ES8605518A1 - Procedimiento para preparar derivados de 4-oxo-pirido(2,3-d)pirimidina - Google Patents
Procedimiento para preparar derivados de 4-oxo-pirido(2,3-d)pirimidinaInfo
- Publication number
- ES8605518A1 ES8605518A1 ES548007A ES548007A ES8605518A1 ES 8605518 A1 ES8605518 A1 ES 8605518A1 ES 548007 A ES548007 A ES 548007A ES 548007 A ES548007 A ES 548007A ES 8605518 A1 ES8605518 A1 ES 8605518A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrido
- oxo
- preparation
- pyrimidine derivatives
- medicaments containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4-OXO-PIRIDO2,3-DPIRIMIDINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES UN RADICAL DE ANILLO AROMATICO O HETEROAROMATICO; R2 ES NITRILO, CARBOXILO O ALCOXICARBONILO C1-6; R3 REPRESENTA ALQUILO C1-4 O AMINO; Y R4 ES HIDROGENO O ALQUILO C1-4. CONSISTE EN LA REACCION DE CONDENSACION DE S-TRIAZINA CON UNA DIHIDROPIRIDINA DE FORMULA (II), EN LA QUE R2 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES Y R1 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE FUERTE. TAMBIEN SE PUEDE CONDENSAR UN COMPUESTO DE FORMULA (III), EN LA QUE R3 ES ALQUILO C1-6 Y R1 Y R2 TIENEN LOS SIGNIFICADOS ANTERIORES, CON 6-AMINO-5-HIDROXIPIRIDINA, EN UN DISOLVENTE POLAR A TEMPERATURA ENTRE 60JC Y 120JC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843438350 DE3438350A1 (de) | 1984-10-19 | 1984-10-19 | 4-oxo-pyrido (2,3-d) pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8605518A1 true ES8605518A1 (es) | 1986-03-16 |
| ES548007A0 ES548007A0 (es) | 1986-03-16 |
Family
ID=6248307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES548007A Expired ES8605518A1 (es) | 1984-10-19 | 1985-10-18 | Procedimiento para preparar derivados de 4-oxo-pirido(2,3-d)pirimidina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4677108A (es) |
| EP (1) | EP0180833B1 (es) |
| JP (1) | JPS61100581A (es) |
| CN (1) | CN85107634B (es) |
| AT (1) | ATE44743T1 (es) |
| AU (1) | AU579196B2 (es) |
| CA (1) | CA1260936A (es) |
| DD (1) | DD242406A5 (es) |
| DE (2) | DE3438350A1 (es) |
| DK (1) | DK478485A (es) |
| ES (1) | ES8605518A1 (es) |
| GR (1) | GR852525B (es) |
| HU (1) | HU192728B (es) |
| ZA (1) | ZA857990B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3438351A1 (de) * | 1984-10-19 | 1986-04-24 | Gödecke AG, 1000 Berlin | 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
| DE3501696A1 (de) * | 1985-01-19 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| IT1229118B (it) * | 1988-07-29 | 1991-07-22 | Simes | Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista |
| US20050009849A1 (en) * | 2003-01-03 | 2005-01-13 | Veach Darren R. | Pyridopyrimidine kinase inhibitors |
| CN109824675A (zh) * | 2019-04-09 | 2019-05-31 | 唐山师范学院 | 一种4-氯吡咯并嘧啶的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE525394A (es) * | ||||
| US3673184A (en) * | 1970-09-02 | 1972-06-27 | Dainippon Pharmaceutical Co | Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives |
| US4271164A (en) * | 1979-04-16 | 1981-06-02 | Warner-Lambert Company | 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives |
| US4361700A (en) * | 1980-05-20 | 1982-11-30 | James S. Waldron | Pyridopyrimidinone derivatives |
| US4432981A (en) * | 1982-11-05 | 1984-02-21 | Sterling Drug Inc. | 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones |
| US4560753A (en) * | 1982-11-05 | 1985-12-24 | Sterling Drug Inc. | 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones |
| DE3438351A1 (de) * | 1984-10-19 | 1986-04-24 | Gödecke AG, 1000 Berlin | 4-alkoxy-pyrido(2,3-d)pyrimidin-derivate, verfahren zu deren herstellung und deren verwendung |
-
1984
- 1984-10-19 DE DE19843438350 patent/DE3438350A1/de not_active Withdrawn
-
1985
- 1985-10-16 US US06/787,845 patent/US4677108A/en not_active Expired - Fee Related
- 1985-10-16 CN CN85107634A patent/CN85107634B/zh not_active Expired
- 1985-10-17 ZA ZA857990A patent/ZA857990B/xx unknown
- 1985-10-17 CA CA000493199A patent/CA1260936A/en not_active Expired
- 1985-10-17 JP JP60230047A patent/JPS61100581A/ja active Pending
- 1985-10-18 DK DK478485A patent/DK478485A/da not_active Application Discontinuation
- 1985-10-18 DE DE8585113269T patent/DE3571619D1/de not_active Expired
- 1985-10-18 DD DD85281878A patent/DD242406A5/de not_active IP Right Cessation
- 1985-10-18 ES ES548007A patent/ES8605518A1/es not_active Expired
- 1985-10-18 EP EP85113269A patent/EP0180833B1/de not_active Expired
- 1985-10-18 AU AU48857/85A patent/AU579196B2/en not_active Ceased
- 1985-10-18 AT AT85113269T patent/ATE44743T1/de not_active IP Right Cessation
- 1985-10-18 HU HU854036A patent/HU192728B/hu unknown
- 1985-10-18 GR GR852525A patent/GR852525B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU192728B (en) | 1987-06-29 |
| ATE44743T1 (de) | 1989-08-15 |
| EP0180833A1 (de) | 1986-05-14 |
| DE3438350A1 (de) | 1986-04-24 |
| DK478485A (da) | 1986-04-20 |
| ES548007A0 (es) | 1986-03-16 |
| DK478485D0 (da) | 1985-10-18 |
| US4677108A (en) | 1987-06-30 |
| JPS61100581A (ja) | 1986-05-19 |
| CN85107634A (zh) | 1987-05-13 |
| ZA857990B (en) | 1986-06-25 |
| HUT39180A (en) | 1986-08-28 |
| DD242406A5 (de) | 1987-01-28 |
| EP0180833B1 (de) | 1989-07-19 |
| AU4885785A (en) | 1986-04-24 |
| GR852525B (es) | 1986-02-19 |
| CA1260936A (en) | 1989-09-26 |
| DE3571619D1 (en) | 1989-08-24 |
| CN85107634B (zh) | 1988-07-06 |
| AU579196B2 (en) | 1988-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG103417A (en) | Condensed pyrimidine bicyclic derivatives | |
| HUT52769A (en) | Process for producing pyrimidine derivatives and pharmaceutical compositions containing them | |
| BG102789A (en) | Parimido[5,4-d]pyrimidines, medicamentous forms containing them, their application and method for their preparation | |
| ES8606347A1 (es) | Un procedimiento para preparar derivados de purina | |
| ES8605518A1 (es) | Procedimiento para preparar derivados de 4-oxo-pirido(2,3-d)pirimidina | |
| PT77850A (en) | Process for preparing new pharmacologically active pyrazolopyridines and of pharmaceutical compositions containing the same | |
| ES8705463A1 (es) | Un procedimiento para la preparacion de 1-metil-4,5-dihi- droorotil-histidil-prolinamida | |
| MY103593A (en) | Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation | |
| AU578125B2 (en) | Pyrazine diazohydroxide compounds | |
| PT79909A (en) | Process for preparing 6-substituted-5-phenyltetrazolo<1,5-a><1,2,4>tetrazolo<1,5-c>pyrimidines | |
| EP0181636A3 (en) | 2 5-cyanopyridine-2-diazohydroxide, basic salts and methods for production and use | |
| FR2593812B1 (fr) | Derives na-substitues des na-arylsulfonylaminoacyl p-amidinophenylalaninamides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant | |
| MY103900A (en) | 6-substituted 2'', 3''-dideoxynucleosides and pharmaceutical compositions |