JPS5583727A - Purification of ortho ester - Google Patents

Purification of ortho ester

Info

Publication number
JPS5583727A
JPS5583727A JP15710678A JP15710678A JPS5583727A JP S5583727 A JPS5583727 A JP S5583727A JP 15710678 A JP15710678 A JP 15710678A JP 15710678 A JP15710678 A JP 15710678A JP S5583727 A JPS5583727 A JP S5583727A
Authority
JP
Japan
Prior art keywords
alkyl
ortho ester
aqueous alkali
purification
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15710678A
Other languages
Japanese (ja)
Other versions
JPS6210215B2 (en
Inventor
Norihiko Masunari
Shuji Ueda
Nobuhiro Danno
Toshiyuki Kusuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Synthetic Chemical Industry Co Ltd
Original Assignee
Nippon Synthetic Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Synthetic Chemical Industry Co Ltd filed Critical Nippon Synthetic Chemical Industry Co Ltd
Priority to JP15710678A priority Critical patent/JPS5583727A/en
Publication of JPS5583727A publication Critical patent/JPS5583727A/en
Publication of JPS6210215B2 publication Critical patent/JPS6210215B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To purify the title compound in high yield, by alcoholysis of the imido ether hydrochloride obtained through the reaction of an organic nitrile with an alcohol and hydrogen chloride, and by the contact of the compound thus formed with an aqueous alkali.
CONSTITUTION: A solution containing an ortho ester formed in accordance with the formula(R1 is alkyl, aryl, etc.; R2 is alkyl, cycloalkyl, etc.; R3 is alkyl, alkenyl, etc.; R4 is R2 or R3), is purified with about 2W10wt% of aqueous alkali, e.g. a hydroxide or carbonate of Na and K (especially NaOH) in an amount of 20W 50mol% based in NH4Cl in the formed solution.
EFFECT: Little hydrolysis of ortho ester, removal of almost all of the impurities, and high quality.
USE: Intermediates for medicines, and reagents.
COPYRIGHT: (C)1980,JPO&Japio
JP15710678A 1978-12-19 1978-12-19 Purification of ortho ester Granted JPS5583727A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15710678A JPS5583727A (en) 1978-12-19 1978-12-19 Purification of ortho ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15710678A JPS5583727A (en) 1978-12-19 1978-12-19 Purification of ortho ester

Publications (2)

Publication Number Publication Date
JPS5583727A true JPS5583727A (en) 1980-06-24
JPS6210215B2 JPS6210215B2 (en) 1987-03-05

Family

ID=15642354

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15710678A Granted JPS5583727A (en) 1978-12-19 1978-12-19 Purification of ortho ester

Country Status (1)

Country Link
JP (1) JPS5583727A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130622A (en) * 2011-11-28 2013-06-05 重庆紫光化工股份有限公司 Preparation method of trimethyl orthoformate
JP2014208698A (en) * 2007-04-11 2014-11-06 第一三共株式会社 Method for producing neuraminic acid derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108012A (en) * 1975-03-19 1976-09-25 Kuraray Co Orutoesuteruno seizohoho

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108012A (en) * 1975-03-19 1976-09-25 Kuraray Co Orutoesuteruno seizohoho

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014208698A (en) * 2007-04-11 2014-11-06 第一三共株式会社 Method for producing neuraminic acid derivative
CN103130622A (en) * 2011-11-28 2013-06-05 重庆紫光化工股份有限公司 Preparation method of trimethyl orthoformate

Also Published As

Publication number Publication date
JPS6210215B2 (en) 1987-03-05

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