
AU2019252941A1 (en) 2020-11-19
AR114780A1 (es) 2020-10-14
CL2021001956A1 (es) 2022-02-04
TWI811335B (zh) 2023-08-11
JP2019206514A (ja) 2019-12-05
IL277943A (en) 2020-11-30
JP6965395B2 (ja) 2021-11-10
CN118615457A (zh) 2024-09-10
JP2022036932A (ja) 2022-03-08
US11648317B2 (en) 2023-05-16
MX2022014457A (es) 2022-12-08
UA128064C2 (uk) 2024-03-27
WO2019200322A1 (en) 2019-10-17
CN113384711A (zh) 2021-09-14
BR112020020802A2 (pt) 2021-01-12
PE20201503A1 (es) 2020-12-29

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