CN85107634B - 4-氧化-吡啶并(2，3-d)嘧啶-衍生物的制造方法 - Google Patents
4-氧化-吡啶并(2，3-d)嘧啶-衍生物的制造方法 Download PDFInfo
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- CN85107634B CN85107634B CN85107634A CN85107634A CN85107634B CN 85107634 B CN85107634 B CN 85107634B CN 85107634 A CN85107634 A CN 85107634A CN 85107634 A CN85107634 A CN 85107634A CN 85107634 B CN85107634 B CN 85107634B
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- 238000000034 method Methods 0.000 title claims description 16
- XKEBMWRWBWRQAO-UHFFFAOYSA-N 1h-pyrido[2,3-d]pyrimidin-4-one Chemical class C1=CC=C2C(=O)N=CNC2=N1 XKEBMWRWBWRQAO-UHFFFAOYSA-N 0.000 title abstract 2
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3438350.6 | 1984-10-19 | ||
| DE19843438350 DE3438350A1 (de) | 1984-10-19 | 1984-10-19 | 4-oxo-pyrido (2,3-d) pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85107634A CN85107634A (zh) | 1987-05-13 |
| CN85107634B true CN85107634B (zh) | 1988-07-06 |
Family
ID=6248307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85107634A Expired CN85107634B (zh) | 1984-10-19 | 1985-10-16 | 4-氧化-吡啶并(2，3-d)嘧啶-衍生物的制造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4677108A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0180833B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS61100581A (cg-RX-API-DMAC10.html) |
| CN (1) | CN85107634B (cg-RX-API-DMAC10.html) |
| AT (1) | ATE44743T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU579196B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1260936A (cg-RX-API-DMAC10.html) |
| DD (1) | DD242406A5 (cg-RX-API-DMAC10.html) |
| DE (2) | DE3438350A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK478485A (cg-RX-API-DMAC10.html) |
| ES (1) | ES8605518A1 (cg-RX-API-DMAC10.html) |
| GR (1) | GR852525B (cg-RX-API-DMAC10.html) |
| HU (1) | HU192728B (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA857990B (cg-RX-API-DMAC10.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3438351A1 (de) * | 1984-10-19 | 1986-04-24 | Gödecke AG, 1000 Berlin | 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
| DE3501696A1 (de) * | 1985-01-19 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| IT1229118B (it) * | 1988-07-29 | 1991-07-22 | Simes | Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista |
| WO2004063195A1 (en) * | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
| CN109824675A (zh) * | 2019-04-09 | 2019-05-31 | 唐山师范学院 | 一种4-氯吡咯并嘧啶的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE525394A (cg-RX-API-DMAC10.html) * | ||||
| US3673184A (en) * | 1970-09-02 | 1972-06-27 | Dainippon Pharmaceutical Co | Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives |
| US4271164A (en) * | 1979-04-16 | 1981-06-02 | Warner-Lambert Company | 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives |
| US4361700A (en) * | 1980-05-20 | 1982-11-30 | James S. Waldron | Pyridopyrimidinone derivatives |
| US4560753A (en) * | 1982-11-05 | 1985-12-24 | Sterling Drug Inc. | 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones |
| US4432981A (en) * | 1982-11-05 | 1984-02-21 | Sterling Drug Inc. | 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones |
| DE3438351A1 (de) * | 1984-10-19 | 1986-04-24 | Gödecke AG, 1000 Berlin | 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
-
1984
- 1984-10-19 DE DE19843438350 patent/DE3438350A1/de not_active Withdrawn
-
1985
- 1985-10-16 US US06/787,845 patent/US4677108A/en not_active Expired - Fee Related
- 1985-10-16 CN CN85107634A patent/CN85107634B/zh not_active Expired
- 1985-10-17 JP JP60230047A patent/JPS61100581A/ja active Pending
- 1985-10-17 ZA ZA857990A patent/ZA857990B/xx unknown
- 1985-10-17 CA CA000493199A patent/CA1260936A/en not_active Expired
- 1985-10-18 HU HU854036A patent/HU192728B/hu unknown
- 1985-10-18 DK DK478485A patent/DK478485A/da not_active Application Discontinuation
- 1985-10-18 DE DE8585113269T patent/DE3571619D1/de not_active Expired
- 1985-10-18 GR GR852525A patent/GR852525B/el unknown
- 1985-10-18 ES ES548007A patent/ES8605518A1/es not_active Expired
- 1985-10-18 AU AU48857/85A patent/AU579196B2/en not_active Ceased
- 1985-10-18 EP EP85113269A patent/EP0180833B1/de not_active Expired
- 1985-10-18 DD DD85281878A patent/DD242406A5/de not_active IP Right Cessation
- 1985-10-18 AT AT85113269T patent/ATE44743T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0180833A1 (de) | 1986-05-14 |
| GR852525B (cg-RX-API-DMAC10.html) | 1986-02-19 |
| ES8605518A1 (es) | 1986-03-16 |
| DE3571619D1 (en) | 1989-08-24 |
| DK478485A (da) | 1986-04-20 |
| JPS61100581A (ja) | 1986-05-19 |
| ATE44743T1 (de) | 1989-08-15 |
| ZA857990B (en) | 1986-06-25 |
| EP0180833B1 (de) | 1989-07-19 |
| US4677108A (en) | 1987-06-30 |
| AU4885785A (en) | 1986-04-24 |
| DD242406A5 (de) | 1987-01-28 |
| DK478485D0 (da) | 1985-10-18 |
| HU192728B (en) | 1987-06-29 |
| DE3438350A1 (de) | 1986-04-24 |
| CA1260936A (en) | 1989-09-26 |
| HUT39180A (en) | 1986-08-28 |
| CN85107634A (zh) | 1987-05-13 |
| AU579196B2 (en) | 1988-11-17 |
| ES548007A0 (es) | 1986-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C13 | Decision | ||
| GR02 | Examined patent application | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |