AR079441A1 - Derivados de heterociclos-piperidinas condensadas piperazinil-1-alcanona o de heterociclo-pirrolidinas condensadas-piperazinil-1-alcanona y su utiliza-cion como inhibidores de p75 - Google Patents

Derivados de heterociclos-piperidinas condensadas piperazinil-1-alcanona o de heterociclo-pirrolidinas condensadas-piperazinil-1-alcanona y su utiliza-cion como inhibidores de p75

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Publication number
AR079441A1
AR079441A1 ARP100104601A ARP100104601A AR079441A1 AR 079441 A1 AR079441 A1 AR 079441A1 AR P100104601 A ARP100104601 A AR P100104601A AR P100104601 A ARP100104601 A AR P100104601A AR 079441 A1 AR079441 A1 AR 079441A1
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AR
Argentina
Prior art keywords
group
atom
alcanona
piperazinil
condensed
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ARP100104601A
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English (en)
Inventor
Marco Baroni
Françoise Bono
Valentina Vercesi
Sandrine Delbary-Gossart
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Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR079441A1 publication Critical patent/AR079441A1/es

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Abstract

Así como su procedimiento de preparacion y su aplicacion en terapéutica para enfermedades neurodegenerativas, afecciones cardiovasculares, neuropatías, cáncer, alergia, asma, osteoporosis, etc. Reivindicacion 1: Compuesto que responde a la formula (1): en la que: - A representa un grupo: (2); - n representa 1 o 2; - m representa 0 o 1; - Y representa un átomo de carbono, de nitrogeno, de azufre o de oxígeno o un enlace sencillo o doble; - X, X1 y X2 representan un átomo de carbono, de nitrogeno, de azufre o de oxigeno, entendiéndose que al menos uno de X, X1, X2 es diferente de un átomo de carbono; - R y R1 situados en cualquiera de las posiciones disponibles, representan independientemente uh átomo de hidrogeno, un átomo de halogeno, un grupo alquilo(C1-4), alcoxi(C1-4), un radical perfluoroalquilo, trifluorometoxi, un ciano, un grupo COOH, COOalquilo, CONR5R6 o NHCOR5; o R1 representa un grupo elegido entre: (3) quedando inalterada la definicion de R; - R y R1 situados en cualquiera de las posiciones disponibles, representan independientemente un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo(C1-4), alcoxi(C1-4), un radical perfluoroalquilo, trifluorometoxi, un ciano, un grupo COOH, COOalquilo, CONR5R6 o NHCOR5; - W- es un heterociclo nitrogenado elegido entre: (4); - 1-2 representa 1 o 2; - 1-3 representa 1, 2 o 3; - R2 representa un grupo de formula: (5); - R7 y R6 situados en cualquiera de las posiciones disponibles, representan independientemente un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo(C1-4), alcoxi(C1-4), un radical trifluorometilo, trifluorometoxi, un ciano, un grupo COOH, COOalquilo, COOcicloalquilo, alquiloSO, alquiloSO2; CONH2, CONR5R6 o NHCOR5; o una de R7 y R8 representa un heterociclo seleccionado entre: (6); - Z representa un átomo de oxigeno o de azufre; R5 y R6 representan un hidrogeno o un grupo alquilo C1-6 en estado de base o de sal de adicion a un ácido.
ARP100104601A 2009-12-14 2010-12-13 Derivados de heterociclos-piperidinas condensadas piperazinil-1-alcanona o de heterociclo-pirrolidinas condensadas-piperazinil-1-alcanona y su utiliza-cion como inhibidores de p75 AR079441A1 (es)

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FR0906023A FR2953839A1 (fr) 2009-12-14 2009-12-14 Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75

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FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75

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US8957211B2 (en) 2015-02-17
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MA33915B1 (fr) 2013-01-02
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