HK1144556A1 - Inhibition of tumor metastasis by anti-neuropilin antibodies - Google Patents

Inhibition of tumor metastasis by anti-neuropilin antibodies

Info

Publication number
HK1144556A1
HK1144556A1 HK10111154.7A HK10111154A HK1144556A1 HK 1144556 A1 HK1144556 A1 HK 1144556A1 HK 10111154 A HK10111154 A HK 10111154A HK 1144556 A1 HK1144556 A1 HK 1144556A1
Authority
HK
Hong Kong
Prior art keywords
inhibition
tumor metastasis
neuropilin
antibodies
neuropilin antibodies
Prior art date
Application number
HK10111154.7A
Other languages
English (en)
Chinese (zh)
Inventor
Yan Wu
Wei-Ching Liang
Ryan Jefferson Watts
Anil Durgadas Bagri
Original Assignee
健泰科生物技術公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 健泰科生物技術公司 filed Critical 健泰科生物技術公司
Publication of HK1144556A1 publication Critical patent/HK1144556A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK10111154.7A 2007-05-17 2010-11-30 Inhibition of tumor metastasis by anti-neuropilin antibodies HK1144556A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069179 WO2008143665A1 (en) 2007-05-17 2007-05-17 Inhibition of tumor metastasis by anti neuropilin 2 antibodies

Publications (1)

Publication Number Publication Date
HK1144556A1 true HK1144556A1 (en) 2011-02-25

Family

ID=39301228

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10102110.9A HK1134040A1 (en) 2007-05-17 2010-03-01 Inhibition of tumor metastasis by anti neuropilin 2 antibodies
HK10111154.7A HK1144556A1 (en) 2007-05-17 2010-11-30 Inhibition of tumor metastasis by anti-neuropilin antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK10102110.9A HK1134040A1 (en) 2007-05-17 2010-03-01 Inhibition of tumor metastasis by anti neuropilin 2 antibodies

Country Status (17)

Country Link
US (2) US8648173B2 (xx)
EP (1) EP2152307B1 (xx)
JP (1) JP5745840B2 (xx)
KR (1) KR101520115B1 (xx)
CN (1) CN101754771B (xx)
AU (1) AU2007353778B9 (xx)
BR (1) BRPI0721660A2 (xx)
CA (1) CA2687247A1 (xx)
CR (1) CR11126A (xx)
ES (1) ES2469743T3 (xx)
HK (2) HK1134040A1 (xx)
IL (1) IL202005A (xx)
MA (1) MA31435B1 (xx)
MX (1) MX2009012421A (xx)
NO (1) NO20093542L (xx)
UA (1) UA99292C2 (xx)
WO (1) WO2008143665A1 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2162552A4 (en) * 2007-05-11 2010-06-30 Univ Johns Hopkins BIOMARKERS FOR MELANOMES
EP2488874A4 (en) * 2009-10-13 2013-08-14 Univ Johns Hopkins BIOMARKERS FOR THE IDENTIFICATION OF MELANOMOTUM CELLS
ES2708565T3 (es) 2013-03-15 2019-04-10 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
US10174385B2 (en) 2013-12-20 2019-01-08 Trustees Of Boston University Assays and methods relating to the treatment of melanoma
JP2020517638A (ja) 2017-04-20 2020-06-18 エータイアー ファーマ, インコーポレイテッド 肺の炎症を治療するための組成物および方法
CN110997724A (zh) * 2017-06-06 2020-04-10 斯特库伯株式会社 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CA3096222A1 (en) * 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
US11807687B2 (en) 2019-10-03 2023-11-07 Atyr Pharma, Inc. Therapeutic compositions comprising anti-NRP2 antibodies
CN114277152A (zh) * 2022-01-14 2022-04-05 张赟建 用于预测甲状腺乳头状癌淋巴结转移的特异性基因及制备方法
CN114262683B (zh) * 2022-03-01 2022-06-17 中国科学院动物研究所 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
SI1325932T1 (xx) 1997-04-07 2005-08-31 Genentech Inc
DK1695985T3 (da) 1997-04-07 2011-06-14 Genentech Inc Fremgangsmåde til dannelse af humaniserede antistoffer ved tilfældig mutagenese
WO1999029858A1 (en) 1997-12-09 1999-06-17 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
AU1810499A (en) * 1997-12-09 1999-06-28 Children's Medical Center Corporation Antagonists of neuropilin receptor functional and use thereof
US6417169B1 (en) * 1998-04-23 2002-07-09 Genesense Technologies Inc. Insulin-like growth factor II antisense oligonucleotide sequences and methods of using same to inhibit cell growth
US20030113324A1 (en) * 2001-10-01 2003-06-19 Kari Alitalo Neuropilin/VEGF-C/VEGFR-3 materials and methods
EP1513879B1 (en) 2002-06-03 2018-08-22 Genentech, Inc. Synthetic antibody phage libraries
EP1439192A1 (en) * 2003-01-15 2004-07-21 Xerion Pharmaceuticals AG Neuropilin-1 inhibitors
CN1886149A (zh) 2003-09-23 2006-12-27 路德维格癌症研究院 Vegf-c或vegf-d物质及刺激神经干细胞的方法
UA96139C2 (xx) * 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)$антитело к нейропилину-1 (nrp1)

Also Published As

Publication number Publication date
IL202005A (en) 2014-11-30
UA99292C2 (uk) 2012-08-10
WO2008143665A1 (en) 2008-11-27
EP2152307B1 (en) 2014-04-16
US8648173B2 (en) 2014-02-11
NO20093542L (no) 2010-02-12
MA31435B1 (fr) 2010-06-01
KR101520115B1 (ko) 2015-05-13
MX2009012421A (es) 2009-12-01
CN101754771B (zh) 2015-03-04
JP2010527350A (ja) 2010-08-12
JP5745840B2 (ja) 2015-07-08
ES2469743T3 (es) 2014-06-18
EP2152307A1 (en) 2010-02-17
US8920805B2 (en) 2014-12-30
US20140234312A1 (en) 2014-08-21
US20100172921A1 (en) 2010-07-08
AU2007353778B9 (en) 2014-04-03
CA2687247A1 (en) 2008-11-27
AU2007353778B2 (en) 2013-11-07
HK1134040A1 (en) 2010-04-16
KR20100018567A (ko) 2010-02-17
BRPI0721660A2 (pt) 2013-01-22
IL202005A0 (en) 2010-06-16
CR11126A (es) 2010-05-19
CN101754771A (zh) 2010-06-23
AU2007353778A1 (en) 2008-11-27

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190521