CN108613860A - Liquid-based pelleter - Google Patents

Abstract

The present invention provides a kind of liquid-based pelleters, including frame structure, displacement drive and film-making functional unit；The displacement drive is respectively mounted on the frame structure with film-making functional unit, and the displacement drive includes transport structure and picks and places structure, picks and places structure on transport structure；The frame structure includes pedestal (1), protective cover (2) and supporting rack (3), pedestal (1) is detachably connected with protective cover (2) and forms protective zone in inside, and support frame as described above (3) is installed in film-making functional unit in protective zone.The position that the present invention passes through all parts of reasonably arranging so that compact overall structure is reasonable, reduces size, saves manufacturing cost；Moving displacement of transport structure during entire film-making is reduced simultaneously, reduces energy consumption.

Description

Liquid-based tablet machine

technical field

The invention relates to the field of medical devices, in particular to a liquid-based tablet maker.

Background technique

The liquid-based film maker is used for the preparation of human cell specimens before pathological analysis. It is composed of stirring, cell adsorption, cell transfer, and cell filtration devices. It is specially designed for various professional experiments in clinical, disease control, quality inspection, and quality departments. It is a product designed and manufactured for the automated production of chambers. The liquid-based film maker is based on the principle of liquid-based cytology, adopts low-adsorption microporous filtration membrane filtration technology, and through membrane pad printing, cooperates with a special sample diluent and a cationic high-adsorption slide to make a slide on the slide. A uniform thin layer of cells facilitates further examination and diagnosis.

Existing liquid-based tablet machines usually require manual assistance, and there is a possibility that the operator may come into contact with the sample, and there are defects in the convenience and safety of use.

Contents of the invention

Aiming at the defects in the prior art, the object of the present invention is to provide a liquid-based tablet maker.

The liquid-based tablet-making machine provided according to the present invention includes a frame structure, a displacement drive assembly and a tablet-making functional assembly;

Both the displacement drive assembly and the film-making functional assembly are installed on the frame structure, the displacement drive assembly includes a transport structure and a pick-and-place structure, and the pick-and-place structure is installed on the transport structure;

The frame structure includes a base, a protective cover and a support frame. The base is connected with the protective cover to form a protective space inside. The film-making functional components are installed in the protective space, and the support frame is installed in whole or in part in the protective space.

Preferably, the support frame is provided with X-axis guide rails, the transport structure includes a beam, and the two ends of the beam along the length extension direction are respectively slidably connected to two X-axis guide rails;

An X-axis drive device is provided on the support frame and/or the crossbeam, and the X-axis drive device can drive the crossbeam to slide along the X-axis guide rail.

Preferably, the transport structure also includes a Y-axis driving device and a Y-axis connecting piece, the Y-axis connecting piece is slidably mounted on the beam, and the Y-axis driving device drives the Y-axis connecting piece to move along the length extension direction of the beam; the pick-and-place The structure is firmly mounted on the Y-axis connector.

Preferably, the X-axis driving device and/or the Y-axis driving device includes any one or more of the following structures: a screw structure, a rack and pinion structure, a roller structure, a pneumatic rod structure, and a hydraulic cylinder structure.

Preferably, a plurality of pick-and-place structures include a first jaw, a second jaw, and a liquid suction device; the pick-and-place structure and the Y-axis connector are in one-to-one correspondence or are different in number; the one or more Y The shaft connector is provided with a Z-axis displacement structure.

Preferably, the liquid suction device includes a main body part and a TIP installation part integrally formed or fastened, and the central axis of the main body part and the central axis of the TIP installation part are not on the same straight line.

Preferably, the film-making functional components include a sputum cup placement device, a filter cup placement device, a glass slide placement device, a TIP placement device, an oscillator, a cap screwing device, and a filtration module installed on the base.

Preferably, the sputum cup placement device, the filter cup placement device, and the glass slide placement device are sequentially arranged along the length of the base; in addition, the vibrator and the capping device are installed on the side where the sputum cup placement device is located, and the filter module is installed on the filter The side where the cup placement device is located, and the TIP placement device is installed on the side where the glass slide placement device is located.

Preferably, the capping device is equipped with a diaphragm pump;

The slide placement device includes a slide rack, and the slide rack is equipped with a heating device;

The filter module includes a filter cup clamping device, a glass slide turning structure, a vacuum nozzle and a vacuum air pipe; the filter cup clamping device and the glass slide turning structure are respectively provided with a clamping space for the filter cup, a glass slide clamping space; the filter cup clamping device is installed on one side of the slide flipping structure; the filter cup clamping device and the slide flipping structure are respectively equipped with a filter cup clamping cylinder and a slide flipping cylinder; The slide turning structure is turned over by the drive of the slide turning cylinder, and makes the slide stick on the cup opening of the filter cup in the filter cup clamping device; the vacuum suction nozzle is connected with the vacuum air pipe, and the vacuum suction nozzle is equipped with a suction The nozzle drives the air cylinder; the other end of the two ends of the vacuum air pipe along the length extension direction opposite to the connection end of the vacuum suction nozzle is connected with a vacuum generator.

Preferably, a display screen is also included, and the display screen is installed on the frame structure and located outside the protected space.

Compared with the prior art, the present invention has the following beneficial effects:

1. By rationally arranging the positions of each component, the present invention makes the overall structure compact and reasonable, reduces the size, and saves manufacturing costs; at the same time, it reduces the movement displacement of the transport structure during the entire tablet production process and reduces energy consumption;

2. Realize real liquefaction film production: all samples are automatically added with digestive fluid and buffer solution to realize sample liquefaction;

3. The present invention adopts membrane filtration: the membrane printing rate is high, and the enrichment is efficient;

4. Equipped with a display screen, easy to operate and understand;

5. Biological safety: realize liquefaction and sterilization without opening the cover;

6. The entire production process of the present invention can be fully automated without human intervention.

Description of drawings

Other characteristics, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings:

Fig. 1 is a three-dimensional structural schematic diagram of a liquid-based film maker with a part of the protective cover hidden;

Figure 2 is a schematic diagram of the internal structure of the protective space of the liquid-based film maker;

Fig. 3 is the front view of the liquid-based film maker;

Fig. 4 is a schematic structural diagram of a liquid suction device and a filter module;

Fig. 5 is a flow chart of the liquid-based tablet making method.

The figure shows:

Detailed ways

The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

In describing the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", The orientation or positional relationship indicated by "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the referred device Or elements must have a certain orientation, be constructed and operate in a certain orientation, and thus should not be construed as limiting the invention.

As shown in Figures 1 to 3, the liquid-based tablet machine provided by the present invention includes a frame structure, a displacement drive assembly, and a film-making functional assembly; the displacement drive assembly and the film-making functional assembly are all installed on the frame structure, and the The displacement drive assembly includes a transport structure and a pick-and-place structure, and the pick-and-place structure is installed on the transport structure.

The frame structure includes a base 1, a protective cover 2 and a support frame 3, the base 1 is connected with the protective cover 2 and forms a protective space inside, the film-making functional components are installed in the protective space, and the support frame 3 is wholly or partially Installed in a protected space. In the embodiment, the protective cover 2 includes a side panel and a main panel, the side panel is directly installed on the base 1 and the support frame 3, and the main panel is hingedly installed on the support frame 3, that is to say, the main panel is supported by The frame 3 is indirectly installed on the base 1, which is convenient to open or close to operate or protect the internal structure of the protected space.

The support frame 3 is provided with an X-axis guide rail 4, and the transport structure includes a crossbeam 5, and the two ends of the crossbeam 5 along the length extension direction are respectively slidably connected to the two X-axis guide rails 4; the support frame 3 and/or the crossbeam 5 An X-axis driving device 6 is provided, and the X-axis driving device 6 can drive the beam 5 to slide along the X-axis guide rail 4 .

The transport structure also includes a Y-axis drive device 7 and a Y-axis connector 8, the Y-axis connector 8 is slidably mounted on the beam 5, and the Y-axis drive device 7 drives the Y-axis connector 8 to move along the length extension direction of the beam 5; The pick-and-place structure is fastened on the Y-axis connector 8 .

The X-axis driving device 6 and/or the Y-axis driving device 7 include any one or more of the following structures: a screw structure, a rack and pinion structure, a roller structure, a pneumatic rod structure, and a hydraulic cylinder structure. For the screw structure and the rack and pinion structure, it can be driven by a motor and complete self-locking after the beam 5 reaches the target position; for the roller structure, a friction pair can be configured, and when the beam 5 reaches the target position, it is fixed on the support frame by friction 3 above; taking the X-axis driving device 6 as an example, for the pneumatic rod structure or the hydraulic rod structure, the two ends are respectively connected with the beam 5 and the support frame 3, and the beam 5 is driven to move along the X-axis direction through stretching. Of course, the X-axis driving device 6 and/or the Y-axis driving device 7 may also be other structures capable of producing linear displacement, such as linear motors.

The multiple pick-and-place structures include the first jaw 9, the second jaw 10, and the liquid suction device 11; the pick-and-place structure and the Y-axis connector 8 correspond to each other or are different in number; the one or more The Y-axis connecting piece 8 is provided with a Z-axis displacement structure. In practical application, the first gripper 9 is used to grip the sputum cup and the filter plate, the second gripper 10 is used to grip the glass slide, and the liquid suction device 11 is used to install the TIP (that is, the pipetting tip or suction liquid head). The Z-axis displacement structure is used to adjust the position of the pick-and-place structure in the up-and-down direction, and may specifically be a structure capable of linear displacement such as a pneumatic structure, a hydraulic structure, a screw structure, or a linear motor.

Preferably, the liquid suction device 11 includes a body part 12 and a TIP installation part 13 that are integrally formed or fastened, and the central axis of the main body part 12 and the central axis of the TIP installation part 13 are not on the same straight line.

The film-making functional components include a sputum cup placement device 14 , a filter cup placement device 15 , a glass slide placement device 16 , a TIP placement device 17 , an oscillator 18 , a capping device 19 , and a filter module 20 installed on the base 1 . In the embodiment, the sputum cup placement device 14, the filter cup placement device 15, and the glass slide placement device 16 are sequentially arranged along the length of the base; in addition, the oscillator 18 and the cap screwing device 19 are installed on the side where the sputum cup placement device 14 is located. , the filter module 20 is installed on the side where the filter cup placement device 15 is located, and the TIP placement device 17 is installed on the side where the glass slide placement device 16 is located. Through the arrangement of the above positions, on the one hand, the space can be allocated reasonably according to the size of each film-making functional component, and the size of the protective space can be reduced; The movement distance of the displacement drive components reduces power consumption.

Preferably, the screw cap device 19 is equipped with a diaphragm pump for adding buffer solution to the sputum cup on the screw cap device 19 .

Preferably, the slide placement device 16 includes a slide rack, and the slide placement device 16 is used for placing slides. Preferably, the slide rack is equipped with a heating device.

Preferably, as shown in FIG. 4 , the filter module 20 includes a filter cup clamping device, a slide glass flipping structure 22, a vacuum suction nozzle and a vacuum air tube 25; The clamping space for the filter cup and the clamping space for the glass slide are respectively provided; the filter cup clamping device is installed on one side of the slide flipping structure 22; the filter cup clamping device and the slide glass flipping structure 22 are respectively equipped with There is a filter cup clamping cylinder 21 and a glass slide turning cylinder 23; the glass slide turning structure 22 is turned over under the drive of the glass slide turning cylinder 23, and makes the glass slide stick to the filter cup in the filter cup clamping device on the rim of the cup. The vacuum suction nozzle is connected with the vacuum air pipe 25, wherein the vacuum suction nozzle is equipped with a suction nozzle driving cylinder 24, which is used to drive the vacuum suction nozzle to move up and down to insert or leave the filter cup on the filter cup clamping device; the vacuum air pipe 25 is along the A vacuum generator is connected to the other end opposite to the end connected with the vacuum suction nozzle among the two ends in the extending direction of the length.

Preferably, the pick-and-place structure further includes a pressing cylinder head, and the pressing cylinder head is used to press the glass slide onto the filter cup for pad printing operation. The pad printing process is as follows: Flip the glass slide with the flipping structure 22 and press it on the filter cup. At this time, the slide glass and the filter cup can be pressed to pad print. At the same time, in order to increase the pad printing effect, The vacuum generator will release the vacuum suddenly after being pressed, and the pad printing effect can also be increased due to the pressure of the negative pressure recoil.

Preferably, the liquid-based tablet machine also includes a display screen 26 mounted on the frame structure and located outside the protected space. The display screen 26 is connected with the film production functional components, combined with the application of the sensor, it can be used to display the state of the instrument and allow the user to select the number of samples, and can also realize functions such as prompting and alarming.

As shown in Figure 5, the method for liquid-based tablet production using the liquid-based tablet machine provided by the present invention includes the following steps: sputum cup processing step: processing the sample liquid inside the sputum cup to obtain pre-treated liquid; filtering cup action steps : The pretreatment liquid is filtered in a filter cup to obtain a film-making liquid; slide action steps: the slide is in contact with the filter cup filled with the film-making liquid for pad printing to obtain a liquid-based sheet.

The sputum cup processing step includes a piercing and shaking step and a stirring and sucking step;

The step of piercing and shaking comprises the following steps:

Step S1.1.1: puncture the sputum cup containing the sample liquid on the sputum cup placement device 14, and inject digestive juice into the sputum cup;

Step S1.1.2: Clamp the sputum cup onto the oscillator 18, and set the time for oscillation;

The step of stirring and absorbing liquid comprises the following steps:

Step S1.2.1: Clamp the sputum cup onto the screw cap device 19, and unscrew the cover of the sputum cup;

Step S1.2.2: adding buffer solution into the sputum cup;

Step S1.2.3: The suction device 11 drives the TIP to insert into the sputum cup to stir the liquid inside the sputum cup to obtain the pretreatment liquid, so that the suction TIP absorbs the pretreatment liquid;

Step S1.2.4: After the cap screwing device 19 tightens the lid of the sputum cup, the sputum cup is clamped and put back on the sputum cup placement device 14 .

The puncturing and shaking step also includes step S1.1.3: pick and place the vibrated sputum cup back on the sputum cup placement device 14, and return to step S1.1.1 until all sputum cups on the sputum cup placement device 14 are completed Piercing and concussion operations;

In the step S1.1.2, the set time of oscillation is 5-10s;

In the step S1.2.2, a diaphragm pump is used to add buffer solution into the sputum cup;

In the step S1.2.3, the TIP is eccentrically inserted into the sputum cup.

The action steps of the filter cup include the following steps:

Step S2.1: Take out the filter cup from the filter cup placement device 15 and load it on the filter module 20;

Step S2.2: Hold the vacuum nozzle against the filter cup to draw negative pressure inside the filter cup;

Step S2.3: After injecting the pretreatment liquid in the TIP into the filter cup, unplug the TIP from the liquid suction device 11;

Step S2.4: Pull out the upper filter cover of the filter cup.

In the step S2.2, the vacuum nozzle moves upward to withstand the filter cup, and the vacuum generator draws negative pressure inside the filter cup;

In the step S2.3, after the TIP is moved above the filter cup, the pretreatment liquid in the TIP is injected into the filter cup; after the TIP is moved to the waste area, the TIP is unplugged.

The slide action step consists of the following steps:

Step S3.1: taking out the slide from the slide placement device 16;

Step S3.2: place the glass slide in the filter module 20 and flip it 90 degrees;

Step S3.3: The glass slide contacts the filter cup for pad printing;

Step S3.4: Take out the slides that have been pad-printed, and put the slides back on the slide placement device 16 .

In the step S3.3, use the compression cylinder head to press the glass slide on the filter cup for pad printing; the vacuum generator releases the vacuum during pad printing, and under the action of negative pressure recoil pressure, increase the pad printing Effect.

The liquid-based tablet method also includes the following steps:

Step S4.1: Press the filter cover back onto the filter cup;

Step S4.2: Put the filter plate back on the filter cup placement device 15 .

Both the sputum cup and the filter plate are clamped by the first clamping jaw 9 provided, and the slide glass is clamped by the second clamping jaw 10 provided. The filter cup comprises a low adsorption microporous filter membrane; the glass slide comprises a cationic high adsorption slide.

Preferred embodiment:

1.1 Sample tray capacity: 1-36; it can be determined according to the number of samples.

1.2 Automatic film production process is fully automated, the overall process is divided into: shock, digestion, liquid addition, dilution, filtration, film production and other processes.

1.3 When the film preparation is completed, the smear has been dried and can be directly used for staining microscopy.

1.4 There is no need for human intervention in the sample digestion process, which ensures the safety of the inspectors.

1.5 The advanced membrane filtration technology and membrane transfer technology are adopted to make the smear evenly distributed and the transfer efficiency is high.

1.6 Automatic ultraviolet sterilization, the ultraviolet sterilization is automatically turned on after the operation is completed.

1.7 Capacity: 1-36 slides can be stained at one time, and more than 50 slides can be produced per hour.

1.8 Customers only need to add sputum cup and filter cup to start tablet production.

1.9 The entire digestion process is carried out in the sputum cup, and there is no risk of biological hazards for the inspectors.

1.10 Fully enclosed system, no need to be close to the sink, and does not pollute the laboratory environment.

1.11 Touch screen operation, the number of samples can be customized.

1.12 full Chinese operation interface, 10-inch flat touch screen visual operation, the operation is very convenient.

1.13 Built-in full sensor module, which can detect whether each consumable is ready.

1.14 It can be set for different samples, sputum samples, pleural fluid, cerebrospinal fluid, lavage fluid, urine, human exfoliated cell samples.

Specific embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above, and those skilled in the art may make various changes or modifications within the scope of the claims, which do not affect the essence of the present invention. In the case of no conflict, the embodiments of the present application and the features in the embodiments can be combined with each other arbitrarily.

Claims (10)

1. A liquid-based film maker, characterized in that it comprises a frame structure, a displacement drive assembly and a film-making functional assembly; Both the displacement drive assembly and the film-making functional assembly are installed on the frame structure, the displacement drive assembly includes a transport structure and a pick-and-place structure, and the pick-and-place structure is installed on the transport structure; The frame structure includes a base (1), a protective cover (2) and a support frame (3), the base (1) is connected to the protective cover (2) and forms a protective space inside, and the film-making functional components are installed on In the protected space, the supporting frame (3) is installed in whole or in part in the protected space. 2. The liquid-based tablet maker according to claim 1, characterized in that, the support frame (3) is provided with an X-axis guide rail (4), and the transport structure includes a beam (5) along which the beam (5) Both ends of the length extension direction are respectively slidably connected to the two X-axis guide rails (4); An X-axis drive device (6) is arranged on the support frame (3) and/or the beam (5), and the X-axis drive device (6) can drive the beam (5) to slide along the X-axis guide rail (4). 3. The liquid-based tablet maker according to claim 2, characterized in that, the transport structure further comprises a Y-axis drive device (7) and a Y-axis connector (8), and the Y-axis connector (8) slides Installed on the beam (5), the Y-axis driving device (7) drives the Y-axis connector (8) to move along the length extension direction of the beam (5); the pick-and-place structure is tightly installed on the Y-axis connector (8) . 4. The liquid-based tablet maker according to claim 3, characterized in that, the X-axis driving device (6) and/or the Y-axis driving device (7) comprise any one or more of the following structures: lead screw structure , rack and pinion structure, roller structure, pneumatic rod structure, hydraulic cylinder structure. 5. The liquid-based tablet maker according to claim 3, characterized in that, the plurality of pick-and-place structures include a first jaw (9), a second jaw (10) and a liquid suction device (11); The pick-and-place structure and the Y-axis connectors (8) correspond one-to-one or are different in quantity; the one or more Y-axis connectors (8) are provided with a Z-axis displacement structure. 6. The liquid-based tablet making machine according to claim 5, characterized in that, the liquid suction device (11) comprises a body part (12) and a TIP installation part (13) integrally formed or tightly connected, and the body part (12 ) is not on the same straight line as the central axis of the TIP mounting portion (13). 7. The liquid-based tablet-making machine according to claim 1, characterized in that, the tablet-making functional components include a sputum cup placement device (14), a filter cup placement device (15), a carrier Slide placement device (16), TIP placement device (17), oscillator (18), cap screwing device (19), filter module (20). 8. The liquid-based film making machine according to claim 7, characterized in that, the sputum cup placement device (14), the filter cup placement device (15), and the glass slide placement device (16) are arranged in the direction extending along the length of the base Arranged sequentially; in addition, the oscillator (18) and cap screwing device (19) are installed on the side where the sputum cup placement device (14) is located, the filter module (20) is installed on the side where the filter cup placement device (15) is located, and the TIP placement device ( 17) Installed on the side where the slide placement device (16) is located. 9. The liquid-based tablet maker according to claim 7, characterized in that, the capping device (19) is equipped with a diaphragm pump; The slide placement device (16) includes a slide rack, and the slide rack is equipped with a heating device; The filter module (20) comprises a filter cup clamping device, a slide glass overturning structure (22), a vacuum suction nozzle and a vacuum air pipe (25); the filter cup clamping device, the slide glass overturning structure (22) The clamping space for the filter cup and the clamping space for the slide glass are provided; the clamping device for the filter cup is installed on one side of the slide flipping structure (22); the clamping device for the filter cup and the flipping structure for the slide glass (22) The filter cup clamping cylinder (21) and the glass slide turning cylinder (23) are equipped respectively; the glass slide turning structure (22) turns over under the drive of the glass slide turning cylinder (23), and makes the Paste on the cup mouth of the filter cup in the filter cup clamping device; the vacuum nozzle is connected with the vacuum air pipe (25), and the vacuum suction nozzle is equipped with a suction nozzle driving cylinder (24); the vacuum air pipe (25) extends along the length A vacuum generator is connected to the other end of the two ends opposite to the end connected with the vacuum suction nozzle. 10. The liquid-based tablet making machine according to claim 1, further comprising a display screen (26), the display screen (26) being installed on the frame structure and located outside the protective space.