CN201449349U - Automatic liquid based lamina cell smear machine - Google Patents
Automatic liquid based lamina cell smear machine Download PDFInfo
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- CN201449349U CN201449349U CN2009200553216U CN200920055321U CN201449349U CN 201449349 U CN201449349 U CN 201449349U CN 2009200553216 U CN2009200553216 U CN 2009200553216U CN 200920055321 U CN200920055321 U CN 200920055321U CN 201449349 U CN201449349 U CN 201449349U
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Abstract
The utility model belongs to the technical field of cell pathology detection and biological research, particularly discloses an automatic liquid based lamina cell smear machine, comprising a shell and a machine body. An inner framework, a mounting baseboard and a mounting vertical board are disposed in the machine body. The front space of the mounting baseboard and the mounting vertical board form a working cabin of the cell smear machine. An operation panel which is connected with an electrical control system disposed in the machine body is disposed in front of the shell. A sampling mechanical arm is disposed in the working cabin. A batching suction tube is sleeved on the sampling mechanical arm. A sample storage liquid cup is disposed under the sampling mechanical arm. The bottom of the sample storage liquid cup is provided with a centrifugal stirring system. A slide mounting device is disposed above the sampling mechanical arm. The left side of the slide mounting device is correspondingly provided with an automatic separating device for glass slide. A slide cup base is fixed on the mounting vertical board and is disposed on the left lower position of the slide mounting device in the working cabin. A slide cup is disposed on the slide cup base. The slide mounting device is further provided with an automatic film tube discharging device. The smear machine has excellent cell sampling efficiency. The batching suction tube having a filter film can automatically drop off without manpower. The slide can automatically drop off for efficiently preventing secondary intersecting infection, promoting the diagnostic precision and increasing the degree of automation for manufacturing slide.
Description
Technical field
The utility model belongs to cell pathology detection, biological study technical field, and is particularly a kind of from hydrodynamic based thin-layer cell smearing machine.
Background technology
At present, in medical biological study technical field, often need the pair cell sample to handle.The pair cell specimen preparation mainly adopted the mode pair cell sample of manual film-making to handle in the past, nowadays along with progress of science and technology, what worked out that the cell smear machine adopts is that the mode method pair cell sample of crust formula smear is handled, though this crust formula smear method is widely used, but can there be 6～6.5 false negative result, the composition of the efficient diagnosis in the cell can not accurately be provided; The instrument reseting performance is poor simultaneously, but also need take out quantitative suction pipe with hand.Therefore, there are some incomplete places in the process that prior art is made the cell wave plate: for example: cell transfer film pipe can not come off fully, also needs to take out with hand, and slide also is difficult to drop fully automatically, has the possibility of secondary pollution.In addition, the waste liquid passing away caliber of the mechanical arm of existing pelleter is less, the distance of waste liquid outlet and waste liquid suction pipe is far away simultaneously, the waste liquid passing away of easy etching mechanism hand when waste liquid is flowed through waste liquid eliminating passage, once, can make waste liquid get rid of passage stops up, cell is less when causing cell transfer, even white sheet phenomenon occurs, and automaticity is not high, film-making efficient is low and stop up the liquid traffic channel, maintenance rate is high, has secondary pollution.
The utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, provide a kind of from hydrodynamic based thin-layer cell smearing machine, this cell smear machine can form uniform thin-layer cell on slide, cell sample is effective, the quantitative suction pipe that has filtering membrane in addition can come off automatically and need not staff and directly unload, slide can drop automatically, effectively control by the closely device (10mm) of waste liquid outlet and waste liquid suction pipe simultaneously and stop up the liquid traffic channel, thereby make the smooth and easy maintenance rate that reduced of removal waste fluid, effectively prevent the secondary cross-infection, improve accurate rate of diagnosis, film-making automaticity height.
In order to realize above-mentioned technical purpose, the utility model is realized by following technical scheme:
Described in the utility model from hydrodynamic based thin-layer cell smearing machine, comprise casing and body, be provided with inner skeleton in the described body, base plate is installed and riser is installed, described installation base plate is fixed on the inner skeleton, described installation riser is vertically set on the top, middle part that base plate is installed, the front space of described installation base plate and installation riser forms the working bin of cell smear machine, the place ahead of described casing also is provided with the guidance panel that is connected with the set electric control system of internal body, be provided with in the described working bin and be used to sample and transfer samples to sampling mechanical arm on the slide, sampling is socketed with on the mechanical arm and is used for the quantitative suction pipe that adherent cell sample and end are provided with diaphragm, the below of described sampling mechanical arm is provided with sample retention liquid cup, the bottom of sample retention liquid cup is provided with the uniform centrifugal stirring system of the sample that makes in the sample retention liquid cup, the top of described sampling mechanical arm is provided with the slide erecting device that is used to install slide, the left side of described slide erecting device is also corresponding be provided with and with slide fall to automatically in the slide cup fall the microslide device automatically, described slide cup is fixed on the left side lower position of installing on the riser and placing slide erecting device in the working bin, the slide cup places on the slide cup, also is provided with on the described slide erecting device moving back automatically of coming off automatically of quantitative suction pipe unloaded the film pipe unit.
Further improvement as above-mentioned technology, the vertical opening chute that is provided with on the described installation riser, described sampling mechanical arm comprises the pivot arm that is arranged in the opening chute and stretches out from the place ahead of working bin, place the rear side that riser is installed to be used to control the actuator linkage of pivot arm rotation and lifting, be connected with on the described pivot arm from sample and preserve the suction sample mouth of drawing sample the cup, described suction sample mouth comprises suction nozzle lid and suction nozzle body portion, wherein the outer race on the top of suction nozzle body portion is provided with the slip pushing sleeve, the lower part of described suction sample mouth body is arranged with quantitative suction pipe, the diaphragm that the end of this quantitative suction pipe is provided with adsorbable cell and waste liquid is passed through, the top of described suction sample mouth is provided with the sampling gland, this sampling gland is connected with slip pushing sleeve one by passing the sliding axle of inhaling sample mouth cap portion, the outer race of described sliding axle is provided with compression spring, the junction of described suction sample mouth and pivot arm is provided with the waste liquid escape hole, described pivot arm inside is provided with waste liquid corresponding to the waste liquid escape hole and gets rid of passage, be provided with the waste liquid vent pipe in this waste liquid passing away, the end of described waste liquid vent pipe is provided with vacuum suction pump, to the waste liquid recycling can, the caliber of waste liquid vent pipe is 4～5mm. to this vacuum suction pump usually with waste collection
Specifically, described actuator linkage comprises the rotating driving device of driven in rotation arm rotation and the lifting drive of driven in rotation arm lifting, shown in lifting drive comprise and place the lifting motor of installing on the base plate, the belt wheel transmission one that is connected with the output shaft of lifting motor, be used for slide track component to the motion guide of belt wheel transmission one, between the slide rail bearing bottom described slide track component is installed on and the transmission upper bracket on top, described being with synchronously is connected with the lifting platen, and this lifting platen is connected on the slide rail by the slider roller group corresponding to the slide rail position; Described rotating driving device comprises electric rotating machine, the gear driving pair coaxial with the motor shaft of electric rotating machine, the follower gear of described gear driving pair is installed on the lifting platen, the gear shaft of described follower gear passes the opening chute that riser is installed fixedlys connected with the pivot arm of sampling mechanical arm, and the sampling mechanical arm is freely rotated in 360 degree scopes.
For whether the waste liquid that can monitor in real time in the waste liquid recycling can is filled, warning device when the waste liquid in the waste liquid recycling can is full of is set on the described waste liquid recycling can, this warning device comprises the signal wire that is connected waste liquid recycling can top, be installed in the hummer on the wiring board of electric control system, when the waste liquid recycling can was full, hummer sent the sound.
In the utility model; described slide erecting device comprises rotary electric machine; the support flap coaxial with rotary electric machine; the below of described support flap is connected with slide location-plate and the slide clamping plate that are used to clamp slide by coupling shaft; slide location-plate and slide clamping plate are movably hinged; and be provided with at the pin joint place of the two and be convenient to the torsion spring that the slide clamping plate reset; the top of described support flap is provided with signal plate and sensor; the periphery of this signal plate and sensor is covered with protective cover; describedly move back automatically that to unload the film pipe unit be to be fixed on to support on the flap and unload moving back of quantitative suction pipe and unload depression bar when supporting to can be used for moving back when the flap dextrorotation turn 90 degrees, this moves back and unloads depression bar is " L " type depression bar structure.
In the utility model, it is described that to fall the microslide device automatically be to be arranged on the push rod holder of the slide push rod on the riser being installed and being used for fixing the slide push rod, after the dextrorotation of described slide erecting device turn 90 degrees, the slide push rod backed down the slide clamping plate corresponding to the end position of slide clamping plate and slide is unclamped automatically and falls in the slide cup.
In order to make the cell tissue of the sample in the sample retention liquid cup can be adsorbed on uniformly on the filtration membrane of quantitative suction pipe end, top, described centrifugal stirring system comprises stirring motor, the synchronous pulley transmission two coaxial with the motor shaft of stirring motor, be connected with driven shaft by bearing, bearing cap and bearing holder (housing, cover) on the output shaft of synchronous pulley transmission two, described driven shaft passes the installation base plate and its upper end is set with sample retention liquid cup, and described sample retention liquid cup is positioned on this sample retention liquid cup.Specifically, described stirring motor places to be installed the riser rear side and places the top position that base plate is installed, and described synchronous pulley transmission comprises the synchronous tape spool coaxial with motor shaft, synchronous pulley two, synchronous band, synchronous pulley one.
Wiring board described in the utility model in the electric control system is provided with the password locking system, uses for the ease of operator's observation simultaneously, and the position of corresponding working bin is provided with the transparent panel of arc on the described casing.
Compared with prior art, the beneficial effects of the utility model are:
(1) the utility model is owing to be adsorbed on the end filtration membrane of quantitative suction pipe by the cell of sampling mechanical arm with the sample retention liquid of sample retention liquid cup, spend by the pivot arm 180 of rotation sampling mechanical arm then, the filtration membrane that is adsorbed with cell tissue evenly and is closely contacted with slide, thereby comparatively fully be transferred to cell tissue on the slide, rotate the slide erecting device then, after the slide dextrorotation turn 90 degrees, slide vertically is provided with, back down the slide clamping plate by the slide push rod again, slide is successfully fallen in the slide cup, thereby finish whole cell tissue in the sample retention liquid is passed by quantitative suction pipe smoothly and be loaded onto slide, automaticity is high and be convenient to operation;
(2) to exclude passage caliber (about 4.5mm) bigger for the waste liquid in the utility model sampling mechanical arm, waste liquid escape hole place just is connected with the waste liquid vent pipe simultaneously, waste liquid passing away caliber less (2.00mm) in this and the existing mechanical arm, the waste liquid drain does not run through whole waste liquid passing away, because the mordant waste liquid meeting corrosion waste liquid passing away in the smaller sample of whole passage caliber, make the waste liquid passing away stop up easily, cell is few when causing cell transfer like this, occur white sheet phenomenon sometimes, seriously influenced accurately performance of cell sampling ground; And the utility model waste liquid passing away caliber is big, and the waste liquid drain runs through whole passage, and waste liquid is expelled in the waste liquid recycling can completely, the cell that is transferred on the filtration membrane of quantitative suction pipe is more, avoid the generation of white phenomenon, simultaneously by the warning system of waste liquid recycling can to how much the monitoring of the waste liquid amount of waste liquid recycling can inside, when waste liquid was filled, warning system was sent the sound to remind the user;
(3) the utility model has been owing to used centrifugal stirring system, makes before smear work that sample stirs in the sample retention liquid cup, guarantee cell tissue evenly, make the cell that shifts can intactly reflect the efficient diagnosis composition in the sample;
(4) the utility model is provided with to be fixed on to support on the flap and can be used for moving back " L " type that unloads quantitative suction pipe when the dextrorotation of support flap turn 90 degrees and moves back and unload depression bar, move back by this " L " type and to unload depression bar and press down the sampling gland, because the sampling gland is connected with slip pushing sleeve one, and then promotion slip pushing sleeve is released quantitative suction pipe downwards, making quantitative suction pipe come off from suction sample mouth withdraws from, fall in the sample retention liquid cup, avoided the secondary pollution of directly quantitative suction pipe being taken out with staff in the prior art may, also improve its automation mechanized operation performance simultaneously.
(5) the utility model backs down slide clamping plate one end by the slide push rod, opens the slide clamping plate, makes the slide free-falling to the slide cup, designs ingenious, novel, simple to operation;
(6) the utility model smearing machine film-making process is quick, and whole film-making process is no more than 1.5 minutes;
(7) the utility model smearing machine can reset to each parts before film-making work and after finishing in real time accurately, and reseting performance is good, guarantees that the smooth and easy of film-making work carries out.
Description of drawings
Below in conjunction with the drawings and specific embodiments the utility model is described in detail:
Fig. 1 is the utility model cell smear machine structural representation;
Fig. 2 is the inner structure schematic perspective view of the utility model cell smear machine;
Fig. 3 is the Facad structure synoptic diagram of above-mentioned Fig. 2;
Fig. 4 is the mechanical arm configuration synoptic diagram of sampling in the utility model;
Fig. 5 is the synoptic diagram of the actuator linkage of sampling mechanical arm in the utility model;
Fig. 6 is the smearing machine inner side structural representation when sampling mechanical arm turns over after the turnback the cell transfer on the quantitative suction pipe diaphragm to slide in the utility model;
Fig. 7 is the waste liquid recycling can structural representation in the utility model;
Fig. 8 is a slide erecting device structural representation in the utility model;
Fig. 9 is a centrifugal stir system design synoptic diagram in the utility model;
Figure 10 moves back in the utility model to unload quantitative suction pipe and drop slide process synoptic diagram automatically.
Embodiment
Described in the utility model from hydrodynamic based thin-layer cell smearing machine, as Fig. 1, Fig. 2, shown in Figure 3, this cell smear machine, comprise casing 100 and body, be provided with inner skeleton 103 in the described body, base plate 102 is installed and riser 101 is installed, base plate 101 wherein is installed to be fixed on the inner skeleton 103, riser 102 is installed is vertically set on the top, middle part that base plate 101 is installed, the front space that base plate 101 and installation riser 102 are installed forms the working bin of cell smear machine, and the bottom of casing 100 is provided with the feet 127 that is used to support whole smearing machine; In addition, also be provided with the guidance panel 118 that is connected with the set electric control system of internal body at the right forward side of casing 100 medium position, arc is arranged in the front portion of casing 100, and be provided with the transparent display panel 117 of arc on the casing corresponding to the position of working bin, become to be slidingly connected between this arc transparent display panel 117 and the casing 100, it is little to take up room, and volume is little, and handled easily.
As shown in Figure 1 to Figure 3, in working bin, be provided with and be used to sample and transfer samples to sampling mechanical arm 109 on the slide, concrete structure such as Fig. 4 of sampling mechanical arm 109, Fig. 5, shown in Figure 6, be socketed with on the described sampling mechanical arm 109 and be used for the quantitative suction pipe 1099 that adherent cell sample and end are provided with filtration membrane, the below of sampling mechanical arm 109 is provided with sample retention liquid cup 126, the bottom of sample retention liquid cup 126 is provided with the uniform centrifugal stirring system 106 of the sample that makes in the sample retention liquid cup 126, in addition, the top of described sampling mechanical arm 109 is provided with the slide erecting device 110 that is used to install slide, the left side of this slide erecting device 110 is also corresponding to be provided with slide fallen to automatically and to fall the microslide device automatically in the slide cup 124, the slide cup is fixed on the left side lower position of installing on the riser 102 and placing slide erecting device 110 in the working bin, slide cup 124 places on the slide cup 125, also is provided with on the slide erecting device 110 moving back automatically of coming off automatically of quantitative suction pipe unloaded the film pipe unit.
As Fig. 1, Fig. 4, shown in Figure 6, the vertical opening chute 1021 that is provided with on the riser 102 is installed, as shown in Figure 3, sampling mechanical arm 109 comprises the pivot arm 1091 that is arranged in the opening chute and stretches out from the place ahead of working bin, place the rear side that riser 102 is installed to be used to control the actuator linkage 104 of pivot arm rotation and lifting, wherein be connected with on the pivot arm 1091 from sample and preserve the suction sample mouth 1097 of drawing sample the cup, inhale sample mouth 1097 and comprise suction nozzle lid and suction nozzle body portion, wherein the outer race on the top of suction nozzle body portion is provided with slip pushing sleeve 1098, the lower part of inhaling sample mouth 1097 bodys is arranged with quantitative suction pipe, the filtration membrane that the end of this quantitative suction pipe is provided with adsorbable cell and waste liquid is passed through, the top of inhaling sample mouth 1097 is provided with the sampling gland, this sampling gland is connected with slip pushing sleeve 1098 one by passing the sliding axle 1094 of inhaling sample mouth 1097 cap portion, and the outer race of sliding axle 1094 is provided with compression spring 1096.In addition, be provided with waste liquid escape hole 1093 in the junction of inhaling sample mouth 1097 and pivot arm 1091, described pivot arm 1091 inside are provided with waste liquid corresponding to the waste liquid escape hole and get rid of passage, be provided with waste liquid vent pipe 1092 in this waste liquid passing away, the end of waste liquid vent pipe 1092 is provided with vacuum suction pump 1069 (as shown in Figure 9), vacuum suction pump 1069 with waste collection to waste liquid recycling can 20, in order to detect the vacuum tightness of vacuum suction pump 1069 timely, described installation riser 102 rear sides also are provided with baroceptor 1071 and air pressure are carried out the converter 1070 of store buffer.
As shown in Figure 5, described actuator linkage 104 comprises the rotating driving device of driven in rotation arm 1091 rotations and the lifting drive of driven in rotation arm lifting, wherein lifting drive comprises the lifting motor 1047 that places on the installation base plate, the synchronous pulley transmission one that is connected with the output shaft of lifting motor 1047, be used for to its guiding of motion of belt wheel transmission one and the slide track component 1051 of supporting role, wherein synchronous pulley transmission one comprises synchronous pulley 1, synchronous pulley 2 1059, be stretched in and be with one 1051 synchronously on synchronous pulley 1 and the synchronous pulley 2 1059, the synchronous wheel shaft 1055 of synchronous pulley 2 1059 is connected on the transmission upper bracket 1057 by synchronous band bearing 1056, between the slide rail bearing 1049 bottom slide track component 1051 is installed on and the transmission upper bracket 1057 on top, be with synchronously and be connected with lifting platen 1041 on one 1050, this lifting platen 1041 is connected on the slide track component 1051 by slider roller group 30 corresponding to the slide rail position.
As shown in Figure 5, rotating driving device comprises electric rotating machine (not shown), the gear driving pair coaxial with the motor shaft of electric rotating machine, the gear shaft of described driving gear 1045 is coaxial with motor shaft, and gear shaft 1,043 one ends of follower gear 1042 are installed on the lifting platen 1041, the other end of gear shaft 1043 passes the opening chute 1021 that riser 102 is installed fixedlys connected with the pivot arm 1091 of sampling mechanical arm 109, and sampling mechanical arm 109 is freely rotated in 360 degree scopes.In addition, when starting lifting motor 1047, lifting motor drives one transmission of belt wheel transmission, thereby realizes the synchronization lifting of lifting platen 1041, and then drives sampling mechanical arm 109 synchronization liftings.By as can be known aforementioned,, finish from sample retention liquid cup, taking out cell sample and it being transferred to the process of slide 1111 in time of sampling mechanical arm 109 by actuator linkage can realize comparatively easily sampling lifting of mechanical arm ground and 360 degree rotations.
In addition, in order to respond to the suitable position of lifting platen 1041 preferably, guarantee that quantitative suction pipe 1099 can accurately take a sample and cell sample is transferred on the slide 1111, be connected with signal plate bearing 1056,1054 on the described transmission upper bracket, be connected signal plate 1052 and sensor 1053 on the signal plate bearing 1054; In addition, turn 90 degrees again and stop the rotation, also be connected with signal plate bearing 1044 on the described lifting platen 1041, and be connected signal plate and sensor (not shown) on this signal plate bearing 1044 in order to respond to pivot arm 1091 dextrorotation accurately.As shown in Figure 7, warning device when the waste liquid in the waste liquid recycling can is full of is set on the described waste liquid recycling can, be connected with two waste liquid connecting pipes and a signal line on the described waste liquid recycling can 20, this waste liquid connecting pipe is connected with the waste liquid vent pipe 1092 of sampling in the mechanical arm 109, warning device comprises the signal wire that is connected waste liquid recycling can 20 tops and is installed in hummer on the wiring board of electric control system, when liquid is filled in the waste liquid recycling can 20, hummer sends the sound, plays the effect of prompting.
As shown in Figure 8; slide erecting device 110 described in the utility model comprises rotary electric machine 130 (indicating among Figure 10); support flap 1102 with rotary electric machine 130 rotating shafts coaxial 1101; support flap 1102 and pass the mounting hole of being located on the installation riser; the unified horizontal level of described support flap 1102 is provided with sensor one bearing 121 and signal plate 120; the below of described support flap 1102 is connected with slide location-plate 1103 and the slide clamping plate 1104 that are used to clamp slide by coupling shaft 1105; the outer race of described coupling shaft 1105 is provided with spring 1110; and slide location-plate 1103 is corresponding hinged in left end with slide clamping plate 1104; and be provided with at the pin joint place of the two and be convenient to the torsion spring 1112 that can in time reset after slide clamping plate 1104 are opened; the top of described support flap 1102 is provided with signal plate 1108 and sensor support base 1107; this signal plate 1108 is with sensor support base 1107 and place the periphery of the sensor on the sensor support base 1107 to be covered with protective cover 1106; describedly move back automatically that to unload the film pipe unit be to be fixed on to support on the flap and unload moving back of quantitative suction pipe 1099 and unload depression bar 1109 when supporting to can be used for moving back when the flap dextrorotation turn 90 degrees, this moves back and unloads depression bar 1109 is " L " type depression bar structure.
As Fig. 1, Fig. 2, shown in Figure 10, it is described that to fall the microslide device automatically be to be arranged on the push rod holder 123 of the slide push rod 122 on the riser 102 being installed and being used for fixing slide push rod 122, after described slide erecting device 110 dextrorotations turn 90 degrees, slide push rod 122 backed down slide clamping plate 1104 corresponding to the end position of slide clamping plate 1104 and slide is unclamped automatically and falls to slide cup 124.
As shown in Figure 9, centrifugal stirring system 106 described in the utility model comprises stirring motor 1068, the synchronous pulley transmission two coaxial with the output shaft 1067 of stirring motor 1068, pass through bearing on the output shaft of synchronous pulley transmission two, bearing cap 1063 and bearing holder (housing, cover) 1064 are connected with driven shaft 1061, described driven shaft 1061 passes installation base plate 101 and its upper end is set with sample retention liquid cup 1060, described sample retention liquid cup 126 is positioned on this sample retention liquid cup 1060, this stirring motor 1068 places to be installed riser 102 rear sides and places the top position that base plate 101 is installed, and described synchronous pulley transmission two specifically comprises the synchronous pulley wheel shaft that the output shaft 1067 of stirring motor 1068 is coaxial, synchronous pulley 2 1066, synchronous pulley 1, be stretched in synchronous pulley one, 2 1066, be with one 1064 synchronously between 1065.
In the utility model, in order to improve the password locking function of smearing machine, the control chip of wiring board is provided with the password locking system in the described electric control system, can control user's the right to use by the password locking system, the user opens smearing machine, the interface that needs user cipher to enter can appear on the guidance panel 118 of smearing machine, have only input right user password just can carry out next step film-making smear work, and from guidance panel 118, can also reflect for example number of quantitative suction pipe 1099 of next spendable supporting consumptive material, when the number of matching used quantitative suction pipe 1099 is close to zero, user's information of purchase in time on guidance panel 118, also can occur reminding, guarantee the specificity that reagent is selected like this.
The course of work from hydrodynamic based thin-layer cell smearing machine of the present utility model is
(1) a certain mode of operation of starting up, described smearing machine can satisfy the film-making requirement of different specimens by 8 mode of operations for you to choose;
(2) enter certain mode of operation, the operation beginning, smearing machine can reset accurately to each parts, and installs slide between the slide clamping plate 1104 of slide erecting device 110 and slide location-plate 1103, puts quantitative suction pipe 1099 at the suction sample mouth 1097 of sampling mechanical arm 109;
(3) sampling mechanical arm 109 moves down the bottom position that makes quantitative suction pipe 1099 enter in the sample retention liquid cup 126 and approach sample retention liquid cup 126, at this moment, centrifugal stirring system 106 work, cell sample liquid in the sample retention liquid cup 126 is adsorbed on the filtration membrane of quantitative suction pipe 1099 equably, waste liquid enters to quantitative suction pipe 1099 inside simultaneously, sampling mechanical arm 109 turns over turnback clockwise, in process turningly, sampling mechanical arm 109 pause secondaries make waste liquid be expelled to waste liquid recycling can 20 by the effect of vacuum suction pump 1069 by the waste liquid vent pipe;
When (4) sampling mechanical arm 109 turns over turnback, rising makes the filtration membrane of quantitative suction pipe 1099 touch the cell collection district on the slide, slow again up-samples mechanical arm 109, quantitatively the end filtration membrane of suction pipe 1099 compresses the place, cell collection district of glass 1111, the cell tissue on the filtration membrane can be transferred to fully and up hill and dale the place, cell collection district of slide this moment;
(5) slide erecting device 110 clockwise 90 degree are rotated down, the vertical top position that places slide cup 124 of slide 1111 will be made, the upper end of slide clamping plate 1104 is corresponding to slide push rod 122 positions at this moment, back down slide clamping plate 1104 by slide push rod 122, slide is automatically fallen in the slide cup 124;
(6) continue to move up the sampling mechanical arm 109, at this moment, " L " type move back unload depression bar 1109 press down the sampling gland 1095, because sampling gland 1095 is connected with slip pushing sleeve 1098 one, and then promotion slip pushing sleeve 1098 is released quantitative suction pipe 1099 downwards, make quantitative suction pipe 1099 come off and withdraw from, fall in the sample retention liquid cup 126, thereby finish the process that drops automatically quantitative suction pipe 1099 from inhaling sample mouth 1097.
Above process be whole smearing machine sampling, gather cell sample, slide drops and the quantitative process that comes off of suction pipe, so circulation can be carried out the process of next smear, each film-making process is no more than 1.5 minutes, film-making is quick and convenient.
The utility model is not limited to above-mentioned embodiment, if various changes of the present utility model or modification are not broken away from spirit and scope of the present utility model, if these are changed and modification belongs within claim of the present utility model and the equivalent technologies scope, then the utility model also comprises these changes and modification.
Claims (10)
1. from hydrodynamic based thin-layer cell smearing machine, comprise casing and body, be provided with inner skeleton in the described body, base plate is installed and riser is installed, described installation base plate is fixed on the inner skeleton, described installation riser is vertically set on the top, middle part that base plate is installed, the front space of described installation base plate and installation riser forms the working bin of cell smear machine, the place ahead of described casing also is provided with the guidance panel that is connected with the set electric control system of internal body, it is characterized in that: be provided with in the described working bin and be used to sample and transfer samples to sampling mechanical arm on the slide, sampling is socketed with on the mechanical arm and is used for the quantitative suction pipe that adherent cell sample and end are provided with diaphragm, the below of described sampling mechanical arm is provided with sample retention liquid cup, the bottom of sample retention liquid cup is provided with the uniform centrifugal stirring system of the sample that makes in the sample retention liquid cup, the top of described sampling mechanical arm is provided with the slide erecting device that is used to install slide, the left side of described slide erecting device is also corresponding be provided with and with slide fall to automatically in the slide cup fall the microslide device automatically, described slide cup is fixed on the left side lower position of installing on the riser and placing slide erecting device in the working bin, the slide cup places on the slide cup, also is provided with on the described slide erecting device moving back automatically of coming off automatically of quantitative suction pipe unloaded the film pipe unit.
2. according to claim 1 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: the vertical opening chute that is provided with on the described installation riser, described sampling mechanical arm comprises the pivot arm that is arranged in the opening chute and stretches out from the place ahead of working bin, place the rear side that riser is installed to be used to control the actuator linkage of pivot arm rotation and lifting, be connected with on the described pivot arm from sample and preserve the suction sample mouth of drawing sample the cup, described suction sample mouth comprises suction nozzle lid and suction nozzle body portion, wherein the outer race on the top of suction nozzle body portion is provided with the slip pushing sleeve, the lower part of described suction sample mouth body is arranged with quantitative suction pipe, the diaphragm that the end of this quantitative suction pipe is provided with adsorbable cell and waste liquid is passed through, the top of described suction sample mouth is provided with the sampling gland, this sampling gland is connected with slip pushing sleeve one by passing the sliding axle of inhaling sample mouth cap portion, the outer race of described sliding axle is provided with compression spring, the junction of described suction sample mouth and pivot arm is provided with the waste liquid escape hole, described pivot arm inside is provided with waste liquid corresponding to the waste liquid escape hole and gets rid of passage, be provided with the waste liquid vent pipe in this waste liquid passing away, the end of described waste liquid vent pipe is provided with vacuum suction pump, by vacuum suction pump with waste collection to the waste liquid recycling can.
3. according to claim 2 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: described actuator linkage comprises the rotating driving device of driven in rotation arm rotation and the lifting drive of driven in rotation arm lifting, shown in lifting drive comprise and place the lifting motor of installing on the base plate, the belt wheel transmission one that is connected with the output shaft of lifting motor, be used for slide track component to the motion guide of belt wheel transmission one, between the slide rail bearing bottom described slide track component is installed on and the transmission upper bracket on top, described being with synchronously is connected with the lifting platen, and this lifting platen is connected on the slide rail by the slider roller group corresponding to the slide rail position; Described rotating driving device comprises electric rotating machine, the gear driving pair coaxial with the motor shaft of electric rotating machine, the follower gear of described gear driving pair is installed on the lifting platen, the gear shaft of described follower gear passes the opening chute that riser is installed fixedlys connected with the pivot arm of sampling mechanical arm, and the sampling mechanical arm is freely rotated in 360 degree scopes.
4. according to claim 3 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: the warning device when the waste liquid in the waste liquid recycling can is full of is set on the described waste liquid recycling can, this warning device comprises the signal wire that is connected waste liquid recycling can top, be installed in the hummer on the wiring board of electric control system, when the waste liquid recycling can was full, hummer sent the sound.
5. according to claim 4 from hydrodynamic based thin-layer cell smearing machine; it is characterized in that: described slide erecting device comprises rotary electric machine; the support flap coaxial with rotary electric machine; the below of described support flap is connected with slide location-plate and the slide clamping plate that are used to clamp slide by coupling shaft; slide location-plate and slide clamping plate are movably hinged; and be provided with at the pin joint place of the two and be convenient to the torsion spring that the slide clamping plate reset; the top of described support flap is provided with signal plate and sensor; the periphery of this signal plate and sensor is covered with protective cover; describedly move back automatically that to unload the film pipe unit be to be fixed on to support on the flap and unload moving back of quantitative suction pipe and unload depression bar when supporting to can be used for moving back when the flap dextrorotation turn 90 degrees, this moves back and unloads depression bar is " L " type depression bar structure.
6. according to claim 5 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: described to fall the microslide device automatically be to be arranged on the push rod holder of the slide push rod on the riser being installed and being used for fixing the slide push rod, after the dextrorotation of described slide erecting device turn 90 degrees, the slide push rod backed down the slide clamping plate corresponding to the end position of slide clamping plate and slide is unclamped automatically and falls in the slide cup.
7. according to claim 6 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: described centrifugal stirring system comprises stirring motor, the synchronous pulley transmission two coaxial with the motor shaft of stirring motor, be connected with driven shaft by bearing, bearing cap and bearing holder (housing, cover) on the output shaft of synchronous pulley transmission two, described driven shaft passes the installation base plate and its upper end is set with sample retention liquid cup, and described sample retention liquid cup is positioned on this sample retention liquid cup.
8. according to claim 7 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: described stirring motor places to be installed the riser rear side and places the top position that base plate is installed, described synchronous pulley transmission comprises the synchronous tape spool coaxial with motor shaft, synchronous pulley two, synchronous band, synchronous pulley one.
9. according to claim 1 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: the wiring board in the described electric control system is provided with the password locking system.
10. according to claim 1 from hydrodynamic based thin-layer cell smearing machine, it is characterized in that: the front portion of described casing is an arcuate structure, and the position of corresponding working bin is provided with the transparent panel of arc on the described casing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009200553216U CN201449349U (en) | 2009-04-24 | 2009-04-24 | Automatic liquid based lamina cell smear machine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200553216U CN201449349U (en) | 2009-04-24 | 2009-04-24 | Automatic liquid based lamina cell smear machine |
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| CN201449349U true CN201449349U (en) | 2010-05-05 |
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| CN2009200553216U Expired - Fee Related CN201449349U (en) | 2009-04-24 | 2009-04-24 | Automatic liquid based lamina cell smear machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102607905A (en) * | 2012-02-03 | 2012-07-25 | 山东建筑大学 | Device for automatically coating reagent on medical glass sheet |
| CN103837389A (en) * | 2014-03-25 | 2014-06-04 | 李秀荣 | Glass slide coating device |
| CN104155170A (en) * | 2014-08-28 | 2014-11-19 | 河南科技大学第一附属医院 | Slice-pushing and slice-arranging device of glass slide |
| CN106441974A (en) * | 2016-08-12 | 2017-02-22 | 福建工程学院 | Agricultural product automatic sampling instrument |
| CN108531392A (en) * | 2018-06-26 | 2018-09-14 | 佛山市第人民医院（中山大学附属佛山医院） | Cell separation machine temperature control system suitable for purification of islet cells |
| CN108613860A (en) * | 2018-07-27 | 2018-10-02 | 上海皓信生物科技有限公司 | Liquid-based pelleter |
| CN109030151A (en) * | 2018-07-27 | 2018-12-18 | 上海皓信生物科技有限公司 | Liquid-based flaking method |
| CN109297786A (en) * | 2018-12-07 | 2019-02-01 | 浙江易柏生物技术有限公司 | A kind of membrane type pelleter and its flaking method |
| CN110646256A (en) * | 2019-08-26 | 2020-01-03 | 四川金域医学检验中心有限公司 | Sheet taking device and method of liquid-based cell smear device |
| CN111466368A (en) * | 2020-03-30 | 2020-07-31 | 上海国兴医疗器械有限公司 | Liquid-based cell preservation liquid sealing device and using method thereof |
| CN111551417A (en) * | 2020-04-01 | 2020-08-18 | 郑州中普医疗器械有限公司 | Automatic film making device |
| CN114739776A (en) * | 2022-06-09 | 2022-07-12 | 山东师范大学 | Clinical laboratory uses blood smear device |
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| CN102607905A (en) * | 2012-02-03 | 2012-07-25 | 山东建筑大学 | Device for automatically coating reagent on medical glass sheet |
| CN103837389A (en) * | 2014-03-25 | 2014-06-04 | 李秀荣 | Glass slide coating device |
| CN104155170A (en) * | 2014-08-28 | 2014-11-19 | 河南科技大学第一附属医院 | Slice-pushing and slice-arranging device of glass slide |
| CN106441974A (en) * | 2016-08-12 | 2017-02-22 | 福建工程学院 | Agricultural product automatic sampling instrument |
| CN106441974B (en) * | 2016-08-12 | 2023-06-02 | 福建工程学院 | Automatic sampling instrument for agricultural products |
| CN108531392A (en) * | 2018-06-26 | 2018-09-14 | 佛山市第人民医院（中山大学附属佛山医院） | Cell separation machine temperature control system suitable for purification of islet cells |
| CN108531392B (en) * | 2018-06-26 | 2023-06-06 | 佛山市第一人民医院（中山大学附属佛山医院） | Cell separator temperature control system suitable for islet cell purification |
| CN109030151A (en) * | 2018-07-27 | 2018-12-18 | 上海皓信生物科技有限公司 | Liquid-based flaking method |
| CN109030151B (en) * | 2018-07-27 | 2021-05-25 | 上海皓信生物科技有限公司 | Liquid-based tableting method |
| CN108613860A (en) * | 2018-07-27 | 2018-10-02 | 上海皓信生物科技有限公司 | Liquid-based pelleter |
| CN109297786A (en) * | 2018-12-07 | 2019-02-01 | 浙江易柏生物技术有限公司 | A kind of membrane type pelleter and its flaking method |
| CN109297786B (en) * | 2018-12-07 | 2023-12-01 | 浙江易柏生物技术有限公司 | Film type pelleter and pelleter method thereof |
| CN110646256A (en) * | 2019-08-26 | 2020-01-03 | 四川金域医学检验中心有限公司 | Sheet taking device and method of liquid-based cell smear device |
| CN111466368A (en) * | 2020-03-30 | 2020-07-31 | 上海国兴医疗器械有限公司 | Liquid-based cell preservation liquid sealing device and using method thereof |
| CN111551417A (en) * | 2020-04-01 | 2020-08-18 | 郑州中普医疗器械有限公司 | Automatic film making device |
| CN111551417B (en) * | 2020-04-01 | 2023-08-11 | 郑州中普医疗器械有限公司 | Automatic film-making device |
| CN114739776B (en) * | 2022-06-09 | 2022-08-23 | 山东师范大学 | Clinical laboratory uses blood smear device |
| CN114739776A (en) * | 2022-06-09 | 2022-07-12 | 山东师范大学 | Clinical laboratory uses blood smear device |
| CN115144247B (en) * | 2022-09-02 | 2022-11-15 | 深圳明灏生物科技有限公司 | Smear device for liquid-based thin-layer cell detection |
| CN115144247A (en) * | 2022-09-02 | 2022-10-04 | 深圳明灏生物科技有限公司 | Smear device for liquid-based thin-layer cell detection |
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