CR20120314A - NUEVOS DERIVADOS DE (HETEROCICLO-PIPERIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA O DE (HETEROCICLO-PIRROLIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA Y SU UTILIZACIÓN COMO INHIBIDORES DE p75 - Google Patents
NUEVOS DERIVADOS DE (HETEROCICLO-PIPERIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA O DE (HETEROCICLO-PIRROLIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA Y SU UTILIZACIÓN COMO INHIBIDORES DE p75Info
- Publication number
- CR20120314A CR20120314A CR20120314A CR20120314A CR20120314A CR 20120314 A CR20120314 A CR 20120314A CR 20120314 A CR20120314 A CR 20120314A CR 20120314 A CR20120314 A CR 20120314A CR 20120314 A CR20120314 A CR 20120314A
- Authority
- CR
- Costa Rica
- Prior art keywords
- heteroycycle
- piperazinil
- condensed
- piperidine
- conetensed
- Prior art date
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C08G61/123—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds
- C08G61/126—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds with a five-membered ring containing one sulfur atom in the ring
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Abstract
La invención se refiere a derivados de (heterociclo-piperidina condensadas)-(piperazinil)-1-alcanona y a (heterociclo-pirrolidina condensadas)-(piperazinil)-1-alcanona de fórmula general (I) en la que A, W, n y, R2 son tales como se definen en la reivindicación 1, así como su procedimiento de preparación y su aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0906023A FR2953839A1 (fr) | 2009-12-14 | 2009-12-14 | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20120314A true CR20120314A (es) | 2012-07-12 |
Family
ID=42246205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20120314A CR20120314A (es) | 2009-12-14 | 2012-06-11 | NUEVOS DERIVADOS DE (HETEROCICLO-PIPERIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA O DE (HETEROCICLO-PIRROLIDINA CONDENSADA)-(PIPERAZINIL)-1-ALCANONA Y SU UTILIZACIÓN COMO INHIBIDORES DE p75 |
Country Status (41)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| KR102279347B1 (ko) * | 2016-12-15 | 2021-07-21 | 한국생명공학연구원 | 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN107245074B (zh) * | 2017-06-20 | 2019-04-09 | 牡丹江医学院附属红旗医院 | 用于治疗脑梗死的化合物及其制备方法 |
| KR20200136384A (ko) | 2018-02-05 | 2020-12-07 | 알케르메스, 인코포레이티드 | 통증 치료용 화합물 |
| JP2023511302A (ja) * | 2020-01-13 | 2023-03-17 | アプタバイオ セラピューティクス インコーポレイテッド | 新規なピラゾール誘導体 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457869A1 (fr) * | 1979-05-09 | 1980-12-26 | Sanofi Sa | Derives de thieno(2',3'; 4,5) pyrido (1,2-a) pyrazine, leur procede de preparation et leur application therapeutique |
| FR2744448B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| DK0930883T3 (da) | 1996-10-21 | 2006-05-22 | Nps Allelix Corp | Neurotrofinantagonister til behandling af epilepsi, Alzheimers sygdom og smerte |
| JP2003514508A (ja) | 1997-07-01 | 2003-04-15 | ノボ ノルディスク アクティーゼルスカブ | グルカゴン拮抗剤／逆作用剤 |
| GB9905010D0 (en) * | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| AU4198400A (en) | 1999-04-06 | 2000-10-23 | Krenitsky Pharmaceuticals Inc. | Neurotrophic thio substituted pyrimidines |
| US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| IL153254A0 (en) * | 2000-06-29 | 2003-07-06 | Lundbeck & Co As H | Indole derivatives useful for the treatment of cns disorders |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| UA77526C2 (en) | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| TW200413351A (en) * | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| FR2862968B1 (fr) | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| FR2862967B1 (fr) | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| AU2005206570A1 (en) * | 2004-01-23 | 2005-08-04 | Novartis Vaccines And Diagnostics, Inc. | Tetrahydrocarboline compounds as anticancer agents |
| US7465726B2 (en) * | 2004-08-02 | 2008-12-16 | Osi Pharmaceuticals, Inc. | Substituted pyrrolo[2.3-B]pyridines |
| KR20100122508A (ko) * | 2008-03-05 | 2010-11-22 | 타가셉트 인코포레이티드 | 디아자비시클로알칸의 니코틴 아세틸콜린 수용체 서브-타입 선택성 아미드 |
| CN101284838B (zh) * | 2008-06-06 | 2011-05-04 | 天津药物研究院 | 含噻吩并吡啶的哌嗪类衍生物、其制备方法和用途 |
| FR2932482B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2953836B1 (fr) | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
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2009
- 2009-12-14 FR FR0906023A patent/FR2953839A1/fr active Pending
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2010
- 2010-12-13 BR BR112012014208A patent/BR112012014208A8/pt not_active Application Discontinuation
- 2010-12-13 KR KR1020127018349A patent/KR101724386B1/ko active IP Right Grant
- 2010-12-13 PL PL10801662T patent/PL2513108T3/pl unknown
- 2010-12-13 ES ES10801662.7T patent/ES2541366T3/es active Active
- 2010-12-13 WO PCT/FR2010/052685 patent/WO2011080444A1/fr active Application Filing
- 2010-12-13 ME MEP-2015-96A patent/ME02164B/me unknown
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- 2010-12-13 RS RS20150438A patent/RS54068B1/en unknown
- 2010-12-13 CA CA2784152A patent/CA2784152C/fr not_active Expired - Fee Related
- 2010-12-13 NZ NZ600593A patent/NZ600593A/en not_active IP Right Cessation
- 2010-12-13 SI SI201030967T patent/SI2513108T1/sl unknown
- 2010-12-13 HU HUE10801662A patent/HUE024988T2/hu unknown
- 2010-12-13 DK DK10801662.7T patent/DK2513108T3/en active
- 2010-12-13 PT PT108016627T patent/PT2513108E/pt unknown
- 2010-12-13 EP EP10801662.7A patent/EP2513108B1/fr active Active
- 2010-12-13 MX MX2012006865A patent/MX2012006865A/es active IP Right Grant
- 2010-12-13 TW TW099143563A patent/TW201130850A/zh unknown
- 2010-12-13 AU AU2010338110A patent/AU2010338110B2/en not_active Ceased
- 2010-12-13 CN CN201080062705.6A patent/CN102741248B/zh active Active
- 2010-12-13 PE PE2012000829A patent/PE20121507A1/es not_active Application Discontinuation
- 2010-12-13 AR ARP100104601A patent/AR079441A1/es unknown
- 2010-12-13 EA EA201290504A patent/EA021985B1/ru not_active IP Right Cessation
- 2010-12-13 MA MA35053A patent/MA33915B1/fr unknown
- 2010-12-13 JP JP2012543873A patent/JP5735979B2/ja active Active
- 2010-12-14 UY UY33105A patent/UY33105A/es not_active Application Discontinuation
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2012
- 2012-06-05 TN TNP2012000285A patent/TN2012000285A1/fr unknown
- 2012-06-06 DO DO2012000156A patent/DOP2012000156A/es unknown
- 2012-06-06 GT GT201200177A patent/GT201200177A/es unknown
- 2012-06-07 US US13/490,904 patent/US8580790B2/en active Active
- 2012-06-11 CR CR20120314A patent/CR20120314A/es unknown
- 2012-06-12 EC ECSP12011970 patent/ECSP12011970A/es unknown
- 2012-06-12 NI NI201200104A patent/NI201200104A/es unknown
- 2012-06-13 HN HN2012001262A patent/HN2012001262A/es unknown
- 2012-06-13 CL CL2012001579A patent/CL2012001579A1/es unknown
- 2012-06-13 IL IL220376A patent/IL220376A/en not_active IP Right Cessation
- 2012-06-14 CO CO12100074A patent/CO6501122A2/es unknown
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2013
- 2013-03-13 HK HK13103129.3A patent/HK1175783A1/xx not_active IP Right Cessation
- 2013-10-08 US US14/048,752 patent/US8957211B2/en active Active
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2015
- 2015-06-30 HR HRP20150707TT patent/HRP20150707T1/hr unknown
- 2015-07-01 CY CY20151100570T patent/CY1116542T1/el unknown
- 2015-07-01 SM SM201500155T patent/SMT201500155B/xx unknown
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