SG10201506405YA - Polypeptides That Bind Myostatin, Compositions And Methods - Google Patents
Polypeptides That Bind Myostatin, Compositions And MethodsInfo
- Publication number
- SG10201506405YA SG10201506405YA SG10201506405YA SG10201506405YA SG10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA SG 10201506405Y A SG10201506405Y A SG 10201506405YA
- Authority
- SG
- Singapore
- Prior art keywords
- polypeptides
- compositions
- methods
- bind myostatin
- myostatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37409510P | 2010-08-16 | 2010-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201506405YA true SG10201506405YA (en) | 2015-10-29 |
Family
ID=44583430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013011564A SG187867A1 (en) | 2010-08-16 | 2011-08-15 | Antibodies that bind myostatin, compositions and methods |
SG10201506405YA SG10201506405YA (en) | 2010-08-16 | 2011-08-15 | Polypeptides That Bind Myostatin, Compositions And Methods |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013011564A SG187867A1 (en) | 2010-08-16 | 2011-08-15 | Antibodies that bind myostatin, compositions and methods |
Country Status (17)
Country | Link |
---|---|
US (2) | US8999343B2 (en) |
EP (1) | EP2606066A1 (en) |
JP (2) | JP2013537425A (en) |
KR (1) | KR20140005864A (en) |
CN (2) | CN105440134A (en) |
AU (2) | AU2011292197B2 (en) |
CA (1) | CA2808382A1 (en) |
CL (1) | CL2013000460A1 (en) |
CO (1) | CO6690763A2 (en) |
CR (1) | CR20130112A (en) |
EA (1) | EA201390242A1 (en) |
MA (1) | MA34520B1 (en) |
MX (1) | MX2013001845A (en) |
NZ (1) | NZ608206A (en) |
PE (1) | PE20131340A1 (en) |
SG (2) | SG187867A1 (en) |
WO (1) | WO2012024242A1 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
CN101874042B9 (en) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | Method for changing isoelectric point of antibody by using amino acid substitution of CDR |
NZ602884A (en) | 2008-04-11 | 2014-08-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
NZ608206A (en) | 2010-08-16 | 2015-02-27 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
KR102385507B1 (en) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
KR102048189B1 (en) | 2011-11-14 | 2019-11-25 | 리제너론 파아마슈티컬스, 인크. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
JP6774164B2 (en) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | Mouse FcγRII specific Fc antibody |
RU2729831C2 (en) | 2012-08-24 | 2020-08-12 | Чугаи Сейяку Кабусики Кайся | Versions of fcγriib-specific fc-region |
RS62009B1 (en) | 2012-09-13 | 2021-07-30 | Bristol Myers Squibb Co | Fibronectin based scaffold domain proteins that bind to myostatin |
EP3783017A1 (en) | 2013-04-02 | 2021-02-24 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
LT2981822T (en) | 2013-05-06 | 2020-12-28 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
EP2853898B1 (en) | 2013-09-27 | 2017-01-04 | Medizinische Hochschule Hannover | Analysis of myostatin in serum |
CN106103480B (en) | 2014-01-10 | 2021-10-22 | 安奈普泰斯生物有限公司 | Antibodies against interleukin-33 (IL-33) |
WO2015157629A2 (en) | 2014-04-10 | 2015-10-15 | Obi Pharma Inc. | Antibodies, pharmaceutical compositions and uses thereof |
WO2016073853A1 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
WO2016073879A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
TWI695068B (en) | 2014-11-24 | 2020-06-01 | 美商身體邏輯股份有限公司 | Nucleic acid compounds for binding growth differentiation factor 11 |
SG11201700841QA (en) * | 2014-12-19 | 2017-03-30 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
CN114773469A (en) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | Antibodies comprising an ion concentration-dependent antigen-binding domain, FC region variants, IL-8-binding antibodies and uses thereof |
MA41919A (en) * | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES |
MX2017013267A (en) | 2015-04-15 | 2018-08-15 | Regeneron Pharma | Methods of increasing strength and functionality with gdf8 inhibitors. |
EP3922645A1 (en) * | 2015-09-15 | 2021-12-15 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
US10287345B2 (en) * | 2016-01-08 | 2019-05-14 | Scholar Rock, Inc. | Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies |
US10799559B2 (en) * | 2016-04-25 | 2020-10-13 | Five Prime Therapeutics, Inc. | NOPE for treatment of pathological muscle loss and weakness |
KR20230169484A (en) | 2016-06-13 | 2023-12-15 | 스칼러 락, 인크. | Use of myostatin inhibitors and combination therapies |
SG11201801024XA (en) | 2016-08-05 | 2018-05-30 | Chugai Pharmaceutical Co Ltd | Therapeutic or preventive compositions for il-8-related diseases |
US11155611B2 (en) | 2017-01-06 | 2021-10-26 | Scholar Rock, Inc. | Compositions and methods for making and using anti-myostatin antibodies |
US11857599B2 (en) | 2017-04-03 | 2024-01-02 | Acceleron Pharma Inc. | Compositions and methods for treating spinal muscular atrophy |
WO2019169283A1 (en) | 2018-03-01 | 2019-09-06 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition |
CN111793123B (en) * | 2019-04-08 | 2022-03-08 | 中国农业大学 | Mutant of myostatin MSTN and application thereof |
US20220331290A1 (en) * | 2019-09-24 | 2022-10-20 | Myo-Tec-Sci | Pharmaceutical composition for preventing or treating sarcopenia, containing unnatural amino acid |
CN114891101B (en) * | 2021-12-02 | 2023-06-16 | 吉林省农业科学院 | Bovine myostatin protein monoclonal antibody and application thereof |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
US6010902A (en) | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
ATE158021T1 (en) | 1990-08-29 | 1997-09-15 | Genpharm Int | PRODUCTION AND USE OF NON-HUMAN TRANSGENT ANIMALS FOR THE PRODUCTION OF HETEROLOGUE ANTIBODIES |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
AU8727291A (en) | 1990-10-29 | 1992-06-11 | Cetus Oncology Corporation | Bispecific antibodies, method of production, and uses thereof |
US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
DE4118120A1 (en) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | TETRAVALENT BISPECIFIC RECEPTORS, THEIR PRODUCTION AND USE |
LU91067I2 (en) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab and its variants and immunochemical derivatives including immotoxins |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
JPH05244982A (en) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | Humanized b-b10 |
US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
PT672141E (en) | 1992-10-23 | 2003-09-30 | Immunex Corp | METHODS OF PREPARATION OF SOLUVEAL OLIGOMERIC PROTEINS |
ES2201076T3 (en) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | GROWTH DIFFERENTIATION FACTOR-8. |
US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
EP1075272B1 (en) | 1998-05-06 | 2009-07-15 | Metamorphix, Inc. | Methods for treating diabetes by inhibiting gdf-8 |
CA2341029A1 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
AR042545A1 (en) | 2002-12-20 | 2005-06-22 | Amgen Inc | BINDING AGENTS THAT INHIBIT MIOSTATINE |
US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
WO2004101511A2 (en) * | 2003-05-09 | 2004-11-25 | Protein Design Labs, Inc | Anti-ip-10 antibodies and methods of using thereof for the treatment of inflamatory bowel diseases |
AU2004245025A1 (en) | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (GDF8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
UA93855C2 (en) | 2003-12-31 | 2011-03-25 | Шеринг-Плау Лтд. | Neutralizing epitope-based growth enhancing vaccine |
WO2006104978A2 (en) | 2005-03-25 | 2006-10-05 | Curagen Corporation | Antibodies against the tenascin major antigens |
DOP2006000093A (en) | 2005-04-25 | 2007-01-31 | Pfizer | ANTIBODIES AGAINST MYOSTATIN |
JP5052517B2 (en) * | 2005-10-06 | 2012-10-17 | イーライ リリー アンド カンパニー | Anti-myostatin antibody |
UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
WO2007067616A2 (en) | 2005-12-06 | 2007-06-14 | Amgen Inc | Uses of myostatin antagonists |
AU2007279456A1 (en) * | 2006-08-03 | 2008-02-07 | Myostin Therapeutics Pty Ltd | Myostatin antagonists |
KR101123531B1 (en) | 2006-09-05 | 2012-04-20 | 일라이 릴리 앤드 캄파니 | Anti-myostatin antibodies |
CL2007002567A1 (en) | 2006-09-08 | 2008-02-01 | Amgen Inc | ISOLATED PROTEINS FROM LINK TO ACTIVINE TO HUMAN. |
TWI454479B (en) | 2007-03-06 | 2014-10-01 | Amgen Inc | Variant activin receptor polypeptides and uses thereof |
US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
PE20091163A1 (en) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | ANTIBODIES FOR GDF8 |
UA107921C2 (en) | 2008-11-26 | 2015-03-10 | Amgen Inc | Variants of polypeptide of receptor ivr activin and their use |
JO3340B1 (en) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | Antibodies to human gdf8 |
NZ608206A (en) | 2010-08-16 | 2015-02-27 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
KR102048189B1 (en) | 2011-11-14 | 2019-11-25 | 리제너론 파아마슈티컬스, 인크. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
KR20140108562A (en) | 2011-12-19 | 2014-09-11 | 암젠 인코퍼레이티드 | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
-
2011
- 2011-08-15 NZ NZ608206A patent/NZ608206A/en not_active IP Right Cessation
- 2011-08-15 AU AU2011292197A patent/AU2011292197B2/en not_active Ceased
- 2011-08-15 MA MA35726A patent/MA34520B1/en unknown
- 2011-08-15 CN CN201510954088.5A patent/CN105440134A/en active Pending
- 2011-08-15 SG SG2013011564A patent/SG187867A1/en unknown
- 2011-08-15 EP EP11745910.7A patent/EP2606066A1/en not_active Withdrawn
- 2011-08-15 WO PCT/US2011/047806 patent/WO2012024242A1/en active Application Filing
- 2011-08-15 JP JP2013524918A patent/JP2013537425A/en active Pending
- 2011-08-15 CA CA2808382A patent/CA2808382A1/en not_active Abandoned
- 2011-08-15 US US13/816,894 patent/US8999343B2/en not_active Expired - Fee Related
- 2011-08-15 CN CN201180044739.7A patent/CN103221426B/en not_active Expired - Fee Related
- 2011-08-15 PE PE2013000298A patent/PE20131340A1/en not_active Application Discontinuation
- 2011-08-15 SG SG10201506405YA patent/SG10201506405YA/en unknown
- 2011-08-15 EA EA201390242A patent/EA201390242A1/en unknown
- 2011-08-15 KR KR1020137006764A patent/KR20140005864A/en not_active Application Discontinuation
- 2011-08-15 MX MX2013001845A patent/MX2013001845A/en not_active Application Discontinuation
-
2013
- 2013-02-15 CL CL2013000460A patent/CL2013000460A1/en unknown
- 2013-03-11 CO CO13047993A patent/CO6690763A2/en unknown
- 2013-03-13 CR CR20130112A patent/CR20130112A/en unknown
-
2015
- 2015-03-19 US US14/663,377 patent/US20150322144A1/en not_active Abandoned
- 2015-08-26 AU AU2015218478A patent/AU2015218478A1/en not_active Abandoned
-
2016
- 2016-05-27 JP JP2016105716A patent/JP2016198098A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2011292197A1 (en) | 2013-04-04 |
MX2013001845A (en) | 2013-08-27 |
CN103221426A (en) | 2013-07-24 |
SG187867A1 (en) | 2013-03-28 |
US20150322144A1 (en) | 2015-11-12 |
JP2016198098A (en) | 2016-12-01 |
EP2606066A1 (en) | 2013-06-26 |
US8999343B2 (en) | 2015-04-07 |
EA201390242A1 (en) | 2013-07-30 |
WO2012024242A1 (en) | 2012-02-23 |
NZ608206A (en) | 2015-02-27 |
AU2015218478A1 (en) | 2015-09-17 |
US20130209489A1 (en) | 2013-08-15 |
KR20140005864A (en) | 2014-01-15 |
CL2013000460A1 (en) | 2014-03-28 |
JP2013537425A (en) | 2013-10-03 |
CO6690763A2 (en) | 2013-06-17 |
MA34520B1 (en) | 2013-09-02 |
AU2011292197B2 (en) | 2015-05-28 |
CN105440134A (en) | 2016-03-30 |
CN103221426B (en) | 2016-01-13 |
CR20130112A (en) | 2013-05-15 |
PE20131340A1 (en) | 2013-11-29 |
CA2808382A1 (en) | 2012-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10201506405YA (en) | Polypeptides That Bind Myostatin, Compositions And Methods | |
HK1205751A1 (en) | Conjugates, particles, compositions, and related methods | |
EP2605799A4 (en) | Conjugates, particles, compositions, and related methods | |
GB201002983D0 (en) | Nutritinal composition | |
GB201006699D0 (en) | Composition | |
GB201021186D0 (en) | Composition | |
EP2629742A4 (en) | Hair-mending compositions and associated methods | |
ZA201302113B (en) | Caspofungin composition | |
GB201006178D0 (en) | Composition | |
EP2558500A4 (en) | Proteins that bind pi16 and uses thereof | |
GB201021269D0 (en) | Composition | |
GB201017048D0 (en) | Composition | |
ZA201300804B (en) | Anti-vegfr-3 antibody compositions | |
GB201019988D0 (en) | Composition | |
GB201016970D0 (en) | Composition | |
GB201007531D0 (en) | Composition | |
GB201006214D0 (en) | Composition | |
GB201006204D0 (en) | Composition | |
GB201004717D0 (en) | Composition | |
GB201010657D0 (en) | Composition | |
GB201006175D0 (en) | Composition | |
PL2534235T3 (en) | Composition | |
GB201018130D0 (en) | Composition | |
GB201014967D0 (en) | Composition | |
GB201006182D0 (en) | Composition |