MX2022011907A - Agentes de arni para inhibir la expresión de pnpla3, composiciones farmacéuticas de estos, y métodos de uso. - Google Patents

Agentes de arni para inhibir la expresión de pnpla3, composiciones farmacéuticas de estos, y métodos de uso.

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Publication number
MX2022011907A
MX2022011907A MX2022011907A MX2022011907A MX2022011907A MX 2022011907 A MX2022011907 A MX 2022011907A MX 2022011907 A MX2022011907 A MX 2022011907A MX 2022011907 A MX2022011907 A MX 2022011907A MX 2022011907 A MX2022011907 A MX 2022011907A
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MX
Mexico
Prior art keywords
pnpla3
rnai agents
methods
alcoholic
pharmaceutical compositions
Prior art date
Application number
MX2022011907A
Other languages
English (en)
Inventor
Tao Pei
Anthony Nicholas
Zhao Xu
Casi Schienebeck
Zhi- Ming Ding
Original Assignee
Arrowhead Pharmaceuticals Inc
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Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MX2022011907A publication Critical patent/MX2022011907A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente descripción se relaciona con agentes de ARNi, p. ej., agentes de ARNi bicatenarios, capaces de inhibir la expresión génica de la proteína 3 que contiene el dominio fosfolipasa tipo patatina (PNPLA3). También se describen composiciones farmacéuticas que incluyen agentes de ARNi del PNPLA3 y métodos de uso de estos. Los agentes de ARNi del PNPLA3 descritos en la presente descripción pueden conjugarse con ligandos de direccionamiento para facilitar el suministro a las células, incluidos los hepatocitos. El suministro de los agentes de ARNi del PNPLA3 in vivo proporciona la inhibición de la expresión génica de PNPLA3. Los agentes de ARNi pueden usarse en métodos de tratamiento de enfermedades y trastornos relacionados con PNPLA3, que incluyen hepatopatía grasa no alcohólica (NAFLD), esteatohepatitis no alcohólica (NASH), fibrosis hepática y enfermedades hepáticas no alcohólicas o alcohólicas, incluida la cirrosis.
MX2022011907A 2020-03-26 2021-03-26 Agentes de arni para inhibir la expresión de pnpla3, composiciones farmacéuticas de estos, y métodos de uso. MX2022011907A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063000137P 2020-03-26 2020-03-26
PCT/US2021/024299 WO2021195467A2 (en) 2020-03-26 2021-03-26 RNAi AGENTS FOR INHIBITING EXPRESSION OF PNPLA3, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE

Publications (1)

Publication Number Publication Date
MX2022011907A true MX2022011907A (es) 2023-01-05

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MX2022011907A MX2022011907A (es) 2020-03-26 2021-03-26 Agentes de arni para inhibir la expresión de pnpla3, composiciones farmacéuticas de estos, y métodos de uso.

Country Status (20)

Country Link
US (1) US20210301294A1 (es)
EP (1) EP4125932A2 (es)
JP (1) JP2023519246A (es)
KR (1) KR20220158011A (es)
CN (1) CN115397436A (es)
AR (1) AR121672A1 (es)
AU (1) AU2021242321A1 (es)
BR (1) BR112022019241A2 (es)
CA (1) CA3176418A1 (es)
CL (2) CL2022002580A1 (es)
CO (1) CO2022013746A2 (es)
CR (1) CR20220532A (es)
DO (1) DOP2022000204A (es)
EC (1) ECSP22075322A (es)
IL (1) IL296718A (es)
MX (1) MX2022011907A (es)
PE (1) PE20230345A1 (es)
TW (1) TW202202153A (es)
UY (1) UY39138A (es)
WO (1) WO2021195467A2 (es)

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KR20230115344A (ko) * 2016-09-02 2023-08-02 애로우헤드 파마슈티컬스 인코포레이티드 표적화 리간드
JP2020524485A (ja) 2017-06-02 2020-08-20 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物及びその使用方法
US11603532B2 (en) 2017-06-02 2023-03-14 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2023196941A1 (en) * 2022-04-08 2023-10-12 Arrowhead Pharmaceuticals, Inc. Treatment of a non-alcoholic fatty liver disease

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US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
NL9201440A (nl) 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
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JP2018510621A (ja) * 2015-02-13 2018-04-19 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． パタチン様ホスホリパーゼドメイン含有３（ＰＮＰＬＡ３）ｉＲＮＡ組成物およびその使用方法
KR20230048446A (ko) 2016-03-07 2023-04-11 애로우헤드 파마슈티컬스 인코포레이티드 치료용 화합물을 위한 표적화 리간드
US10036024B2 (en) * 2016-06-03 2018-07-31 Purdue Research Foundation siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
KR20230115344A (ko) * 2016-09-02 2023-08-02 애로우헤드 파마슈티컬스 인코포레이티드 표적화 리간드
CN117701562A (zh) * 2017-09-14 2024-03-15 箭头药业股份有限公司 用于抑制血管生成素-样3(ANGPTL3)的表达的RNAi剂和组合物以及使用方法
UY38003A (es) * 2017-12-12 2019-06-28 Amgen Inc Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas

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DOP2022000204A (es) 2023-04-30
CL2022002580A1 (es) 2023-03-24
CR20220532A (es) 2022-11-28
TW202202153A (zh) 2022-01-16
UY39138A (es) 2021-09-30
IL296718A (en) 2022-11-01
AR121672A1 (es) 2022-06-29
CN115397436A (zh) 2022-11-25
CL2023002586A1 (es) 2024-01-26
CO2022013746A2 (es) 2022-10-31
ECSP22075322A (es) 2022-10-31
JP2023519246A (ja) 2023-05-10
PE20230345A1 (es) 2023-03-01
EP4125932A2 (en) 2023-02-08
US20210301294A1 (en) 2021-09-30
BR112022019241A2 (pt) 2022-11-16
WO2021195467A2 (en) 2021-09-30
WO2021195467A3 (en) 2021-11-11
KR20220158011A (ko) 2022-11-29
CA3176418A1 (en) 2021-09-30
AU2021242321A1 (en) 2022-10-06

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