CO2022002001A2 - Usos terapéuticos de anticuerpos anti-variable delta 1 de tcr - Google Patents
Usos terapéuticos de anticuerpos anti-variable delta 1 de tcrInfo
- Publication number
- CO2022002001A2 CO2022002001A2 CONC2022/0002001A CO2022002001A CO2022002001A2 CO 2022002001 A2 CO2022002001 A2 CO 2022002001A2 CO 2022002001 A CO2022002001 A CO 2022002001A CO 2022002001 A2 CO2022002001 A2 CO 2022002001A2
- Authority
- CO
- Colombia
- Prior art keywords
- therapeutic uses
- tcr delta
- antibodies
- variable antibodies
- variable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención se refiere a anticuerpos anti-Vδ1 o fragmentos de estos para su uso en métodos para tratar un cáncer, una enfermedad infecciosa o una enfermedad inflamatoria en un sujeto que lo necesite.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1911799.3A GB201911799D0 (en) | 2019-08-16 | 2019-08-16 | Novel Antibodies |
GBGB2010760.3A GB202010760D0 (en) | 2020-07-13 | 2020-07-13 | Novel antibodies |
PCT/GB2020/051959 WO2021032963A1 (en) | 2019-08-16 | 2020-08-14 | Therapeutic uses of anti-tcr delta variable 1 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022002001A2 true CO2022002001A2 (es) | 2022-04-08 |
Family
ID=72148174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0002001A CO2022002001A2 (es) | 2019-08-16 | 2022-02-24 | Usos terapéuticos de anticuerpos anti-variable delta 1 de tcr |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220403025A1 (es) |
EP (2) | EP4013505A1 (es) |
JP (2) | JP2022544683A (es) |
KR (2) | KR20220084020A (es) |
CN (2) | CN114222585A (es) |
AU (2) | AU2020332878A1 (es) |
BR (1) | BR112022002837A2 (es) |
CA (2) | CA3145517A1 (es) |
CL (1) | CL2022000368A1 (es) |
CO (1) | CO2022002001A2 (es) |
IL (1) | IL290537A (es) |
MX (1) | MX2022002075A (es) |
WO (2) | WO2021032963A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10519236B2 (en) | 2018-01-23 | 2019-12-31 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
CA3113605A1 (en) | 2018-09-19 | 2020-03-26 | Lava Therapeutics B.V. | Novel bispecific antibodies for use in the treatment of hematological malignancies |
EP4434541A2 (en) * | 2019-01-23 | 2024-09-25 | New York University | Antibodies specific to delta 1 chain of t cell receptor |
GB202002581D0 (en) * | 2020-02-24 | 2020-04-08 | Gammadelta Therapeutics Ltd | Novel antibodies |
WO2022034562A1 (en) * | 2020-08-14 | 2022-02-17 | GammaDelta Therapeutics Limited | Multispecific anti-tcr delta variable 1 antibodies |
CA3207265A1 (en) | 2021-02-17 | 2022-08-25 | Mihriban Tuna | Anti-tcr delta variable 1 antibodies |
EP4147716A1 (en) * | 2021-09-10 | 2023-03-15 | Samatva Research Corporation | Anti-virus moiety immobilised in a matrix |
CA3208653A1 (en) | 2022-02-17 | 2022-08-25 | Mihriban Tuna | Multispecific anti-tcr delta variable 1 antibodies |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2546268A1 (en) | 2011-07-13 | 2013-01-16 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Internalising immunoglobulin |
CN102295702B (zh) * | 2011-08-26 | 2014-01-29 | 中国科学院微生物研究所 | 一种针对t细胞受体可变区特异性单抗的制备方法 |
GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
EP3307875B1 (en) | 2015-06-09 | 2021-12-15 | Lymphact - Lymphocyte Activation Technologies, S.A. | Methods for the production of tcr gamma delta+ t cells |
CA3003077A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Research Technology Limited | Expansion of non-haematopoietic tissue-resident .gamma.delta. t cells and uses of these cells |
IL301527A (en) | 2016-05-12 | 2023-05-01 | Adicet Bio Inc | Methods for selective expansion of gamma delta T-cell populations and preparations thereof |
GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
US10546518B2 (en) | 2017-05-15 | 2020-01-28 | Google Llc | Near-eye display with extended effective eyebox via eye tracking |
US10519236B2 (en) * | 2018-01-23 | 2019-12-31 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
-
2020
- 2020-08-14 MX MX2022002075A patent/MX2022002075A/es unknown
- 2020-08-14 US US17/633,439 patent/US20220403025A1/en active Pending
- 2020-08-14 CN CN202080057206.1A patent/CN114222585A/zh active Pending
- 2020-08-14 EP EP20758308.9A patent/EP4013505A1/en active Pending
- 2020-08-14 JP JP2022509648A patent/JP2022544683A/ja active Pending
- 2020-08-14 WO PCT/GB2020/051959 patent/WO2021032963A1/en active Application Filing
- 2020-08-14 CN CN202080065477.1A patent/CN114514245A/zh active Pending
- 2020-08-14 CA CA3145517A patent/CA3145517A1/en active Pending
- 2020-08-14 JP JP2022509647A patent/JP2022545196A/ja active Pending
- 2020-08-14 EP EP20758305.5A patent/EP4013504A1/en active Pending
- 2020-08-14 KR KR1020227008860A patent/KR20220084020A/ko unknown
- 2020-08-14 WO PCT/GB2020/051955 patent/WO2021032960A1/en unknown
- 2020-08-14 AU AU2020332878A patent/AU2020332878A1/en active Pending
- 2020-08-14 BR BR112022002837A patent/BR112022002837A2/pt unknown
- 2020-08-14 CA CA3145523A patent/CA3145523A1/en active Pending
- 2020-08-14 KR KR1020227008859A patent/KR20220084019A/ko unknown
- 2020-08-14 AU AU2020333406A patent/AU2020333406A1/en active Pending
-
2022
- 2022-02-10 IL IL290537A patent/IL290537A/en unknown
- 2022-02-15 CL CL2022000368A patent/CL2022000368A1/es unknown
- 2022-02-24 CO CONC2022/0002001A patent/CO2022002001A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021032960A1 (en) | 2021-02-25 |
EP4013505A1 (en) | 2022-06-22 |
KR20220084020A (ko) | 2022-06-21 |
CA3145517A1 (en) | 2021-02-25 |
IL290537A (en) | 2022-04-01 |
MX2022002075A (es) | 2022-03-17 |
CN114514245A (zh) | 2022-05-17 |
KR20220084019A (ko) | 2022-06-21 |
EP4013504A1 (en) | 2022-06-22 |
JP2022545196A (ja) | 2022-10-26 |
JP2022544683A (ja) | 2022-10-20 |
CA3145523A1 (en) | 2021-02-25 |
CL2022000368A1 (es) | 2022-09-30 |
CN114222585A (zh) | 2022-03-22 |
WO2021032963A1 (en) | 2021-02-25 |
AU2020332878A1 (en) | 2022-01-27 |
BR112022002837A2 (pt) | 2022-05-10 |
US20220403025A1 (en) | 2022-12-22 |
AU2020333406A1 (en) | 2022-01-27 |
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