JPS5583727A - Purification of ortho ester - Google Patents
Purification of ortho esterInfo
- Publication number
- JPS5583727A JPS5583727A JP15710678A JP15710678A JPS5583727A JP S5583727 A JPS5583727 A JP S5583727A JP 15710678 A JP15710678 A JP 15710678A JP 15710678 A JP15710678 A JP 15710678A JP S5583727 A JPS5583727 A JP S5583727A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ortho ester
- aqueous alkali
- purification
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To purify the title compound in high yield, by alcoholysis of the imido ether hydrochloride obtained through the reaction of an organic nitrile with an alcohol and hydrogen chloride, and by the contact of the compound thus formed with an aqueous alkali.
CONSTITUTION: A solution containing an ortho ester formed in accordance with the formula(R1 is alkyl, aryl, etc.; R2 is alkyl, cycloalkyl, etc.; R3 is alkyl, alkenyl, etc.; R4 is R2 or R3), is purified with about 2W10wt% of aqueous alkali, e.g. a hydroxide or carbonate of Na and K (especially NaOH) in an amount of 20W 50mol% based in NH4Cl in the formed solution.
EFFECT: Little hydrolysis of ortho ester, removal of almost all of the impurities, and high quality.
USE: Intermediates for medicines, and reagents.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15710678A JPS5583727A (en) | 1978-12-19 | 1978-12-19 | Purification of ortho ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15710678A JPS5583727A (en) | 1978-12-19 | 1978-12-19 | Purification of ortho ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5583727A true JPS5583727A (en) | 1980-06-24 |
JPS6210215B2 JPS6210215B2 (en) | 1987-03-05 |
Family
ID=15642354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15710678A Granted JPS5583727A (en) | 1978-12-19 | 1978-12-19 | Purification of ortho ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5583727A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103130622A (en) * | 2011-11-28 | 2013-06-05 | 重庆紫光化工股份有限公司 | Preparation method of trimethyl orthoformate |
JP2014208698A (en) * | 2007-04-11 | 2014-11-06 | 第一三共株式会社 | Method for producing neuraminic acid derivative |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51108012A (en) * | 1975-03-19 | 1976-09-25 | Kuraray Co | Orutoesuteruno seizohoho |
-
1978
- 1978-12-19 JP JP15710678A patent/JPS5583727A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51108012A (en) * | 1975-03-19 | 1976-09-25 | Kuraray Co | Orutoesuteruno seizohoho |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014208698A (en) * | 2007-04-11 | 2014-11-06 | 第一三共株式会社 | Method for producing neuraminic acid derivative |
CN103130622A (en) * | 2011-11-28 | 2013-06-05 | 重庆紫光化工股份有限公司 | Preparation method of trimethyl orthoformate |
Also Published As
Publication number | Publication date |
---|---|
JPS6210215B2 (en) | 1987-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2000603A6 (en) | Process for the preparation of aryl-piperidine carbinols. | |
JPS5692859A (en) | Preparation of hydroxyalkylaminosulfnonic acid | |
JPS5583727A (en) | Purification of ortho ester | |
DE3370615D1 (en) | Process for the preparation of 1,2-diols | |
HUT41015A (en) | Process for preparing amino-thiazole-acetic acid derivatives | |
JPS57185287A (en) | Purification of bis(alkylbenzylidene)sorbitol | |
ATE18208T1 (en) | N-(4-HYDROXYPHENYL)ACETIC ACID ESTERS FROM 5BENZOYL-1-METHYLPYRROL-2-ACETIC ACID. | |
KR840004408A (en) | Process for preparing spiro- (mono and di) -fluorofluorene compounds | |
JPS5576881A (en) | Preparation of high-purity coproporphyrin 3 alkali salt | |
HRP921076B1 (en) | Process for the preparation of opticalla active 2-(tetrahydropyran-2.yloxy)-1-propanol, new intermediate used in that process, and its application | |
JPS54112816A (en) | Preparation of dialkyl malonate | |
JPS57130964A (en) | Purification of acetone cyanohydrin | |
JPS5655356A (en) | Preparation of alkylenediamine derivative | |
JPS554346A (en) | Preparation of cephapirin sodium | |
JPS55122755A (en) | Production of n-carboxymethyltaurine alkali metal salt | |
JPS6468A (en) | Tertiary amino-alcohol compound and production of optically active secondary alcohol using said compound | |
JPS57209256A (en) | Novel salt of aminobutyric acid derivative | |
JPS5718695A (en) | Preparation of 5-hydroxymethyl-1-beta-d- arabinofuranosyluracil | |
JPS54148743A (en) | Production of methoclopramide | |
JPS579756A (en) | Novel acetal compound and its preparation | |
JPS5711960A (en) | Preparation of mercaptoamine | |
JPS5312830A (en) | Preparation of dinitrodiphenyl ether | |
JPS5699448A (en) | Preparation of lower alkoxyaniline | |
JPS57149257A (en) | 4-benzyloxyphenylacetamide | |
JPS57175197A (en) | Cysteine-glucuronolactone salt |