CL2022002670A1 - Anticuerpos contra amiloide-bcon piroglutamato y usos de estos (divisional solicitud 202102473). - Google Patents

Anticuerpos contra amiloide-bcon piroglutamato y usos de estos (divisional solicitud 202102473).

Info

Publication number
CL2022002670A1
CL2022002670A1 CL2022002670A CL2022002670A CL2022002670A1 CL 2022002670 A1 CL2022002670 A1 CL 2022002670A1 CL 2022002670 A CL2022002670 A CL 2022002670A CL 2022002670 A CL2022002670 A CL 2022002670A CL 2022002670 A1 CL2022002670 A1 CL 2022002670A1
Authority
CL
Chile
Prior art keywords
pyroglutamate
antibodies against
divisional application
against amyloid
antigen
Prior art date
Application number
CL2022002670A
Other languages
English (en)
Inventor
VAN BROECK Bianca
Mercken Marc
Edwards Wilson
Singh Sanjaya
Luo Jinquan
LA PORTE Sherry
Ganesan Rajkumar
Huang Chichi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2022002670A1 publication Critical patent/CL2022002670A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención proporciona anticuerpos o fragmentos de unión al antígeno de estos que se unen a AB 3pE y métodos para elaborar y usar los anticuerpos o fragmentos de unión al antígeno de estos, que incluyen el uso para formulaciones, administración y kits. El anticuerpo y fragmentos de unión al antígeno de este y los métodos descritos son útiles para el diagnóstico, pronóstico y tratamiento de la enfermedad de Alzheimer u otras enfermedades relacionadas con el amiloide B.
CL2022002670A 2019-03-26 2022-09-29 Anticuerpos contra amiloide-bcon piroglutamato y usos de estos (divisional solicitud 202102473). CL2022002670A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962823785P 2019-03-26 2019-03-26

Publications (1)

Publication Number Publication Date
CL2022002670A1 true CL2022002670A1 (es) 2023-03-31

Family

ID=70008544

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2021002473A CL2021002473A1 (es) 2019-03-26 2021-09-23 Anticuerpos para el piroglutamato amiloide-8 y sus usos.
CL2022002670A CL2022002670A1 (es) 2019-03-26 2022-09-29 Anticuerpos contra amiloide-bcon piroglutamato y usos de estos (divisional solicitud 202102473).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2021002473A CL2021002473A1 (es) 2019-03-26 2021-09-23 Anticuerpos para el piroglutamato amiloide-8 y sus usos.

Country Status (21)

Country Link
US (3) US20220177560A1 (es)
EP (1) EP3946603A1 (es)
JP (1) JP2022526528A (es)
KR (1) KR20210143858A (es)
CN (1) CN113891746A (es)
AU (1) AU2020245031A1 (es)
BR (1) BR112021019107A2 (es)
CA (1) CA3134785A1 (es)
CL (2) CL2021002473A1 (es)
CO (1) CO2021014028A2 (es)
CR (1) CR20210492A (es)
DO (1) DOP2021000199A (es)
EA (1) EA202192606A1 (es)
EC (1) ECSP21079184A (es)
IL (1) IL286634A (es)
JO (1) JOP20210265A1 (es)
MA (1) MA55491A (es)
MX (1) MX2021011715A (es)
PE (1) PE20212266A1 (es)
SG (1) SG11202110504XA (es)
WO (1) WO2020193644A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023000949A (es) 2020-07-23 2023-02-22 Othair Prothena Ltd Anticuerpos anti-beta-amiloide (abeta).
KR102655944B1 (ko) * 2021-10-28 2024-04-12 애브비 인코포레이티드 항-아밀로이드 베타 항체 및 이의 사용 방법
TW202400636A (zh) 2022-03-11 2024-01-01 比利時商健生藥品公司 多特異性抗體及其用途(一)
TW202346355A (zh) 2022-03-11 2023-12-01 比利時商健生藥品公司 多特異性抗體及其用途(二)
WO2023170295A1 (en) 2022-03-11 2023-09-14 Janssen Pharmaceutica Nv Multispecific antibodies and uses thereof
WO2024133925A1 (en) 2022-12-22 2024-06-27 Bioarctic Ab Antibody which binds to abetape3

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Also Published As

Publication number Publication date
MA55491A (fr) 2022-02-09
BR112021019107A2 (pt) 2021-11-30
AU2020245031A1 (en) 2021-10-21
US20200308261A1 (en) 2020-10-01
PE20212266A1 (es) 2021-11-30
EP3946603A1 (en) 2022-02-09
CA3134785A1 (en) 2020-10-01
CL2021002473A1 (es) 2022-04-22
SG11202110504XA (en) 2021-10-28
EA202192606A1 (ru) 2022-01-24
CR20210492A (es) 2021-11-19
IL286634A (en) 2021-10-31
MX2021011715A (es) 2021-12-10
JOP20210265A1 (ar) 2023-01-30
DOP2021000199A (es) 2022-07-15
US20220106387A1 (en) 2022-04-07
CN113891746A (zh) 2022-01-04
JP2022526528A (ja) 2022-05-25
ECSP21079184A (es) 2021-11-30
US20220177560A1 (en) 2022-06-09
KR20210143858A (ko) 2021-11-29
US11236155B2 (en) 2022-02-01
WO2020193644A1 (en) 2020-10-01
CO2021014028A2 (es) 2021-10-29

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