JPS6422849A - Purification of 3-(3,4-dihydroxyphenyl)serine - Google Patents

Purification of 3-(3,4-dihydroxyphenyl)serine

Info

Publication number
JPS6422849A
JPS6422849A JP17775787A JP17775787A JPS6422849A JP S6422849 A JPS6422849 A JP S6422849A JP 17775787 A JP17775787 A JP 17775787A JP 17775787 A JP17775787 A JP 17775787A JP S6422849 A JPS6422849 A JP S6422849A
Authority
JP
Japan
Prior art keywords
dops
dihydroxyphenyl
crude
serine
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17775787A
Other languages
Japanese (ja)
Other versions
JPH0796537B2 (en
Inventor
Shoji Nagata
Naohito Ohashi
Kozo Shimako
Toshio Nishizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to JP62177757A priority Critical patent/JPH0796537B2/en
Publication of JPS6422849A publication Critical patent/JPS6422849A/en
Publication of JPH0796537B2 publication Critical patent/JPH0796537B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PURPOSE:To easily obtain the titled compound in high efficiency at a low temperature, advantageously on an industrial scale, by neutralizing a crude 3-(3,4- dihydroxyphenyl)serine solution containing a mineral acid with a base. CONSTITUTION:3-(3,4-Dihydroxyphenyl)serine (hereinafter called DOPS) can be obtained in purified state by neutralizing a crude DOPS solution composed of water or a hydrous alcoholic solvent [e.g. methanol containing >=50%(W/W) of water] and containing >=1 equivalent of a mineral acid [e.g. 1-2 equivalent of H2SO4 or HCl based on crude DOPS] with a base (e.g. NaOH, KOH, diethylamine or triethylamine). The present process has advantages such as low-temperature operation to avoid the thermal deterioration of DOPS, etc., compared with conventional water-recrystallization process.
JP62177757A 1987-07-16 1987-07-16 Method for purifying 3- (3,4-dihydroxyphenyl) serine Expired - Lifetime JPH0796537B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62177757A JPH0796537B2 (en) 1987-07-16 1987-07-16 Method for purifying 3- (3,4-dihydroxyphenyl) serine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62177757A JPH0796537B2 (en) 1987-07-16 1987-07-16 Method for purifying 3- (3,4-dihydroxyphenyl) serine

Publications (2)

Publication Number Publication Date
JPS6422849A true JPS6422849A (en) 1989-01-25
JPH0796537B2 JPH0796537B2 (en) 1995-10-18

Family

ID=16036594

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62177757A Expired - Lifetime JPH0796537B2 (en) 1987-07-16 1987-07-16 Method for purifying 3- (3,4-dihydroxyphenyl) serine

Country Status (1)

Country Link
JP (1) JPH0796537B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000601A1 (en) * 2000-06-26 2002-01-03 Kaneka Corporation Process for producing 3-amino-2-hydroxypropionic acid derivatives
CN103086906A (en) * 2011-11-03 2013-05-08 重庆圣华曦药业股份有限公司 Droxidopa crystal and preparation method thereof
CN113307741A (en) * 2020-02-26 2021-08-27 东莞市东阳光仿制药研发有限公司 Method for preparing droxidopa

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58216146A (en) * 1982-06-09 1983-12-15 Sumitomo Chem Co Ltd Preparation of optical active-threo-3-(3,4- dihydroxyphenyl)serine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58216146A (en) * 1982-06-09 1983-12-15 Sumitomo Chem Co Ltd Preparation of optical active-threo-3-(3,4- dihydroxyphenyl)serine

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000601A1 (en) * 2000-06-26 2002-01-03 Kaneka Corporation Process for producing 3-amino-2-hydroxypropionic acid derivatives
US7057066B2 (en) 2000-06-26 2006-06-06 Kaneka Corporation Process for producing 3-amino-2-hydroxypropionic acid derivatives
CN103086906A (en) * 2011-11-03 2013-05-08 重庆圣华曦药业股份有限公司 Droxidopa crystal and preparation method thereof
CN113307741A (en) * 2020-02-26 2021-08-27 东莞市东阳光仿制药研发有限公司 Method for preparing droxidopa

Also Published As

Publication number Publication date
JPH0796537B2 (en) 1995-10-18

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