CN210534173U

CN210534173U - Full-automatic carousel device for chemiluminescence immunoassay

Info

Publication number: CN210534173U
Application number: CN201921361550.0U
Authority: CN
Inventors: 王鹏; 邱胜聪; 叶芦苇; 鲜志强; 冯蕾
Original assignee: Chengdu Seamaty Technology Co ltd
Current assignee: Chengdu Seamaty Technology Co ltd
Priority date: 2019-08-21
Filing date: 2019-08-21
Publication date: 2020-05-15
Anticipated expiration: 2029-08-21

Abstract

The utility model discloses a carousel device for full-automatic chemiluminescence immune analysis, including carousel and rotation motor, the carousel dress rotates the motor drive carousel and rotates on rotating the motor, is provided with the capillary more than one on the carousel and bears the weight of the hole. The rotary table is an incubation rotary table and comprises a table body, heat preservation cotton and an electric heating film, wherein the electric heating film is wound on the table body, and the heat preservation cotton is wound on the electric heating film. The utility model discloses not only can play the effect of transporting, still play the effect of incubation, simplify the instrument, reduce the volume of whole automation equipment for whole automation equipment is more miniaturized.

Description

Full-automatic carousel device for chemiluminescence immunoassay

Technical Field

The utility model relates to a biochemical analysis device especially relates to an utilize chemiluminescence method to carry out immunoassay's instrument.

Background

ChemiLuminescence (CL) is a type of molecular luminescence spectroscopy, and is a trace analysis method for determining the content of an analyte by detecting the ChemiLuminescence intensity of a system by using an instrument according to the principle that the concentration of the analyte in a chemical detection system and the ChemiLuminescence intensity of the system are in a linear quantitative relationship under a certain condition. The chemiluminescence method has wide application in the fields of trace metal ions, various inorganic compounds, organic compound analysis and biology.

Chemiluminescence immunoassay (CLIA) is a technique for detecting and analyzing various antigens, antibodies, hormones, enzymes, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and a high-specificity immunoreaction. Is an immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay. The chemiluminescence method has the advantages of high sensitivity, strong specificity, high accuracy, wide detection range and the like. Compared with the semi-quantitative enzyme-linked immunosorbent assay, the chemiluminescence assay is real quantitative, and the detection speed is higher and more convenient. Meanwhile, the chemiluminescent marker is stable, the effective period of the reagent is long, and the requirement of clinical application is greatly facilitated. The existing chemiluminescence immunoassay needs to use a carrier for detection after reaction, the existing carrier mainly comprises a microporous plate, an enzyme label plate and a capillary, and the microporous plate and the enzyme label plate have the defect of large sample loading amount, and the sample loading amount of the capillary is very small, so the capillary is used as the carrier for chemiluminescence immunoassay, which is a common mode.

The chemiluminescence immunoassay using the capillary as a carrier mainly comprises the following steps: coating the capillary, centrifuging the blood sample, sucking the blood sample by the capillary, performing multiple capillary purges and sucking reagents, incubating and detecting. That is, to realize a full-automatic chemiluminescence immunoassay (the carrier is a capillary), all the steps need to be automatically completed, and a capillary transport device is needed to automatically complete all the steps, so that the capillary is transported to each corresponding device to realize the steps. The existing capillary tube loading and transporting device generally adopts the mode of transferring the capillary tube to each device through negative pressure adsorption or a mechanical arm to finish corresponding steps, and the transferring device with the structure has large floor area and complicated mechanical structure, thereby causing the volume of the whole automatic instrument to be large.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the transfer device used by the full-automatic chemiluminescence immunoassay analyzer, the turntable device provided by the invention not only can play a role in transferring, but also can simplify the instrument, reduce the volume of the whole automatic instrument and enable the whole automatic instrument to be more miniaturized.

In order to solve the technical problem, the utility model discloses the technical scheme who adopts is:

the utility model provides a carousel device for full-automatic chemiluminescence immunoassay which characterized in that: the capillary tube bearing device comprises a rotary table and a rotary motor, wherein the rotary table is arranged on the rotary motor, the rotary motor drives the rotary table to rotate, and more than one capillary tube bearing hole is formed in the rotary table. The capillary tube is arranged in the capillary tube bearing hole, and the turntable rotates to drive the capillary tube to rotate to a required position.

The spring leaf is installed to the inboard of carousel, and the spring leaf is located capillary bearing hole department, and is spacing at the capillary bearing downthehole with the capillary.

The spring piece comprises a main body and a bending body, at least one bending body is arranged on the main body, the main body is fixed on the turntable, and the bending body is located at the capillary bearing hole.

The carousel is the incubation carousel, and it includes disk body, heat preservation cotton and electrical heating membrane, and the electrical heating membrane is wrapped around on the disk body, and the heat preservation cotton is wrapped around on the electrical heating membrane, through the heating of electrical heating membrane, provides suitable incubation temperature for the capillary, and the heat preservation cotton plays a thermal-insulated heat retaining effect.

In order to ensure the proper temperature for the capillary tube, the tray body is also provided with a temperature sensor which is connected with a controller, and the controller is connected with the electric heating film and is used for controlling the electric heating film to heat. The temperature of the incubation is detected at any time, and the constant temperature of the incubation rotating disc is ensured.

Compared with the prior art, the utility model discloses following beneficial effect has:

the utility model provides a carousel device has changed into the centre gripping capillary with the mode that current manipulator or negative pressure adsorb the transportation and has carried out the annular rotation and just can carry each device department with the capillary and carry out relevant immunoassay step and handle, the linear station of carousel has been changed into with the linear station that current manipulator or negative pressure adsorb the transportation, the volume of whole automation equipment can be dwindled very obviously, no longer adopt robotic arm or negative pressure to adsorb the mode of transporting simultaneously, just also do not need complicated manipulator or vacuum apparatus, only need a carousel can realize, the transfer device has been simplified greatly, the production cost is reduced, the volume of transfer device has also been reduced, and then the volume of whole automation equipment is dwindled.

The utility model discloses the spring leaf is installed to the inboard of carousel, and the spring leaf is located capillary bearing hole department, and is spacing at the capillary bearing hole with the capillary. The capillary tube is limited in the capillary tube bearing hole under the action of the spring piece. Avoid the capillary to fall from the incubation carousel in the pivoted process, cause the capillary to damage.

The utility model discloses the carousel is incubation carousel, and it includes disk body, heat preservation cotton and electrical heating membrane, and electrical heating membrane wraps on the disk body, and the cotton package that keeps warm is on electrical heating membrane, through the electrical heating membrane heating, provides suitable incubation temperature for the capillary, and the heat preservation cotton plays a thermal-insulated heat retaining effect, and the carousel of incubating like this has not only played the effect of transporting the capillary, but also has played the effect of incubation capillary. The transfer and incubation device is integrated, the volume of the whole automatic instrument is further reduced, and the whole automatic instrument is simplified.

Drawings

FIG. 1 is a schematic structural view of a turntable device of the present invention;

fig. 2 is a schematic view of another view direction structure of the turntable device of the present invention;

fig. 3 is a schematic structural diagram of the full-automatic chemiluminescence immunoassay analyzer formed by matching the present invention with other devices.

The device comprises a reference numeral 1, a capillary storage component, 2, a capillary pushing-out component, 3, a turntable device, 30, an incubation turntable, 301, a tray body, 302, heat preservation cotton, 303, an electric heating film, 31, a rotating motor, 32, a capillary bearing hole, 33, a spring piece, 4, a blowing component, 5, a sample component, 6, a reagent component, 7, a detection component, 8, a bottom plate, 9 and a capillary.

Detailed Description

The present invention will be further described with reference to the following examples, which are only some, but not all, of the examples of the present invention. Based on the embodiments in the present invention, other embodiments used by those skilled in the art without creative work belong to the protection scope of the present invention. The utility model discloses the position word that appears in like "preceding", "back", "left", "right", has only represented relative position relation, all is the description of going on to the position of fig. 3 to the position around not necessarily being actual, consequently can not do the restrictive understanding.

The utility model provides a carousel device for full-automatic chemiluminescence immunoassay, the device undertake two functions, and a function is exactly the capillary transport function, transports each subassembly department with the capillary and carries out corresponding action, and another function is exactly the incubation function, replaces the incubation device. The advantages are that: the rotary disc is an annular station, so that the volume of the equipment can be reduced, and the device is reduced, the equipment is optimized and the volume of the equipment is reduced by replacing an incubation device.

As shown in FIG. 1 and FIG. 2, the main component of the present invention is an incubation rotary disk 30, which is rotated by a rotation motor 31, and a plurality of capillary bearing holes 32 are formed in the incubation rotary disk. After the capillary tube is pushed out of the capillary cartridge, it is sent into the capillary bearing hole 32, so that the incubation turntable rotates to drive the capillary tube to rotate to a required position.

Install spring leaf 33 at the right side of incubation carousel, through spring leaf 33 effect with capillary spacing in capillary bearing hole 32, avoid the capillary to fall from incubation carousel in the pivoted in-process, cause the capillary to damage.

The specific structure of the incubation rotating disc 30 comprises a disc body 301, heat preservation cotton 302 and an electric heating film 303, wherein the electric heating film 303 is wound on the disc body, the heat preservation cotton 302 is wound on the electric heating film 303, the electric heating film is used for heating to provide proper incubation temperature for the capillary, and the heat preservation cotton plays a role in heat insulation, so that the incubation rotating disc not only plays a role in transporting the capillary, but also plays a role in incubating the capillary. Certainly, in order to ensure the proper incubation temperature of the capillary, a temperature sensor is also arranged on the disc body, so that the incubation temperature can be detected at any time, and the constant temperature of the incubation rotary disc can be ensured.

A rotation motor 31 is installed at the left side of the incubation carousel 30.

As shown in FIG. 3, the utility model provides a full-automatic chemiluminescence immunoassay device, the device's effect is all steps of realizing blood sample chemiluminescence immunoassay, and whole automation mechanized operation, the user only need load the blood sample, and the starting equipment can carry out full automated inspection, the automated generation testing result. The device has the following specific structure:

the method comprises the following steps: capillary storage component 1, capillary push-out component 2, carousel device 3, gas blowing component 4, sample subassembly 5, reagent subassembly 6, detection module 7 and bottom plate 8, above-mentioned subassembly is all installed on bottom plate 8. Their relative positional relationship is: capillary release subassembly 2 is located the left side of capillary storage component 1, carousel device 3 is located the right side of capillary storage component 1, blowing component 4 is located carousel device 3's left side, and blowing component 4 is located capillary storage component 1 and capillary release subassembly 2's front side, and capillary storage component 1 and capillary release subassembly 2 pass through the mounting panel and install in the left side of 3 side parts on carousel device, and the left side in carousel device 3 the latter half is installed to blowing component 4. The sample assembly 5, the reagent assembly 6 and the detection assembly 7 are all positioned on the right side of the turntable device 3, the reagent assembly 6 is positioned in the middle of the sample assembly 5 and the detection assembly 7, the sample assembly 5 is positioned on the front right side of the turntable device, and the detection assembly is positioned on the right back side of the turntable device. And a waste liquid groove is arranged below the sample assembly, the air blowing assembly and the reagent assembly, the waste liquid groove is arranged below the bottom plate, and the waste liquid groove is used for collecting waste liquid generated by the sample assembly, the air blowing assembly and the reagent assembly.

The capillary tube pushing assembly 2 pushes out the capillary tube in the capillary tube storage assembly 1 and sends the capillary tube to the rotary table device 3, the rotary table device 3 rotates to convey the capillary tube 9 to the positions of the sample assembly 5, the blowing assembly 4, the reagent assembly 6 and the detection assembly 7, the blowing assembly is used for removing residual liquid in the capillary tube 9, the sample assembly is used for providing a blood sample for the capillary tube, the reagent assembly is used for providing a reagent for the capillary tube, and the detection assembly is used for detecting the number of photons emitted by the detection capillary tube.

Claims

1. The utility model provides a carousel device for full-automatic chemiluminescence immunoassay which characterized in that: the capillary tube bearing device comprises a rotary table and a rotary motor, wherein the rotary table is arranged on the rotary motor, the rotary motor drives the rotary table to rotate, and more than one capillary tube bearing hole is formed in the rotary table.

2. The carousel device for full-automatic chemiluminescence immunoassay according to claim 1, wherein: the spring leaf is installed to the inboard of carousel, and the spring leaf is located capillary bearing hole department, and is spacing at the capillary bearing downthehole with the capillary.

3. The carousel device for full-automatic chemiluminescence immunoassay according to claim 2, wherein: the spring piece comprises a main body and a bending body, at least one bending body is arranged on the main body, the main body is fixed on the turntable, and the bending body is located at the capillary bearing hole.

4. The carousel device for full-automatic chemiluminescence immunoassay according to claim 1, wherein: the rotary table is an incubation rotary table and comprises a table body, heat preservation cotton and an electric heating film, wherein the electric heating film is wound on the table body, and the heat preservation cotton is wound on the electric heating film.

5. The carousel device for full-automatic chemiluminescence immunoassay according to claim 4, wherein: the temperature sensor is installed on the tray body and connected with a controller, and the controller is connected with the electric heating film.