CR20130112A - Polipéptidos que enlazan miostatina, composiciones y métodos - Google Patents
Polipéptidos que enlazan miostatina, composiciones y métodosInfo
- Publication number
- CR20130112A CR20130112A CR20130112A CR20130112A CR20130112A CR 20130112 A CR20130112 A CR 20130112A CR 20130112 A CR20130112 A CR 20130112A CR 20130112 A CR20130112 A CR 20130112A CR 20130112 A CR20130112 A CR 20130112A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- myostatin
- polypeptides
- compositions
- link
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Abstract
Existen antagonistas de miostatina selectivos descritos (incluyendo anticuerpos), ácidos nucleicos que los codifican, y métodos para hacerlos y usarlos. Los anticuerpos neutralizantes reconocen el epítopo conformacional cerca de la posición 21 hasta 31 y posición 50 hasta 60.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37409510P | 2010-08-16 | 2010-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20130112A true CR20130112A (es) | 2013-05-15 |
Family
ID=44583430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20130112A CR20130112A (es) | 2010-08-16 | 2013-03-13 | Polipéptidos que enlazan miostatina, composiciones y métodos |
Country Status (17)
Country | Link |
---|---|
US (2) | US8999343B2 (es) |
EP (1) | EP2606066A1 (es) |
JP (2) | JP2013537425A (es) |
KR (1) | KR20140005864A (es) |
CN (2) | CN105440134A (es) |
AU (2) | AU2011292197B2 (es) |
CA (1) | CA2808382A1 (es) |
CL (1) | CL2013000460A1 (es) |
CO (1) | CO6690763A2 (es) |
CR (1) | CR20130112A (es) |
EA (1) | EA201390242A1 (es) |
MA (1) | MA34520B1 (es) |
MX (1) | MX2013001845A (es) |
NZ (1) | NZ608206A (es) |
PE (1) | PE20131340A1 (es) |
SG (2) | SG10201506405YA (es) |
WO (1) | WO2012024242A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5624276B2 (ja) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | 抗体の血中動態を制御する方法 |
JP5334319B2 (ja) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Cdrのアミノ酸置換により抗体の等電点を改変する方法 |
KR20220162801A (ko) | 2008-04-11 | 2022-12-08 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
CN105440134A (zh) | 2010-08-16 | 2016-03-30 | 安姆根公司 | 结合肌肉生长抑制素的抗体、组合物和方法 |
EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
LT2780368T (lt) | 2011-11-14 | 2018-03-12 | Regeneron Pharmaceuticals, Inc. | Kompozicijos ir būdai raumenų masės padidinimui ir raumenų sustiprinimui, specifiškai antagonizuojant gdf8 ir (arba) aktiviną a |
BR112015001955A2 (pt) | 2012-08-24 | 2017-11-07 | Chugai Pharmaceutical Co Ltd | variante de região fc específica de fcgamariib |
US11236168B2 (en) | 2012-08-24 | 2022-02-01 | Chugai Seiyaku Kabushiki Kaisha | Mouse FcγammaRII-specific Fc antibody |
US8933199B2 (en) | 2012-09-13 | 2015-01-13 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind to myostatin |
WO2014163101A1 (ja) | 2013-04-02 | 2014-10-09 | 中外製薬株式会社 | Fc領域改変体 |
EP3816625A1 (en) | 2013-05-06 | 2021-05-05 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
EP2853898B1 (en) | 2013-09-27 | 2017-01-04 | Medizinische Hochschule Hannover | Analysis of myostatin in serum |
BR112016016020B1 (pt) * | 2014-01-10 | 2024-02-27 | Anaptysbio, Inc | Agente de ligação (il-33) de interleucina-33, célula procariótica isolada, composição e uso do referido agente |
TWI697503B (zh) | 2014-04-10 | 2020-07-01 | 台灣浩鼎生技股份有限公司 | 抗體、產生該抗體之融合瘤、包含該抗體之藥學組成物及其用途 |
EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
WO2016073906A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
WO2016085860A1 (en) | 2014-11-24 | 2016-06-02 | Somalogic, Inc. | Nucleic acid compounds for binding growth differentiation factor 11 |
KR20180054923A (ko) * | 2014-12-19 | 2018-05-24 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
MX2017008978A (es) | 2015-02-05 | 2017-10-25 | Chugai Pharmaceutical Co Ltd | Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos. |
MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
EA201792298A1 (ru) | 2015-04-15 | 2018-04-30 | Регенерон Фармасьютикалз, Инк. | Способы увеличения силы и функциональности с помощью ингибиторов gdf8 |
IL305148A (en) * | 2015-09-15 | 2023-10-01 | Scholar Rock Inc | Anti-pro/hidden myostatin antibodies and their uses |
US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドScholar Rock,Inc. | 抗プロ/潜在型ミオスタチン抗体およびその使用方法 |
CN115975044A (zh) * | 2016-04-25 | 2023-04-18 | 戊瑞治疗有限公司 | 用于治疗病理性肌肉损失和虚弱的nope |
HUE051480T2 (hu) | 2016-06-13 | 2021-03-01 | Scholar Rock Inc | Miosztatin-inhibitorok alkalmazása és kombinációs terápiák |
US11053308B2 (en) | 2016-08-05 | 2021-07-06 | Chugai Seiyaku Kabushiki Kaisha | Method for treating IL-8-related diseases |
AU2018205270B2 (en) | 2017-01-06 | 2022-08-11 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
WO2018187209A1 (en) * | 2017-04-03 | 2018-10-11 | Acceleron Pharma Inc. | Compositions and methods for treating spinal muscular atrophy |
KR20200128125A (ko) | 2018-03-01 | 2020-11-11 | 리제너론 파아마슈티컬스, 인크. | 신체 조성을 변경하기 위한 방법 |
CN111793123B (zh) * | 2019-04-08 | 2022-03-08 | 中国农业大学 | 一种肌肉生长抑制素mstn的突变体及其应用 |
US20220331290A1 (en) * | 2019-09-24 | 2022-10-20 | Myo-Tec-Sci | Pharmaceutical composition for preventing or treating sarcopenia, containing unnatural amino acid |
CN114891101B (zh) * | 2021-12-02 | 2023-06-16 | 吉林省农业科学院 | 一种牛肌肉生长抑制素蛋白单克隆抗体及其应用 |
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-
2011
- 2011-08-15 CN CN201510954088.5A patent/CN105440134A/zh active Pending
- 2011-08-15 CN CN201180044739.7A patent/CN103221426B/zh not_active Expired - Fee Related
- 2011-08-15 NZ NZ608206A patent/NZ608206A/en not_active IP Right Cessation
- 2011-08-15 AU AU2011292197A patent/AU2011292197B2/en not_active Ceased
- 2011-08-15 JP JP2013524918A patent/JP2013537425A/ja active Pending
- 2011-08-15 EA EA201390242A patent/EA201390242A1/ru unknown
- 2011-08-15 PE PE2013000298A patent/PE20131340A1/es not_active Application Discontinuation
- 2011-08-15 MA MA35726A patent/MA34520B1/fr unknown
- 2011-08-15 MX MX2013001845A patent/MX2013001845A/es not_active Application Discontinuation
- 2011-08-15 CA CA2808382A patent/CA2808382A1/en not_active Abandoned
- 2011-08-15 WO PCT/US2011/047806 patent/WO2012024242A1/en active Application Filing
- 2011-08-15 US US13/816,894 patent/US8999343B2/en not_active Expired - Fee Related
- 2011-08-15 EP EP11745910.7A patent/EP2606066A1/en not_active Withdrawn
- 2011-08-15 SG SG10201506405YA patent/SG10201506405YA/en unknown
- 2011-08-15 SG SG2013011564A patent/SG187867A1/en unknown
- 2011-08-15 KR KR1020137006764A patent/KR20140005864A/ko not_active Application Discontinuation
-
2013
- 2013-02-15 CL CL2013000460A patent/CL2013000460A1/es unknown
- 2013-03-11 CO CO13047993A patent/CO6690763A2/es unknown
- 2013-03-13 CR CR20130112A patent/CR20130112A/es unknown
-
2015
- 2015-03-19 US US14/663,377 patent/US20150322144A1/en not_active Abandoned
- 2015-08-26 AU AU2015218478A patent/AU2015218478A1/en not_active Abandoned
-
2016
- 2016-05-27 JP JP2016105716A patent/JP2016198098A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2015218478A1 (en) | 2015-09-17 |
US20150322144A1 (en) | 2015-11-12 |
CL2013000460A1 (es) | 2014-03-28 |
WO2012024242A1 (en) | 2012-02-23 |
US20130209489A1 (en) | 2013-08-15 |
CO6690763A2 (es) | 2013-06-17 |
AU2011292197B2 (en) | 2015-05-28 |
AU2011292197A1 (en) | 2013-04-04 |
MX2013001845A (es) | 2013-08-27 |
JP2016198098A (ja) | 2016-12-01 |
SG187867A1 (en) | 2013-03-28 |
CA2808382A1 (en) | 2012-02-23 |
CN105440134A (zh) | 2016-03-30 |
EP2606066A1 (en) | 2013-06-26 |
NZ608206A (en) | 2015-02-27 |
MA34520B1 (fr) | 2013-09-02 |
EA201390242A1 (ru) | 2013-07-30 |
CN103221426B (zh) | 2016-01-13 |
SG10201506405YA (en) | 2015-10-29 |
PE20131340A1 (es) | 2013-11-29 |
US8999343B2 (en) | 2015-04-07 |
JP2013537425A (ja) | 2013-10-03 |
KR20140005864A (ko) | 2014-01-15 |
CN103221426A (zh) | 2013-07-24 |
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