CO4700445A1 - Esteres nitricos de derivados del acido 2-(2,6-dihalofenil- amino)fenilacetoxiacetico y sus procedimientos de prepara- cion - Google Patents

Esteres nitricos de derivados del acido 2-(2,6-dihalofenil- amino)fenilacetoxiacetico y sus procedimientos de prepara- cion

Info

Publication number
CO4700445A1
CO4700445A1 CO96013810A CO96013810A CO4700445A1 CO 4700445 A1 CO4700445 A1 CO 4700445A1 CO 96013810 A CO96013810 A CO 96013810A CO 96013810 A CO96013810 A CO 96013810A CO 4700445 A1 CO4700445 A1 CO 4700445A1
Authority
CO
Colombia
Prior art keywords
linear
carbon atoms
branched alkyl
alkyl chain
dihalophenylamino
Prior art date
Application number
CO96013810A
Other languages
English (en)
Inventor
Masia Xavier Serra
Sallent Joan Pi
Original Assignee
Prodes Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodes Sa filed Critical Prodes Sa
Publication of CO4700445A1 publication Critical patent/CO4700445A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esteres nítricos de derivados del ácido 2-(2,6-dihalofenilamino)fenilacetoxiacético de fórmula general (I):donde:A es flúor, cloro o bromo;X significa oxígeno, NH ó NR donde R significa una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono;R1 y R2 significan, independientemente, hidrógeno o una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono;n es un número comprendido entre 1 y 10.Procedimiento de preparación de esteres nítricos de derivados del ácido 2.(2,6-dihalofenilamino) fenilacetoxiacético de fórmula general (I):donde:A es flúor, cloro o bromo;X significa O, NH ó NR donde R significa una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono;R1 y R2 significan independientemente, hidrógeno o una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono;n es un número comprendido entre 1 y 10, caracterizado por efectuar la condensación del correspondiente ácido 2-(2,6-dihalofenilamino)fenilacetoxiacético de fórmula (IV) donde A es flúor, cloro o bromo. con un derivado de fórmula general (V)donde Y puede ser OH, NH2 o bien NHR siendo R una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono, R1 y R2 significan, independientemente, hidrógeno o una cadena alquílica lineal o ramificada de 1 a 6 átomos de carbono y n es un número comprendido entre 1 y 10, en presencia de un agente de condensación adecuado en un disolvente orgánico aprótico. Procedimiento de preparación de esteres nítricos de derivados del ácido 2-(2,6-dihalofenilamino)fenilacetoxiacético de fórmula general (I): ...
CO96013810A 1995-04-19 1996-03-20 Esteres nitricos de derivados del acido 2-(2,6-dihalofenil- amino)fenilacetoxiacetico y sus procedimientos de prepara- cion CO4700445A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09500756A ES2092962B1 (es) 1995-04-19 1995-04-19 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.

Publications (1)

Publication Number Publication Date
CO4700445A1 true CO4700445A1 (es) 1998-12-29

Family

ID=8290121

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96013810A CO4700445A1 (es) 1995-04-19 1996-03-20 Esteres nitricos de derivados del acido 2-(2,6-dihalofenil- amino)fenilacetoxiacetico y sus procedimientos de prepara- cion

Country Status (15)

Country Link
US (1) US5844696A (es)
EP (1) EP0738706B1 (es)
JP (1) JPH0920738A (es)
KR (1) KR960037641A (es)
CN (1) CN1138027A (es)
AT (1) ATE171936T1 (es)
AU (1) AU683790B2 (es)
CA (1) CA2174287A1 (es)
CO (1) CO4700445A1 (es)
DE (1) DE69600739D1 (es)
ES (1) ES2092962B1 (es)
HU (1) HUP9600996A3 (es)
NO (1) NO961537L (es)
NZ (1) NZ286388A (es)
ZA (1) ZA962981B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
WO1999062865A1 (en) * 1998-06-03 1999-12-09 Jae Chul Kim Haloethyl-2-[ (2,6-dichlorophenyl) amino] phenylacetoxyacetate derivatives and their use as an intermediate to synthesize aceclofenac
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
WO2003103602A2 (en) * 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES520813A0 (es) * 1983-03-21 1984-05-16 Prodes Sa Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico.
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Also Published As

Publication number Publication date
KR960037641A (ko) 1996-11-19
AU683790B2 (en) 1997-11-20
EP0738706A1 (en) 1996-10-23
HU9600996D0 (en) 1996-06-28
CA2174287A1 (en) 1996-10-20
AU5042896A (en) 1996-10-31
NO961537L (no) 1996-10-21
US5844696A (en) 1998-12-01
ZA962981B (en) 1996-10-22
HUP9600996A2 (en) 1996-11-28
NZ286388A (en) 1997-03-24
ES2092962B1 (es) 1997-07-16
ES2092962A1 (es) 1996-12-01
JPH0920738A (ja) 1997-01-21
NO961537D0 (no) 1996-04-18
DE69600739D1 (de) 1998-11-12
HUP9600996A3 (en) 1997-11-28
EP0738706B1 (en) 1998-10-07
ATE171936T1 (de) 1998-10-15
CN1138027A (zh) 1996-12-18

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