SG10201506405YA - Polypeptides That Bind Myostatin, Compositions And Methods - Google Patents
Polypeptides That Bind Myostatin, Compositions And MethodsInfo
- Publication number
- SG10201506405YA SG10201506405YA SG10201506405YA SG10201506405YA SG10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA
- Authority
- SG
- Singapore
- Prior art keywords
- polypeptides
- compositions
- methods
- bind myostatin
- myostatin
- Prior art date
Links
- 102000004472 Myostatin Human genes 0.000 title 1
- 108010056852 Myostatin Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37409510P | 2010-08-16 | 2010-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201506405YA true SG10201506405YA (en) | 2015-10-29 |
Family
ID=44583430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013011564A SG187867A1 (en) | 2010-08-16 | 2011-08-15 | Antibodies that bind myostatin, compositions and methods |
SG10201506405YA SG10201506405YA (en) | 2010-08-16 | 2011-08-15 | Polypeptides That Bind Myostatin, Compositions And Methods |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013011564A SG187867A1 (en) | 2010-08-16 | 2011-08-15 | Antibodies that bind myostatin, compositions and methods |
Country Status (17)
Country | Link |
---|---|
US (2) | US8999343B2 (en) |
EP (1) | EP2606066A1 (en) |
JP (2) | JP2013537425A (en) |
KR (1) | KR20140005864A (en) |
CN (2) | CN103221426B (en) |
AU (2) | AU2011292197B2 (en) |
CA (1) | CA2808382A1 (en) |
CL (1) | CL2013000460A1 (en) |
CO (1) | CO6690763A2 (en) |
CR (1) | CR20130112A (en) |
EA (1) | EA201390242A1 (en) |
MA (1) | MA34520B1 (en) |
MX (1) | MX2013001845A (en) |
NZ (1) | NZ608206A (en) |
PE (1) | PE20131340A1 (en) |
SG (2) | SG187867A1 (en) |
WO (1) | WO2012024242A1 (en) |
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JP2013537425A (en) | 2010-08-16 | 2013-10-03 | アムジエン・インコーポレーテツド | Polypeptides, compositions and methods that bind to myostatin |
CN108715614A (en) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | The antigen binding molecules combined are repeated with polymolecular antigen |
AU2012339722B2 (en) | 2011-11-14 | 2017-09-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A |
EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
CA2882272C (en) | 2012-08-24 | 2023-08-29 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc region variant |
ES2879387T3 (en) | 2012-09-13 | 2021-11-22 | Bristol Myers Squibb Co | Fibronectin-based scaffold domain proteins that bind to myostatin |
AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
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RU2019118984A (en) * | 2014-01-10 | 2019-08-06 | Анаптисбайо, Инк. | ANTIBODIES AIMED AGAINST INTERLEUKIN-33 (IL-33) |
BR112016020009A2 (en) | 2014-04-10 | 2017-10-17 | Obi Pharma Inc | antibody, pharmaceutical composition, method for inhibiting cancer cell proliferation, hybridoma |
WO2016073879A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
CA3005158A1 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
JP6768651B2 (en) | 2014-11-24 | 2020-10-14 | ソマロジック, インコーポレイテッドSomaLogic, Inc. | Nucleic acid compound for binding to proliferative differentiation factor 11 |
JP6227191B1 (en) * | 2014-12-19 | 2017-11-08 | 中外製薬株式会社 | Anti-myostatin antibody, polypeptide comprising mutant Fc region, and method of use |
KR102605798B1 (en) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
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MA49661A (en) | 2015-04-15 | 2020-06-03 | Regeneron Pharma | METHOD OF INCREASING RESISTANCE AND FUNCTIONALITY WITH GDF-8 INHIBITORS |
EP3922645A1 (en) * | 2015-09-15 | 2021-12-15 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
JP7141336B2 (en) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | Anti-myostatin antibodies and methods of use |
WO2017120523A2 (en) | 2016-01-08 | 2017-07-13 | Scholar Rock, Inc. | Anti-pro/latent myostatin antibodies and methods of use thereof |
CN115975044A (en) * | 2016-04-25 | 2023-04-18 | 戊瑞治疗有限公司 | NOPE for the treatment of pathological muscle loss and weakness |
SI3368069T1 (en) | 2016-06-13 | 2021-03-31 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
JP6527643B2 (en) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Composition for treating or preventing IL-8 related diseases |
EP4218817A3 (en) * | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
WO2018187209A1 (en) * | 2017-04-03 | 2018-10-11 | Acceleron Pharma Inc. | Compositions and methods for treating spinal muscular atrophy |
CN111787981A (en) | 2018-03-01 | 2020-10-16 | 瑞泽恩制药公司 | Method of altering body composition |
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CA2856436A1 (en) | 2005-12-06 | 2007-06-14 | Amgen Inc. | Uses of myostatin antagonists |
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EA015916B1 (en) | 2006-09-05 | 2011-12-30 | Эли Лилли Энд Компани | Monoclonal antibodies to myostatin and use thereof |
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TWI573802B (en) | 2007-03-06 | 2017-03-11 | 安美基公司 | Variant activin receptor polypeptides and uses thereof |
PE20091163A1 (en) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | ANTIBODIES FOR GDF8 |
BRPI0920962A2 (en) | 2008-11-26 | 2016-07-12 | Amgen Inc | activin receptor polypeptide variants and uses thereof |
JO3340B1 (en) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | Antibodies to human gdf8 |
JP2013537425A (en) | 2010-08-16 | 2013-10-03 | アムジエン・インコーポレーテツド | Polypeptides, compositions and methods that bind to myostatin |
AU2012339722B2 (en) | 2011-11-14 | 2017-09-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A |
EP2793925B1 (en) | 2011-12-19 | 2019-03-20 | Amgen Inc. | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
-
2011
- 2011-08-15 JP JP2013524918A patent/JP2013537425A/en active Pending
- 2011-08-15 MA MA35726A patent/MA34520B1/en unknown
- 2011-08-15 SG SG2013011564A patent/SG187867A1/en unknown
- 2011-08-15 EP EP11745910.7A patent/EP2606066A1/en not_active Withdrawn
- 2011-08-15 KR KR1020137006764A patent/KR20140005864A/en not_active Application Discontinuation
- 2011-08-15 MX MX2013001845A patent/MX2013001845A/en not_active Application Discontinuation
- 2011-08-15 CN CN201180044739.7A patent/CN103221426B/en not_active Expired - Fee Related
- 2011-08-15 CA CA2808382A patent/CA2808382A1/en not_active Abandoned
- 2011-08-15 CN CN201510954088.5A patent/CN105440134A/en active Pending
- 2011-08-15 PE PE2013000298A patent/PE20131340A1/en not_active Application Discontinuation
- 2011-08-15 AU AU2011292197A patent/AU2011292197B2/en not_active Ceased
- 2011-08-15 NZ NZ608206A patent/NZ608206A/en not_active IP Right Cessation
- 2011-08-15 EA EA201390242A patent/EA201390242A1/en unknown
- 2011-08-15 SG SG10201506405YA patent/SG10201506405YA/en unknown
- 2011-08-15 WO PCT/US2011/047806 patent/WO2012024242A1/en active Application Filing
- 2011-08-15 US US13/816,894 patent/US8999343B2/en not_active Expired - Fee Related
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2013
- 2013-02-15 CL CL2013000460A patent/CL2013000460A1/en unknown
- 2013-03-11 CO CO13047993A patent/CO6690763A2/en unknown
- 2013-03-13 CR CR20130112A patent/CR20130112A/en unknown
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2015
- 2015-03-19 US US14/663,377 patent/US20150322144A1/en not_active Abandoned
- 2015-08-26 AU AU2015218478A patent/AU2015218478A1/en not_active Abandoned
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2016
- 2016-05-27 JP JP2016105716A patent/JP2016198098A/en active Pending
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AU2011292197A1 (en) | 2013-04-04 |
JP2016198098A (en) | 2016-12-01 |
US8999343B2 (en) | 2015-04-07 |
US20130209489A1 (en) | 2013-08-15 |
EA201390242A1 (en) | 2013-07-30 |
CN103221426B (en) | 2016-01-13 |
CA2808382A1 (en) | 2012-02-23 |
US20150322144A1 (en) | 2015-11-12 |
WO2012024242A1 (en) | 2012-02-23 |
CL2013000460A1 (en) | 2014-03-28 |
CN105440134A (en) | 2016-03-30 |
CR20130112A (en) | 2013-05-15 |
AU2015218478A1 (en) | 2015-09-17 |
CN103221426A (en) | 2013-07-24 |
SG187867A1 (en) | 2013-03-28 |
NZ608206A (en) | 2015-02-27 |
PE20131340A1 (en) | 2013-11-29 |
KR20140005864A (en) | 2014-01-15 |
JP2013537425A (en) | 2013-10-03 |
EP2606066A1 (en) | 2013-06-26 |
MX2013001845A (en) | 2013-08-27 |
MA34520B1 (en) | 2013-09-02 |
AU2011292197B2 (en) | 2015-05-28 |
CO6690763A2 (en) | 2013-06-17 |
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