CR20140587A - Metodo para producir iduronato-2-sulfatasa recombinante - Google Patents
Metodo para producir iduronato-2-sulfatasa recombinanteInfo
- Publication number
- CR20140587A CR20140587A CR20140587A CR20140587A CR20140587A CR 20140587 A CR20140587 A CR 20140587A CR 20140587 A CR20140587 A CR 20140587A CR 20140587 A CR20140587 A CR 20140587A CR 20140587 A CR20140587 A CR 20140587A
- Authority
- CR
- Costa Rica
- Prior art keywords
- iduronate
- producing
- recombinant
- sulfatase
- recombinant sulfatase
- Prior art date
Links
- 102000005262 Sulfatase Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108060007951 sulfatase Proteins 0.000 title 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000012679 serum free medium Substances 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
- C12Y108/99—Oxidoreductases acting on sulfur groups as donors (1.8) with other acceptors (1.8.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/40—Nucleotides, nucleosides or bases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666712P | 2012-06-29 | 2012-06-29 | |
| PCT/US2013/048601 WO2014005036A1 (en) | 2012-06-29 | 2013-06-28 | Method of producing recombinant iduronate-2-sulfatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140587A true CR20140587A (es) | 2015-04-06 |
Family
ID=49778402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140587A CR20140587A (es) | 2012-06-29 | 2014-12-17 | Metodo para producir iduronato-2-sulfatasa recombinante |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20140004097A1 (enExample) |
| EP (1) | EP2867367A4 (enExample) |
| JP (1) | JP2015523074A (enExample) |
| KR (1) | KR20150037908A (enExample) |
| CN (1) | CN104583414A (enExample) |
| AU (1) | AU2013282417A1 (enExample) |
| BR (1) | BR112014032544A2 (enExample) |
| CA (1) | CA2877492A1 (enExample) |
| CL (1) | CL2014003569A1 (enExample) |
| CO (1) | CO7240395A2 (enExample) |
| CR (1) | CR20140587A (enExample) |
| DO (1) | DOP2014000297A (enExample) |
| EA (1) | EA201492185A1 (enExample) |
| HK (2) | HK1209458A1 (enExample) |
| IL (1) | IL236324A0 (enExample) |
| IN (1) | IN2014DN11272A (enExample) |
| MX (1) | MX2015000188A (enExample) |
| PE (1) | PE20150603A1 (enExample) |
| PH (1) | PH12014502870A1 (enExample) |
| SG (1) | SG11201408755TA (enExample) |
| WO (1) | WO2014005036A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| CN104662150B (zh) | 2012-07-31 | 2018-07-10 | 比奥阿赛斯技术有限公司 | 脱磷酸化的溶酶体贮积症蛋白及其使用方法 |
| JP6586412B2 (ja) | 2013-03-13 | 2019-10-02 | バイオアシス テクノロジーズ インコーポレイテッド | ｐ９７のフラグメントおよびその使用 |
| ES2762672T3 (es) * | 2014-02-19 | 2020-05-25 | Bioasis Technologies Inc | Proteínas de fusión de P97-IDS |
| WO2016126339A1 (en) | 2015-02-05 | 2016-08-11 | R.P. Scherer Technologies, Llc | Activated formylglycine-generating enzymes and methods of producing and using the same |
| JP7515235B2 (ja) * | 2015-10-07 | 2024-07-12 | ハイゼンガ，ジョエル | ヒト老化から防御するためおよびそれによる劣化を修復するための生物学的経路のリセット |
| IL259186B2 (en) | 2015-11-09 | 2023-03-01 | Scherer Technologies Llc R P | Anti-cd22-maytensin antibody conjugates and methods of using them |
| KR102539167B1 (ko) * | 2016-07-25 | 2023-06-02 | 리플리겐 코포레이션 | 교번 접선 유동식의 신속한 수확 |
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4330597A (en) | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| DE60032349T2 (de) * | 1999-04-26 | 2007-07-12 | Genentech, Inc., South San Francisco | Zellenzuchtverfahren für glycoproteine |
| US6890736B1 (en) * | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
| EP2325302B1 (en) * | 2003-02-11 | 2016-01-06 | Shire Human Genetic Therapies, Inc. | Cells that coexpress a sulfatase and a C-formylglycine generating enzyme and methods and uses thereof |
| US20050019914A1 (en) * | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| WO2005113765A2 (en) * | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
| DK2267024T3 (da) * | 2005-06-03 | 2012-06-25 | Ares Trading Sa | Fremstilling af rekombinant II-18 bindingsprotein |
| AU2006322028C1 (en) * | 2005-12-08 | 2025-09-04 | Amgen Inc. | Improved host cells and culture methods |
| AR070198A1 (es) * | 2008-01-18 | 2010-03-17 | Biomarin Pharm Inc | Elaboracion de enzimas lisosomales sulfatasa humanas activas y altamente fosforiladas y sus usos |
| DK2485761T3 (da) * | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
| US20130196410A1 (en) * | 2010-03-05 | 2013-08-01 | Alnylam Pharmaceuticals, Inc | Compositions and methods for modifying the glycosylation pattern of a polypeptide |
| HRP20191924T1 (hr) | 2010-06-25 | 2020-01-10 | Shire Human Genetic Therapies, Inc. | Postupci i sastavi za isporuku iduronat-2-sulfataze u cns |
| KR101158673B1 (ko) * | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
| US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
-
2013
- 2013-03-14 US US13/829,811 patent/US20140004097A1/en not_active Abandoned
- 2013-06-28 BR BR112014032544A patent/BR112014032544A2/pt not_active IP Right Cessation
- 2013-06-28 PE PE2014002540A patent/PE20150603A1/es not_active Application Discontinuation
- 2013-06-28 HK HK15110043.9A patent/HK1209458A1/xx unknown
- 2013-06-28 CN CN201380042616.9A patent/CN104583414A/zh active Pending
- 2013-06-28 EA EA201492185A patent/EA201492185A1/ru unknown
- 2013-06-28 HK HK15110518.5A patent/HK1209790A1/xx unknown
- 2013-06-28 CA CA2877492A patent/CA2877492A1/en not_active Abandoned
- 2013-06-28 WO PCT/US2013/048601 patent/WO2014005036A1/en not_active Ceased
- 2013-06-28 KR KR1020157002278A patent/KR20150037908A/ko not_active Withdrawn
- 2013-06-28 SG SG11201408755TA patent/SG11201408755TA/en unknown
- 2013-06-28 MX MX2015000188A patent/MX2015000188A/es unknown
- 2013-06-28 IN IN11272DEN2014 patent/IN2014DN11272A/en unknown
- 2013-06-28 EP EP13810106.8A patent/EP2867367A4/en not_active Withdrawn
- 2013-06-28 JP JP2015520577A patent/JP2015523074A/ja active Pending
- 2013-06-28 AU AU2013282417A patent/AU2013282417A1/en not_active Abandoned
-
2014
- 2014-12-17 CR CR20140587A patent/CR20140587A/es unknown
- 2014-12-17 IL IL236324A patent/IL236324A0/en unknown
- 2014-12-22 PH PH12014502870A patent/PH12014502870A1/en unknown
- 2014-12-22 DO DO2014000297A patent/DOP2014000297A/es unknown
- 2014-12-26 CO CO14284195A patent/CO7240395A2/es unknown
- 2014-12-29 CL CL2014003569A patent/CL2014003569A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2014003569A1 (es) | 2015-04-17 |
| EP2867367A4 (en) | 2016-02-24 |
| WO2014005036A1 (en) | 2014-01-03 |
| EP2867367A1 (en) | 2015-05-06 |
| MX2015000188A (es) | 2015-04-08 |
| HK1209458A1 (en) | 2016-04-01 |
| CO7240395A2 (es) | 2015-04-17 |
| PE20150603A1 (es) | 2015-05-27 |
| PH12014502870A1 (en) | 2015-02-23 |
| EA201492185A1 (ru) | 2015-10-30 |
| IL236324A0 (en) | 2015-02-26 |
| CN104583414A (zh) | 2015-04-29 |
| IN2014DN11272A (enExample) | 2015-10-09 |
| AU2013282417A1 (en) | 2015-01-29 |
| BR112014032544A2 (pt) | 2017-08-01 |
| KR20150037908A (ko) | 2015-04-08 |
| HK1209790A1 (en) | 2016-04-08 |
| SG11201408755TA (en) | 2015-02-27 |
| CA2877492A1 (en) | 2014-01-03 |
| JP2015523074A (ja) | 2015-08-13 |
| DOP2014000297A (es) | 2015-04-15 |
| US20140004097A1 (en) | 2014-01-02 |
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