CO2020014506A2 - Anticuerpos anti-cd3 y usos de estos - Google Patents
Anticuerpos anti-cd3 y usos de estosInfo
- Publication number
- CO2020014506A2 CO2020014506A2 CONC2020/0014506A CO2020014506A CO2020014506A2 CO 2020014506 A2 CO2020014506 A2 CO 2020014506A2 CO 2020014506 A CO2020014506 A CO 2020014506A CO 2020014506 A2 CO2020014506 A2 CO 2020014506A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibodies
- relates
- present
- specifically bind
- tmeff2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La presente invención se relaciona con anticuerpos que se unen específicamente a CD3. La presente invención se relaciona con anticuerpos que se unen específicamente al PSMA. La presente invención se relaciona con anticuerpos que se unen específicamente a CD3 y PSMA. La presente invención se relaciona con anticuerpos que se unen específicamente a IL1RAP. La presente invención se relaciona con anticuerpos que se unen específicamente a CD33. La presente invención se relaciona con anticuerpos que se unen específicamente a CD3 e IL1RAP. La presente invención se relaciona con anticuerpos que se unen específicamente a CD3 y CD33. La presente invención se relaciona con anticuerpos que se unen específicamente a TMEFF2. La presente invención se relaciona con anticuerpos que se unen específicamente a CD3 y TMEFF2. La presente invención se relaciona con fragmentos de los anticuerpos, polinucleótidos que codifican los anticuerpos o fragmentos de estos, y métodos de preparación y usos de estos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862676081P | 2018-05-24 | 2018-05-24 | |
PCT/IB2019/054188 WO2019224717A2 (en) | 2018-05-24 | 2019-05-21 | Anti-cd3 antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020014506A2 true CO2020014506A2 (es) | 2020-12-10 |
Family
ID=67211773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0014506A CO2020014506A2 (es) | 2018-05-24 | 2020-11-23 | Anticuerpos anti-cd3 y usos de estos |
Country Status (25)
Country | Link |
---|---|
US (2) | US11603405B2 (es) |
EP (1) | EP3802608A2 (es) |
JP (1) | JP2021524249A (es) |
KR (1) | KR20210012007A (es) |
CN (1) | CN112912397A (es) |
AR (1) | AR115422A1 (es) |
AU (1) | AU2019274656A1 (es) |
BR (1) | BR112020023508A2 (es) |
CA (1) | CA3101271A1 (es) |
CL (1) | CL2020003033A1 (es) |
CO (1) | CO2020014506A2 (es) |
CR (1) | CR20200568A (es) |
EA (1) | EA202092847A1 (es) |
EC (1) | ECSP20075215A (es) |
IL (1) | IL278846A (es) |
JO (1) | JOP20200302A1 (es) |
MA (1) | MA52773A (es) |
MX (1) | MX2020012587A (es) |
NI (1) | NI202000089A (es) |
PE (1) | PE20210132A1 (es) |
PH (1) | PH12020551920A1 (es) |
SG (1) | SG11202011270QA (es) |
TW (1) | TW202012443A (es) |
UY (1) | UY38245A (es) |
WO (1) | WO2019224717A2 (es) |
Families Citing this family (17)
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EP4129327A1 (en) | 2015-08-28 | 2023-02-08 | Amunix Pharmaceuticals, Inc. | Chimeric polypeptide assembly and methods of making and using the same |
EP3638697A4 (en) | 2017-06-12 | 2021-07-07 | Bluefin Biomedicine, Inc. | ANTI-IL1RAP ANTIBODIES AND ANTIBODY INGREDIENT CONJUGATES |
MA52772A (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech Inc | Anticorps anti-tmeff2 monospécifiques et multispécifiques et leurs utilisations |
CR20200563A (es) | 2018-05-24 | 2021-05-11 | Janssen Biotech Inc | Agentes aglutinantes de psma y usos de estos |
JOP20190116A1 (ar) * | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
MX2021000488A (es) * | 2018-07-19 | 2021-04-12 | Regeneron Pharma | Anticuerpos anti-bcma x anti-cd3 biespecificos y usos de estos. |
CA3136888A1 (en) | 2019-04-19 | 2020-10-22 | Janssen Biotech, Inc. | Methods of treating prostate cancer with an anti- psma/cd3 antibody |
CA3147735A1 (en) * | 2019-07-26 | 2021-02-04 | Janssen Biotech, Inc. | Proteins comprising kallikrein related peptidase 2 antigen binding domains and their uses |
TW202210510A (zh) | 2020-05-27 | 2022-03-16 | 美商健生生物科技公司 | 包含cd3抗原結合域之蛋白質及其用途 |
AU2021317111A1 (en) | 2020-07-29 | 2023-03-30 | Janssen Biotech, Inc. | Proteins comprising HLA-G antigen binding domains and their uses |
MX2023003041A (es) | 2020-09-16 | 2023-05-09 | Amgen Inc | Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer. |
JP2023548034A (ja) | 2020-10-22 | 2023-11-15 | ヤンセン バイオテツク,インコーポレーテツド | デルタ様リガンド3(dll3)抗原結合ドメインを含むタンパク質及びその使用 |
US20230073821A1 (en) * | 2021-08-27 | 2023-03-09 | International Business Machines Corporation | Antigen-binding proteins targeting coronavirus (cov) variants |
WO2023178645A1 (zh) * | 2022-03-25 | 2023-09-28 | 嘉和生物药业有限公司 | 靶向cd3的抗体及其应用 |
WO2024062074A1 (en) * | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
WO2024089551A1 (en) | 2022-10-25 | 2024-05-02 | Janssen Biotech, Inc. | Msln and cd3 binding agents and methods of use thereof |
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MA52772A (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech Inc | Anticorps anti-tmeff2 monospécifiques et multispécifiques et leurs utilisations |
CR20200563A (es) | 2018-05-24 | 2021-05-11 | Janssen Biotech Inc | Agentes aglutinantes de psma y usos de estos |
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2019
- 2019-05-21 JP JP2020565282A patent/JP2021524249A/ja active Pending
- 2019-05-21 WO PCT/IB2019/054188 patent/WO2019224717A2/en unknown
- 2019-05-21 CR CR20200568A patent/CR20200568A/es unknown
- 2019-05-21 MA MA052773A patent/MA52773A/fr unknown
- 2019-05-21 PE PE2020001886A patent/PE20210132A1/es unknown
- 2019-05-21 MX MX2020012587A patent/MX2020012587A/es unknown
- 2019-05-21 US US16/418,082 patent/US11603405B2/en active Active
- 2019-05-21 CA CA3101271A patent/CA3101271A1/en active Pending
- 2019-05-21 BR BR112020023508-3A patent/BR112020023508A2/pt unknown
- 2019-05-21 EP EP19737219.6A patent/EP3802608A2/en active Pending
- 2019-05-21 CN CN201980049271.7A patent/CN112912397A/zh active Pending
- 2019-05-21 KR KR1020207037046A patent/KR20210012007A/ko unknown
- 2019-05-21 AU AU2019274656A patent/AU2019274656A1/en active Pending
- 2019-05-21 EA EA202092847A patent/EA202092847A1/ru unknown
- 2019-05-21 SG SG11202011270QA patent/SG11202011270QA/en unknown
- 2019-05-21 JO JOP/2020/0302A patent/JOP20200302A1/ar unknown
- 2019-05-24 AR ARP190101400A patent/AR115422A1/es unknown
- 2019-05-24 UY UY0001038245A patent/UY38245A/es unknown
- 2019-05-24 TW TW108118086A patent/TW202012443A/zh unknown
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2020
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- 2020-11-23 CL CL2020003033A patent/CL2020003033A1/es unknown
- 2020-11-23 CO CONC2020/0014506A patent/CO2020014506A2/es unknown
- 2020-11-23 NI NI202000089A patent/NI202000089A/es unknown
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2023
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JOP20200302A1 (ar) | 2020-11-23 |
WO2019224717A2 (en) | 2019-11-28 |
PE20210132A1 (es) | 2021-01-19 |
MX2020012587A (es) | 2021-04-28 |
CA3101271A1 (en) | 2019-11-28 |
CN112912397A (zh) | 2021-06-04 |
NI202000089A (es) | 2021-01-21 |
BR112020023508A2 (pt) | 2021-03-30 |
KR20210012007A (ko) | 2021-02-02 |
JP2021524249A (ja) | 2021-09-13 |
SG11202011270QA (en) | 2020-12-30 |
US11603405B2 (en) | 2023-03-14 |
AR115422A1 (es) | 2021-01-20 |
US20200048349A1 (en) | 2020-02-13 |
WO2019224717A9 (en) | 2021-02-04 |
TW202012443A (zh) | 2020-04-01 |
IL278846A (en) | 2021-01-31 |
CL2020003033A1 (es) | 2021-04-16 |
CR20200568A (es) | 2021-02-26 |
PH12020551920A1 (en) | 2021-06-14 |
EA202092847A1 (ru) | 2021-04-20 |
AU2019274656A1 (en) | 2020-11-26 |
ECSP20075215A (es) | 2020-12-31 |
WO2019224717A3 (en) | 2020-03-05 |
UY38245A (es) | 2019-11-29 |
EP3802608A2 (en) | 2021-04-14 |
US20230322924A1 (en) | 2023-10-12 |
MA52773A (fr) | 2021-04-14 |
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