CN210155150U - Full-automatic magnetic particle chemiluminescence immunoassay analyzer - Google Patents
Full-automatic magnetic particle chemiluminescence immunoassay analyzer Download PDFInfo
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- CN210155150U CN210155150U CN201920807728.3U CN201920807728U CN210155150U CN 210155150 U CN210155150 U CN 210155150U CN 201920807728 U CN201920807728 U CN 201920807728U CN 210155150 U CN210155150 U CN 210155150U
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Abstract
The utility model discloses a full-automatic magnetic particle chemiluminescence immunoassay analyzer, an analyzer body comprises a detection case, a detection storage box and a main control case, the top of the detection case is provided with the detection storage box which is fixedly connected with the detection storage box, the top of the detection storage box is provided with a movable end cover, the inside of the detection storage box is provided with a reagent kit seat plate which is detachably connected with the detection storage box, the right side of the detection case is provided with the main control case, the top of the main control case is provided with an electronic display screen, and a main control core plate is arranged in the main control case, the utility model applies the chemiluminescence immunoassay principle combining a luminescence system and an immunoassay method to carry out quantitative and qualitative detection on various analytes in human serum, blood plasma or other body fluids, has high intelligent degree, can automatically run all test processes, realizes full-automatic operation, and has high detection efficiency, and the detection precision is high, the detection result is more accurate, the clinical diagnosis is convenient, the application prospect is wide, and the popularization and the application are facilitated.
Description
Technical Field
The utility model relates to a medical treatment check out test set technical field especially relates to a full-automatic magnetic particle chemiluminescence immunoassay appearance.
Background
In biochemical experiments, a chemiluminescence immunoassay analyzer is generally used for detecting and analyzing body fluid, the chemiluminescence immunoassay analysis combines a chemiluminescence measuring technology with high sensitivity and a high-specificity immunoreaction, is used for detecting and analyzing various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, medicaments and the like, and is a latest immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay, the chemiluminescence immunoassay analysis comprises two parts, namely a chemiluminescence analysis system and an immunoreaction system, the chemiluminescence analysis system utilizes a chemiluminescence substance to be catalyzed by a catalyst and oxidized by an oxidant to form an excited intermediate, and simultaneously emits photons (hM) when the excited intermediate returns to a stable ground state, the light quantum yield is measured by a luminescence signal measuring instrument. The immunoreaction system is to label the luminous matter (excited to produce excited state intermediate under the excitation of reactant) directly onto antigen (chemiluminescence immunoassay) or antibody (immunochemiluminescence assay), or to act enzyme on the luminous substrate. However, the conventional chemiluminescence immunoassay analyzer has low accuracy and low detection efficiency, and therefore, there is an urgent need to develop a fully automatic magnetic particle chemiluminescence immunoassay analyzer to solve the above-mentioned technical problems.
In view of this, the present invention is especially provided.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a full-automatic magnetic particle chemiluminescence immunoassay appearance, the chemiluminescence immunoassay principle that applied lighting system and immunoassay method combined, carry out ration and qualitative detection to various analyte in human serum, plasma or other body fluids, intelligent degree is high, but the whole test procedure of automatic operation, realize full automatic operation, detection efficiency has not only been improved, but also higher detection precision has, the testing result is more accurate, the clinical diagnosis of being convenient for, wide application prospect has, and the popularization and application are favorable to.
In order to achieve the above object, the utility model provides a full-automatic magnetic particle chemiluminescence immunoassay analyzer, which comprises an analyzer body and is characterized in that the analyzer body comprises a detection case, a detection storage box and a main control case, wherein the top of the detection case is provided with the detection storage box, the detection case is fixedly connected with the detection storage box, the top of the detection storage box is provided with a movable end cover, the inside of the detection storage box is provided with a kit seat disk, the kit seat disk is detachably connected with the detection storage box, the right side of the detection case is provided with the main control case, the top of the main control case is provided with an electronic display screen, the inside of the main control case is provided with a main control core plate, the main control core plate comprises a three-dimensional mechanical arm module, a reagent sample disk module, a cleaning detection module, a needle cross arm module, a mechanical arm module and an incubation module, the motion control module, the liquid path module and the communication module are communicated with each other.
Preferably, a sample tube hole site, a kit hole site and a magnetic bead bottle hole site are sequentially arranged on the kit seat plate from outside to inside, the sample tube hole site, the kit hole site and the magnetic bead bottle hole site are respectively used for placing a sample tube, a kit and a magnetic bead bottle, the magnetic bead bottle has a mixing function, and is mixed uniformly by adopting a gear rotation mode.
Preferably, there are 60 sample tube holes, 20 reagent kit holes, and 20 magnetic bead bottle holes.
Preferably, the three-dimensional mechanical arm module is responsible for holding the reaction tube rack, and the built-in manipulator completes a series of actions of moving the reaction tube to the incubation tray, cleaning the detection tray and finally throwing the reaction tube to the waste barrel.
Preferably, the cleaning detection module comprises a cleaning module and a detection module, the cleaning module is used for cleaning magnetic beads, the detection module is used for detecting fluorescence, and the spectral measurement range of the detection module is 300 nm-650 nm.
Preferably, the needle cross arm module adopts a sample adding needle to add sample and reagent.
Preferably, the incubation module comprises an incubation tray, the incubation tray is designed by adopting a 90-hole site, the temperature accuracy is a set value +/-0.2 ℃, and the temperature fluctuation degree is not more than 0.5 ℃.
Preferably, the communication module adopts a CAN-BUS system BUS for communication.
Preferably, the sample adding precision CV of the solution preparation of the analyzer body at 100 mu L is less than 1%.
Preferably, the linear correlation coefficient r of the analyzer body is more than or equal to 0.99 within the concentration range of not less than 2 orders of magnitude, and the intra-batch measurement repeatability of the analyzer body has a coefficient of variation CV of less than or equal to 8%.
The utility model provides a pair of full-automatic magnetic particle chemiluminescence immunoassay appearance has following beneficial effect.
1. The utility model discloses the chemiluminescence immunoassay principle that uses luminescent system and immunoassay method to combine carries out ration and qualitative detection to various analyte in human serum, plasma or other body fluids, and intelligent degree is high.
2. The utility model discloses but the whole test process of automatic operation realizes full automatic operation, has not only improved detection efficiency, has higher detection precision moreover, and the testing result is more accurate, and the clinical diagnosis of being convenient for has wide application prospect, is favorable to popularizing and applying.
Drawings
Fig. 1 is a schematic view of the overall structure of a fully automatic magnetic particle chemiluminescence immunoassay analyzer provided by the present invention;
fig. 2 is a schematic structural view of a kit tray of a full-automatic magnetic particle chemiluminescence immunoassay analyzer provided by the present invention;
fig. 3 is a schematic diagram of the principle structure of a master control core board of a full-automatic magnetic particle chemiluminescence immunoassay analyzer provided by the present invention.
In the figure:
1. the analyzer body 2, the detection case 3, the detection storage box 4, the main control case 5, the kit seat plate 6, the electronic display screen 7, the main control core plate 8, the sample tube hole site 9, the kit hole site 10 and the magnetic bead bottle hole site.
Detailed Description
The present invention will be further described with reference to the following specific embodiments and accompanying drawings to facilitate understanding of the present invention.
As shown in fig. 1, the overall structure of the fully automatic magnetic particle chemiluminescence immunoassay analyzer provided by the present invention is schematically illustrated. This full-automatic magnetic particle chemiluminescence immunoassay appearance includes analysis appearance body 1, analysis appearance body 1 is including detecting quick-witted case 2, detects storage box 3 and main control machine case 4, the top that detects quick-witted case 2 is equipped with detects storage box 3, detect quick-witted case 2 with detect storage box 3 fixed connection, the top that detects storage box 3 is equipped with movable end cover, the inside that detects storage box 3 is equipped with kit seat dish 5, kit seat dish 5 with detect the detachable connection of storage box 3, the right side that detects quick-witted case 2 is equipped with main control machine case 4, the top of main control machine case 4 is equipped with electronic display 6, the inside of main control machine case 4 is equipped with main control core 7. As shown in fig. 3, it is a schematic diagram of the principle structure of a master control core board of a full-automatic magnetic particle chemiluminescence immunoassay analyzer provided by the present invention. The main control core plate 7 comprises a three-dimensional mechanical arm module, a reagent sample tray module, a cleaning detection module, a needle cross arm module, a manipulator module, an incubation module, a motion control module, a liquid path module and a communication module, wherein the three-dimensional mechanical arm module, the reagent sample tray module, the cleaning detection module, the needle cross arm module, the manipulator module, the incubation module, the motion control module, the liquid path module and the communication module are all communicated with one another.
As shown in fig. 2, the utility model provides a structure diagram of a full-automatic magnetic particle chemiluminescence immunoassay analyzer kit tray. Preferably, a sample tube hole site 8, a kit hole site 9 and a magnetic bead bottle hole site 10 are sequentially arranged on the kit seat tray 5 from outside to inside, the sample tube hole site 8, the kit hole site 9 and the magnetic bead bottle hole site 10 are respectively used for placing a sample tube, a kit and a magnetic bead bottle, and the magnetic bead bottle has a blending function and is blended in a gear rotating mode. Preferably, there are 60 sample tube well sites 8, 20 reagent kit well sites 9, and 20 magnetic bead bottle well sites 10.
The three-dimensional mechanical arm module is responsible for containing the reaction tube rack, and the built-in mechanical arm completes a series of actions of moving the reaction tube to the incubation tray, cleaning the detection tray and finally throwing the reaction tube to the waste barrel. The cleaning detection module comprises a cleaning module and a detection module, the cleaning module is used for cleaning magnetic beads, the detection module is used for completing fluorescence detection, and the spectral measurement range of the detection module is 300 nm-650 nm. The reagent sample tray module is used for placing reagents and samples, and the motion control module is used for controlling the mechanical motion of each module. The needle cross arm module adopts a sample adding needle to add samples and reagents. The incubation module comprises an incubation disc, the incubation disc is designed by adopting 90-hole sites, the temperature accuracy is a set value +/-0.2 ℃, and the temperature fluctuation degree is not more than 0.5 ℃. The communication module adopts a CAN-BUS system BUS for communication. The liquid preparation and sample adding precision CV of the analyzer body 1 is less than 1% when the volume is 100 mu L, the linear correlation coefficient r of the analyzer body 1 is more than or equal to 0.99 within the concentration range of not less than 2 orders of magnitude, the batch measurement repeatability of the analyzer body 1 is realized, and the coefficient of variation CV is less than or equal to 8%.
The utility model discloses the chemiluminescence immunoassay principle that applied lighting system and immunoassay method combined carries out ration and qualitative detection to various analyte in human serum, plasma or other body fluids, and intelligent degree is high, but the whole test procedure of automatic operation realizes full automatic operation, has not only improved detection efficiency, has higher detection precision moreover, and the testing result is more accurate, and the clinical diagnosis of being convenient for has wide application prospect, is favorable to popularizing and applying.
The present invention has been described in detail with reference to specific embodiments, and the description of the embodiments is only for the purpose of helping understanding the core idea of the present invention. It should be understood that any obvious modifications, equivalents and other improvements made by those skilled in the art without departing from the spirit of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. A full-automatic magnetic particle chemiluminescence immunoassay analyzer comprises an analyzer body, and is characterized in that the analyzer body comprises a detection case, a detection storage box and a main control case, wherein the top of the detection case is provided with the detection storage box, the detection case is fixedly connected with the detection storage box, the top of the detection storage box is provided with a movable end cover, the inside of the detection storage box is provided with a kit seat disk, the kit seat disk is detachably connected with the detection storage box, the right side of the detection case is provided with the main control case, the top of the main control case is provided with an electronic display screen, the inside of the main control case is provided with a main control core plate, the main control core plate comprises a three-dimensional mechanical arm module, a reagent sample disk module, a cleaning detection module, a needle cross arm module, a mechanical arm module, an incubation module, a motion control module, a liquid path module and a communication module, all the modules are communicated with each other.
2. The full-automatic magnetic particle chemiluminescence immunoassay analyzer of claim 1, wherein a sample tube hole site, a kit hole site and a magnetic bead bottle hole site are sequentially arranged on the kit seat tray from outside to inside, the sample tube hole site, the kit hole site and the magnetic bead bottle hole site are respectively used for placing a sample tube, a kit and a magnetic bead bottle, and the magnetic bead bottle has a mixing function and is mixed uniformly by adopting a gear rotation mode.
3. The fully automatic magnetic particle chemiluminescence immunoassay analyzer of claim 2, wherein there are 60 sample tube well sites, 20 reagent kit well sites, and 20 magnetic bead vial well sites.
4. The full-automatic magnetic particle chemiluminescence immunoassay analyzer of claim 3, wherein the three-dimensional mechanical arm module is responsible for holding a reaction tube rack, and the built-in manipulator is used for completing a series of actions of moving the reaction tube to the incubation tray, cleaning the detection tray and finally throwing the reaction tube to the waste barrel.
5. The full-automatic magnetic particle chemiluminescence immunoassay analyzer of claim 4, wherein the cleaning and detection module comprises a cleaning module and a detection module, the cleaning module is used for cleaning magnetic beads, the detection module is used for performing fluorescence detection, and the spectral measurement range of the detection module is 300 nm-650 nm.
6. The fully automatic magnetic particle chemiluminescence immunoassay analyzer of claim 5, wherein the pin cross arm module employs a sample loading pin for sample loading and reagent loading.
7. The fully automated magnetic particle chemiluminescence immunoassay analyzer of claim 6, wherein the incubation module comprises an incubation tray with a 90-well design, temperature accuracy of the set value ± 0.2 ℃ and temperature fluctuation of no more than 0.5 ℃.
8. The full-automatic magnetic particle chemiluminescence immunoassay analyzer of claim 7, wherein the communication module communicates by using a CAN-BUS system BUS.
9. The full-automatic magnetic particle chemiluminescence immunoassay analyzer according to claim 8, wherein the sample preparation precision CV of the analyzer body at 100 μ L is less than 1%.
10. The full-automatic magnetic particle chemiluminescence immunoassay analyzer according to claim 9, wherein the linear correlation coefficient r of the analyzer body is not less than 0.99 within a concentration range of not less than 2 orders of magnitude, the in-batch measurement repeatability of the analyzer body is not more than 8% of the coefficient of variation CV.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201920807728.3U CN210155150U (en) | 2019-05-29 | 2019-05-29 | Full-automatic magnetic particle chemiluminescence immunoassay analyzer |
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| CN201920807728.3U CN210155150U (en) | 2019-05-29 | 2019-05-29 | Full-automatic magnetic particle chemiluminescence immunoassay analyzer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112147338A (en) * | 2020-08-31 | 2020-12-29 | 浙江博实生物科技有限公司 | Time-resolved fluorescence immunoassay kit for detecting immunoglobulin G4, and preparation method and detection method thereof |
| CN112180104A (en) * | 2020-08-31 | 2021-01-05 | 浙江博实生物科技有限公司 | Time-resolved fluorescence immunoassay kit based on anti-mullerian hormone AMH, and preparation method and detection method thereof |
-
2019
- 2019-05-29 CN CN201920807728.3U patent/CN210155150U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112147338A (en) * | 2020-08-31 | 2020-12-29 | 浙江博实生物科技有限公司 | Time-resolved fluorescence immunoassay kit for detecting immunoglobulin G4, and preparation method and detection method thereof |
| CN112180104A (en) * | 2020-08-31 | 2021-01-05 | 浙江博实生物科技有限公司 | Time-resolved fluorescence immunoassay kit based on anti-mullerian hormone AMH, and preparation method and detection method thereof |
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Granted publication date: 20200317 |