EA202190800A1 - РНКи АГЕНТЫ ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ 17БЕТА-HSD ТИПА 13 (HSD17B13), ИХ КОМПОЗИЦИИ И СПОСОБЫ ПРИМЕНЕНИЯ - Google Patents
РНКи АГЕНТЫ ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ 17БЕТА-HSD ТИПА 13 (HSD17B13), ИХ КОМПОЗИЦИИ И СПОСОБЫ ПРИМЕНЕНИЯInfo
- Publication number
- EA202190800A1 EA202190800A1 EA202190800A EA202190800A EA202190800A1 EA 202190800 A1 EA202190800 A1 EA 202190800A1 EA 202190800 A EA202190800 A EA 202190800A EA 202190800 A EA202190800 A EA 202190800A EA 202190800 A1 EA202190800 A1 EA 202190800A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hsd17b13
- rnai agents
- methods
- alcoholic
- 17beta
- Prior art date
Links
- 102100037429 17-beta-hydroxysteroid dehydrogenase 13 Human genes 0.000 title abstract 6
- 101000806241 Homo sapiens 17-beta-hydroxysteroid dehydrogenase 13 Proteins 0.000 title abstract 6
- 230000014509 gene expression Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 108091030071 RNAI Proteins 0.000 abstract 6
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 230000009368 gene silencing by RNA Effects 0.000 abstract 6
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 4
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 2
- 101150025032 13 gene Proteins 0.000 abstract 1
- 108010060191 3(17)-hydroxysteroid dehydrogenase Proteins 0.000 abstract 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 101150000579 Hsd17b13 gene Proteins 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B2/00—Friction-grip releasable fastenings
- F16B2/02—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening
- F16B2/06—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action
- F16B2/08—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action using bands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B63—SHIPS OR OTHER WATERBORNE VESSELS; RELATED EQUIPMENT
- B63B—SHIPS OR OTHER WATERBORNE VESSELS; EQUIPMENT FOR SHIPPING
- B63B25/00—Load-accommodating arrangements, e.g. stowing, trimming; Vessels characterised thereby
- B63B25/002—Load-accommodating arrangements, e.g. stowing, trimming; Vessels characterised thereby for goods other than bulk goods
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B7/00—Connections of rods or tubes, e.g. of non-circular section, mutually, including resilient connections
- F16B7/04—Clamping or clipping connections
- F16B7/044—Clamping or clipping connections for rods or tubes being in angled relationship
- F16B7/048—Clamping or clipping connections for rods or tubes being in angled relationship for rods or for tubes without using the innerside thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B63—SHIPS OR OTHER WATERBORNE VESSELS; RELATED EQUIPMENT
- B63B—SHIPS OR OTHER WATERBORNE VESSELS; EQUIPMENT FOR SHIPPING
- B63B17/00—Vessels parts, details, or accessories, not otherwise provided for
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Ocean & Marine Engineering (AREA)
- Adornments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее описание относится к РНКи агентам, например двухцепочечным РНКи агентам, способным ингибировать экспрессию гена 17-гидроксистероидной дегидрогеназы типа 13 (HSD17B13 или 17-HSD13). Также описаны фармацевтические композиции, которые включают HSD17B13 РНКи агенты, и способы их применения. HSD17B13 РНКи агенты, описанные в настоящем документе, могут быть конъюгированы с направляющими лигандами, чтобы облегчить доставку в клетки, включая гепатоциты. Доставка HSD17B13 РНКи агентов in vivo предназначена для ингибирования экспрессии HSD17B13 гена. РНКи агенты могут использоваться в способах лечения HSD17B13-родственных заболеваний или расстройств, включая неалкогольную жировую болезнь печени (НАЖБП), неалкогольный стеатогепатит (НАСГ), фиброз печени и алкогольную или неалкогольную болезнь печени, включая цирроз.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962890220P | 2019-08-22 | 2019-08-22 | |
PCT/US2019/051707 WO2020061177A1 (en) | 2018-09-19 | 2019-09-18 | Rnai agents for inhibiting expression of 17beta-hsd type 13- (hsd17b13), compositions thereof, and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202190800A1 true EA202190800A1 (ru) | 2021-08-19 |
Family
ID=74645483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202190800A EA202190800A1 (ru) | 2019-08-22 | 2019-09-18 | РНКи АГЕНТЫ ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ 17БЕТА-HSD ТИПА 13 (HSD17B13), ИХ КОМПОЗИЦИИ И СПОСОБЫ ПРИМЕНЕНИЯ |
Country Status (2)
Country | Link |
---|---|
US (1) | US11745831B2 (ru) |
EA (1) | EA202190800A1 (ru) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7077302B2 (en) * | 2001-12-10 | 2006-07-18 | Louis Chuang | Apparatus for selectively attaching a first object to a second object in a desired orientation |
US8387939B2 (en) * | 2006-04-20 | 2013-03-05 | The Flewelling Ford Family Trust | Mounting support with light |
US8132700B2 (en) * | 2007-08-02 | 2012-03-13 | Trek Bicycle Corporation | Bicycle accessory mounting system |
US7594631B1 (en) * | 2008-08-27 | 2009-09-29 | Carnevali Jeffrey D | Quick connect rail mount |
US8840078B2 (en) * | 2013-01-29 | 2014-09-23 | Chris DeWald | Portable beverage holder |
JP6498666B2 (ja) * | 2013-06-13 | 2019-04-10 | ナイト・アイズ,インコーポレーテッド | 円筒形表面への取付けのための調節可能取付け具 |
-
2019
- 2019-09-18 EA EA202190800A patent/EA202190800A1/ru unknown
-
2020
- 2020-08-27 US US16/948,007 patent/US11745831B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20210053656A1 (en) | 2021-02-25 |
US11745831B2 (en) | 2023-09-05 |
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