CO2021014028A2 - Anticuerpos contra amiloide-β con piroglutamato y usos de estos - Google Patents
Anticuerpos contra amiloide-β con piroglutamato y usos de estosInfo
- Publication number
- CO2021014028A2 CO2021014028A2 CONC2021/0014028A CO2021014028A CO2021014028A2 CO 2021014028 A2 CO2021014028 A2 CO 2021014028A2 CO 2021014028 A CO2021014028 A CO 2021014028A CO 2021014028 A2 CO2021014028 A2 CO 2021014028A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibodies
- amyloid
- antigen
- binding fragments
- pyroglutamate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962823785P | 2019-03-26 | 2019-03-26 | |
| PCT/EP2020/058395 WO2020193644A1 (en) | 2019-03-26 | 2020-03-25 | ANTIBODIES TO PYROGLUTAMATE AMYLOID-ß AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021014028A2 true CO2021014028A2 (es) | 2021-10-29 |
Family
ID=70008544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0014028A CO2021014028A2 (es) | 2019-03-26 | 2021-10-20 | Anticuerpos contra amiloide-β con piroglutamato y usos de estos |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11236155B2 (ko) |
| EP (1) | EP3946603A1 (ko) |
| JP (1) | JP2022526528A (ko) |
| KR (1) | KR20210143858A (ko) |
| CN (1) | CN113891746A (ko) |
| AU (1) | AU2020245031A1 (ko) |
| BR (1) | BR112021019107A2 (ko) |
| CA (1) | CA3134785A1 (ko) |
| CL (2) | CL2021002473A1 (ko) |
| CO (1) | CO2021014028A2 (ko) |
| CR (1) | CR20210492A (ko) |
| DO (1) | DOP2021000199A (ko) |
| EA (1) | EA202192606A1 (ko) |
| EC (1) | ECSP21079184A (ko) |
| IL (1) | IL286634A (ko) |
| JO (1) | JOP20210265A1 (ko) |
| MA (1) | MA55491A (ko) |
| MX (1) | MX2021011715A (ko) |
| PE (1) | PE20212266A1 (ko) |
| SG (1) | SG11202110504XA (ko) |
| WO (1) | WO2020193644A1 (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL300059A (en) | 2020-07-23 | 2023-03-01 | Othair Prothena Ltd | Anti-Abata antibodies |
| WO2023077091A1 (en) * | 2021-10-28 | 2023-05-04 | Abbvie Inc. | Anti-amyloid beta antibodies and methods of using the same |
| TW202400636A (zh) * | 2022-03-11 | 2024-01-01 | 比利時商健生藥品公司 | 多特異性抗體及其用途(一) |
| WO2023170295A1 (en) * | 2022-03-11 | 2023-09-14 | Janssen Pharmaceutica Nv | Multispecific antibodies and uses thereof |
| TW202346355A (zh) * | 2022-03-11 | 2023-12-01 | 比利時商健生藥品公司 | 多特異性抗體及其用途(二) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
| US5642870A (en) | 1992-08-05 | 1997-07-01 | Sargis; Ike | Switch stand |
| US5761894A (en) | 1996-09-25 | 1998-06-09 | Magic Circle Corporation | Grass striping attachment for lawn mowers |
| US9907485B2 (en) | 2004-10-15 | 2018-03-06 | Brainlab Ag | Targeted immunization and plaque destruction against Alzheimer's disease |
| ES2396555T3 (es) * | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
| PT2289909E (pt) | 2005-11-30 | 2015-02-10 | Abbvie Inc | Método de rastreio, processo de purificação de globulómeros a-beta não difundíveis, anticorpos selectivos contra os referidos globulómeros a-beta não difundíveis e processo para o fabrico dos referidos anticorpos |
| IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| JP2011527338A (ja) | 2008-07-09 | 2011-10-27 | ユニバーシティー オブ チューリッヒ | 神経新生を促進する方法 |
| CN102131519B (zh) | 2008-07-21 | 2016-01-13 | 前体生物药物股份公司 | 诊断抗体测定 |
| CN102574915B (zh) | 2009-08-06 | 2014-10-22 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
| KR20130004579A (ko) * | 2010-02-23 | 2013-01-11 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 조성물 및 방법 |
| US8795664B2 (en) | 2010-06-04 | 2014-08-05 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Monoclonal antibodies targeting amyloid beta oligomers |
| PL3042917T3 (pl) * | 2010-08-12 | 2018-07-31 | Eli Lilly And Company | Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie |
| WO2012021475A2 (en) | 2010-08-12 | 2012-02-16 | Eli Lilly And Company | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF |
| EP2511296A1 (en) | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
| ITRM20120383A1 (it) | 2012-03-20 | 2013-09-21 | Uni Degli Studi Di Milano B Icocca | Metodo e kit per la rivelazione di anticorpi. |
| WO2015175769A1 (en) | 2014-05-15 | 2015-11-19 | Biogen Ma Inc. | Methods for the detection of amyloid beta oligomers in biological samples |
| WO2015191825A1 (en) | 2014-06-13 | 2015-12-17 | Biogen Ma Inc. | Methods for the detection and measurement of amyloid beta in biological samples |
| KR20240056627A (ko) * | 2014-08-07 | 2024-04-30 | 노파르티스 아게 | 안지오포이에틴-유사 4 항체 및 사용 방법 |
| EP3234611A1 (en) | 2014-12-19 | 2017-10-25 | Probiodrug AG | Novel method for the detection of pglu-abeta peptides |
| CN108699139B (zh) | 2015-07-16 | 2022-06-24 | 维沃永治疗公众有限公司 | 人源化抗体 |
| JOP20170004B1 (ar) | 2016-01-15 | 2022-09-15 | Lilly Co Eli | الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته |
| TW201740954A (zh) | 2016-03-16 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
| EP3249388A1 (en) | 2016-05-23 | 2017-11-29 | Raman Health Technologies, S.L | Method for diagnosing alzheimer´s disease |
| BR112018075300A2 (pt) | 2016-06-07 | 2019-04-30 | Biogen International Neuroscience Gmbh | métodos para tratamento do mal de alzheimer |
| US10988529B2 (en) | 2016-08-09 | 2021-04-27 | Eli Lilly And Company | Combination therapy |
| AR110470A1 (es) | 2016-10-21 | 2019-04-03 | Lilly Co Eli | Terapia de combinación para tratar la enfermedad de alzheimer |
| TW201827467A (zh) * | 2016-11-03 | 2018-08-01 | 比利時商健生藥品公司 | 焦穀胺酸類澱粉蛋白－β之抗體及其用途 |
| JOP20190247A1 (ar) | 2017-04-20 | 2019-10-20 | Lilly Co Eli | أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها |
| WO2018204546A2 (en) * | 2017-05-02 | 2018-11-08 | Prothena Biosciences Limited | Antibodies recognizing tau |
| IL272773B2 (en) | 2017-08-22 | 2024-06-01 | Biogen Ma Inc | Pharmaceutical preparations containing anti-amyloid cell antibodies |
| AU2019346645A1 (en) * | 2018-09-27 | 2021-04-29 | Marengo Therapeutics, Inc. | CSF1R/CCR2 multispecific antibodies |
-
2020
- 2020-03-25 SG SG11202110504XA patent/SG11202110504XA/en unknown
- 2020-03-25 WO PCT/EP2020/058395 patent/WO2020193644A1/en active Application Filing
- 2020-03-25 JO JOP/2021/0265A patent/JOP20210265A1/ar unknown
- 2020-03-25 CR CR20210492A patent/CR20210492A/es unknown
- 2020-03-25 PE PE2021001598A patent/PE20212266A1/es unknown
- 2020-03-25 US US16/829,029 patent/US11236155B2/en active Active
- 2020-03-25 EA EA202192606A patent/EA202192606A1/ru unknown
- 2020-03-25 EP EP20714579.8A patent/EP3946603A1/en active Pending
- 2020-03-25 AU AU2020245031A patent/AU2020245031A1/en active Pending
- 2020-03-25 BR BR112021019107A patent/BR112021019107A2/pt unknown
- 2020-03-25 MX MX2021011715A patent/MX2021011715A/es unknown
- 2020-03-25 KR KR1020217034312A patent/KR20210143858A/ko active Search and Examination
- 2020-03-25 JP JP2021557190A patent/JP2022526528A/ja active Pending
- 2020-03-25 US US17/598,280 patent/US20220177560A1/en active Pending
- 2020-03-25 MA MA055491A patent/MA55491A/fr unknown
- 2020-03-25 CA CA3134785A patent/CA3134785A1/en active Pending
- 2020-03-25 CN CN202080039618.2A patent/CN113891746A/zh active Pending
-
2021
- 2021-09-23 CL CL2021002473A patent/CL2021002473A1/es unknown
- 2021-09-23 IL IL286634A patent/IL286634A/en unknown
- 2021-09-23 DO DO2021000199A patent/DOP2021000199A/es unknown
- 2021-10-20 CO CONC2021/0014028A patent/CO2021014028A2/es unknown
- 2021-10-26 EC ECSENADI202179184A patent/ECSP21079184A/es unknown
- 2021-12-17 US US17/554,461 patent/US20220106387A1/en active Pending
-
2022
- 2022-09-29 CL CL2022002670A patent/CL2022002670A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020245031A1 (en) | 2021-10-21 |
| CL2022002670A1 (es) | 2023-03-31 |
| CR20210492A (es) | 2021-11-19 |
| EA202192606A1 (ru) | 2022-01-24 |
| ECSP21079184A (es) | 2021-11-30 |
| US11236155B2 (en) | 2022-02-01 |
| WO2020193644A1 (en) | 2020-10-01 |
| MX2021011715A (es) | 2021-12-10 |
| US20220106387A1 (en) | 2022-04-07 |
| JOP20210265A1 (ar) | 2023-01-30 |
| CA3134785A1 (en) | 2020-10-01 |
| CN113891746A (zh) | 2022-01-04 |
| DOP2021000199A (es) | 2022-07-15 |
| CL2021002473A1 (es) | 2022-04-22 |
| US20220177560A1 (en) | 2022-06-09 |
| JP2022526528A (ja) | 2022-05-25 |
| SG11202110504XA (en) | 2021-10-28 |
| US20200308261A1 (en) | 2020-10-01 |
| BR112021019107A2 (pt) | 2021-11-30 |
| EP3946603A1 (en) | 2022-02-09 |
| IL286634A (en) | 2021-10-31 |
| KR20210143858A (ko) | 2021-11-29 |
| PE20212266A1 (es) | 2021-11-30 |
| MA55491A (fr) | 2022-02-09 |
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