CN208818553U - Liquid-based pelleter - Google Patents
Liquid-based pelleter Download PDFInfo
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- CN208818553U CN208818553U CN201821291633.2U CN201821291633U CN208818553U CN 208818553 U CN208818553 U CN 208818553U CN 201821291633 U CN201821291633 U CN 201821291633U CN 208818553 U CN208818553 U CN 208818553U
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Abstract
The utility model provides a kind of liquid-based pelleter, includes frame structure, displacement drive and film-making functional unit;The displacement drive and film-making functional unit are respectively mounted on the frame structure, and the displacement drive includes transport structure and picks and places structure, are picked and placed structure and are mounted on transport structure;The frame structure includes pedestal (1), shield (2) and support frame (3), pedestal (1) and shield (2) are detachably connected and form protective zone in inside, and support frame as described above (3) and film-making functional unit are installed in protective zone.The utility model reduces size so that compact overall structure is reasonable by the position for all parts of reasonably arranging, and saves manufacturing cost;Moving displacement of transport structure during entire film-making is reduced simultaneously, reduces energy consumption.
Description
Technical field
The utility model relates to medical instruments fields, and in particular, to a kind of liquid-based pelleter.
Background technique
Liquid-based pelleter is used for the film-making before pathological analysis to human body cell sample, is turned by stirring, cell absorption, cell
Move, cell filtering device composition, be aim at clinic, disease control, quality inspection, quality department all kinds of specialized laboratories automatic sheet
And the product manufactured and designed.Liquid-based pelleter be according to liquid based cytology principle, using low adsorption micro porous filtration membrane filtration technique,
By film bat printing mode, cooperates dedicated Sample dilution and the high absorption glass slide of cation, one is made on glass slide
Uniform cell thin, convenient for further examining and diagnosing.
A possibility that existing liquid-based pelleter usually requires human assistance operation, and there are operator and sample contacts,
The convenience used and safety all existing defects.
Utility model content
For the defects in the prior art, the purpose of the utility model is to provide a kind of liquid-based pelleters.
It include frame structure, displacement drive and film-making function according to liquid-based pelleter provided by the utility model
Component;
The displacement drive and film-making functional unit are respectively mounted on the frame structure, and the displacement drive includes
Transport structure and pick-and-place structure, pick and place structure and are mounted on transport structure;
The frame structure includes pedestal, shield and support frame, and pedestal connect with shield and formed in inside anti-
Space is protected, the film-making functional unit is mounted in protective zone, and support frame is mounted in protective zone in whole or in part.
Preferably, X-axis guide rail is provided on support frame as described above, transport structure includes crossbeam, and crossbeam is along length extending direction
Both ends be slidably connected in two X-axis guide rails respectively;
X-axis driving device is provided on support frame and/or crossbeam, the X-axis driving device can drive crossbeam to lead along X-axis
Rail sliding.
Preferably, transport structure also includes Y-axis driving device and Y-axis connector, and the Y-axis connector is slidably mounted on cross
Liang Shang, Y-axis driving device driving Y-axis connector are moved along crossbeam length extending direction;The pick-and-place fastening structure is mounted on Y-axis
On connector.
Preferably, X-axis driving device and/or Y-axis driving device include following any or various structures: lead screw knot
Structure, gear & rack structure, roller structure, air pressure rod structure, hydraulic cylinder structure.
It preferably, include the first clamping jaw, the second clamping jaw and liquid absorption device in multiple pick-and-place structures;Pick and place structure and Y
Shaft coupling piece quantitatively corresponds or exists different;Z axis displacement knot is provided on one or more of Y-axis connectors
Structure.
Preferably, liquid absorption device includes the main part and TIP mounting portion for being integrally formed or being fastenedly connected, the axis of main part
The central axes of line and TIP mounting portion are not arranged on the same straight line.
Preferably, film-making functional unit includes Sputum cup apparatus for placing, filter cup apparatus for placing, the load glass of installation on the base
Piece apparatus for placing, TIP apparatus for placing, concussion instrument, cap rotating device, filter module group.
Preferably, Sputum cup apparatus for placing, filter cup apparatus for placing, glass slide apparatus for placing are along base length extending direction
On be sequentially arranged;In addition concussion instrument and cap rotating device are mounted on side where Sputum cup apparatus for placing, and filter module group is mounted on filter cup
Side where apparatus for placing, TIP apparatus for placing are mounted on side where glass slide apparatus for placing.
Preferably, the cap rotating device is equipped with diaphragm pump;
The glass slide apparatus for placing includes glass frame, and glass frame is equipped with heating device;
The filter module group includes filter cup clamping device, glass slide overturning structure, vacuum slot and vacuum tracheae;It crosses
The clamping space of filter cup, the clamping space of glass slide are respectively arranged on filter bowl clamping device, glass slide overturning structure;Filtering
Cup clamping device is mounted on the side of glass slide overturning structure;Filter cup clamping device, glass slide overturning structure have been separately equipped with
Filter cup clamping cylinder, glass slide tumble cylinder;Glass slide overturning structure is flipped under the driving of glass slide tumble cylinder,
And on the rim of a cup for the filter cup that glass slide is attached in filter cup clamping device;Vacuum slot is connected with vacuum tracheae, vacuum
Suction nozzle is equipped with suction nozzle driving cylinder;Vacuum tracheae is along the both ends of length extending direction with respect to another with vacuum slot connecting pin
One end is connected with vacuum generator.
It preferably, also include display screen, the display screen installation on the frame structure, and is located at except protective zone.
Compared with prior art, the utility model have it is following the utility model has the advantages that
1, the utility model reduces ruler so that compact overall structure is reasonable by the position for all parts of reasonably arranging
It is very little, save manufacturing cost;Moving displacement of transport structure during entire film-making is reduced simultaneously, reduces energy consumption;
2, realize really liquefaction film-making: all samples add digestive juice and buffer automatically, realize sample liquefaction;
3, the utility model is filtered using film: film bat printing rate is high, and enrichment is efficient;
4, it is equipped with display screen, it is easily operated, it is easily understood;
5, bio-safety: covered, liquefaction sterilization processing is realized;
6, the entire film-making process of the utility model can be realized automatically, be not necessarily to human intervention.
Detailed description of the invention
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other spies of the utility model
Sign, objects and advantages will become more apparent upon:
Fig. 1 is the schematic perspective view after liquid-based pelleter hidden parts shield;
Fig. 2 is liquid-based pelleter protective zone schematic diagram of internal structure;
Fig. 3 is liquid-based pelleter front view;
Fig. 4 is liquid absorption device and filter module group structural schematic diagram;
Fig. 5 is liquid-based flaking method flow chart.
It is shown in figure:
Specific embodiment
The utility model is described in detail combined with specific embodiments below.Following embodiment will be helpful to this field
Technical staff further understands the utility model, but does not limit the utility model in any form.It should be pointed out that ability
For the those of ordinary skill in domain, without departing from the concept of the premise utility, various modifications and improvements can be made.
These are all within the protection scope of the present invention.
In the description of the present invention, it should be understood that term " on ", "lower", "front", "rear", "left", "right",
The orientation or positional relationship of the instructions such as "vertical", "horizontal", "top", "bottom", "inner", "outside" be orientation based on the figure or
Positional relationship is merely for convenience of describing the present invention and simplifying the description, rather than the device or member of indication or suggestion meaning
Part must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.
As shown in Figure 1 to Figure 3, liquid-based pelleter provided by the utility model include frame structure, displacement drive with
And film-making functional unit;The displacement drive and film-making functional unit are respectively mounted on the frame structure, the displacement drive
Component includes transport structure and picks and places structure, picks and places structure and is mounted on transport structure.
The frame structure includes pedestal 1, shield 2 and support frame 3, and pedestal 1 connect with shield 2 and in internal shape
At protective zone, the film-making functional unit is mounted in protective zone, and support frame 3 is mounted on protective zone in whole or in part
In.In embodiment, the shield 2 includes side panel and main panel, and side panel is directly installed on pedestal 1 and support frame 3, and
Main panel is then hingedly mounted on support frame 3, that is to say, that main panel is indirectly attached on pedestal 1 by support frame 3, convenient
It opens or closes so that protective zone internal structure is operated or be protected.
Be provided with X-axis guide rail 4 on support frame as described above 3, transport structure includes crossbeam 5, crossbeam 5 along length extending direction two
End is slidably connected at respectively in two X-axis guide rails 4;X-axis driving device 6, the X-axis are provided on support frame 3 and/or crossbeam 5
Driving device 6 can drive crossbeam 5 to slide along X-axis guide rail 4.
Transport structure also includes Y-axis driving device 7 and Y-axis connector 8, and the Y-axis connector 8 is slidably mounted on crossbeam 5
On, Y-axis driving device 7 drives Y-axis connector 8 to move along 5 length extending direction of crossbeam;The pick-and-place fastening structure is mounted on Y
On shaft coupling piece 8.
X-axis driving device 6 and/or Y-axis driving device 7 include following any or various structures: screw structure, gear
Rack structure, roller structure, air pressure rod structure, hydraulic cylinder structure.For screw structure, gear & rack structure, electricity can be passed through
Machine driving is simultaneously completed self-locking after crossbeam 5 reaches target position;For roller structure, friction pair can be configured, when crossbeam 5 reaches
Behind target position, by being frictionally held on support frame 3;By taking X-axis driving device 6 as an example, for air pressure rod structure or hydraulic
Rod structure, both ends are connected with crossbeam 5, support frame 3 respectively, are moved in the X-axis direction by flexible driving crossbeam 5.Certainly, the X
Axial brake device 6 and/or Y-axis driving device 7 can also be that other can generate the structure of straight-line displacement, such as linear motor
Deng.
It include the first clamping jaw 9, the second clamping jaw 10 and liquid absorption device 11 in multiple pick-and-place structures;Pick and place structure and Y-axis
Connector 8 quantitatively corresponds or exists different;Z axis displacement knot is provided on one or more of Y-axis connectors 8
Structure.In practical application, the first clamping jaw 9 is inhaled for clamping Sputum cup and filter plate, second clamping jaw 10 for clamping glass slide
Liquid device 11 is for installing TIP (i.e. pipetting head or fluid suction head).The Z axis displacement structure picks and places structure in upper and lower for adjusting
Upward position, specifically can be pneumatic structure, hydraulic structure, screw structure or linear motor etc. can generate straight-line displacement
Structure.
Preferably, liquid absorption device 11 includes the main part 12 and TIP mounting portion 13 for being integrally formed or being fastenedly connected, main part
12 central axes and the central axes of TIP mounting portion 13 are not arranged on the same straight line.
Film-making functional unit includes Sputum cup apparatus for placing 14, the filter cup apparatus for placing 15, glass slide being mounted on pedestal 1
Apparatus for placing 16, TIP apparatus for placing 17, concussion instrument 18, cap rotating device 19, filter module group 20.In embodiment, Sputum cup apparatus for placing
14, filter cup apparatus for placing 15, glass slide apparatus for placing 16 are sequentially arranged along base length extending direction;In addition concussion instrument
18 are mounted on 14 place side of Sputum cup apparatus for placing with cap rotating device 19, and filter module group 20 is mounted on where filter cup apparatus for placing 15
Side, TIP apparatus for placing 17 are mounted on 16 place side of glass slide apparatus for placing.It, on the one hand being capable of root by the arrangement of above-mentioned position
Space distribution is rationally carried out according to the size of each film-making functional unit, reduces the size of protective zone;On the other hand, in conjunction with
Liquid-based pelleter carries out the operating process of film-making, reduces the move distance of displacement drive, reduces power consumption.
Preferably, the cap rotating device 19 is equipped with diaphragm pump, for buffering to be added in the Sputum cup on cap rotating device 19
Liquid.
Preferably, the glass slide apparatus for placing 16 includes glass frame, and glass slide apparatus for placing 16 is for placing glass slide.
Preferably, glass frame is equipped with heating device.
Preferably, as shown in figure 4, the filter module group 20 include filter cup clamping device, it is glass slide overturning structure 22, true
Suction mouth and vacuum tracheae 25;The clamping of filter cup is respectively arranged on filter cup clamping device, glass slide overturning structure 22
Space, glass slide clamping space;Filter cup clamping device is mounted on the side of glass slide overturning structure 22;Filter cup clamps dress
It sets, glass slide overturning structure 22 has been separately equipped with filter cup clamping cylinder 21, glass slide tumble cylinder 23;Glass slide overturns structure
22 are flipped under the driving of glass slide tumble cylinder 23, and glass slide is made to be attached to the filter cup in filter cup clamping device
Rim of a cup on.The vacuum slot is connected with vacuum tracheae 25, and wherein vacuum slot is equipped with suction nozzle driving cylinder 24, for driving
The filter cup that dynamic vacuum slot moves up and down to be inserted into or leave on filter cup clamping device;Vacuum tracheae 25 is along length extension side
To both ends in respect to the other end with vacuum slot connecting pin be connected with vacuum generator.
Preferably, the pick-and-place structure also includes compression socket cap, and the compression socket cap is for glass slide to be pressed on
Bat printing operation is carried out on filter cup.The process of the bat printing are as follows: glass slide is overturn by glass slide overturning structure 22, is pressed in
On filter cup, at this moment glass slide and filter cup compress can bat printing, while in order to increase bat printing effect, vacuum generator can pressed
It is next, vacuum is bled off suddenly, due to the pressure of negative pressure recoil, can also increase bat printing effect.
Preferably, liquid-based pelleter also includes display screen 26, and the installation of display screen 26 on the frame structure, and is located at anti-
It protects except space.Display screen 26 is connected with film-making functional unit, in conjunction with the application of sensor, is displayed for the state of instrument
Number of samples is selected with for user, can also realize the functions such as prompt alarm.
As shown in figure 5, the use of the method that liquid-based pelleter provided by the utility model carries out liquid-based film-making including following step
Rapid: Sputum cup processing step: handling Sputum cup internal specimen liquid, obtains pretreating liquid;Filter cup action step: will be pre-
Film-making liquid is obtained by filtration in treatment liquid in filter cup;Glass slide action step: glass slide contacts the mistake for filling film-making liquid
Filter bowl carries out bat printing, obtains Thinprep.
The Sputum cup processing step includes to puncture concussion step and stirring imbibing step;
The concussion step that punctures comprises the steps of:
Step S1.1.1: the Sputum cup equipped with sample liquid on Sputum cup apparatus for placing 14 is punctured, injects and disappears in Sputum cup
Change liquid;
Step S1.1.2: by Sputum cup clamping to concussion instrument 18, setting time is shaken;
The stirring imbibing step comprises the steps of:
Step S1.2.1: by Sputum cup clamping to cap rotating device 19, Sputum cup lid is unscrewed;
Step S1.2.2: buffer is added into Sputum cup;
Step S1.2.3: liquid absorption device 11 drives TIP to be inserted into Sputum cup and is stirred acquisition in advance to Sputum cup internal liquid
Treatment liquid enables and draws TIP absorption pretreating liquid;
Step S1.2.4: after cap rotating device 19 screws Sputum cup lid, Sputum cup clamping is put back into Sputum cup apparatus for placing 14
On.
The concussion step that punctures also includes step S1.1.3: the Sputum cup clamping after concussion is put back into Sputum cup apparatus for placing
On 14, S1.1.1 is returned to step, until Sputum cup completion all on Sputum cup apparatus for placing 14 is punctured and operated with concussion;
In the step S1.1.2, the setting time of concussion is 5~10s;
In the step S1.2.2, buffer is added into Sputum cup using diaphragm pump;
In the step S1.2.3, TIP bias is inserted into Sputum cup.
The filter cup action step comprises the steps of:
Step S2.1: filter cup is taken out from filter cup apparatus for placing 15, and is loaded into filter module group 20;
Step S2.2: making vacuum slot withstand filter cup, takes out negative pressure to filter cup inside;
Step S2.3: after the pretreating liquid in TIP is injected into filter cup, TIP is pulled out from liquid absorption device 11;
Step S2.4: the filtering upper cover of filter cup is chosen.
In the step S2.2, vacuum slot, which moves upwards, withstands filter cup, by vacuum generator to filter cup inside
Take out negative pressure;
In the step S2.3, after TIP is moved to above filter cup, the pretreating liquid in TIP will be injected into
In filter bowl;TIP is pulled out after TIP is moved to abandoned stope.
Glass slide action step comprises the steps of:
Step S3.1: glass slide is taken out from glass slide apparatus for placing 16;
Step S3.2: glass slide is placed in filter module group 20 and carries out 90 degree of overturnings;
Step S3.3: glass slide contact filtration cup carries out bat printing;
Step S3.4: the glass slide for completing bat printing is taken out, and is returned the slide into glass slide apparatus for placing 16.
In the step S3.3, glass slide is pressed on filter cup using compression socket cap and carries out bat printing;It is true when bat printing
Empty generator bleeds off vacuum, under the action of negative pressure kickback pressure, increases bat printing effect.
Liquid-based flaking method also comprises the steps of:
Step S4.1: filtering upper cover is pushed back on filter cup;
Step S4.2: filter plate is put back on filter cup apparatus for placing 15.
The first clamping jaw 9 that the Sputum cup passes through setting with filter plate is clamped, the second folder that glass slide passes through setting
Pawl 10 is clamped.The filter cup includes low adsorption micropore filtering film;The glass slide, which includes that cation is high, adsorbs glass slide.
Preferred embodiment:
1.1 sample disc capacity: 1-36;It can be determined according to sample size difference.
1.2 automatic sheet processes are full-automatic, and overall flow is divided into: concussion, digestion, liquid feeding, dilution, filtering, film-making
Etc. processes.
When 1.3 film-makings are completed, smear has been dried, and can be directly used for dyeing microscopic examination.
1.4 film-making digestion process samples are not necessarily to manual operation intervention, ensure that the safety of reviewer.
1.5 use advanced membrane filtration technique and film transfer technique, so that smear is uniformly distributed, transfer efficiency is high.
1.6 automation ultraviolet disinfections, automatically turn on ultraviolet sterilization after operation.
1.7 capacity: 1-36 slides can be once dyed, per hour film-making >=50 slide.
1.8 clients, which only need to add Sputum cup and filter cup, can start film-making.
1.9 entire digestion process are carried out in Sputum cup, and reviewer does not have the risk of biohazard.
1.10 totally-enclosed systems do not need not pollute laboratory environment close to sink.
1.11 touch screen operations, can customize number of samples.
1.12 complete Chinese operation interfaces, 10 cun of Flat panel touch display screen visualized operations, operation is very easy.
Full sensing module built in 1.13, can detecte whether each consumptive material is ready to.
1.14 can be configured for different samples, sputum specimen, Pleural effusions, cerebrospinal fluid, irrigating solution, urine, human body
Cast-off cells sample.
Specific embodiment of the utility model is described above.It is to be appreciated that the utility model not office
It is limited to above-mentioned particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims,
This has no effect on the substantive content of the utility model.In the absence of conflict, the spy in embodiments herein and embodiment
Sign can be arbitrarily combined with each other.
Claims (10)
1. a kind of liquid-based pelleter, which is characterized in that include frame structure, displacement drive and film-making functional unit;
The displacement drive and film-making functional unit are respectively mounted on the frame structure, and the displacement drive includes to transport
Structure and pick-and-place structure, pick and place structure and are mounted on transport structure;
The frame structure includes pedestal (1), shield (2) and support frame (3), pedestal (1) connect with shield (2) and
Inside forms protective zone, and the film-making functional unit is mounted in protective zone, and support frame (3) is mounted on anti-in whole or in part
It protects in space.
2. liquid-based pelleter according to claim 1, which is characterized in that support frame as described above is provided with X-axis guide rail on (3)
(4), transport structure includes crossbeam (5), and crossbeam (5) is slidably connected at two X-axis guide rails along the both ends of length extending direction respectively
(4) on;
It is provided with X-axis driving device (6) on support frame (3) and/or crossbeam (5), the X-axis driving device (6) can drive cross
Beam (5) is slided along X-axis guide rail (4).
3. liquid-based pelleter according to claim 2, which is characterized in that transport structure also include Y-axis driving device (7) with
Y-axis connector (8), the Y-axis connector (8) are slidably mounted on crossbeam (5), and Y-axis driving device (7) drives Y-axis connector
(8) it is moved along crossbeam (5) length extending direction;The pick-and-place fastening structure is mounted on Y-axis connector (8).
4. liquid-based pelleter according to claim 3, which is characterized in that X-axis driving device (6) and/or Y-axis driving device
(7) comprising following any or appoint various structures: screw structure, gear & rack structure, roller structure, air pressure rod structure, hydraulic
Cylinder structure.
5. liquid-based pelleter according to claim 3, which is characterized in that include the first clamping jaw in multiple pick-and-place structures
(9), the second clamping jaw (10) and liquid absorption device (11);Structure and Y-axis connector (8) are picked and placed quantitatively to correspond or exist
It is different;Z axis displacement structure is provided on one or more of Y-axis connectors (8).
6. liquid-based pelleter according to claim 5, which is characterized in that liquid absorption device (11) includes to be integrally formed or fasten
The main part (12) of connection and TIP mounting portion (13), the central axes of main part (12) and the central axes of TIP mounting portion (13) do not exist
On same straight line.
7. liquid-based pelleter according to claim 1, which is characterized in that film-making functional unit includes to be mounted on pedestal (1)
On Sputum cup apparatus for placing (14), filter cup apparatus for placing (15), glass slide apparatus for placing (16), TIP apparatus for placing (17), shake
Swing instrument (18), cap rotating device (19), filter module group (20).
8. liquid-based pelleter according to claim 7, which is characterized in that Sputum cup apparatus for placing (14), filter cup place dress
Set (15), glass slide apparatus for placing (16) is sequentially arranged along base length extending direction;In addition concussion instrument (18) and spiral cover
Device (19) is mounted on side where Sputum cup apparatus for placing (14), and filter module group (20) is mounted on where filter cup apparatus for placing (15)
Side, TIP apparatus for placing (17) are mounted on side where glass slide apparatus for placing (16).
9. liquid-based pelleter according to claim 7, which is characterized in that the cap rotating device (19) is equipped with diaphragm pump;
The glass slide apparatus for placing (16) includes glass frame, and glass frame is equipped with heating device;
The filter module group (20) includes filter cup clamping device, glass slide overturning structure (22), vacuum slot and vacuum gas
It manages (25);Filter cup clamping device, glass slide overturn the clamping space, glass slide that filter cup is respectively arranged on structure (22)
Clamp space;Filter cup clamping device is mounted on the side of glass slide overturning structure (22);Filter cup clamping device, glass slide turn over
Rotation structure (22) has been separately equipped with filter cup clamping cylinder (21), glass slide tumble cylinder (23);Glass slide overturns structure (22)
It is flipped under the driving of glass slide tumble cylinder (23), and glass slide is made to be attached to the filter cup in filter cup clamping device
Rim of a cup on;Vacuum slot is connected with vacuum tracheae (25), and vacuum slot is equipped with suction nozzle driving cylinder (24);Vacuum tracheae
(25) vacuum generator is connected with respect to the other end with vacuum slot connecting pin along the both ends of length extending direction.
10. liquid-based pelleter according to claim 1, which is characterized in that also include display screen (26), the display screen
(26) it installs on the frame structure, and is located at except protective zone.
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CN2018212067576 | 2018-07-27 | ||
CN201821206757 | 2018-07-27 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108613860A (en) * | 2018-07-27 | 2018-10-02 | 上海皓信生物科技有限公司 | Liquid-based pelleter |
CN110186737A (en) * | 2019-06-27 | 2019-08-30 | 宁波舜宇仪器有限公司 | A kind of liquid-based specimens film-making dyeing all-in-one machine |
-
2018
- 2018-08-12 CN CN201821291633.2U patent/CN208818553U/en active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108613860A (en) * | 2018-07-27 | 2018-10-02 | 上海皓信生物科技有限公司 | Liquid-based pelleter |
CN110186737A (en) * | 2019-06-27 | 2019-08-30 | 宁波舜宇仪器有限公司 | A kind of liquid-based specimens film-making dyeing all-in-one machine |
CN110186737B (en) * | 2019-06-27 | 2023-06-20 | 宁波舜宇仪器有限公司 | Liquid-based sample slice-making and dyeing integrated machine |
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