CR11126A - Inhibicion de metastasis de tumor por anticuerpos anti neuropilina 2 - Google Patents

Inhibicion de metastasis de tumor por anticuerpos anti neuropilina 2

Info

Publication number
CR11126A
CR11126A CR11126A CR11126A CR11126A CR 11126 A CR11126 A CR 11126A CR 11126 A CR11126 A CR 11126A CR 11126 A CR11126 A CR 11126A CR 11126 A CR11126 A CR 11126A
Authority
CR
Costa Rica
Prior art keywords
inhibition
tumor metastasis
antibodies
neuropilin
neuropilin antibodies
Prior art date
Application number
CR11126A
Other languages
English (en)
Inventor
Yan Wu
Wei-Ching Liang
Ryan Jefferson Watts
Anil Durgadas Bagri
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CR11126A publication Critical patent/CR11126A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La solicitud proporciona antagonistas Nrp2, tales como anticuerpos anti-Nrp2, y su uso en la prevencion y tratamiento de metastasis de tumor.
CR11126A 2007-05-17 2009-11-24 Inhibicion de metastasis de tumor por anticuerpos anti neuropilina 2 CR11126A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069179 WO2008143665A1 (en) 2007-05-17 2007-05-17 Inhibition of tumor metastasis by anti neuropilin 2 antibodies

Publications (1)

Publication Number Publication Date
CR11126A true CR11126A (es) 2010-05-19

Family

ID=39301228

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11126A CR11126A (es) 2007-05-17 2009-11-24 Inhibicion de metastasis de tumor por anticuerpos anti neuropilina 2

Country Status (17)

Country Link
US (2) US8648173B2 (es)
EP (1) EP2152307B1 (es)
JP (1) JP5745840B2 (es)
KR (1) KR101520115B1 (es)
CN (1) CN101754771B (es)
AU (1) AU2007353778B9 (es)
BR (1) BRPI0721660A2 (es)
CA (1) CA2687247A1 (es)
CR (1) CR11126A (es)
ES (1) ES2469743T3 (es)
HK (2) HK1134040A1 (es)
IL (1) IL202005A (es)
MA (1) MA31435B1 (es)
MX (1) MX2009012421A (es)
NO (1) NO20093542L (es)
UA (1) UA99292C2 (es)
WO (1) WO2008143665A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008251381B2 (en) * 2007-05-11 2014-10-30 The Johns Hopkins University Biomarkers for melanoma
JP2013507641A (ja) * 2009-10-13 2013-03-04 ザ・ジョンズ・ホプキンス・ユニバーシティー 黒色腫腫瘍細胞の識別のためのバイオマーカー
ES2708565T3 (es) 2013-03-15 2019-04-10 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
US10174385B2 (en) * 2013-12-20 2019-01-08 Trustees Of Boston University Assays and methods relating to the treatment of melanoma
WO2018195338A1 (en) 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
JP2020522562A (ja) * 2017-06-06 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法
AU2019247511A1 (en) * 2018-04-06 2020-10-22 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
JP2022551603A (ja) 2019-10-03 2022-12-12 エータイアー ファーマ， インコーポレイテッド 抗ｎｒｐ２抗体を含む組成物および方法
CN114277152A (zh) * 2022-01-14 2022-04-05 张赟建 用于预测甲状腺乳头状癌淋巴结转移的特异性基因及制备方法
CN114262683B (zh) * 2022-03-01 2022-06-17 中国科学院动物研究所 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
PT1787999E (pt) 1997-04-07 2010-11-11 Genentech Inc Anticorpos anti-vegf
DE69829891T2 (de) 1997-04-07 2005-10-06 Genentech, Inc., South San Francisco Anti-VEGF Antikörper
CA2313348A1 (en) * 1997-12-09 1999-06-17 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
EP1037925A2 (en) * 1997-12-09 2000-09-27 Children's Medical Center Corporation Antagonists of neuropilin receptor functional and use thereof
US6417169B1 (en) * 1998-04-23 2002-07-09 Genesense Technologies Inc. Insulin-like growth factor II antisense oligonucleotide sequences and methods of using same to inhibit cell growth
US20030113324A1 (en) 2001-10-01 2003-06-19 Kari Alitalo Neuropilin/VEGF-C/VEGFR-3 materials and methods
JP4753578B2 (ja) 2002-06-03 2011-08-24 ジェネンテック， インコーポレイテッド 合成抗体ファージライブラリー
EP1439192A1 (en) * 2003-01-15 2004-07-21 Xerion Pharmaceuticals AG Neuropilin-1 inhibitors
EP1663293A2 (en) * 2003-09-23 2006-06-07 Ludwig Institute For Cancer Research Vege-cor vege-d materials and methods for stimulation of neural stem cells
UA96139C2 (uk) * 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)

Also Published As

Publication number Publication date
IL202005A (en) 2014-11-30
KR101520115B1 (ko) 2015-05-13
US8920805B2 (en) 2014-12-30
IL202005A0 (en) 2010-06-16
HK1144556A1 (en) 2011-02-25
UA99292C2 (uk) 2012-08-10
MX2009012421A (es) 2009-12-01
MA31435B1 (fr) 2010-06-01
AU2007353778B2 (en) 2013-11-07
CN101754771A (zh) 2010-06-23
BRPI0721660A2 (pt) 2013-01-22
US20100172921A1 (en) 2010-07-08
WO2008143665A1 (en) 2008-11-27
CA2687247A1 (en) 2008-11-27
EP2152307B1 (en) 2014-04-16
AU2007353778B9 (en) 2014-04-03
HK1134040A1 (en) 2010-04-16
KR20100018567A (ko) 2010-02-17
NO20093542L (no) 2010-02-12
ES2469743T3 (es) 2014-06-18
CN101754771B (zh) 2015-03-04
US20140234312A1 (en) 2014-08-21
AU2007353778A1 (en) 2008-11-27
US8648173B2 (en) 2014-02-11
EP2152307A1 (en) 2010-02-17
JP5745840B2 (ja) 2015-07-08
JP2010527350A (ja) 2010-08-12

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