UY38382A - Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso - Google Patents

Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

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Publication number
UY38382A
UY38382A UY0001038382A UY38382A UY38382A UY 38382 A UY38382 A UY 38382A UY 0001038382 A UY0001038382 A UY 0001038382A UY 38382 A UY38382 A UY 38382A UY 38382 A UY38382 A UY 38382A
Authority
UY
Uruguay
Prior art keywords
agents
arni
hsd17b13
methods
17beta
Prior art date
Application number
UY0001038382A
Other languages
English (en)
Inventor
Zhen Li
Rui Zhu
A Morales Shawn
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of UY38382A publication Critical patent/UY38382A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2320/00—Applications; Uses
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

la presente divulgación se refiere a agentes de arni, por ejemplo, agentes de arni de doble hebra, capaces de inhibir la expresión génica de 17ß-hidroxiesteroide deshidrogenasa tipo 13 (hsd17b13 o 17ß-hsd13). asimismo, se dan a conocer composiciones farmacéuticas que comprenden agentes de arni contra hsd17b13 y métodos para la utilización de las mismas. los agentes de arni contra hsd17b13 conforme a lo divulgado en la presente memoria pueden estar conjugados a ligandos dirigidos a la diana para facilitar el transporte hacia las células, incluidos los hepatocitos.
UY0001038382A 2018-09-19 2019-09-19 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso UY38382A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862733320P 2018-09-19 2018-09-19
US201862773707P 2018-11-30 2018-11-30
US201962890220P 2019-08-22 2019-08-22

Publications (1)

Publication Number Publication Date
UY38382A true UY38382A (es) 2020-03-31

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ID=69887755

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UY0001038382A UY38382A (es) 2018-09-19 2019-09-19 Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso

Country Status (20)

Country Link
US (1) US20220056454A1 (es)
EP (1) EP3852769A4 (es)
JP (1) JP7488254B2 (es)
KR (1) KR20210061380A (es)
CN (1) CN113164509A (es)
AU (1) AU2019342117A1 (es)
BR (1) BR112021005137A2 (es)
CA (1) CA3109553A1 (es)
CL (1) CL2021000669A1 (es)
CO (1) CO2021003446A2 (es)
CR (1) CR20210186A (es)
EC (1) ECSP21027262A (es)
IL (1) IL281597A (es)
MX (1) MX2021003077A (es)
PE (1) PE20211212A1 (es)
PH (1) PH12021550423A1 (es)
SG (1) SG11202101698WA (es)
TW (1) TW202024324A (es)
UY (1) UY38382A (es)
WO (1) WO2020061177A1 (es)

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EP3506913A4 (en) * 2016-09-02 2020-06-10 Arrowhead Pharmaceuticals, Inc. TARGETING LIGANDS
MX2020009812A (es) * 2018-03-21 2021-01-08 Regeneron Pharma COMPOSICIONES DE ARNI DE 17ß-HIDROXIESTEROIDE DESHIDROGENASA TIPO 13 (HSD17B13) Y MÉTODOS DE USO DE LAS MISMAS.
PE20211755A1 (es) 2018-12-21 2021-09-07 Ionis Pharmaceuticals Inc Moduladores de la expresion de hsd17b13
MX2022015169A (es) * 2020-06-01 2023-07-03 Amgen Inc Constructos de arni para inhibir la expresion de hsd17b13 y metodos de uso de los mismos.
WO2022098748A1 (en) * 2020-11-06 2022-05-12 Inipharm, Inc. Uses for hsd17b13 inhibitors
IL303536A (en) 2020-12-23 2023-08-01 Regeneron Pharma Treatment of liver diseases with DFFA-like activator inhibitors causing B-cell death
WO2022223015A1 (zh) * 2021-04-22 2022-10-27 上海拓界生物医药科技有限公司 靶向第13型17β-羟基类固醇脱氢酶的siRNA和siRNA缀合物
KR20240053635A (ko) * 2021-09-08 2024-04-24 알리고스 테라퓨틱스 인코포레이티드 변형된 짧은 간섭 핵산 (sina) 분자 및 그의 용도
WO2023109945A1 (zh) * 2021-12-16 2023-06-22 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
US20230193392A1 (en) 2021-12-20 2023-06-22 Regeneron Pharmaceuticals, Inc. Methods Of Identifying And Evaluating Liver Inflammation And Liver Fibrosis In A Subject By Determining A Stratified Score Based On Gene Expression
TW202339773A (zh) * 2022-01-20 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓＲＮＡ、其應用及製備方法
WO2023196941A1 (en) 2022-04-08 2023-10-12 Arrowhead Pharmaceuticals, Inc. Treatment of a non-alcoholic fatty liver disease
WO2023212019A1 (en) * 2022-04-28 2023-11-02 Enanta Pharmaceuticals, Inc. Pyrimidinone-containing 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors
CN116515835A (zh) * 2022-04-29 2023-08-01 北京福元医药股份有限公司 用于抑制HSD17B13表达的siRNA、其缀合物和药物组合物及其用途
WO2023213284A1 (zh) * 2022-05-06 2023-11-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2024131916A1 (en) * 2022-12-22 2024-06-27 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of 17beta-hydroxysteroid dehydrogenase type 13 (hsd17b13)

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CN103520724B (zh) * 2013-10-23 2016-05-25 江苏美迪森生物医药有限公司 Hsd17b13蛋白或其编码基因的抑制剂的新用途
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JOP20210043A1 (ar) * 2015-10-01 2017-06-16 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
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TWI826365B (zh) * 2017-01-10 2023-12-21 美商愛羅海德製藥公司 α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法
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MX2020009812A (es) * 2018-03-21 2021-01-08 Regeneron Pharma COMPOSICIONES DE ARNI DE 17ß-HIDROXIESTEROIDE DESHIDROGENASA TIPO 13 (HSD17B13) Y MÉTODOS DE USO DE LAS MISMAS.

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PH12021550423A1 (en) 2021-09-20
CR20210186A (es) 2021-06-14
IL281597A (en) 2021-05-31
CL2021000669A1 (es) 2021-10-29
EP3852769A1 (en) 2021-07-28
ECSP21027262A (es) 2021-05-31
MX2021003077A (es) 2021-05-27
JP2022501040A (ja) 2022-01-06
CN113164509A (zh) 2021-07-23
WO2020061177A1 (en) 2020-03-26
AU2019342117A2 (en) 2021-03-11
PE20211212A1 (es) 2021-07-05
EP3852769A4 (en) 2023-12-13
TW202024324A (zh) 2020-07-01
KR20210061380A (ko) 2021-05-27
BR112021005137A2 (pt) 2021-06-15
SG11202101698WA (en) 2021-04-29
AU2019342117A1 (en) 2021-03-04
CO2021003446A2 (es) 2021-04-08
CA3109553A1 (en) 2020-03-26
JP7488254B2 (ja) 2024-05-21
US20220056454A1 (en) 2022-02-24

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