CO2021003446A2 - Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso - Google Patents

Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

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Publication number
CO2021003446A2
CO2021003446A2 CONC2021/0003446A CO2021003446A CO2021003446A2 CO 2021003446 A2 CO2021003446 A2 CO 2021003446A2 CO 2021003446 A CO2021003446 A CO 2021003446A CO 2021003446 A2 CO2021003446 A2 CO 2021003446A2
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Colombia
Prior art keywords
hsd17b13
rnai agents
agents
methods
expression
Prior art date
Application number
CONC2021/0003446A
Other languages
English (en)
Spanish (es)
Inventor
Zhen Li
Rui Zhu
Shawn A Morales
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of CO2021003446A2 publication Critical patent/CO2021003446A2/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CONC2021/0003446A 2018-09-19 2021-03-17 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso CO2021003446A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862733320P 2018-09-19 2018-09-19
US201862773707P 2018-11-30 2018-11-30
US201962890220P 2019-08-22 2019-08-22
PCT/US2019/051707 WO2020061177A1 (en) 2018-09-19 2019-09-18 Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use

Publications (1)

Publication Number Publication Date
CO2021003446A2 true CO2021003446A2 (es) 2021-04-08

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CONC2021/0003446A CO2021003446A2 (es) 2018-09-19 2021-03-17 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

Country Status (21)

Country Link
US (1) US12534728B2 (https=)
EP (1) EP3852769A4 (https=)
JP (3) JP7488254B2 (https=)
KR (1) KR102769565B1 (https=)
CN (1) CN113164509B (https=)
AU (1) AU2019342117A1 (https=)
BR (1) BR112021005137A2 (https=)
CA (1) CA3109553A1 (https=)
CL (1) CL2021000669A1 (https=)
CO (1) CO2021003446A2 (https=)
CR (1) CR20210186A (https=)
EC (1) ECSP21027262A (https=)
IL (1) IL281597A (https=)
MX (1) MX2021003077A (https=)
MY (1) MY209138A (https=)
PE (1) PE20211212A1 (https=)
PH (1) PH12021550423A1 (https=)
SG (1) SG11202101698WA (https=)
TW (2) TW202540423A (https=)
UY (1) UY38382A (https=)
WO (1) WO2020061177A1 (https=)

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TW202400791A (zh) * 2022-05-06 2024-01-01 大陸商蘇州瑞博生物技術股份有限公司 一種核酸、含有該核酸的組合物與綴合物及製備方法和用途
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