CO5570671A2 - Derivado de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte de acidos biliares en el ileon (ibat) para el tratamiento de hiperlipidemia - Google Patents
Derivado de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte de acidos biliares en el ileon (ibat) para el tratamiento de hiperlipidemiaInfo
- Publication number
- CO5570671A2 CO5570671A2 CO04032561A CO04032561A CO5570671A2 CO 5570671 A2 CO5570671 A2 CO 5570671A2 CO 04032561 A CO04032561 A CO 04032561A CO 04032561 A CO04032561 A CO 04032561A CO 5570671 A2 CO5570671 A2 CO 5570671A2
- Authority
- CO
- Colombia
- Prior art keywords
- 6alkyl
- 4alkyl
- amino
- hydrogen
- benzotiazepina
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1.- Un compuesto de fórmula (I): en donde:Rv se selecciona de hidrógeno o C1-6alquilo;uno de R1 y R2 se seleccionan de hidrógeno o C1-6alquilo o C2-6alquenilo y el otro se selecciona de C1-6alquilo C2-6alquenilo;Rx y Ry se seleccionan independientemente de hidrógeno, hidroxi, amino, mercapto, C1-6alquilo, C1-6alcoxi, N-(C1-6alquil)amino, N,N-(C1-6alquiI)2amino, C1-6alquilS(O)a en donde a es 0 a 2;M se selecciona de -N- o -CH-;Rz se selecciona de halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, C1-6alcoxi, C1-6alcanoilo, C1-6aIcanoiloxi, N-(C1-6alquil)amino, N,N-(C1-6alquiI)2amino, C1-6aIcanoilamino, N-(C1-6alquil)carbamoilo, N,N-(C1-6alquiI)2carbamoilo, C1-6alquilS(O)a en donde a es 0 a 2, C1-6aIcoxicarbonilo, N-(C1-6alquil)sulfamoilo y N,N-(C1-6alquil)2sulfamoilo;v es 0-5;uno de R4 y R5 es un grupo de fórmula (lA): R3 y R6 y los demás de R4 y R5 se seleccionan independientemente de hidrógeno, halo, nitro, ciano, hidroxi, amino, carboxi, carbamoilo, mercapto, sulfamoilo, C1-4alquilo, C2-4alquenilo, C2-4alquinilo, C1-4alcoxi, C1-4alcanoilo, C1-4alcanoiloxi, N-(C1-4alquil)amino, N,N-(C1-4alquiI)2amino, C1-4alcanoilamino, N-(C1-4 alquil)carbamoilo, N,N-(C1-4alquil)2carbamoilo, C1-4alquilS(O)a en donde a es 0 a 2, C1-4alcoxicarbonilo, N-(C1-4alquil)sulfamoilo y N,N-(C1-4alquil)2sulfamoilo; en donde R3 y R6 y los demás de R4 y R5 pueden sustituirse opcionalmente en carbono por uno o más R16;X es -O-, -N(Ra)-, -S(O)b- o-CH(Ra)-; en donde Ra es hidrógeno o C1-6alquilo y b es 0-2;Anillo A es arilo o heteroarilo; ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0121768A GB0121768D0 (en) | 2001-09-08 | 2001-09-08 | Chemical compounds |
GB0209463A GB0209463D0 (en) | 2002-04-25 | 2002-04-25 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5570671A2 true CO5570671A2 (es) | 2005-10-31 |
Family
ID=26246524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04032561A CO5570671A2 (es) | 2001-09-08 | 2004-04-06 | Derivado de benzotiazepina y benzotiadiazepina con actividad inhibidora de transporte de acidos biliares en el ileon (ibat) para el tratamiento de hiperlipidemia |
Country Status (29)
Country | Link |
---|---|
US (1) | US7132416B2 (es) |
EP (1) | EP1427423B9 (es) |
JP (2) | JP3616635B2 (es) |
KR (1) | KR100935623B1 (es) |
CN (1) | CN1582151A (es) |
AR (1) | AR037089A1 (es) |
AT (1) | ATE349214T1 (es) |
AU (1) | AU2002329387B2 (es) |
BR (1) | BRPI0212346B1 (es) |
CA (1) | CA2459449C (es) |
CO (1) | CO5570671A2 (es) |
CY (1) | CY1106348T1 (es) |
DE (1) | DE60217136T2 (es) |
DK (1) | DK1427423T5 (es) |
ES (1) | ES2278045T3 (es) |
HK (1) | HK1065258A1 (es) |
HU (1) | HU227623B1 (es) |
IL (2) | IL160691A0 (es) |
IS (1) | IS7170A (es) |
MX (1) | MXPA04002179A (es) |
MY (1) | MY131995A (es) |
NO (1) | NO327041B1 (es) |
NZ (1) | NZ531796A (es) |
PL (1) | PL216023B1 (es) |
PT (1) | PT1427423E (es) |
RU (1) | RU2305681C2 (es) |
TW (1) | TWI331143B (es) |
UY (1) | UY27436A1 (es) |
WO (1) | WO2003022286A1 (es) |
Families Citing this family (78)
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SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
GB0213669D0 (en) * | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
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GB0304194D0 (en) * | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
AU2008202120B2 (en) * | 2003-04-05 | 2009-12-17 | Albireo Ab | Use of an IBAT inhibitor for the treatment of prophylaxis of constipation |
GB0307918D0 (en) * | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
GB0314131D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
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ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
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WO2024121431A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Cocrystals of odevixibat |
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GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
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GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
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GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
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