UY38382A - Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso - Google Patents

Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

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Publication number
UY38382A
UY38382A UY0001038382A UY38382A UY38382A UY 38382 A UY38382 A UY 38382A UY 0001038382 A UY0001038382 A UY 0001038382A UY 38382 A UY38382 A UY 38382A UY 38382 A UY38382 A UY 38382A
Authority
UY
Uruguay
Prior art keywords
agents
arni
hsd17b13
methods
17beta
Prior art date
Application number
UY0001038382A
Other languages
English (en)
Inventor
Zhen Li
Rui Zhu
A Morales Shawn
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of UY38382A publication Critical patent/UY38382A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

la presente divulgación se refiere a agentes de arni, por ejemplo, agentes de arni de doble hebra, capaces de inhibir la expresión génica de 17ß-hidroxiesteroide deshidrogenasa tipo 13 (hsd17b13 o 17ß-hsd13). asimismo, se dan a conocer composiciones farmacéuticas que comprenden agentes de arni contra hsd17b13 y métodos para la utilización de las mismas. los agentes de arni contra hsd17b13 conforme a lo divulgado en la presente memoria pueden estar conjugados a ligandos dirigidos a la diana para facilitar el transporte hacia las células, incluidos los hepatocitos.
UY0001038382A 2018-09-19 2019-09-19 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso UY38382A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862733320P 2018-09-19 2018-09-19
US201862773707P 2018-11-30 2018-11-30
US201962890220P 2019-08-22 2019-08-22

Publications (1)

Publication Number Publication Date
UY38382A true UY38382A (es) 2020-03-31

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ID=69887755

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UY0001038382A UY38382A (es) 2018-09-19 2019-09-19 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

Country Status (20)

Country Link
US (1) US20220056454A1 (es)
EP (1) EP3852769A4 (es)
JP (2) JP7488254B2 (es)
KR (1) KR20210061380A (es)
CN (1) CN113164509A (es)
AU (1) AU2019342117A1 (es)
BR (1) BR112021005137A2 (es)
CA (1) CA3109553A1 (es)
CL (1) CL2021000669A1 (es)
CO (1) CO2021003446A2 (es)
CR (1) CR20210186A (es)
EC (1) ECSP21027262A (es)
IL (1) IL281597A (es)
MX (1) MX2021003077A (es)
PE (1) PE20211212A1 (es)
PH (1) PH12021550423A1 (es)
SG (1) SG11202101698WA (es)
TW (1) TW202024324A (es)
UY (1) UY38382A (es)
WO (1) WO2020061177A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201912835QA (en) * 2016-09-02 2020-02-27 Arrowhead Pharmaceuticals Inc Targeting ligands
AU2019239971A1 (en) * 2018-03-21 2020-09-03 Regeneron Pharmaceuticals, Inc. 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof
JOP20210158A1 (ar) * 2018-12-21 2023-01-30 Ionis Pharmaceuticals Inc مُعَدِّلات التعبير الجيني عن hsd17b13
WO2021247885A2 (en) * 2020-06-01 2021-12-09 Amgen Inc. Rnai constructs for inhibiting hsd17b13 expression and methods of use thereof
WO2022098748A1 (en) * 2020-11-06 2022-05-12 Inipharm, Inc. Uses for hsd17b13 inhibitors
US12018259B2 (en) 2020-12-23 2024-06-25 Regeneron Pharmaceuticals, Inc. Treatment of liver diseases with cell death inducing DFFA like effector B (CIDEB) inhibitors
JP2024515194A (ja) * 2021-04-22 2024-04-05 上海拓界生物医薬科技有限公司 １７β－ヒドロキシステロイドデヒドロゲナーゼの１３型を標的とするｓｉＲＮＡ及びｓｉＲＮＡ複合体
AU2022343115A1 (en) * 2021-09-08 2024-03-14 Aligos Therapeutics, Inc. Modified short interfering nucleic acid (sina) molecules and uses thereof
TW202333751A (zh) * 2021-12-16 2023-09-01 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其製備方法及應用
US20230193392A1 (en) 2021-12-20 2023-06-22 Regeneron Pharmaceuticals, Inc. Methods Of Identifying And Evaluating Liver Inflammation And Liver Fibrosis In A Subject By Determining A Stratified Score Based On Gene Expression
WO2023138663A1 (zh) * 2022-01-20 2023-07-27 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
WO2023196941A1 (en) 2022-04-08 2023-10-12 Arrowhead Pharmaceuticals, Inc. Treatment of a non-alcoholic fatty liver disease
WO2023212019A1 (en) * 2022-04-28 2023-11-02 Enanta Pharmaceuticals, Inc. Pyrimidinone-containing 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors
WO2023208109A1 (zh) * 2022-04-29 2023-11-02 北京福元医药股份有限公司 用于抑制HSD17B13表达的siRNA、其缀合物和药物组合物及其用途
WO2023213284A1 (zh) * 2022-05-06 2023-11-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2024131916A1 (en) * 2022-12-22 2024-06-27 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of 17beta-hydroxysteroid dehydrogenase type 13 (hsd17b13)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1067697A (en) * 1995-12-05 1997-06-27 Jouko Antero Oikarinen Hsd17b1 promoter, enhancer, silencer and use thereof
KR20070085113A (ko) * 2004-05-11 2007-08-27 가부시키가이샤 알파젠 Rna간섭을 생기게 하는 폴리뉴클레오티드, 및 이를 이용한유전자발현억제 방법
CN103520724B (zh) * 2013-10-23 2016-05-25 江苏美迪森生物医药有限公司 Hsd17b13蛋白或其编码基因的抑制剂的新用途
CA2968114A1 (en) * 2014-11-17 2016-05-26 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
JOP20210043A1 (ar) * 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
UY37146A (es) 2016-03-07 2017-09-29 Arrowhead Pharmaceuticals Inc Ligandos de direccionamiento para compuestos terapéuticos
IL267959B2 (en) * 2017-01-10 2024-07-01 Arrowhead Pharmaceuticals Inc Alpha-1 antitrypsin (AAT) RNAi agents, preparations containing AAT RNAi agents and their uses
WO2018136702A1 (en) * 2017-01-23 2018-07-26 Regeneron Pharmaceuticals, Inc. Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
AU2019239971A1 (en) * 2018-03-21 2020-09-03 Regeneron Pharmaceuticals, Inc. 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof

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WO2020061177A1 (en) 2020-03-26
PE20211212A1 (es) 2021-07-05
JP2024112838A (ja) 2024-08-21
PH12021550423A1 (en) 2021-09-20
US20220056454A1 (en) 2022-02-24
BR112021005137A2 (pt) 2021-06-15
JP2022501040A (ja) 2022-01-06
EP3852769A4 (en) 2023-12-13
CR20210186A (es) 2021-06-14
CN113164509A (zh) 2021-07-23
CL2021000669A1 (es) 2021-10-29
AU2019342117A2 (en) 2021-03-11
CO2021003446A2 (es) 2021-04-08
MX2021003077A (es) 2021-05-27
IL281597A (en) 2021-05-31
AU2019342117A1 (en) 2021-03-04
TW202024324A (zh) 2020-07-01
KR20210061380A (ko) 2021-05-27
SG11202101698WA (en) 2021-04-29
JP7488254B2 (ja) 2024-05-21
EP3852769A1 (en) 2021-07-28
CA3109553A1 (en) 2020-03-26
ECSP21027262A (es) 2021-05-31

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