ES2081747A1 - Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. - Google Patents

Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2081747A1
ES2081747A1 ES09301917A ES9301917A ES2081747A1 ES 2081747 A1 ES2081747 A1 ES 2081747A1 ES 09301917 A ES09301917 A ES 09301917A ES 9301917 A ES9301917 A ES 9301917A ES 2081747 A1 ES2081747 A1 ES 2081747A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
hydroxycarbonylalkyl
drugs
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301917A
Other languages
English (en)
Other versions
ES2081747B1 (es
Inventor
Jover Antonio Torrens
Prio Jose Mas
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES9301917A priority Critical patent/ES2081747B1/es
Publication of ES2081747A1 publication Critical patent/ES2081747A1/es
Application granted granted Critical
Publication of ES2081747B1 publication Critical patent/ES2081747B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

AMIDAS DERIVADAS DE TIENOPIRROLES, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. COMPUESTOS DE FORMULA GENERAL (I), DONDE: X1 Y X2, DIFERENTES, CORRESPONDEN A CARBONO O AZUFRE, INDISTINTAMENTE R1 REPRESENTA COMPUESTOS DE FORMULA (IA) O (IB); R2 ES HIDROGENO O ALQUILO DE C1-C6; R3 Y R4 SON HIDROGENO, ALQUILO, HALOGENO, HIUROXILO, ALCOXILO, CIANO O NITRO, INDISTINTAMENTE; R5 ES HIDROGENO, ALQUILO DE C1-C6, ARILO, ARALQUILO, ALCOXICARBONILO, FENILALQUILOXICARBONILO, ALQUILSULFONILO, TENILSULFONILO, ALQUILOXIALQUILO O HIDROXICARBONILALQUILO; R6 ES HIDROGENO, ALQUILO DE C1-C6, HIDROXICARBONILALQUILO, ALCOXICARBONILO O ALCOXICARBONILALQUILO; R7 ES HIDROGENO, ALCOXILO O HALOGENO; R8 ES 3-INDOLILMETILO, HIDROXICARBONILALQUILO O BENCILOXICARBONILALQUILO; R9 ES HIDROXILO O NITROGENO UNIDO A R10 Y R11; R10 Y R11 SON, INDEPENDIENTEMENTE, HIDROGENO ALQUILO DE C1-C6, PREFERENTEMENTE N-PENTILO O HIDROXICARBONILALQUILO; -Z7 Z2 REPRESENTA C=N- O N-C=O. SU PROCEDIMIENTO DE PREPARACION, CONSISTENTE EN REACCIONAR DERIVADOS CARBOXILICOS CON AMINAS RACEMICAS EN DISOLVENTES ORGANICOS ANHIDRO O HIDRATADOS, SUS SALES FISIOLOGICAMENTE ACEPTABLES, COMO MEDICAMENTOS DESTINADOS AL TRATAMIENTO, ENTRE OTROS, DE LAS DISFUNCIONES INTESTINALES.
ES9301917A 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2081747B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301917A ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301917A ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2081747A1 true ES2081747A1 (es) 1996-03-01
ES2081747B1 ES2081747B1 (es) 1997-01-16

Family

ID=8283002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301917A Expired - Lifetime ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Country Status (1)

Country Link
ES (1) ES2081747B1 (es)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1088824A3 (en) * 1999-09-30 2001-06-27 Pfizer Products Inc. Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors
WO2003074531A1 (en) * 2002-03-06 2003-09-12 Astrazeneca Ab Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
US7115648B2 (en) 2002-03-06 2006-10-03 Astrazeneca Ab Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
US7129249B2 (en) 2002-03-06 2006-10-31 Astrazeneca Ab Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase
US7138415B2 (en) 2002-03-06 2006-11-21 Astrazeneca Ab Indolamid derivatives which possess glycogenphosphorylase inhibitory activity
US7166636B2 (en) 2002-03-06 2007-01-23 Astrazeneca Ab Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity
US7169927B2 (en) 2002-03-06 2007-01-30 Astrazeneca Ab Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7893098B2 (en) 2003-12-29 2011-02-22 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
US8097760B2 (en) 2006-03-31 2012-01-17 Sunovion Pharmacuticals Inc. Preparation of chiral amides and amines
US8669291B2 (en) 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US8877975B2 (en) 2006-01-06 2014-11-04 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
US11072618B2 (en) 2016-12-09 2021-07-27 Denali Therapeutics Inc. Compounds, compositions and methods
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293726A1 (en) 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
EP0252809A2 (fr) * 1986-07-08 1988-01-13 Synthelabo Dérivés du nitrofuranne, leur préparation et leur application en thérapeutique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
EP0252809A2 (fr) * 1986-07-08 1988-01-13 Synthelabo Dérivés du nitrofuranne, leur préparation et leur application en thérapeutique

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
EP1088824A3 (en) * 1999-09-30 2001-06-27 Pfizer Products Inc. Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
WO2002020530A1 (en) * 2000-09-06 2002-03-14 Astrazeneca Ab Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors
US7129249B2 (en) 2002-03-06 2006-10-31 Astrazeneca Ab Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase
US7115648B2 (en) 2002-03-06 2006-10-03 Astrazeneca Ab Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
US7122567B2 (en) 2002-03-06 2006-10-17 Astrazeneca Ab Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity
US7138415B2 (en) 2002-03-06 2006-11-21 Astrazeneca Ab Indolamid derivatives which possess glycogenphosphorylase inhibitory activity
US7166636B2 (en) 2002-03-06 2007-01-23 Astrazeneca Ab Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity
US7169927B2 (en) 2002-03-06 2007-01-30 Astrazeneca Ab Indole-amide derivatives and their use as glycogen phosphorylase inhibitors
CN1307183C (zh) * 2002-03-06 2007-03-28 阿斯特拉曾尼卡有限公司 具有糖原磷酸化酶抑制活性的杂环酰胺衍生物
US7332515B2 (en) 2002-03-06 2008-02-19 Astrazeneca Ab Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity
WO2003074531A1 (en) * 2002-03-06 2003-09-12 Astrazeneca Ab Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity
US7893098B2 (en) 2003-12-29 2011-02-22 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
US9868718B2 (en) 2006-01-06 2018-01-16 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
US10562878B2 (en) 2006-01-06 2020-02-18 Sunovion Pharamceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
US8877975B2 (en) 2006-01-06 2014-11-04 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
US8097760B2 (en) 2006-03-31 2012-01-17 Sunovion Pharmacuticals Inc. Preparation of chiral amides and amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
US8669291B2 (en) 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US9586888B2 (en) 2007-05-31 2017-03-07 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US9815850B2 (en) 2016-02-05 2017-11-14 Denali Therapeutics Inc. Compounds, compositions and methods
US10131676B2 (en) 2016-02-05 2018-11-20 Denali Therapeutics Inc. Compounds, compositions and methods
US9896458B2 (en) 2016-02-05 2018-02-20 Denali Therapeutics Inc. Compounds, compositions and methods
US10604535B2 (en) 2016-02-05 2020-03-31 Denali Therapeutics Inc. Compounds, compositions and methods
US11072618B2 (en) 2016-12-09 2021-07-27 Denali Therapeutics Inc. Compounds, compositions and methods
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

Also Published As

Publication number Publication date
ES2081747B1 (es) 1997-01-16

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